A rapid and sensitive UPLC-MS/MS method for determination of HZ08 in rat plasma and tissues: Application to a pharmacokinetic study of liposome injections

Journal of Pharmaceutical and Biomedical Analysis

Volumn 102, Issue , 2014, Pages 246-252

  Yan, Fang ^a   Sun, Miaomiao ^a   Hang, Taijun ^a   Sun, Jing ^a   Zhou, Xia ^a   Deng, Xin ^a   Ge, Liang ^a   Qian, Hai ^a   Ya, Ding ^a   Huang, Wenlong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

HZ08; Pharmacokinetics; Rat plasma; Rat tissues; UPLC MS MS

Indexed keywords

ACETONITRILE; AMMONIUM ACETATE; CLOTRIMAZOLE; LIPOSOME; METHANOL; N CYANO 1 [(3,4 DIMETHOXYPHENYL)METHYL] 3,4 DIHYDRO 6,7 DIMETHOXY N OCTYL 2(1H)ISOQUINOLINECARBOXIMIDAMIDE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; ISOQUINOLINE DERIVATIVE; N-CYANO-1-((3,4-DIMETHOXYPHENYL)METHYL)-3,4-DIHYDRO-6,7-DIMETHOXY-N'-OCTYL-2(1H)-ISOQUINOLINE-CARBOXIMIDAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG TISSUE LEVEL; ELECTROSPRAY; ELIMINATION HALF-LIFE; FEMALE; FLOW RATE; LIMIT OF QUANTITATION; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PRECIPITATION; RAT; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; TISSUE DISTRIBUTION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; CALIBRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INJECTION; PROCEDURES; SPRAGUE DAWLEY RAT;

ANIMALS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INJECTIONS; ISOQUINOLINES; LIPOSOMES; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

EID: 84908328608     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.09.017     Document Type: Article

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