메뉴 건너뛰기




Volumn 7, Issue 8, 2014, Pages 4765-4773

Thioredoxin-1 inhibitor PX-12 induces human acute myeloid leukemia cell apoptosis and enhances the sensitivity of cells to arsenic trioxide

Author keywords

Acute myeloid leukemia; Apoptosis; Arsenic trioxide; PX 12

Indexed keywords

ANTINEOPLASTIC AGENT; ARSENIC TRIOXIDE; DISULFIDE; IMIDAZOLE DERIVATIVE; IV 2 COMPOUND; ORGANOARSENIC DERIVATIVE; OXIDE; THIOREDOXIN; TXN PROTEIN, HUMAN;

EID: 84907919427     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (25)

References (43)
  • 1
    • 79951535539 scopus 로고    scopus 로고
    • Acute myeloid leukaemia in the elderly: a review
    • Pollyea DA, Kohrt HE and Medeiros BC. Acute myeloid leukaemia in the elderly: a review. Br J Haematol 2011; 152: 524-542.
    • (2011) Br J Haematol , vol.152 , pp. 524-542
    • Pollyea, D.A.1    Kohrt, H.E.2    Medeiros, B.C.3
  • 5
    • 0036214658 scopus 로고    scopus 로고
    • Advances in the management of acute promyelocytic leukemia and other hematologic malignancies with arsenic trioxide
    • Slack JL, Waxman S, Tricot G, Tallman MS and Bloomfield CD. Advances in the management of acute promyelocytic leukemia and other hematologic malignancies with arsenic trioxide. Oncologist 2002; 7 Suppl 1: 1-13.
    • (2002) Oncologist , vol.7 , Issue.1 , pp. 1-13
    • Slack, J.L.1    Waxman, S.2    Tricot, G.3    Tallman, M.S.4    Bloomfield, C.D.5
  • 8
    • 77957270582 scopus 로고    scopus 로고
    • Anti-miR-21 oligonucleotide sensitizes leukemic K562 cells to arsenic trioxide by inducing apoptosis
    • Li Y, Zhu X, Gu J, Dong D, Yao J, Lin C, Huang K and Fei J. Anti-miR-21 oligonucleotide sensitizes leukemic K562 cells to arsenic trioxide by inducing apoptosis. Cancer Sci 2010; 101: 948-954.
    • (2010) Cancer Sci , vol.101 , pp. 948-954
    • Li, Y.1    Zhu, X.2    Gu, J.3    Dong, D.4    Yao, J.5    Lin, C.6    Huang, K.7    Fei, J.8
  • 10
    • 58149352993 scopus 로고    scopus 로고
    • Thioredoxin system inhibitors as mediators of apoptosis for cancer therapy
    • Tonissen KF and Di Trapani G. Thioredoxin system inhibitors as mediators of apoptosis for cancer therapy. Mol Nutr Food Res 2009; 53: 87-103.
    • (2009) Mol Nutr Food Res , vol.53 , pp. 87-103
    • Tonissen, K.F.1    Di Trapani, G.2
  • 11
    • 84987819153 scopus 로고    scopus 로고
    • Thioredoxin/Txnip: Redoxisome, as a Redox Switch for the Pathogenesis of Diseases
    • Yoshihara E, Masaki S, Matsuo Y, Chen Z, Tian H and Yodoi J. Thioredoxin/Txnip: Redoxisome, as a Redox Switch for the Pathogenesis of Diseases. Front Immunol 2014; 4: 514.
    • (2014) Front Immunol , vol.4 , pp. 514
    • Yoshihara, E.1    Masaki, S.2    Matsuo, Y.3    Chen, Z.4    Tian, H.5    Yodoi, J.6
  • 12
    • 70449107252 scopus 로고    scopus 로고
    • Redox-directed cancer therapeutics: molecular mechanisms and opportunities
    • Wondrak GT. Redox-directed cancer therapeutics: molecular mechanisms and opportunities. Antioxid Redox Signal 2009; 11: 3013-3069.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 3013-3069
    • Wondrak, G.T.1
  • 13
    • 12244275240 scopus 로고    scopus 로고
    • The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging
    • Jordan BF, Runquist M, Raghunand N, Gillies RJ, Tate WR, Powis G and Baker AF. The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging. Clin Cancer Res 2005; 11: 529-536.
    • (2005) Clin Cancer Res , vol.11 , pp. 529-536
    • Jordan, B.F.1    Runquist, M.2    Raghunand, N.3    Gillies, R.J.4    Tate, W.R.5    Powis, G.6    Baker, A.F.7
  • 14
    • 31944432877 scopus 로고    scopus 로고
    • The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma
    • Baker AF, Dragovich T, Tate WR, Ramanathan RK, Roe D, Hsu CH, Kirkpatrick DL and Powis G. The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma. J Lab Clin Med 2006; 147: 83-90.
    • (2006) J Lab Clin Med , vol.147 , pp. 83-90
    • Baker, A.F.1    Dragovich, T.2    Tate, W.R.3    Ramanathan, R.K.4    Roe, D.5    Hsu, C.H.6    Kirkpatrick, D.L.7    Powis, G.8
  • 16
    • 0142144338 scopus 로고    scopus 로고
    • The Thioredoxin Redox Inhibitors 1-Methylpropyl 2-Imidazolyl Disulfide and Pleurotin Inhibit Hypoxia-induced Factor 1α and Vascular Endothelial Growth Factor Formation 1
    • Welsh SJ, Williams RR, Birmingham A, Newman DJ, Kirkpatrick DL and Powis G. The Thioredoxin Redox Inhibitors 1-Methylpropyl 2-Imidazolyl Disulfide and Pleurotin Inhibit Hypoxia-induced Factor 1α and Vascular Endothelial Growth Factor Formation 1. Mol Cancer Ther 2003; 2: 235-243.
    • (2003) Mol Cancer Ther , vol.2 , pp. 235-243
    • Welsh, S.J.1    Williams, R.R.2    Birmingham, A.3    Newman, D.J.4    Kirkpatrick, D.L.5    Powis, G.6
  • 17
    • 55449130109 scopus 로고    scopus 로고
    • The thioredoxin system: a key target in tumour and endothelial cells
    • Mukherjee A and Martin SG. The thioredoxin system: a key target in tumour and endothelial cells. Br J Radiol 2008; 81: S57-68.
    • (2008) Br J Radiol , vol.81 , pp. S57-68
    • Mukherjee, A.1    Martin, S.G.2
  • 18
    • 82255196136 scopus 로고    scopus 로고
    • miR-15a/16-1 enhances retinoic acid-mediated differentiation of leukemic cells and is up-regulated by retinoic acid
    • Gao SM, Yang J, Chen C, Zhang S, Xing CY, Li H, Wu J and Jiang L. miR-15a/16-1 enhances retinoic acid-mediated differentiation of leukemic cells and is up-regulated by retinoic acid. Leuk Lymphoma 2011; 52: 2365-2371.
    • (2011) Leuk Lymphoma , vol.52 , pp. 2365-2371
    • Gao, S.M.1    Yang, J.2    Chen, C.3    Zhang, S.4    Xing, C.Y.5    Li, H.6    Wu, J.7    Jiang, L.8
  • 19
    • 57749084479 scopus 로고    scopus 로고
    • Down-regulation of stathmin is required for TGF-beta inducible early gene 1 induced growth inhibition of pancreatic cancer cells
    • Jiang L, Chen Y, Chan CY, Wang X, Lin L, He ML, Lin MC, Yew DT, Sung JJ, Li JC and Kung HF. Down-regulation of stathmin is required for TGF-beta inducible early gene 1 induced growth inhibition of pancreatic cancer cells. Cancer Lett 2009; 274: 101-108.
    • (2009) Cancer Lett , vol.274 , pp. 101-108
    • Jiang, L.1    Chen, Y.2    Chan, C.Y.3    Wang, X.4    Lin, L.5    He, M.L.6    Lin, M.C.7    Yew, D.T.8    Sung, J.J.9    Li, J.C.10    Kung, H.F.11
  • 20
    • 0033568238 scopus 로고    scopus 로고
    • Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway
    • Jing Y, Dai J, Chalmers-Redman RM, Tatton WG and Waxman S. Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. Blood 1999; 94: 2102-2111.
    • (1999) Blood , vol.94 , pp. 2102-2111
    • Jing, Y.1    Dai, J.2    Chalmers-Redman, R.M.3    Tatton, W.G.4    Waxman, S.5
  • 22
    • 0036547417 scopus 로고    scopus 로고
    • Death and anti-death: tumour resistance to apoptosis
    • Igney FH and Krammer PH. Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer 2002; 2: 277-288.
    • (2002) Nat Rev Cancer , vol.2 , pp. 277-288
    • Igney, F.H.1    Krammer, P.H.2
  • 23
    • 64049106525 scopus 로고    scopus 로고
    • Immunotherapy of acute myeloid leukemia: current approaches
    • Smits EL, Berneman ZN and Van Tendeloo VF. Immunotherapy of acute myeloid leukemia: current approaches. Oncologist 2009; 14: 240-252.
    • (2009) Oncologist , vol.14 , pp. 240-252
    • Smits, E.L.1    Berneman, Z.N.2    Van Tendeloo, V.F.3
  • 24
    • 84879377399 scopus 로고    scopus 로고
    • The prevalent predicament of relapsed acute myeloid leukemia
    • Szer J. The prevalent predicament of relapsed acute myeloid leukemia. Hematology Am Soc Hematol Educ Program 2012; 2012: 43-48.
    • (2012) Hematology Am Soc Hematol Educ Program , vol.2012 , pp. 43-48
    • Szer, J.1
  • 26
    • 0034990527 scopus 로고    scopus 로고
    • Properties and biological activities of thioredoxins
    • Powis G and Montfort WR. Properties and biological activities of thioredoxins. Annu Rev Biophys Biomol Struct 2001; 30: 421-455.
    • (2001) Annu Rev Biophys Biomol Struct , vol.30 , pp. 421-455
    • Powis, G.1    Montfort, W.R.2
  • 28
    • 84891939128 scopus 로고    scopus 로고
    • PX-12 inhibits the growth of A549 lung cancer cells via G2/M phase arrest and ROS-dependent apoptosis
    • You BR, Shin HR and Park WH. PX-12 inhibits the growth of A549 lung cancer cells via G2/M phase arrest and ROS-dependent apoptosis. Int J Oncol 2014; 44: 301-308.
    • (2014) Int J Oncol , vol.44 , pp. 301-308
    • You, B.R.1    Shin, H.R.2    Park, W.H.3
  • 29
    • 79953784421 scopus 로고    scopus 로고
    • A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination
    • Ramanathan RK, Abbruzzese J, Dragovich T, Kirkpatrick L, Guillen JM, Baker AF, Pestano LA, Green S and Von Hoff DD. A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination. Cancer Chemother Pharmacol 2011; 67: 503-509.
    • (2011) Cancer Chemother Pharmacol , vol.67 , pp. 503-509
    • Ramanathan, R.K.1    Abbruzzese, J.2    Dragovich, T.3    Kirkpatrick, L.4    Guillen, J.M.5    Baker, A.F.6    Pestano, L.A.7    Green, S.8    Von Hoff, D.D.9
  • 30
    • 84886794743 scopus 로고    scopus 로고
    • PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion
    • Shin HR, You BR and Park WH. PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion. Oncol Lett 2013; 6: 1804-1810.
    • (2013) Oncol Lett , vol.6 , pp. 1804-1810
    • Shin, H.R.1    You, B.R.2    Park, W.H.3
  • 32
    • 67349157539 scopus 로고    scopus 로고
    • Enhancement of esculetin on arsenic trioxide-provoked apoptosis in human leukemia U937 cells
    • Lin TH, Lu FJ, Yin YF and Tseng TH. Enhancement of esculetin on arsenic trioxide-provoked apoptosis in human leukemia U937 cells. Chem Biol Interact 2009; 180: 61-68.
    • (2009) Chem Biol Interact , vol.180 , pp. 61-68
    • Lin, T.H.1    Lu, F.J.2    Yin, Y.F.3    Tseng, T.H.4
  • 33
    • 0030931876 scopus 로고    scopus 로고
    • Caspases: the executioners of apoptosis
    • Cohen G. Caspases: the executioners of apoptosis. Biochem J 1997; 326: 1-16.
    • (1997) Biochem J , vol.326 , pp. 1-16
    • Cohen, G.1
  • 34
    • 0036020953 scopus 로고    scopus 로고
    • Arsenic trioxide: acute promyelocytic leukemia and beyond
    • Bachleitner-Hofmann T, Kees M and Gisslinger H. Arsenic trioxide: acute promyelocytic leukemia and beyond. Leuk Lymphoma 2002; 43: 1535-1540.
    • (2002) Leuk Lymphoma , vol.43 , pp. 1535-1540
    • Bachleitner-Hofmann, T.1    Kees, M.2    Gisslinger, H.3
  • 35
    • 34547591628 scopus 로고    scopus 로고
    • Arsenic compounds in the treatment of multiple myeloma: a new role for a historical remedy
    • Berenson JR and Yeh HS. Arsenic compounds in the treatment of multiple myeloma: a new role for a historical remedy. Clin Lymphoma Myeloma 2006; 7: 192-198.
    • (2006) Clin Lymphoma Myeloma , vol.7 , pp. 192-198
    • Berenson, J.R.1    Yeh, H.S.2
  • 36
    • 0037192453 scopus 로고    scopus 로고
    • Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines
    • Nakagawa Y, Akao Y, Morikawa H, Hirata I, Katsu K, Naoe T, Ohishi N and Yagi K. Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines. Life Sci 2002; 70: 2253-2269.
    • (2002) Life Sci , vol.70 , pp. 2253-2269
    • Nakagawa, Y.1    Akao, Y.2    Morikawa, H.3    Hirata, I.4    Katsu, K.5    Naoe, T.6    Ohishi, N.7    Yagi, K.8
  • 38
    • 21044458142 scopus 로고    scopus 로고
    • Cell cycle arrest and apoptotic cell death in cultured human gastric carcinoma cells mediated by arsenic trioxide
    • Shao QS, Ye ZY, Ling ZQ and Ke JJ. Cell cycle arrest and apoptotic cell death in cultured human gastric carcinoma cells mediated by arsenic trioxide. World J Gastroenterol 2005; 11: 3451-6.
    • (2005) World J Gastroenterol , vol.11 , pp. 3451-3456
    • Shao, Q.S.1    Ye, Z.Y.2    Ling, Z.Q.3    Ke, J.J.4
  • 39
    • 67650071137 scopus 로고    scopus 로고
    • Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
    • Trachootham D, Alexandre J and Huang P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 2009; 8: 579-591.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 579-591
    • Trachootham, D.1    Alexandre, J.2    Huang, P.3
  • 41
    • 27444441930 scopus 로고    scopus 로고
    • Arsenic trioxide overcomes apoptosis inhibition in K562/ADM cells by regulating vital components in apoptotic pathway
    • Wang DH, Wei HL, Zhao HS, Hao CY, Min ZH and Liu JM. Arsenic trioxide overcomes apoptosis inhibition in K562/ADM cells by regulating vital components in apoptotic pathway. Pharmacol Res 2005; 52: 376-385.
    • (2005) Pharmacol Res , vol.52 , pp. 376-385
    • Wang, D.H.1    Wei, H.L.2    Zhao, H.S.3    Hao, C.Y.4    Min, Z.H.5    Liu, J.M.6
  • 42
    • 0346896407 scopus 로고    scopus 로고
    • Arsenic trioxide inhibits p-glycoprotein expression in multidrug-resistant human leukemia cells that overexpress the MDR1 gene
    • Wei H, Su H, Bai D, Zhao H, Ge J, Wang B, Yao X and Ma L. Arsenic trioxide inhibits p-glycoprotein expression in multidrug-resistant human leukemia cells that overexpress the MDR1 gene. Chin Med J (Engl) 2003; 116: 1644-1648.
    • (2003) Chin Med J (Engl) , vol.116 , pp. 1644-1648
    • Wei, H.1    Su, H.2    Bai, D.3    Zhao, H.4    Ge, J.5    Wang, B.6    Yao, X.7    Ma, L.8
  • 43
    • 41849089734 scopus 로고    scopus 로고
    • Redox status of thioredoxin-1 (TRX1) determines the sensitivity of human liver carcinoma cells (HepG2) to arsenic trioxide-induced cell death
    • Tian C, Gao P, Zheng Y, Yue W, Wang X, Jin H and Chen Q. Redox status of thioredoxin-1 (TRX1) determines the sensitivity of human liver carcinoma cells (HepG2) to arsenic trioxide-induced cell death. Cell Res 2008; 18: 458-471.
    • (2008) Cell Res , vol.18 , pp. 458-471
    • Tian, C.1    Gao, P.2    Zheng, Y.3    Yue, W.4    Wang, X.5    Jin, H.6    Chen, Q.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.