Proliposomes containing a bile salt for oral delivery of Ginkgo biloba extract: Formulation optimization, characterization, oral bioavailability and tissue distribution in rats

European Journal of Pharmaceutical Sciences

Volumn 77, Issue , 2015, Pages 254-264

  Zheng, Bin ^a   Teng, Lirong ^a   Xing, Gaoyang ^a   Bi, Ye ^a   Yang, Shuang ^a   Hao, Fei ^a   Yan, Guodong ^a   Wang, Xinmei ^b   Lee, Robert J ^a,b   Teng, Lesheng ^a   Xie, Jing ^a  

^a JILIN UNIVERSITY   (China)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Ginkgo biloba extract; Oral bioavailability; Proliposomes; Response surface methodology; Tissue distribution

Indexed keywords

DEOXYCHOLATE SODIUM; GINKGO BILOBA EXTRACT; GINKGOLIDE A; GINKGOLIDE B; GINKGOLIDE C; ISORHAMNETIN; KAEMPFEROL; LIPOSOME; PROLIPOSOME; QUERCETIN; UNCLASSIFIED DRUG; BILE ACID; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DELAYED DRUG RELEASE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG SOLUBILITY; FIELD EMISSION SCANNING ELECTRON MICROSCOPY; IN VITRO STUDY; INFRARED SPECTROSCOPY; LIPOSOMAL DELIVERY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; RESPONSE SURFACE METHOD; SPRAY DRYING; SURFACE PROPERTY; TARGET ORGAN; TIME TO MAXIMUM PLASMA CONCENTRATION; TISSUE DISTRIBUTION; ANIMAL; BIOAVAILABILITY; CHEMISTRY; GINKGO BILOBA; HALF LIFE TIME; ORAL DRUG ADMINISTRATION; SCANNING ELECTRON MICROSCOPY; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BILE ACIDS AND SALTS; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; GINKGO BILOBA; HALF-LIFE; LIPOSOMES; MALE; MICROSCOPY, ELECTRON, SCANNING; PLANT EXTRACTS; RATS; RATS, WISTAR; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TISSUE DISTRIBUTION;

EID: 84934285721     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.06.007     Document Type: Article

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