Optimized preparation of vinpocetine proliposomes by a novel method and in vivo evaluation of its pharmacokinetics in New Zealand rabbits

Journal of Controlled Release

Volumn 140, Issue 1, 2009, Pages 61-68

  Xu, Hongtao ^a   He, Ling ^a   Nie, Shufang ^a   Guan, Jin ^a   Zhang, Xiaoning ^b   Yang, Xinggang ^a   Pan, Weisan ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Tsinghua University ^*  (China)

Author keywords

CCD; New Zealand rabbits; Pharmacokinetics; Proliposomes; Vinpocetine

Indexed keywords

ABSORPTION PEAKS; AVERAGE PARTICLE SIZE; CCD; COMPOSITE DESIGNS; CONCENTRATION OF; CONCENTRATION-TIME; ENTRAPMENT EFFICIENCY; FREE FLOWING; FTIR; IN-VIVO; NEW APPROACHES; NEW ZEALAND RABBITS; NOVEL METHODS; ORAL ADMINISTRATION; PHARMACOKINETIC PARAMETERS; PHYSICOCHEMICAL PROPERTY; POORLY WATER-SOLUBLE DRUGS; PROLIPOSOMES; SEM; SOFTWARE PROGRAM; SOYBEAN PHOSPHATIDYLCHOLINE; TEM; VINPOCETINE; XRD;

BIOCHEMISTRY; DIGITAL CAMERAS; FOURIER TRANSFORM INFRARED SPECTROSCOPY; LIPOSOMES; OPTIMIZATION; PHARMACOKINETICS; PHOSPHOLIPIDS; WATER ABSORPTION;

SUSPENSIONS (FLUIDS);

CHOLESTEROL; LIPOSOME; PHOSPHATIDYLCHOLINE; SORBITOL; VINPOCETINE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; GASTROINTESTINAL ABSORPTION; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RABBIT; SUSPENSION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; LIPOSOMES; MALE; NOOTROPIC AGENTS; PARTICLE SIZE; RABBITS; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TIME FACTORS; VINCA ALKALOIDS;

EID: 70349826289     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.07.014     Document Type: Article

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