메뉴 건너뛰기




Volumn 80, Issue 2, 2012, Pages 347-357

Bioavailability enhancement of zaleplon via proliposomes: Role of surface charge

Author keywords

Bioavailability; Perfusion; Proliposomes; Stearylamine; Surface charge; Zaleplon

Indexed keywords

CHOLESTEROL; DICETYL PHOSPHATE; LIPOSOME; OCTADECYLAMINE; PROLIPOSOME; UNCLASSIFIED DRUG; ZALEPLON;

EID: 84856607426     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.10.010     Document Type: Conference Paper
Times cited : (94)

References (49)
  • 1
    • 0030712909 scopus 로고    scopus 로고
    • Improved oral bioavailability of the hypocholesterolemic DMP 565 in dogs following oral dosing in oil and glycol solutions
    • DOI 10.1002/(SICI)1099-081X(199711)18:8<737::AID-BDD59>3.0.CO;2-9
    • D.I. Burcham, M.B. Maurin, E.A. Hausner, and S.M. Huang Improved oral bioavailability of the hypocholestrolemic DMP 565 in dogs following oral dosing in oil and glycol solutions Biopharm. Drug Dispos. 18 1997 737 742 (Pubitemid 27475189)
    • (1997) Biopharmaceutics and Drug Disposition , vol.18 , Issue.8 , pp. 737-742
    • Burcham, D.L.1    Maurin, M.B.2    Hausner, E.A.3    Huang, S.-M.4
  • 2
    • 0032892423 scopus 로고    scopus 로고
    • Liposomes as a topical delivery system: The role of size on transport studied by the EPR imaging method
    • DOI 10.1016/S0168-3659(98)00181-3, PII S0168365998001813
    • M. Sentjurc, K. Vrhovnik, and J. Kristl Liposomes as a topical delivery system: the role of size on transport by the EPR imaging method J. Control. Release 1 1999 87 97 (Pubitemid 29187196)
    • (1999) Journal of Controlled Release , vol.59 , Issue.1 , pp. 87-97
    • Sentjurc, M.1    Vrhovnik, K.2    Kristl, J.3
  • 3
    • 0030614844 scopus 로고    scopus 로고
    • Physicochemical and physiological mechanisms for the effects of food on drug absorption: The role of lipids and pH
    • DOI 10.1021/js960085v
    • W.N. Charman, C.J.H. Porter, S. Mithani, and J.B. Dressman Physicochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH J. Pharm. Sci. 86 1997 269 282 (Pubitemid 27113759)
    • (1997) Journal of Pharmaceutical Sciences , vol.86 , Issue.3 , pp. 269-282
    • Charman, W.N.1    Porter, C.J.H.2    Mithani, S.3    Dressman, J.B.4
  • 5
    • 33751014029 scopus 로고    scopus 로고
    • Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system
    • DOI 10.1016/j.ejps.2006.04.016, PII S0928098706001151
    • C.W. Pouton Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system Eur. J. Pharm. Sci. 29 2006 278 287 (Pubitemid 44740131)
    • (2006) European Journal of Pharmaceutical Sciences , vol.29 , Issue.3-4 SPEC. ISS. , pp. 278-287
    • Pouton, C.W.1
  • 6
    • 33847394968 scopus 로고    scopus 로고
    • Lipids and lipid-based formulations: Optimizing the oral delivery of lipophilic drugs
    • DOI 10.1038/nrd2197, PII NRD2197
    • C.J.H. Porter, N.L. Trevaskis, and W.N. Charman Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs Nat. Rev. Drug Discov. 6 2007 231 248 (Pubitemid 46344627)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.3 , pp. 231-248
    • Porter, C.J.H.1    Trevaskis, N.L.2    Charman, W.N.3
  • 7
    • 0023664860 scopus 로고
    • Spontaneous fusion of phosphatidylcholine vesicles in the fluid phase
    • B.R. Lentz, T.J. Carpenter, and D.R. Alford Spontaneous fusion of phosphatidylcholine vesicles in the fluid phase Biochemistry 26 1987 5389 5397
    • (1987) Biochemistry , vol.26 , pp. 5389-5397
    • Lentz, B.R.1    Carpenter, T.J.2    Alford, D.R.3
  • 9
    • 0030831527 scopus 로고    scopus 로고
    • Encapsulation of calcitonin in liposomes depends on the vesicle preparation method
    • A. Arien, and B. Dupuy Encapsulation of calcitonin in liposomes depends in the vesicle preparation method J. Microencapsul. 14 1997 753 760 (Pubitemid 27483093)
    • (1997) Journal of Microencapsulation , vol.14 , Issue.6 , pp. 753-760
    • Arien, A.1    Dupuy, B.2
  • 10
    • 0032526501 scopus 로고    scopus 로고
    • Oral administration of liposomes containing cyclosporine: A pharmacokinetic study
    • A.M. Al-Meshal Oral administration of liposomes containing cyclosporine: a pharmacokinetic study Int. J. Pharm. 168 1998 163 168
    • (1998) Int. J. Pharm. , vol.168 , pp. 163-168
    • Al-Meshal, A.M.1
  • 11
    • 70349826289 scopus 로고    scopus 로고
    • Optimized preparation of vinpocetine proliposomes by a novel method and in vivo evaluation of its pharmacokinetics in New Zealand rabbits
    • H. Xu, L. He, S. Nie, J. Guan, X. Zhang, X. Yang, and W. Pan Optimized preparation of vinpocetine proliposomes by a novel method and in vivo evaluation of its pharmacokinetics in New Zealand rabbits J. Control. Release 140 2009 61 68
    • (2009) J. Control. Release , vol.140 , pp. 61-68
    • Xu, H.1    He, L.2    Nie, S.3    Guan, J.4    Zhang, X.5    Yang, X.6    Pan, W.7
  • 12
    • 23944494896 scopus 로고    scopus 로고
    • Enhanced intestinal absorption of salmon calcitonin (sCT) from proliposomes containing bile salts
    • K.H. Song, S.J. Chung, and C.K. Shim Enhanced intestinal absorption of salmon calcitonin (sCT) from proliposomes containing bile salts J. Control. Release 106 2005 298 308
    • (2005) J. Control. Release , vol.106 , pp. 298-308
    • Song, K.H.1    Chung, S.J.2    Shim, C.K.3
  • 13
    • 33745891184 scopus 로고    scopus 로고
    • Preparation of silymarin proliposome: A new way to increase oral bioavailability of silymarin in beagle dogs
    • X. Yan-yu, S. Yun-mei, C. Zhi-peng, and P. Qi-neng Preparation of silymarin proliposome: a new way to increase oral bioavailability of silymarin in beagle dogs Int. J. Pharm. 319 2006 162 168
    • (2006) Int. J. Pharm. , vol.319 , pp. 162-168
    • Yan-Yu, X.1    Yun-Mei, S.2    Zhi-Peng, C.3    Qi-Neng, P.4
  • 14
    • 44649202724 scopus 로고    scopus 로고
    • Improved delivery of cromolyn from oral proliposomal beads
    • D.D. Deshmukh, W.R. Ravis, and G.V. Betageri Improved delivery of cromolyn from oral proliposomal beads Int. J. Pharm. 358 2008 28 136
    • (2008) Int. J. Pharm. , vol.358 , pp. 28-136
    • Deshmukh, D.D.1    Ravis, W.R.2    Betageri, G.V.3
  • 15
    • 0033862458 scopus 로고    scopus 로고
    • Zaleplon a review of its use in the treatment of insomnia
    • M. Dooley, and G. Plosker Zaleplon a review of its use in the treatment of insomnia Drugs 60 2000 413 445
    • (2000) Drugs , vol.60 , pp. 413-445
    • Dooley, M.1    Plosker, G.2
  • 16
    • 1842609539 scopus 로고    scopus 로고
    • Comparative pharmacokinetics and pharmacodynamics of short-acting hypnosedatives: Zaleplon, zolpidem and zopiclone
    • DOI 10.2165/00003088-200443040-00002
    • D.R. Drover Comparative pharmacokinetics and pharmacodynamics of short-acting hypnosedatives zaleplon, zolpidem and zopiclone Clin. Pharmacokinet. 43 2004 227 238 (Pubitemid 38429303)
    • (2004) Clinical Pharmacokinetics , vol.43 , Issue.4 , pp. 227-238
    • Drover, D.R.1
  • 17
    • 51449083126 scopus 로고    scopus 로고
    • Development and characterization of zaleplon solid dispersion systems: A technical note
    • A. Waghmare, Y. Pore, and B. Kuchekar Development and characterization of zaleplon solid dispersion systems: a technical note AAPS PharmSciTech 9 2008 536 543
    • (2008) AAPS PharmSciTech , vol.9 , pp. 536-543
    • Waghmare, A.1    Pore, Y.2    Kuchekar, B.3
  • 18
    • 84856621706 scopus 로고    scopus 로고
    • Improved oral delivery of valsartan from maltodextrin based proniosome powders
    • doi:10.1016/j.apt.2011.06.005 in press. doi
    • A. Gurrapu, R. Jukanti, S.R. Bobbala, S. Kanuganti, J.B. Jeevana, Improved oral delivery of valsartan from maltodextrin based proniosome powders, Adv. Powder Technol., in press. doi: 10.1016/j.apt.2011.06.005.
    • Adv. Powder Technol.
    • Gurrapu, A.1    Jukanti, R.2    Bobbala, S.R.3    Kanuganti, S.4    Jeevana, J.B.5
  • 19
    • 79958777017 scopus 로고    scopus 로고
    • Enhanced bioavailability of exemestane via proliposomes based transdermal delivery
    • R. Jukanti, S. Sheela, S. Bandari, and P.R. Veerareddy Enhanced bioavailability of exemestane via proliposomes based transdermal delivery J. Pharm. Sci. 100 2011 3208 3222
    • (2011) J. Pharm. Sci. , vol.100 , pp. 3208-3222
    • Jukanti, R.1    Sheela, S.2    Bandari, S.3    Veerareddy, P.R.4
  • 20
    • 35649017656 scopus 로고    scopus 로고
    • Formulation and optimization of piroxicam proniosomes by 3-factor, 3-level box-behnken design
    • A.B. Solanki, J.R. Parikh, and R.H. Parikh Formulation and optimization of piroxicam proniosomes by 3-factor, 3-level box-behnken design AAPS PharmSciTech 8 2007 E1 E7
    • (2007) AAPS PharmSciTech , vol.8
    • Solanki, A.B.1    Parikh, J.R.2    Parikh, R.H.3
  • 21
    • 24144499309 scopus 로고    scopus 로고
    • Paired helical filaments (PHFs) are a family of single filament structures with a common helical turn period: Negatively stained PHF imaged by TEM and measured before and after sonication, deglycosylation, and dephosphorylation
    • DOI 10.1002/jemt.20197
    • G.C. Ruben, J.Z. Wang, K. Iqbal, and I. Grundke-Iqbal Paired helical filaments (PHFs) are a family of single filament structures with a common helical turn period: negatively stained PHF imaged by TEM and measured before and after sonication, deglycosylation, and dephosphorylation Microsc. Res. Tech. 67 2005 175 195 (Pubitemid 41243635)
    • (2005) Microscopy Research and Technique , vol.67 , Issue.3-4 , pp. 175-195
    • Ruben, G.C.1    Wang, J.-Z.2    Iqbal, K.3    Grundke-Iqbal, I.4
  • 22
    • 0000496231 scopus 로고
    • Evaluation flow properties of solids
    • R.L. Carr Evaluation flow properties of solids Chem. Eng. 72 1965 163 168
    • (1965) Chem. Eng. , vol.72 , pp. 163-168
    • Carr, R.L.1
  • 23
    • 24944496710 scopus 로고    scopus 로고
    • Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration
    • DOI 10.1016/j.jconrel.2005.06.006, PII S0168365905002701
    • K. Manjunath, and V. Venkateswarlu Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration J. Control. Release 107 2005 215 228 (Pubitemid 41319672)
    • (2005) Journal of Controlled Release , vol.107 , Issue.2 , pp. 215-228
    • Manjunath, K.1    Venkateswarlu, V.2
  • 24
    • 79251604716 scopus 로고    scopus 로고
    • Biodistribution of ascorbyl palmitate loaded doxorubicin pegylated liposomes in solid tumor bearing mice
    • R. Jukanti, G. Devraj, A.S. Shashank, and R. Devraj Biodistribution of ascorbyl palmitate loaded doxorubicin pegylated liposomes in solid tumor bearing mice J. Microencapsul. 28 2011 142 149
    • (2011) J. Microencapsul. , vol.28 , pp. 142-149
    • Jukanti, R.1    Devraj, G.2    Shashank, A.S.3    Devraj, R.4
  • 25
    • 70449703285 scopus 로고    scopus 로고
    • Study of gel-forming properties of sucrose esters for thermosensitive drug delivery systems
    • A. Szuts, M. Budai-Szucs, I. Eros, N. Otomo, and P. Szabo-Revesz Study of gel-forming properties of sucrose esters for thermosensitive drug delivery systems Int. J. Pharm. 383 2010 132 137
    • (2010) Int. J. Pharm. , vol.383 , pp. 132-137
    • Szuts, A.1    Budai-Szucs, M.2    Eros, I.3    Otomo, N.4    Szabo-Revesz, P.5
  • 26
    • 78650136991 scopus 로고    scopus 로고
    • Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets
    • M. Malladi, R. Jukanti, N. Nair, S. Wagh, H. Padakanti, and A. Mateti Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets Acta Pharm. 60 2010 267 280
    • (2010) Acta Pharm. , vol.60 , pp. 267-280
    • Malladi, M.1    Jukanti, R.2    Nair, N.3    Wagh, S.4    Padakanti, H.5    Mateti, A.6
  • 27
    • 3042550643 scopus 로고    scopus 로고
    • Development and evaluation of glyburide fast dissolving tablets using solid dispersion technique
    • DOI 10.1081/DDC-120037483
    • M. Valleri, P. Mura, F. Maeshrelli, M. Cirri, and R. Ballerini Development and evaluation of glyburide fast dissolving tablets using solid dispersion technique Drug Dev. Ind. Pharm. 30 2004 525 534 (Pubitemid 38821864)
    • (2004) Drug Development and Industrial Pharmacy , vol.30 , Issue.5 , pp. 525-534
    • Valleri, M.1    Mura, P.2    Maestrelli, F.3    Cirri, M.4    Ballerini, R.5
  • 29
    • 0141430022 scopus 로고    scopus 로고
    • Implications of density correction in gravimetric method for water flux determination using rat single-pass intestinal perfusion technique: A technical note
    • (article 16)
    • C. Issa, P. Gupta, and A.K. Bansal Implications of density correction in gravimetric method for water flux determination using rat single-pass intestinal perfusion technique: a technical note AAPS PharmSciTech 4 2003 (article 16)
    • (2003) AAPS PharmSciTech , vol.4
    • Issa, C.1    Gupta, P.2    Bansal, A.K.3
  • 30
    • 79955969750 scopus 로고    scopus 로고
    • Transdermal delivery of acyclovir sodium via carbopol gels: Role of chemical permeation enhancers
    • R. Jukanti, A. Mateti, S. Bandari, and P.R. Veerareddy Transdermal delivery of acyclovir sodium via carbopol gels: role of chemical permeation enhancers Lett. Drug Des. Discov. 8 2011 381 389
    • (2011) Lett. Drug Des. Discov. , vol.8 , pp. 381-389
    • Jukanti, R.1    Mateti, A.2    Bandari, S.3    Veerareddy, P.R.4
  • 31
    • 32444435496 scopus 로고    scopus 로고
    • High-performance liquid chromatography - Atmospheric pressure chemical ionisation-mass spectrometry determination of zaleplon in human plasma
    • DOI 10.1016/j.jpba.2005.06.031, PII S0731708505004176
    • B. Zhang, Z. Zhang, Y. Tian, F. Xua, and Y. Chen High-performance liquid chromatography-atmospheric pressure chemical ionisation-mass spectrometry determination of zaleplon in human plasma J. Pharm. Biomed. Anal. 40 2006 707 714 (Pubitemid 43227394)
    • (2006) Journal of Pharmaceutical and Biomedical Analysis , vol.40 , Issue.3 , pp. 707-714
    • Zhang, B.1    Zhang, Z.2    Tian, Y.3    Xu, F.4    Chen, Y.5
  • 32
    • 69549112751 scopus 로고    scopus 로고
    • Proliposomes of exemestane for improved oral delivery: Formulation and in vitro evaluation using PAMPA, Caco-2 and rat intestine
    • P.S. Hiremath, K.S. Soppimath, and G.V. Betagiri Proliposomes of exemestane for improved oral delivery: formulation and in vitro evaluation using PAMPA, Caco-2 and rat intestine Int. J. Pharm. 380 2009 96 104
    • (2009) Int. J. Pharm. , vol.380 , pp. 96-104
    • Hiremath, P.S.1    Soppimath, K.S.2    Betagiri, G.V.3
  • 33
    • 7244234718 scopus 로고    scopus 로고
    • Preparation, morphology and in vitro release of chitosan coated liposomes of fluorouracil for colon targeting
    • N.N. Wei, and B.I. Lu Preparation, morphology and in vitro release of chitosan coated liposomes of fluorouracil for colon targeting Acta Pharm. Sinica 38 2003 53 56
    • (2003) Acta Pharm. Sinica , vol.38 , pp. 53-56
    • Wei, N.N.1    Lu, B.I.2
  • 34
    • 0034255532 scopus 로고    scopus 로고
    • In vivo evaluation of doxorubicin carried with long circulating and remote loading proliposome
    • DOI 10.1016/S0378-5173(00)00410-5, PII S0378517300004105
    • W. Junping, Y. Maitani, K. Takayama, and T. Nagao In vivo evaluation of doxorubicin carried with long circulating and remote loading proliposome Int. J. Pharm. 203 2000 61 69 (Pubitemid 30627626)
    • (2000) International Journal of Pharmaceutics , vol.203 , Issue.1-2 , pp. 61-69
    • Junping, W.1    Maitani, Y.2    Takayama, K.3    Nagai, T.4
  • 36
    • 26844459503 scopus 로고    scopus 로고
    • Preparation of interferon-containing liposomes by the powder bed grinding method
    • Z.W. Ye, and W.Q. Liang Preparation of interferon-containing liposomes by the powder bed grinding method J. ZheJiang Univ. (Med. Sci.) 31 2002 433 436
    • (2002) J. ZheJiang Univ. (Med. Sci.) , vol.31 , pp. 433-436
    • Ye, Z.W.1    Liang, W.Q.2
  • 37
    • 26844565423 scopus 로고
    • Studies on the size of rehydrated new liposome from scutellaria proliposome
    • Z.J. Yang, T. Hino, and Y. Kawashima Studies on the size of rehydrated new liposome from scutellaria proliposome J. Chin. Pharm. Univ. 24 1993 161 164
    • (1993) J. Chin. Pharm. Univ. , vol.24 , pp. 161-164
    • Yang, Z.J.1    Hino, T.2    Kawashima, Y.3
  • 38
    • 0036226188 scopus 로고    scopus 로고
    • The study on the preparation of tanshonones propoliposomes by the spray drying method
    • M.Q. Chu, and H.C. Gu The study on the preparation of tanshonones propoliposomes by the spray drying method Chin. Pharm. J. 37 2002 32 35
    • (2002) Chin. Pharm. J. , vol.37 , pp. 32-35
    • Chu, M.Q.1    Gu, H.C.2
  • 39
    • 0034955682 scopus 로고    scopus 로고
    • SEM imaging predicts quality of niosomes from maltodextrin-based proniosomes
    • DOI 10.1023/A:1011037527889
    • A.I. Blazek-Welsh, and D.G. Rhodes SEM imaging predicts quality of niosomes from maltodextrin-based proniosomes Pharm. Res. 18 2001 656 661 (Pubitemid 32595795)
    • (2001) Pharmaceutical Research , vol.18 , Issue.5 , pp. 656-661
    • Blazek-Welsh, A.I.1    Rhodes, D.G.2
  • 40
    • 70350608409 scopus 로고    scopus 로고
    • The characterization and comparison of spray-dried mannitol samples
    • W.L. Hulse, R.T. Forbes, M.C. Bonner, and M. Getrost The characterization and comparison of spray-dried mannitol samples Drug Dev. Ind. Pharm. 35 2009 712 718
    • (2009) Drug Dev. Ind. Pharm. , vol.35 , pp. 712-718
    • Hulse, W.L.1    Forbes, R.T.2    Bonner, M.C.3    Getrost, M.4
  • 41
    • 0029079411 scopus 로고
    • Factors affecting microencapsulation of drugs in liposomes
    • S.B. Kulkarni, G.V. Betageri, and M. Singh Factors affecting microencapsulation of drugs in liposomes J. Microencapsul. 12 1995 229 246
    • (1995) J. Microencapsul. , vol.12 , pp. 229-246
    • Kulkarni, S.B.1    Betageri, G.V.2    Singh, M.3
  • 42
  • 43
    • 0030050088 scopus 로고    scopus 로고
    • Mechanism for enhancement effect of lipid disperse system on percutaneous absorption
    • DOI 10.1021/js950178x
    • T. Ogiso, N. Niinaka, and M. Iwaki Mechanism for enhancement effect of lipid disperse system on percutaneous absorption J. Pharm. Sci. 85 1996 57 64 (Pubitemid 26029626)
    • (1996) Journal of Pharmaceutical Sciences , vol.85 , Issue.1 , pp. 57-64
    • Ogiso, T.1    Niinaka, N.2    Iwaki, M.3
  • 44
    • 0001914001 scopus 로고    scopus 로고
    • Powder flow
    • M. Aulton, second ed. Churchill Livingstone, Longman Group Edinburgh
    • J. Staniforth Powder flow M. Aulton, Pharmaceutics, The Science of Dosage form Design second ed. 2002 Churchill Livingstone, Longman Group Edinburgh 197 210
    • (2002) Pharmaceutics, the Science of Dosage Form Design , pp. 197-210
    • Staniforth, J.1
  • 45
    • 79959701310 scopus 로고    scopus 로고
    • Drug targeting to inflammation: Studies on antioxidant surface loaded diclofenac liposomes
    • R. Jukanti, G. Devaraj, R. Devaraj, and S. Apte Drug targeting to inflammation: studies on antioxidant surface loaded diclofenac liposomes Int. J. Pharm. 414 2011 279 285
    • (2011) Int. J. Pharm. , vol.414 , pp. 279-285
    • Jukanti, R.1    Devaraj, G.2    Devaraj, R.3    Apte, S.4
  • 46
    • 0028218692 scopus 로고
    • The influence of particle size of liposomes on deposition of drug into skin
    • J. Plessis, C. Ramachandran, N. Weiner, and D.G. Miller The influence of particle size of liposomes on deposition of drug into skin Int. J. Pharm. 103 1991 277 282
    • (1991) Int. J. Pharm. , vol.103 , pp. 277-282
    • Plessis, J.1    Ramachandran, C.2    Weiner, N.3    Miller, D.G.4
  • 47
    • 0029092672 scopus 로고
    • Nanoparticles as carriers for oral peptide absorption: Studies on particles uptake and fate
    • A.T. Florence, A.M. Hillery, N. Hussain, and P.U. Jani Nanoparticles as carriers for oral peptide absorption: studies on particles uptake and fate J. Control. Release 36 1995 39 46
    • (1995) J. Control. Release , vol.36 , pp. 39-46
    • Florence, A.T.1    Hillery, A.M.2    Hussain, N.3    Jani, P.U.4
  • 48
    • 79958800073 scopus 로고    scopus 로고
    • Proniosome based drug delivery system of piroxicam
    • A. Chandra, and P.K. Sharma Proniosome based drug delivery system of piroxicam Afr. J. Pharm. Pharmacol. 2 2008 184 190
    • (2008) Afr. J. Pharm. Pharmacol. , vol.2 , pp. 184-190
    • Chandra, A.1    Sharma, P.K.2
  • 49
    • 0037027833 scopus 로고    scopus 로고
    • Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A
    • DOI 10.1016/S0378-5173(02)00461-1, PII S0378517302004611
    • M.H. El-Shabouri Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A Int. J. Pharm. 249 2002 101 108 (Pubitemid 35333436)
    • (2002) International Journal of Pharmaceutics , vol.249 , Issue.1-2 , pp. 101-108
    • El-Shabouri, M.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.