메뉴 건너뛰기




Volumn 36, Issue , 2015, Pages 88-25

Treating Ebola patients: A 'bottom up' approach using generic statins and angiotensin receptor blockers

(2)  Fedson, David S a   Rordam, Ole Martin b  

a NONE   (France)
b NONE   (Norway)

Author keywords

'Bottom up'; Angiotensin receptor blockers; Ebola; Endothelial dysfunction; Host response; Statins

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; ATORVASTATIN; BIPHENYL DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IRBESARTAN; TETRAZOLE DERIVATIVE;

EID: 84934300285     PISSN: 12019712     EISSN: 18783511     Source Type: Journal    
DOI: 10.1016/j.ijid.2015.04.019     Document Type: Short Survey
Times cited : (42)

References (52)
  • 1
    • 84922311621 scopus 로고    scopus 로고
    • West African Ebola epidemic after one year-slowing but not yet under control
    • WHO Ebola response team
    • West African Ebola epidemic after one year-slowing but not yet under control. N Engl J Med 2015, 372:584-587. WHO Ebola response team.
    • (2015) N Engl J Med , vol.372 , pp. 584-587
  • 4
    • 84912539210 scopus 로고    scopus 로고
    • Clinical care of two patients with Ebola virus disease in the United States
    • Lyon G.M., Mehta A.K., Varkey J.B., Brantly K., Plyler L., McElroy A.K., et al. Clinical care of two patients with Ebola virus disease in the United States. N Engl J Med 2014, 371:2402-2409.
    • (2014) N Engl J Med , vol.371 , pp. 2402-2409
    • Lyon, G.M.1    Mehta, A.K.2    Varkey, J.B.3    Brantly, K.4    Plyler, L.5    McElroy, A.K.6
  • 5
    • 84928697923 scopus 로고    scopus 로고
    • Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care
    • Wolf T., Kann G., Becker S., Stephan C., Brodt H.R., de Leuw P., et al. Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care. Lancet 2015, 385:1428-1435.
    • (2015) Lancet , vol.385 , pp. 1428-1435
    • Wolf, T.1    Kann, G.2    Becker, S.3    Stephan, C.4    Brodt, H.R.5    de Leuw, P.6
  • 6
    • 77951709095 scopus 로고    scopus 로고
    • Pleotropic effects of statins-basic research and clinical perspectives
    • Zhou Q., Liao J.K. Pleotropic effects of statins-basic research and clinical perspectives. Circ J 2010, 74:818-826.
    • (2010) Circ J , vol.74 , pp. 818-826
    • Zhou, Q.1    Liao, J.K.2
  • 8
    • 84894487816 scopus 로고    scopus 로고
    • Statins as regulators of redox state in the vascular endothelium: beyond lipid lowering
    • Margaritis M., Channon K.M., Antoniades C. Statins as regulators of redox state in the vascular endothelium: beyond lipid lowering. Antioxid Redox Signal 2014, 20:1198-1215.
    • (2014) Antioxid Redox Signal , vol.20 , pp. 1198-1215
    • Margaritis, M.1    Channon, K.M.2    Antoniades, C.3
  • 10
    • 84874875218 scopus 로고    scopus 로고
    • Inhibition of Rho and Rac geranylgeranylation by atorvastatin is critical for preservation of endothelial junction integrity
    • e59233
    • Xiao H.B., Xiong Q., Ping D., Zuo K.Q. Inhibition of Rho and Rac geranylgeranylation by atorvastatin is critical for preservation of endothelial junction integrity. PLoS One 2013, 8:e59233.
    • (2013) PLoS One , vol.8
    • Xiao, H.B.1    Xiong, Q.2    Ping, D.3    Zuo, K.Q.4
  • 12
    • 0348147492 scopus 로고    scopus 로고
    • Ebola hemorrhagic fever and septic shock
    • Bray M., Mahanty S. Ebola hemorrhagic fever and septic shock. J Infect Dis 2003, 188:1613-1617.
    • (2003) J Infect Dis , vol.188 , pp. 1613-1617
    • Bray, M.1    Mahanty, S.2
  • 13
    • 80054741233 scopus 로고    scopus 로고
    • Basic clinical and laboratory features of filoviral hemorrhagic fever
    • Kortepeter M.G., Bausch D.G., Bray M. Basic clinical and laboratory features of filoviral hemorrhagic fever. J Infect Dis 2011, 204(Suppl 3):S810-S816.
    • (2011) J Infect Dis , vol.204 , Issue.SUPPL 3 , pp. S810-S816
    • Kortepeter, M.G.1    Bausch, D.G.2    Bray, M.3
  • 14
    • 84882637960 scopus 로고    scopus 로고
    • Biomarkers of endothelial activation/dysfunction in infectious diseases
    • Page A.V., Liles W.C. Biomarkers of endothelial activation/dysfunction in infectious diseases. Virulence 2013, 4:507-516.
    • (2013) Virulence , vol.4 , pp. 507-516
    • Page, A.V.1    Liles, W.C.2
  • 15
    • 84923014522 scopus 로고    scopus 로고
    • Endothelial barrier dysfunction in septic shock
    • Opal S.M., van der Poll T. Endothelial barrier dysfunction in septic shock. J Intern Med 2014, 277:277-293.
    • (2014) J Intern Med , vol.277 , pp. 277-293
    • Opal, S.M.1    van der Poll, T.2
  • 16
    • 84355162830 scopus 로고    scopus 로고
    • Do viral infections mimic bacterial sepsis? The role of microvascular permeability: a review of mechanisms and methods
    • Steinberg B.E., Goldenberg N.M., Lee W.L. Do viral infections mimic bacterial sepsis? The role of microvascular permeability: a review of mechanisms and methods. Antiviral Res 2012, 93:2-15.
    • (2012) Antiviral Res , vol.93 , pp. 2-15
    • Steinberg, B.E.1    Goldenberg, N.M.2    Lee, W.L.3
  • 17
    • 84911371938 scopus 로고    scopus 로고
    • Host generic diversity enables Ebola hemorrhagic fever pathogenesis and resistance
    • Rasmussen A.L., Okumura A., Ferris M.T., Green R., Feldmann F., Kelly S.M., et al. Host generic diversity enables Ebola hemorrhagic fever pathogenesis and resistance. Science 2014, 346:987-991.
    • (2014) Science , vol.346 , pp. 987-991
    • Rasmussen, A.L.1    Okumura, A.2    Ferris, M.T.3    Green, R.4    Feldmann, F.5    Kelly, S.M.6
  • 18
    • 84926187312 scopus 로고    scopus 로고
    • Ebola: a holistic approach is required to achieve effective management and control
    • Roca A., Afolabi M.O., Saidu Y., Kampmann B. Ebola: a holistic approach is required to achieve effective management and control. J Allergy Clin Immunol 2015, 135:856-867.
    • (2015) J Allergy Clin Immunol , vol.135 , pp. 856-867
    • Roca, A.1    Afolabi, M.O.2    Saidu, Y.3    Kampmann, B.4
  • 19
    • 84869020353 scopus 로고    scopus 로고
    • Population-based study of statins, angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors on pneumonia-related outcomes
    • Mortensen E.M., Nakashima B., Cornell J., Copeland L.A., Pugh M.J., Anzueto A., et al. Population-based study of statins, angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors on pneumonia-related outcomes. Clin Infect Dis 2012, 55:1466-1473.
    • (2012) Clin Infect Dis , vol.55 , pp. 1466-1473
    • Mortensen, E.M.1    Nakashima, B.2    Cornell, J.3    Copeland, L.A.4    Pugh, M.J.5    Anzueto, A.6
  • 20
    • 84555195641 scopus 로고    scopus 로고
    • Association between use of statins and mortality among patients hospitalized with laboratory-confirmed influenza virus infections: a multistate study
    • Vandermeer M.L., Thomas A.R., Kamimoto L., Reingold A., Gershman K., Meek J., et al. Association between use of statins and mortality among patients hospitalized with laboratory-confirmed influenza virus infections: a multistate study. J Infect Dis 2012, 205:13-19.
    • (2012) J Infect Dis , vol.205 , pp. 13-19
    • Vandermeer, M.L.1    Thomas, A.R.2    Kamimoto, L.3    Reingold, A.4    Gershman, K.5    Meek, J.6
  • 21
    • 84870725702 scopus 로고    scopus 로고
    • Randomized double-blind placebo-controlled trial of 40mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial)
    • Patel J.M., Snaith C., Thickett D.R., Linhartova L., Melody T., Hawkey P., et al. Randomized double-blind placebo-controlled trial of 40mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial). Crit Care 2012, 16:R231.
    • (2012) Crit Care , vol.16 , pp. R231
    • Patel, J.M.1    Snaith, C.2    Thickett, D.R.3    Linhartova, L.4    Melody, T.5    Hawkey, P.6
  • 22
    • 76749114403 scopus 로고    scopus 로고
    • Selective blockade of endothelial NF-κB pathway differentially affects systemic inflammation and multiple organ dysfunction and injury in septic mice
    • Xu H., Ye X., Steibert H., Liu S.F. Selective blockade of endothelial NF-κB pathway differentially affects systemic inflammation and multiple organ dysfunction and injury in septic mice. J Pathol 2010, 220:490-498.
    • (2010) J Pathol , vol.220 , pp. 490-498
    • Xu, H.1    Ye, X.2    Steibert, H.3    Liu, S.F.4
  • 23
    • 18844442889 scopus 로고    scopus 로고
    • Effect of atorvastatin and irbesartan, alone and in combination, on postprandial endothelial dysfunction, oxidative stress and inflammation in type 2 diabetic patients
    • Ceriello A., Assaloni R., Da Ros R., Maier A., Piconi L., Quagliaro L., et al. Effect of atorvastatin and irbesartan, alone and in combination, on postprandial endothelial dysfunction, oxidative stress and inflammation in type 2 diabetic patients. Circulation 2005, 111:2518-2524.
    • (2005) Circulation , vol.111 , pp. 2518-2524
    • Ceriello, A.1    Assaloni, R.2    Da Ros, R.3    Maier, A.4    Piconi, L.5    Quagliaro, L.6
  • 24
    • 84892955353 scopus 로고    scopus 로고
    • Statins and renin-angiotensin system inhibitor combination treatment to prevent cardiovascular disease
    • Lee H.Y., Sakuma I., Ihm S.H., Goh C.W., Koh K.K. Statins and renin-angiotensin system inhibitor combination treatment to prevent cardiovascular disease. Circ J 2014, 78:281-287.
    • (2014) Circ J , vol.78 , pp. 281-287
    • Lee, H.Y.1    Sakuma, I.2    Ihm, S.H.3    Goh, C.W.4    Koh, K.K.5
  • 25
    • 84922471096 scopus 로고    scopus 로고
    • A practical treatment for patients with Ebola virus disease
    • Fedson D.S. A practical treatment for patients with Ebola virus disease. J Infect Dis 2015, 211:661-662.
    • (2015) J Infect Dis , vol.211 , pp. 661-662
    • Fedson, D.S.1
  • 27
    • 12144288615 scopus 로고    scopus 로고
    • Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome
    • Towner J.S., Rollin P.E., Bausch D.G., Sanchez A., Crary S.M., Vincent M., et al. Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome. J Virol 2004, 78:4330-4341.
    • (2004) J Virol , vol.78 , pp. 4330-4341
    • Towner, J.S.1    Rollin, P.E.2    Bausch, D.G.3    Sanchez, A.4    Crary, S.M.5    Vincent, M.6
  • 30
    • 84906079218 scopus 로고    scopus 로고
    • Debate erupts on 'repurposed' drugs for Ebola
    • Enserink M. Debate erupts on 'repurposed' drugs for Ebola. Science 2014, 345:718-719.
    • (2014) Science , vol.345 , pp. 718-719
    • Enserink, M.1
  • 31
    • 84907261920 scopus 로고    scopus 로고
    • Ebolavirus in West Africa, and the use of experimental therapies or vaccines
    • Hoenen T., Feldman H. Ebolavirus in West Africa, and the use of experimental therapies or vaccines. BMC Biol 2014, 12:80.
    • (2014) BMC Biol , vol.12 , pp. 80
    • Hoenen, T.1    Feldman, H.2
  • 34
    • 80054769818 scopus 로고    scopus 로고
    • Real-time monitoring of cardiovascular function in rhesus macaques infected with Zaire ebolavirus
    • Kortepeter M.G., Lawler J.V., Honko A., Bray M., Johnson J.C., Purcell B.K., et al. Real-time monitoring of cardiovascular function in rhesus macaques infected with Zaire ebolavirus. J Infect Dis 2011, 204(Suppl 3):S1000-S1010.
    • (2011) J Infect Dis , vol.204 , Issue.SUPPL 3 , pp. S1000-S1010
    • Kortepeter, M.G.1    Lawler, J.V.2    Honko, A.3    Bray, M.4    Johnson, J.C.5    Purcell, B.K.6
  • 35
    • 84908287083 scopus 로고    scopus 로고
    • Ebola in West Africa: from disease outbreak to humanitarian crisis
    • Piot P., Muyembe J.J., Edmunds W.J. Ebola in West Africa: from disease outbreak to humanitarian crisis. Lancet Infect Dis 2014, 14:1034-1035.
    • (2014) Lancet Infect Dis , vol.14 , pp. 1034-1035
    • Piot, P.1    Muyembe, J.J.2    Edmunds, W.J.3
  • 37
    • 84919723511 scopus 로고    scopus 로고
    • Guidelines for treatment of patients with Ebola virus disease are urgently needed
    • (accessed 10.04.14)
    • Petersen E., Maiga B. Guidelines for treatment of patients with Ebola virus disease are urgently needed. Int J Infect Dis 2015, 30:85-86. Available at: http://dx.doi.org/10.1016/j.ijid.2014.12.002 (accessed 10.04.14).
    • (2015) Int J Infect Dis , vol.30 , pp. 85-86
    • Petersen, E.1    Maiga, B.2
  • 40
    • 84919682888 scopus 로고    scopus 로고
    • Ebola virus disease: clinical care and patient-centred research
    • Roberts I., Perner A. Ebola virus disease: clinical care and patient-centred research. Lancet 2014, 384:2001-2002.
    • (2014) Lancet , vol.384 , pp. 2001-2002
    • Roberts, I.1    Perner, A.2
  • 41
    • 84928698500 scopus 로고    scopus 로고
    • Ebola: the battle plan must include specific treatments
    • Dunning J., Fischer W. Ebola: the battle plan must include specific treatments. Lancet 2015, 385:1373-1375.
    • (2015) Lancet , vol.385 , pp. 1373-1375
    • Dunning, J.1    Fischer, W.2
  • 44
    • 84928701028 scopus 로고    scopus 로고
    • Ebola and provision of critical care
    • on behalf of the Ebola Clinical Care Authors Group
    • Murthy S. Ebola and provision of critical care. Lancet 2015, 385:1392-1393. on behalf of the Ebola Clinical Care Authors Group.
    • (2015) Lancet , vol.385 , pp. 1392-1393
    • Murthy, S.1
  • 45
    • 34548293165 scopus 로고    scopus 로고
    • From scarcity to abundance: pandemic vaccines and other agents for "have not" countries
    • Fedson D.S., Dunnill P. From scarcity to abundance: pandemic vaccines and other agents for "have not" countries. J Public Health Policy 2007, 28:322-340.
    • (2007) J Public Health Policy , vol.28 , pp. 322-340
    • Fedson, D.S.1    Dunnill, P.2
  • 47
    • 84907391790 scopus 로고    scopus 로고
    • Emerging viral diseases: confronting threats with new technologies
    • 253ps10
    • Marston H.D., Folkers G.K., Morens D.M., Fauci A.S. Emerging viral diseases: confronting threats with new technologies. Sci Transl Med 2014, 6:253ps10.
    • (2014) Sci Transl Med , vol.6
    • Marston, H.D.1    Folkers, G.K.2    Morens, D.M.3    Fauci, A.S.4
  • 48
    • 84884742016 scopus 로고    scopus 로고
    • Emerging infectious diseases: threats to human health and global stability
    • e1003467
    • Morens D.M., Fauci A.F. Emerging infectious diseases: threats to human health and global stability. PLoS Pathog 2013, 9:e1003467.
    • (2013) PLoS Pathog , vol.9
    • Morens, D.M.1    Fauci, A.F.2
  • 49
    • 84882370432 scopus 로고    scopus 로고
    • Treating influenza with statins and other immunomodulatory agents
    • Fedson D.S. Treating influenza with statins and other immunomodulatory agents. Antiviral Res 2013, 99:417-435.
    • (2013) Antiviral Res , vol.99 , pp. 417-435
    • Fedson, D.S.1
  • 50
    • 84891810978 scopus 로고    scopus 로고
    • How will physicians respond to the next influenza pandemic?
    • Fedson D.S. How will physicians respond to the next influenza pandemic?. Clin Infect Dis 2014, 58:233-237.
    • (2014) Clin Infect Dis , vol.58 , pp. 233-237
    • Fedson, D.S.1
  • 51
    • 84934329454 scopus 로고    scopus 로고
    • (accessed 10.04.14).
    • Multiple treatments for Ebola virus disease (EVD). ClinicalTrials.gov, NIH, USA; 2015. Available at: (accessed 10.04.14). https://clinicaltrials.gov/ct2/show/NCT02380625.
    • (2015) ClinicalTrials.gov, NIH, USA
  • 52
    • 84967171563 scopus 로고    scopus 로고
    • As Ebola wanes, trials jockey for patients
    • Kupperschmidt K. As Ebola wanes, trials jockey for patients. Science 2015, 348:40.
    • (2015) Science , vol.348 , pp. 40
    • Kupperschmidt, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.