Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in rats

Acta Cirurgica Brasileira

Volumn 28, Issue 4, 2013, Pages 245-250

  Leite, Camila Ferreira ^a   Marangoni, Fábio ^a   Camargo, Enilton Aparecido ^b   Braga, Angélica de Fátima de Assunção ^a   Toro, Ivan Felizardo Contrera ^a   Antunes, Edson ^a   Landucci, Elen Cristina Tiezem ^a   Mussi, Ricardo Kalaf ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b FEDERAL UNIVERSITY OF SERGIPE   (Brazil)

Author keywords

Animal; Inflammation; Models; Pulmonary ventilation; Rats; Simvastatin; Thoracic surgery

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MYELOPEROXIDASE; SIMVASTATIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTERY CLAMP; ARTICLE; BLOOD GAS ANALYSIS; CELL INFILTRATION; CONTROLLED STUDY; ENZYME ACTIVITY; EXTRAVASATION; FEEDING; LUNG EDEMA; MALE; NEUTROPHIL; NONHUMAN; ONE LUNG VENTILATION; PNEUMONIA; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; C-REACTIVE PROTEIN; CYTOKINES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LUNG; MALE; MODELS, ANIMAL; NEUTROPHIL INFILTRATION; ONE-LUNG VENTILATION; PEROXIDASE; RANDOM ALLOCATION; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SIMVASTATIN; THORACIC SURGICAL PROCEDURES;

EID: 84876943741     PISSN: 01028650     EISSN: 16782674     Source Type: Journal    
DOI: 10.1590/S0102-86502013000400003     Document Type: Article

References (20)

1. Olivant Fisher A, Husain K, Wolfson MR, Hubert TL, Rodriguez E, Shaffer TH, Shaffer TH, Theroux MC. Hyperoxia during one lung ventilation: inflammatory and oxidative responses. Pediatr Pulmonol. 2012;47(10):979-86.
2. Tsai JA, Lund M, Lundell L, Nilsson-Ekdahl K. One-lung ventilation during thoracoabdominal esophagectomy elicits complement activation. J Surg Res. 2009;152(2):331-7.
3. Gothard J. Lung injury after thoracic surgery and one-lung ventilation. Curr Opin Anaesthesiol. 2006;19(1):5-10.
4. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 2000;342(18):1334-49.
5. Hothersall E, McSharry C, Thomson NC. Potential therapeutic role for statins in respiratory disease. Thorax. 2006;61(8):729-34.
6. Naidu BV, Woolley SM, Farivar AS, Thomas R, Fraga C, Mulligan MS. Simvastatin ameliorates injury in an experimental model of lung ischemia-reperfusion. J Thorac Cardiovasc Surg. 2003;126(2):482-9.
7. Pruefer D, Scalia R, Lefer AM. Simvastatin inhibits leukocyteendothelial cell interactions and protects against inflammatory processes in normocholesterolemic rats. Arterioscler Thromb Vasc Biol. 1999;19(12):2894-900.
8. Shao H, Shen Y, Liu H, Dong G, Qiang J, Jing H. Simvastatin suppresses lung inflammatory response in a rat cardiopulmonary bypass model. Ann Thorac Surg. 2007;84(6):2011-8.
9. Johnson BA, Iacono AT, Zeevi A, McCurry KR, Duncan SR. Statin use is associated with improved function and survival of lung allografts. Am J Respir Crit Care Med. 2003;167(9):1271-8.
10. Leite CF, Calixto MC, Toro IFC, Antunes E, Mussi RK. Characterization of Pulmonary and systemic inflammatory responses produced by lung re-expansion after one-lung ventilation. J Cardiothorac Vasc Anesth. 2012;26(3):427-32.
11. Leite CF, Toro IFC, Antunes E, Mussi RK. Standardization of a method of prolonged thoracic surgery and mechanical ventilation in rats to evaluate local and systemic inflammation. Acta Cir Bras. 2011;26(1):38-43.
12. de Carvalho MEP, Dolhnikoff M, Meireles SI, Reis LFL, Martins MA, Deheinzelin D. Effects of overinflation on procollagen type III expression in experimental acute lung injury. Crit Care. 2007;11(1):R23.
13. Bradley PP, Priebat DA, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol. 1982;78(3):206-9.
14. Bhabra MS, Hopkinson DN, Shaw TE, Onwu N, Hooper TL. Controlled reperfusion protects lung grafts during a transient early increase in permeability. Ann Thorac Surg. 1998;65(1):187-92.
15. Nezić L, Skrbić R, Dobrić S, Stojiljković MP, Jaćević V, Satara SS, Milovanović ZA, Stojaković N. Simvastatin and indomethacin have similar anti-inflammatory activity in a rat model of acute local inflammation. Basic Clin Pharmacol Toxicol. 2009;104(3):185-91.
16. Padley SPG, Jordan SJ, Goldstraw P, Wells AU, Hansell DM. Asymmetric ARDS following pulmonary resection: CT findings initial observations. Radiology. 2002;223(2):468-73.
17. Yin K, Gribbin E, Emanuel S, Orndorff R, Walker J, Weese J, Fallahnejad M. Histochemical alterations in one lung ventilation. J Surg Res. 2007;137(1):16-20.
18. Liu D, Zeng BX, Zhang SH, Yao SL. Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, reduces pulmonary inflammatory response in a rat model of endotoxemia. Inflamm Res. 2005;54(11):464-70.
19. Liu R, Ishibe Y, Ph D, Ueda M. Isoflurane-sevoflurane adminstration before ischemia attenuates ischemia-reperfusion-induced injury in isolated rat lungs. Anesthesiology. 2000;92(3):833-40.
20. Pleiner J, Schaller G, Mittermayer F, Zorn S, Marsik C, Polterauer S, Kapiotis S, Wolzt M. Simvastatin prevents vascular hyporeactivity during inflammation. Circulation. 2004;110(21):3349-54.