-
2
-
-
84893156549
-
The mismatch between the health research and development (R&D) that is needed and the R&D that is undertaken: An overview of the problem, the causes, and solutions
-
R. F. Viergever, The mismatch between the health research and development (R&D) that is needed and the R&D that is undertaken: An overview of the problem, the causes, and solutions. Glob. Health Action 6, 22450 (2013).
-
(2013)
Glob. Health Action
, vol.6
, pp. 22450
-
-
Viergever, R.F.1
-
3
-
-
84871036375
-
Calculated with data from: Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010
-
R. Lozano, M. Naghavi, K. Foreman, S. Lim, K. Shibuya, V. Aboyans, J. Abraham, T. Adair, R. Aggarwal, S. Y. Ahn, M. Alvarado, H. R. Anderson, L. M. Anderson, K. G. Andrews, C. Atkinson, L. M. Baddour, S. Barker-Collo, D. H. Bartels, M. L. Bell, E. J. Benjamin et al., Calculated with data from: Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2095-2128 (2012).
-
(2012)
Lancet
, vol.380
, pp. 2095-2128
-
-
Lozano, R.1
Naghavi, M.2
Foreman, K.3
Lim, S.4
Shibuya, K.5
Aboyans, V.6
Abraham, J.7
Adair, T.8
Aggarwal, R.9
Ahn, S.Y.10
Alvarado, M.11
Anderson, H.R.12
Anderson, L.M.13
Andrews, K.G.14
Atkinson, C.15
Baddour, L.M.16
Barker-Collo, S.17
Bartels, D.H.18
Bell, M.L.19
Benjamin, E.J.20
more..
-
4
-
-
84903443426
-
Ebola viral disease outbreak - West Africa, 2014
-
M. G. Dixon, I. J. Schafer, Centers for Disease Control and Prevention (CDC), Ebola viral disease outbreak - West Africa, 2014. MMWR Morb. Mortal. Wkly. Rep. 63, 548-551 (2014).
-
(2014)
MMWR Morb. Mortal. Wkly. Rep.
, vol.63
, pp. 548-551
-
-
Dixon, M.G.1
Schafer, I.J.2
Centers for Disease Control and Prevention (CDC)3
-
6
-
-
84904734421
-
Global prevalence of norovirus in cases of gastroenteritis: A systematic review and meta-analysis
-
S. M. Ahmed, A. J. Hall, A. E. Robinson, L. Verhoef, P. Premkumar, U. D. Parashar, M. Koopmans, B. A. Lopman, Global prevalence of norovirus in cases of gastroenteritis: A systematic review and meta-analysis. Lancet Infect. Dis. 14, 725-730 (2014).
-
(2014)
Lancet Infect. Dis.
, vol.14
, pp. 725-730
-
-
Ahmed, S.M.1
Hall, A.J.2
Robinson, A.E.3
Verhoef, L.4
Premkumar, P.5
Parashar, U.D.6
Koopmans, M.7
Lopman, B.A.8
-
9
-
-
78049523629
-
Rapid detection of respiratory tract viral infections and coinfections in patients with influenza-like illnesses by use of reverse transcription-PCR DNA microarray systems
-
F. Renois, D. Talmud, A. Huguenin, L. Moutte, C. Strady, J. Cousson, N. Lévêque, L. Andréoletti, Rapid detection of respiratory tract viral infections and coinfections in patients with influenza-like illnesses by use of reverse transcription-PCR DNA microarray systems. J. Clin. Microbiol. 48, 3836-3842 (2010).
-
(2010)
J. Clin. Microbiol.
, vol.48
, pp. 3836-3842
-
-
Renois, F.1
Talmud, D.2
Huguenin, A.3
Moutte, L.4
Strady, C.5
Cousson, J.6
Lévêque, N.7
Andréoletti, L.8
-
10
-
-
79952363727
-
Ebola haemorrhagic fever
-
H. Feldmann, T. W. Geisbert, Ebola haemorrhagic fever. Lancet 377, 849-862 (2011).
-
(2011)
Lancet
, vol.377
, pp. 849-862
-
-
Feldmann, H.1
Geisbert, T.W.2
-
11
-
-
27944488810
-
SARS assessment clinic: A rapid response to an infectious outbreak
-
T. Rutledge, R. Penciner, K. Popovich, SARS assessment clinic: A rapid response to an infectious outbreak. CJEM 7, 162-167 (2005).
-
(2005)
CJEM
, vol.7
, pp. 162-167
-
-
Rutledge, T.1
Penciner, R.2
Popovich, K.3
-
12
-
-
55749111036
-
A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial
-
J. E. Martin, M. K. Louder, L. A. Holman, I. J. Gordon, M. E. Enama, B. D. Larkin, C. A. Andrews, L. Vogel, R. A. Koup, M. Roederer, R. T. Bailer, P. L. Gomez, M. Nason, J. R. Mascola, G. J. Nabel, B. S. Graham, VRC 301 Study Team, A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial. Vaccine 26, 6338-6343 (2008).
-
(2008)
Vaccine
, vol.26
, pp. 6338-6343
-
-
Martin, J.E.1
Louder, M.K.2
Holman, L.A.3
Gordon, I.J.4
Enama, M.E.5
Larkin, B.D.6
Andrews, C.A.7
Vogel, L.8
Koup, R.A.9
Roederer, M.10
Bailer, R.T.11
Gomez, P.L.12
Nason, M.13
Mascola, J.R.14
Nabel, G.J.15
Graham, B.S.16
-
13
-
-
84899641194
-
Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia
-
A. N. Alagaili, T. Briese, N. Mishra, V. Kapoor, S. C. Sameroff, P. D. Burbelo, E. de Wit, V. J. Munster, L. E. Hensley, I. S. Zalmout, A. Kapoor, J. H. Epstein, W. B. Karesh, P. Daszak, O. B. Mohammed, W. I. Lipkin, Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia. mBio. 5, e00884-e14 (2014).
-
(2014)
mBio.
, vol.5
, pp. e00884-e00914
-
-
Alagaili, A.N.1
Briese, T.2
Mishra, N.3
Kapoor, V.4
Sameroff, S.C.5
Burbelo, P.D.6
De Wit, E.7
Munster, V.J.8
Hensley, L.E.9
Zalmout, I.S.10
Kapoor, A.11
Epstein, J.H.12
Karesh, W.B.13
Daszak, P.14
Mohammed, O.B.15
Lipkin, W.I.16
-
14
-
-
84884232066
-
Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013
-
R. A. Perera, P. Wang, M. R. Gomaa, R. El-Shesheny, A. Kandeil, O. Bagato, L. Y. Siu, M. M. Shehata, A. S. Kayed, Y. Moatasim, M. Li, L. L. Poon, Y. Guan, R. J. Webby, M. A. Ali, J. S. Peiris, G. Kayali, Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013. Euro Surveill. 18, 20574 (2013).
-
(2013)
Euro Surveill.
, vol.18
, pp. 20574
-
-
Perera, R.A.1
Wang, P.2
Gomaa, M.R.3
El-Shesheny, R.4
Kandeil, A.5
Bagato, O.6
Siu, L.Y.7
Shehata, M.M.8
Kayed, A.S.9
Moatasim, Y.10
Li, M.11
Poon, L.L.12
Guan, Y.13
Webby, R.J.14
Ali, M.A.15
Peiris, J.S.16
Kayali, G.17
-
16
-
-
84907396242
-
Ebola - A growing threat?
-
H. Feldmann, Ebola - A growing threat? N. Engl. J. Med. 10.1056/NEJMp1405314 (2014).
-
(2014)
N. Engl. J. Med.
-
-
Feldmann, H.1
-
17
-
-
84881000429
-
Ebola: Facing a new transboundary animal disease?
-
F. Feldmann, H. Feldmann, Ebola: Facing a new transboundary animal disease? Dev. Biol. (Basel) 135, 201-209 (2013).
-
(2013)
Dev. Biol. (Basel)
, vol.135
, pp. 201-209
-
-
Feldmann, F.1
Feldmann, H.2
-
18
-
-
84884689519
-
A host-based RT-PCR gene expression signature to identify acute respiratory viral infection
-
A. K. Zaas, T. Burke, M. Chen, M. McClain, B. Nicholson, T. Veldman, E. L. Tsalik, V. Fowler, E. P. Rivers, R. Otero, S. F. Kingsmore, D. Voora, J. Lucas, A. O. Hero, L. Carin, C. W. Woods, G. S. Ginsburg, A host-based RT-PCR gene expression signature to identify acute respiratory viral infection. Sci. Transl. Med. 5, 203ra126 (2013).
-
(2013)
Sci. Transl. Med.
, vol.5
, pp. 203ra126
-
-
Zaas, A.K.1
Burke, T.2
Chen, M.3
McClain, M.4
Nicholson, B.5
Veldman, T.6
Tsalik, E.L.7
Fowler, V.8
Rivers, E.P.9
Otero, R.10
Kingsmore, S.F.11
Voora, D.12
Lucas, J.13
Hero, A.O.14
Carin, L.15
Woods, C.W.16
Ginsburg, G.S.17
-
19
-
-
84879882264
-
Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies
-
M. Kanekiyo, C. J. Wei, H. M. Yassine, P. M. McTamney, J. C. Boyington, J. R. Whittle, S. S. Rao, W. P. Kong, L. Wang, G. J. Nabel, Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies. Nature 499, 102-106 (2013).
-
(2013)
Nature
, vol.499
, pp. 102-106
-
-
Kanekiyo, M.1
Wei, C.J.2
Yassine, H.M.3
McTamney, P.M.4
Boyington, J.C.5
Whittle, J.R.6
Rao, S.S.7
Kong, W.P.8
Wang, L.9
Nabel, G.J.10
-
20
-
-
77957936654
-
Virus-like particles in vaccine development
-
A. Roldão, M. C. Mellado, L. R. Castilho, M. J. Carrondo, P. M. Alves, Virus-like particles in vaccine development. Expert Rev. Vaccines 9, 1149-1176 (2010).
-
(2010)
Expert Rev. Vaccines
, vol.9
, pp. 1149-1176
-
-
Roldão, A.1
Mellado, M.C.2
Castilho, L.R.3
Carrondo, M.J.4
Alves, P.M.5
-
21
-
-
84907006504
-
Chikungunya at the door - Déjà vu all over again?
-
D. M. Morens, A. S. Fauci, Chikungunya at the door - Déjà vu all over again? N. Engl. J. Med. 10.1056/NEJMp1408509 (2014).
-
(2014)
N. Engl. J. Med.
-
-
Morens, D.M.1
Fauci, A.S.2
-
22
-
-
84906571129
-
-
Centers for Disease Control and Prevention, Chikungunya in the Americas; www.cdc.gov/chikungunya/geo/americas.html.
-
Chikungunya in the Americas
-
-
-
23
-
-
84919842605
-
Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: A phase 1 dose-escalation trial
-
L. J. Chang, K. A. Dowd, F. H. Mendoza, J. G. Saunders, S. Sitar, S. H. Plummer, G. Yamshchikov, U. N. Sarwar, Z. Hu, M. E. Enama, R. T. Bailer, R. A. Koup, R. M. Schwartz, W. Akahata, G. J. Nabel, J. R. Mascola, T. C. Pierson, B. S. Graham, J. E. Ledgerwood, VRC 311 Study Team, Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: A phase 1 dose-escalation trial. Lancet 10.1016/S0140-6736(14)61185-5 (2014)
-
(2014)
Lancet
-
-
Chang, L.J.1
Dowd, K.A.2
Mendoza, F.H.3
Saunders, J.G.4
Sitar, S.5
Plummer, S.H.6
Yamshchikov, G.7
Sarwar, U.N.8
Hu, Z.9
Enama, M.E.10
Bailer, R.T.11
Koup, R.A.12
Schwartz, R.M.13
Akahata, W.14
Nabel, G.J.15
Mascola, J.R.16
Pierson, T.C.17
Graham, B.S.18
Ledgerwood, J.E.19
-
24
-
-
84883187027
-
Broadly neutralizing antibodies and the search for an HIV-1 vaccine: The end of the beginning
-
P. D. Kwong, J. R. Mascola, G. J. Nabel, Broadly neutralizing antibodies and the search for an HIV-1 vaccine: The end of the beginning. Nat. Rev. Immunol. 13, 693-701 (2013).
-
(2013)
Nat. Rev. Immunol.
, vol.13
, pp. 693-701
-
-
Kwong, P.D.1
Mascola, J.R.2
Nabel, G.J.3
-
25
-
-
84887287319
-
HIV surface proteins finally caught going au naturel
-
J. Cohen, HIV surface proteins finally caught going au naturel. Science 342, 546-547 (2013).
-
(2013)
Science
, vol.342
, pp. 546-547
-
-
Cohen, J.1
-
26
-
-
84887627657
-
Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia
-
M. Shingai, Y. Nishimura, F. Klein, H. Mouquet, O. K. Donau, R. Plishka, A. Buckler-White, M. Seaman, M. Piatak, Jr, J. D. Lifson, D. S. Dimitrov, M. C. Nussenzweig, M. A. Martin, Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature 503, 277-280 (2013).
-
(2013)
Nature
, vol.503
, pp. 277-280
-
-
Shingai, M.1
Nishimura, Y.2
Klein, F.3
Mouquet, H.4
Donau, O.K.5
Plishka, R.6
Buckler-White, A.7
Seaman, M.8
Piatak, M.9
Lifson, J.D.10
Dimitrov, D.S.11
Nussenzweig, M.C.12
Martin, M.A.13
-
27
-
-
0005241362
-
Active human immunodeficiency virus protease is required for viral infectivity
-
N. E. Kohl, E. A. Emini, W. A. Schleif, L. J. Davis, J. C. Heimbach, R. A. Dixon, E. M. Scolnick, I. S. Sigal, Active human immunodeficiency virus protease is required for viral infectivity. Proc. Natl. Acad. Sci. U.S.A. 85, 4686-4690 (1988).
-
(1988)
Proc. Natl. Acad. Sci. U.S.A.
, vol.85
, pp. 4686-4690
-
-
Kohl, N.E.1
Emini, E.A.2
Schleif, W.A.3
Davis, L.J.4
Heimbach, J.C.5
Dixon, R.A.6
Scolnick, E.M.7
Sigal, I.S.8
-
28
-
-
0036176766
-
Rational approach to AIDS drug design through structural biology
-
A. Wlodawer, Rational approach to AIDS drug design through structural biology. Annu. Rev. Med. 53, 595-614 (2002).
-
(2002)
Annu. Rev. Med.
, vol.53
, pp. 595-614
-
-
Wlodawer, A.1
-
29
-
-
0028303481
-
A novel assay for the DNA strand-transfer reaction of HIV-1 integrase
-
D. J. Hazuda, J. C. Hastings, A. L. Wolfe, E. A. Emini, A novel assay for the DNA strand-transfer reaction of HIV-1 integrase. Nucleic Acids Res. 22, 1121-1122 (1994).
-
(1994)
Nucleic Acids Res.
, vol.22
, pp. 1121-1122
-
-
Hazuda, D.J.1
Hastings, J.C.2
Wolfe, A.L.3
Emini, E.A.4
-
30
-
-
0024509701
-
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
-
Q. L. Choo, G. Kuo, A. J. Weiner, L. R. Overby, D. W. Bradley, M. Houghton, Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244, 359-362 (1989).
-
(1989)
Science
, vol.244
, pp. 359-362
-
-
Choo, Q.L.1
Kuo, G.2
Weiner, A.J.3
Overby, L.R.4
Bradley, D.W.5
Houghton, M.6
-
31
-
-
0028588064
-
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
-
Y. Chang, E. Cesarman, M. S. Pessin, F. Lee, J. Culpepper, D. M. Knowles, P. S. Moore, Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266, 1865-1869 (1994).
-
(1994)
Science
, vol.266
, pp. 1865-1869
-
-
Chang, Y.1
Cesarman, E.2
Pessin, M.S.3
Lee, F.4
Culpepper, J.5
Knowles, D.M.6
Moore, P.S.7
-
32
-
-
0034953901
-
A newly discovered human pneumovirus isolated from young children with respiratory tract disease
-
B. G. van den Hoogen, J. C. de Jong, J. Groen, T. Kuiken, R. de Groot, R. A. Fouchier, A. D. Osterhaus, A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat. Med. 7, 719-724 (2001).
-
(2001)
Nat. Med.
, vol.7
, pp. 719-724
-
-
Van Den Hoogen, B.G.1
De Jong, J.C.2
Groen, J.3
Kuiken, T.4
De Groot, R.5
Fouchier, R.A.6
Osterhaus, A.D.7
-
33
-
-
0004016899
-
-
World Health Organization, Hepatitis C; www.who.int/mediacentre/factsheets/fs164/en.
-
Hepatitis C
-
-
-
34
-
-
84855918331
-
Gaps in the achievement of eff ectiveness of HCV treatment in national VA practice
-
J. R. Kramer, F. Kanwal, P. Richardson, M. Mei, H. B. El-Serag, Gaps in the achievement of eff ectiveness of HCV treatment in national VA practice. J. Hepatol. 56, 320-325 (2012).
-
(2012)
J. Hepatol.
, vol.56
, pp. 320-325
-
-
Kramer, J.R.1
Kanwal, F.2
Richardson, P.3
Mei, M.4
El-Serag, H.B.5
-
35
-
-
84899101946
-
Curing chronic hepatitis C - The arc of a medical triumph
-
R. T. Chung, T. F. Baumert, Curing chronic hepatitis C - The arc of a medical triumph. N. Engl. J. Med. 370, 1576-1578 (2014).
-
(2014)
N. Engl. J. Med.
, vol.370
, pp. 1576-1578
-
-
Chung, R.T.1
Baumert, T.F.2
-
36
-
-
84885448756
-
Favipiravir (T-705), a novel viral RNA polymerase inhibitor
-
Y. Furuta, B. B. Gowen, K. Takahashi, K. Shiraki, D. F. Smee, D. L. Barnard, Favipiravir (T-705), a novel viral RNA polymerase inhibitor. Antiviral Res. 100, 446-454 (2013).
-
(2013)
Antiviral Res.
, vol.100
, pp. 446-454
-
-
Furuta, Y.1
Gowen, B.B.2
Takahashi, K.3
Shiraki, K.4
Smee, D.F.5
Barnard, D.L.6
-
37
-
-
79960828399
-
Broad-spectrum antiviral therapeutics
-
T. H. Rider, C. E. Zook, T. L. Boettcher, S. T. Wick, J. S. Pancoast, B. D. Zusman, Broad-spectrum antiviral therapeutics. PLOS One 6, e22572 (2011).
-
(2011)
PLOS One
, vol.6
, pp. e22572
-
-
Rider, T.H.1
Zook, C.E.2
Boettcher, T.L.3
Wick, S.T.4
Pancoast, J.S.5
Zusman, B.D.6
-
38
-
-
84874639752
-
An iminosugar with potent inhibition of dengue virus infection in vivo
-
S. T. Perry, M. D. Buck, E. M. Plummer, R. A. Penmasta, H. Batra, E. J. Stavale, K. L. Warfield, R. A. Dwek, T. D. Butters, D. S. Alonzi, S. M. Lada, K. King, B. Klose, U. Ramstedt, S. Shresta, An iminosugar with potent inhibition of dengue virus infection in vivo. Antiviral Res. 98, 35-43 (2013).
-
(2013)
Antiviral Res.
, vol.98
, pp. 35-43
-
-
Perry, S.T.1
Buck, M.D.2
Plummer, E.M.3
Penmasta, R.A.4
Batra, H.5
Stavale, E.J.6
Warfield, K.L.7
Dwek, R.A.8
Butters, T.D.9
Alonzi, D.S.10
Lada, S.M.11
King, K.12
Klose, B.13
Ramstedt, U.14
Shresta, S.15
-
39
-
-
84899439262
-
Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430
-
T. K. Warren, J. Wells, R. G. Panchal, K. S. Stuthman, N. L. Garza, S. A. Van Tongeren, L. Dong, C. J. Retterer, B. P. Eaton, G. Pegoraro, S. Honnold, S. Bantia, P. Kotian, X. Chen, B. R. Taubenheim, L. S. Welch, D. M. Minning, Y. S. Babu, W. P. Sheridan, S. Bavari, Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature 508, 402-405 (2014).
-
(2014)
Nature
, vol.508
, pp. 402-405
-
-
Warren, T.K.1
Wells, J.2
Panchal, R.G.3
Stuthman, K.S.4
Garza, N.L.5
Van Tongeren, S.A.6
Dong, L.7
Retterer, C.J.8
Eaton, B.P.9
Pegoraro, G.10
Honnold, S.11
Bantia, S.12
Kotian, P.13
Chen, X.14
Taubenheim, B.R.15
Welch, L.S.16
Minning, D.M.17
Babu, Y.S.18
Sheridan, W.P.19
Bavari, S.20
more..
-
40
-
-
84907409689
-
Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA
-
E. P. Thi, C. E. Mire, R. Ursic-Bedoya, J. B. Geisbert, A. C. H Lee, K. N. Agans, M. Robbins, D. J. Deer, K. A. Fenton, I. MacLachlan, T. W. Geisbert, Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA. Sci. Transl. Med. 6, 250ra116 (2014).
-
(2014)
Sci. Transl. Med.
, vol.6
, pp. 250ra116
-
-
Thi, E.P.1
Mire, C.E.2
Ursic-Bedoya, R.3
Geisbert, J.B.4
Lee, A.C.H.5
Agans, K.N.6
Robbins, M.7
Deer, D.J.8
Fenton, K.A.9
MacLachlan, I.10
Geisbert, T.W.11
|