메뉴 건너뛰기




Volumn 60, Issue 4, 2015, Pages 919-928

Influence of Rictor and Raptor Expression of mTOR Signaling on Long-Term Outcomes of Patients with Hepatocellular Carcinoma

Author keywords

Hepatic resection; Hepatocellular carcinoma; mTOR; Prognostic factor; Raptor; Rictor; Rictor raptor ratio

Indexed keywords

CARRIER PROTEIN; MESSENGER RNA; MTOR PROTEIN, HUMAN; RICTOR PROTEIN, HUMAN; RPTOR PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE;

EID: 84934284613     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-014-3417-7     Document Type: Article
Times cited : (29)

References (43)
  • 1
    • 0032833628 scopus 로고    scopus 로고
    • Epidemiology of primary liver cancer
    • COI: 1:STN:280:DyaK1Mvks1Gktw%3D%3D, PID: 10518307
    • Bosch X, Ribes J, Borras J. Epidemiology of primary liver cancer. Semin Liver Dis. 1999;19:271–285.
    • (1999) Semin Liver Dis , vol.19 , pp. 271-285
    • Bosch, X.1    Ribes, J.2    Borras, J.3
  • 2
    • 0030699243 scopus 로고    scopus 로고
    • Increase in primary liver cancer in the UK 1979-94
    • COI: 1:STN:280:DyaK1c%2FgtlWjtA%3D%3D, PID: 9343506
    • Taylor-Robinson SD, Foster GR, Arora S, et al. Increase in primary liver cancer in the UK 1979-94. Lancet. 1997;350:1142–1143.
    • (1997) Lancet , vol.350 , pp. 1142-1143
    • Taylor-Robinson, S.D.1    Foster, G.R.2    Arora, S.3
  • 3
    • 0033545541 scopus 로고    scopus 로고
    • Rising incidence of hepatocellular carcinoma in the United States
    • EI-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med. 1999;340:745–750.
    • (1999) N Engl J Med , vol.340 , pp. 745-750
    • EI-Serag, H.B.1    Mason, A.C.2
  • 4
    • 0033947630 scopus 로고    scopus 로고
    • Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma
    • COI: 1:STN:280:DC%2BD3czitVCrug%3D%3D, PID: 10862190
    • Tung-Ping Poon R, Fan ST, Wong J. Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma. Ann Surg. 2000;232:10–24.
    • (2000) Ann Surg , vol.232 , pp. 10-24
    • Tung-Ping Poon, R.1    Fan, S.T.2    Wong, J.3
  • 5
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • COI: 1:CAS:528:DC%2BD28Xhslaqs74%3D, PID: 16469695
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell. 2006;124:471–484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 6
    • 0037108682 scopus 로고    scopus 로고
    • Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
    • COI: 1:CAS:528:DC%2BD38XotFyksLs%3D, PID: 12384518
    • Kenerson HL, Aicher LD, True LD, et al. Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Cancer Res. 2002;62:5645–5650.
    • (2002) Cancer Res , vol.62 , pp. 5645-5650
    • Kenerson, H.L.1    Aicher, L.D.2    True, L.D.3
  • 7
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • COI: 1:CAS:528:DC%2BD38XkvFKltLs%3D, PID: 12094235
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer. 2002;2:489–501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 8
    • 4344602002 scopus 로고    scopus 로고
    • The biology and clinical relevance of the PTEN tumor suppressor pathway
    • COI: 1:CAS:528:DC%2BD2cXpsVWktbk%3D, PID: 15254063
    • Sansal I, Sellers WR. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol. 2004;22:2954–2963.
    • (2004) J Clin Oncol , vol.22 , pp. 2954-2963
    • Sansal, I.1    Sellers, W.R.2
  • 9
    • 11244297916 scopus 로고    scopus 로고
    • Dysregulation of the TSC-mTOR pathway in human disease
    • COI: 1:CAS:528:DC%2BD2cXhtFChsL3M, PID: 15624019
    • Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet. 2005;37:19–24.
    • (2005) Nat Genet , vol.37 , pp. 19-24
    • Inoki, K.1    Corradetti, M.N.2    Guan, K.L.3
  • 10
    • 2942724235 scopus 로고    scopus 로고
    • mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
    • COI: 1:CAS:528:DC%2BD2cXksVais7w%3D, PID: 15156201
    • Majumder PK, Febbo PG, Bikoff R, et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med. 2004;10:594–601.
    • (2004) Nat Med , vol.10 , pp. 594-601
    • Majumder, P.K.1    Febbo, P.G.2    Bikoff, R.3
  • 11
    • 18144399578 scopus 로고    scopus 로고
    • mTOR-targeted therapy of cancer with rapamycin derivatives
    • COI: 1:STN:280:DC%2BD2M7kvVWmsQ%3D%3D, PID: 15728109
    • Vignot S, Faivre S, Aguirre D, et al. mTOR-targeted therapy of cancer with rapamycin derivatives. Ann Oncol. 2005;16:525–537.
    • (2005) Ann Oncol , vol.16 , pp. 525-537
    • Vignot, S.1    Faivre, S.2    Aguirre, D.3
  • 12
    • 33750072949 scopus 로고    scopus 로고
    • mTOR and cancer therapy
    • COI: 1:CAS:528:DC%2BD28XhtVOlsrrN, PID: 17041628
    • Easton JB, Houghton PJ. mTOR and cancer therapy. Oncogene. 2006;25:6436–6446.
    • (2006) Oncogene , vol.25 , pp. 6436-6446
    • Easton, J.B.1    Houghton, P.J.2
  • 13
    • 50049125036 scopus 로고    scopus 로고
    • Abberrant Rheb-mediated mTOR1 activation and Pten haploinsufficiency are cooperative oncogenic events
    • COI: 1:CAS:528:DC%2BD1cXhtVehtr3M, PID: 18708577
    • Nardella C, Chen Z, Salmena L, et al. Abberrant Rheb-mediated mTOR1 activation and Pten haploinsufficiency are cooperative oncogenic events. Genes Dev. 2008;22:2172–2177.
    • (2008) Genes Dev , vol.22 , pp. 2172-2177
    • Nardella, C.1    Chen, Z.2    Salmena, L.3
  • 14
    • 77951026717 scopus 로고    scopus 로고
    • Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis
    • Lu ZH, Shvartsman MB, Lee AY, et al. Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis. Cancer Res. 2010;70:3287–3298.
    • (2010) Cancer Res , vol.70 , pp. 3287-3298
    • Lu, Z.H.1    Shvartsman, M.B.2    Lee, A.Y.3
  • 15
    • 0034901515 scopus 로고    scopus 로고
    • Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition
    • COI: 1:CAS:528:DC%2BD3MXltV2hsL4%3D, PID: 11410517
    • Dudkin L, Dilling MB, Cheshire PJ, et al. Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition. Clin Cancer Res. 2001;7:1758–1764.
    • (2001) Clin Cancer Res , vol.7 , pp. 1758-1764
    • Dudkin, L.1    Dilling, M.B.2    Cheshire, P.J.3
  • 16
    • 33750858427 scopus 로고    scopus 로고
    • Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways
    • COI: 1:CAS:528:DC%2BD28XhtFyqtLzE, PID: 16715128
    • Liu L, Li F, Cardelli JA, et al. Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Oncogene. 2006;25:7029–7040.
    • (2006) Oncogene , vol.25 , pp. 7029-7040
    • Liu, L.1    Li, F.2    Cardelli, J.A.3
  • 17
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signaling controls tumour cell growth
    • COI: 1:CAS:528:DC%2BD28XkvVyrsr8%3D, PID: 16724053
    • Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signaling controls tumour cell growth. Nature. 2006;441:424–430.
    • (2006) Nature , vol.441 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 18
    • 58249085318 scopus 로고    scopus 로고
    • Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer
    • COI: 1:CAS:528:DC%2BD1MXhvVKrsbw%3D, PID: 19047305
    • Wolpin BM, Hezel AF, Abrams T, et al. Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer. J Clin Oncol. 2009;27:193–198.
    • (2009) J Clin Oncol , vol.27 , pp. 193-198
    • Wolpin, B.M.1    Hezel, A.F.2    Abrams, T.3
  • 19
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: a target for cancer therapy
    • COI: 1:CAS:528:DC%2BD2cXjsFSlu7Y%3D, PID: 15122205
    • Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer. 2004;4:335–348.
    • (2004) Nat Rev Cancer , vol.4 , pp. 335-348
    • Bjornsti, M.A.1    Houghton, P.J.2
  • 20
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of AKT/PKB by the rictor-mTOR complex
    • COI: 1:CAS:528:DC%2BD2MXhtlSrtbY%3D, PID: 15718470
    • Sarbassov DD, Guertin DA, Ali SM, et al. Phosphorylation and regulation of AKT/PKB by the rictor-mTOR complex. Science. 2005;307:1098–1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3
  • 21
    • 11144236505 scopus 로고    scopus 로고
    • mTOR and p70 S6 kinase expression in primary liver neoplasms
    • COI: 1:CAS:528:DC%2BD2cXhtFGjs73J, PID: 15623621
    • Sahin F, Kannangai R, Adegbola O, et al. mTOR and p70 S6 kinase expression in primary liver neoplasms. Clin Cancer Res. 2004;10:8421–8425.
    • (2004) Clin Cancer Res , vol.10 , pp. 8421-8425
    • Sahin, F.1    Kannangai, R.2    Adegbola, O.3
  • 22
    • 16344392137 scopus 로고    scopus 로고
    • Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth
    • COI: 1:CAS:528:DC%2BD2MXjslCrs7c%3D, PID: 15770715
    • Schumacher G, Oidtmann M, Rueggeberg A, et al. Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth. World J Gastroenterol. 2005;11:1420–1425.
    • (2005) World J Gastroenterol , vol.11 , pp. 1420-1425
    • Schumacher, G.1    Oidtmann, M.2    Rueggeberg, A.3
  • 23
    • 33947501692 scopus 로고    scopus 로고
    • Mammalian target of rapamycin pathway in hepatocellular carcinomas of patients undergoing liver transplantation
    • COI: 1:CAS:528:DC%2BD2sXjs1Gmurs%3D, PID: 17318075
    • Sieghart W, Fuereder T, Schmid K, et al. Mammalian target of rapamycin pathway in hepatocellular carcinomas of patients undergoing liver transplantation. Transplantation. 2007;83:425–432.
    • (2007) Transplantation , vol.83 , pp. 425-432
    • Sieghart, W.1    Fuereder, T.2    Schmid, K.3
  • 24
    • 34047118033 scopus 로고    scopus 로고
    • Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BD2sXjvFamtb0%3D, PID: 17321636
    • Semela D, Piguet AC, Kolev M, et al. Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma. J Hepatol. 2007;46:840–848.
    • (2007) J Hepatol , vol.46 , pp. 840-848
    • Semela, D.1    Piguet, A.C.2    Kolev, M.3
  • 25
    • 57349087153 scopus 로고    scopus 로고
    • Pivotal role of mTOR signaling in hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BD1MXht1ertr0%3D, PID: 18929564
    • Villanueva A, Chiang DY, Newell P, et al. Pivotal role of mTOR signaling in hepatocellular carcinoma. Gastroenterology. 2008;135:1972–1983.
    • (2008) Gastroenterology , vol.135 , pp. 1972-1983
    • Villanueva, A.1    Chiang, D.Y.2    Newell, P.3
  • 26
    • 0034474498 scopus 로고    scopus 로고
    • The Brisbane 2000 terminology of liver anatomy and resection. Terminology Committee of the International Hepato-Pancreato-Biliary Association
    • Strasberg SM, Belghiti J, Clavien PA. The Brisbane 2000 terminology of liver anatomy and resection. Terminology Committee of the International Hepato-Pancreato-Biliary Association. HPB. 2000;2:333–339.
    • (2000) HPB , vol.2 , pp. 333-339
    • Strasberg, S.M.1    Belghiti, J.2    Clavien, P.A.3
  • 28
    • 0027447928 scopus 로고
    • Simple technique for detecting RNA viruses by PCR in single sections of wax embedded tissue
    • COI: 1:STN:280:DyaK3s3hs12lsw%3D%3D, PID: 8385159
    • Woodall CJ, Watt NJ, Clements GB. Simple technique for detecting RNA viruses by PCR in single sections of wax embedded tissue. J Clin Pathol. 1993;46:276–277.
    • (1993) J Clin Pathol , vol.46 , pp. 276-277
    • Woodall, C.J.1    Watt, N.J.2    Clements, G.B.3
  • 29
    • 0034146097 scopus 로고    scopus 로고
    • Telomerase reverse transcriptase expression is increased early in the Barrett’s metaplasia, dysplasia, adenocarcinoma sequence
    • COI: 1:STN:280:DC%2BD3c7jvFKktA%3D%3D, PID: 10675236
    • Lord RV, Salonga D, Danenberg KD, et al. Telomerase reverse transcriptase expression is increased early in the Barrett’s metaplasia, dysplasia, adenocarcinoma sequence. J Gastrointest Surg. 2000;4:135–142.
    • (2000) J Gastrointest Surg , vol.4 , pp. 135-142
    • Lord, R.V.1    Salonga, D.2    Danenberg, K.D.3
  • 30
    • 0029964835 scopus 로고    scopus 로고
    • A novel method for real time quantitative RT-PCR
    • COI: 1:CAS:528:DyaK28XmsVWru7s%3D, PID: 8908519
    • Gibson UE, Heid CA, Williams PM. A novel method for real time quantitative RT-PCR. Genome Res. 1996;6:995–1001.
    • (1996) Genome Res , vol.6 , pp. 995-1001
    • Gibson, U.E.1    Heid, C.A.2    Williams, P.M.3
  • 31
    • 0029957181 scopus 로고    scopus 로고
    • Real time quantitative PCR
    • COI: 1:CAS:528:DyaK28XmsVWru7w%3D, PID: 8908518
    • Heid CA, Stevens J, Livak KJ, et al. Real time quantitative PCR. Genome Res. 1996;6:986–994.
    • (1996) Genome Res , vol.6 , pp. 986-994
    • Heid, C.A.1    Stevens, J.2    Livak, K.J.3
  • 32
    • 0033565625 scopus 로고    scopus 로고
    • Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes
    • COI: 1:CAS:528:DyaK1MXks1Omsbs%3D, PID: 10416617
    • Kornmann M, Danenberg KD, Arber N, et al. Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes. Cancer Res. 1999;59:3505–3511.
    • (1999) Cancer Res , vol.59 , pp. 3505-3511
    • Kornmann, M.1    Danenberg, K.D.2    Arber, N.3
  • 33
    • 0030824603 scopus 로고    scopus 로고
    • Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: evidence for autocrine and paracrine actions
    • COI: 1:CAS:528:DyaK2sXmsFCitrY%3D, PID: 9333017
    • Kornmann M, Ishiwata T, Beger HG, et al. Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: evidence for autocrine and paracrine actions. Oncogene. 1997;15:1417–1424.
    • (1997) Oncogene , vol.15 , pp. 1417-1424
    • Kornmann, M.1    Ishiwata, T.2    Beger, H.G.3
  • 35
    • 78649826428 scopus 로고    scopus 로고
    • Updates of mTOR inhibitors
    • COI: 1:CAS:528:DC%2BC3cXhs1art7jM, PID: 20812900
    • Zhou H, Luo Y, Huang S. Updates of mTOR inhibitors. Anticancer Agents Med Chem. 2010;10:571–581.
    • (2010) Anticancer Agents Med Chem , vol.10 , pp. 571-581
    • Zhou, H.1    Luo, Y.2    Huang, S.3
  • 36
    • 84887228819 scopus 로고    scopus 로고
    • Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
    • COI: 1:CAS:528:DC%2BC3sXhs1yhsb7O, PID: 24161930
    • Liu P, Gan W, Inuzuka H, et al. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol. 2013;15:1340–1350.
    • (2013) Nat Cell Biol , vol.15 , pp. 1340-1350
    • Liu, P.1    Gan, W.2    Inuzuka, H.3
  • 37
    • 79958696694 scopus 로고    scopus 로고
    • The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
    • COI: 1:CAS:528:DC%2BC3MXntVGltLs%3D, PID: 21659604
    • Hsu PP, Kang SA, Rameseder J, et al. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science. 2011;332:1317–1322.
    • (2011) Science , vol.332 , pp. 1317-1322
    • Hsu, P.P.1    Kang, S.A.2    Rameseder, J.3
  • 38
    • 79958696336 scopus 로고    scopus 로고
    • Quantitative phosphoproteomic analysis identifies the adaptor protein Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
    • COI: 1:CAS:528:DC%2BC3MXntVGltLg%3D, PID: 21659605
    • Yu Y, Yoon SO, Poulogiannis G, et al. Quantitative phosphoproteomic analysis identifies the adaptor protein Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science. 2011;332:1322–1326.
    • (2011) Science , vol.332 , pp. 1322-1326
    • Yu, Y.1    Yoon, S.O.2    Poulogiannis, G.3
  • 39
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
    • COI: 1:CAS:528:DC%2BD2cXntlGks7g%3D, PID: 15306821
    • Um SH, Frigerio F, Watanabe M, et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature. 2004;431:200–205.
    • (2004) Nature , vol.431 , pp. 200-205
    • Um, S.H.1    Frigerio, F.2    Watanabe, M.3
  • 40
    • 34548324283 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule. More than a carcinoma marker and adhesion molecule
    • COI: 1:CAS:528:DC%2BD2sXpsFaitLg%3D, PID: 17600130
    • Trzpis M, McLaughlin PMJ, Leij LMFH, et al. Epithelial cell adhesion molecule. More than a carcinoma marker and adhesion molecule. Am J Pathol. 2007;171:386–395.
    • (2007) Am J Pathol , vol.171 , pp. 386-395
    • Trzpis, M.1    McLaughlin, P.M.J.2    Leij, L.M.F.H.3
  • 41
    • 30644472381 scopus 로고    scopus 로고
    • Frequent high-level expression of the immunotherapeutic target EpCAM in colon, stomach, prostate and lung cancers
    • COI: 1:CAS:528:DC%2BD28XisVGgug%3D%3D, PID: 16404366
    • Went P, Vasei M, Bubendorf L, et al. Frequent high-level expression of the immunotherapeutic target EpCAM in colon, stomach, prostate and lung cancers. Br J Cancer. 2006;94:128–135.
    • (2006) Br J Cancer , vol.94 , pp. 128-135
    • Went, P.1    Vasei, M.2    Bubendorf, L.3
  • 42
    • 78751603857 scopus 로고    scopus 로고
    • Gene expression signature of the gross morphology in hepatocellular carcinoma
    • PID: 21233610
    • Murakata A, Tanaka S, Mogushi K, et al. Gene expression signature of the gross morphology in hepatocellular carcinoma. Ann Surg. 2011;253:94–100.
    • (2011) Ann Surg , vol.253 , pp. 94-100
    • Murakata, A.1    Tanaka, S.2    Mogushi, K.3
  • 43
    • 84898989382 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: reasons for phase III failure and novel perspectives on trial design
    • COI: 1:CAS:528:DC%2BC2cXmtl2msL4%3D, PID: 24589894
    • Llovet JM, Hernandez-Gea V. Hepatocellular carcinoma: reasons for phase III failure and novel perspectives on trial design. Clin Cancer Res. 2014;20:2072–2079.
    • (2014) Clin Cancer Res , vol.20 , pp. 2072-2079
    • Llovet, J.M.1    Hernandez-Gea, V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.