-
1
-
-
0032833628
-
Epidemiology of primary liver cancer
-
COI: 1:STN:280:DyaK1Mvks1Gktw%3D%3D, PID: 10518307
-
Bosch X, Ribes J, Borras J. Epidemiology of primary liver cancer. Semin Liver Dis. 1999;19:271–285.
-
(1999)
Semin Liver Dis
, vol.19
, pp. 271-285
-
-
Bosch, X.1
Ribes, J.2
Borras, J.3
-
2
-
-
0030699243
-
Increase in primary liver cancer in the UK 1979-94
-
COI: 1:STN:280:DyaK1c%2FgtlWjtA%3D%3D, PID: 9343506
-
Taylor-Robinson SD, Foster GR, Arora S, et al. Increase in primary liver cancer in the UK 1979-94. Lancet. 1997;350:1142–1143.
-
(1997)
Lancet
, vol.350
, pp. 1142-1143
-
-
Taylor-Robinson, S.D.1
Foster, G.R.2
Arora, S.3
-
3
-
-
0033545541
-
Rising incidence of hepatocellular carcinoma in the United States
-
EI-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med. 1999;340:745–750.
-
(1999)
N Engl J Med
, vol.340
, pp. 745-750
-
-
EI-Serag, H.B.1
Mason, A.C.2
-
4
-
-
0033947630
-
Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma
-
COI: 1:STN:280:DC%2BD3czitVCrug%3D%3D, PID: 10862190
-
Tung-Ping Poon R, Fan ST, Wong J. Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma. Ann Surg. 2000;232:10–24.
-
(2000)
Ann Surg
, vol.232
, pp. 10-24
-
-
Tung-Ping Poon, R.1
Fan, S.T.2
Wong, J.3
-
5
-
-
32044465506
-
TOR signaling in growth and metabolism
-
COI: 1:CAS:528:DC%2BD28Xhslaqs74%3D, PID: 16469695
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell. 2006;124:471–484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
6
-
-
0037108682
-
Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
-
COI: 1:CAS:528:DC%2BD38XotFyksLs%3D, PID: 12384518
-
Kenerson HL, Aicher LD, True LD, et al. Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Cancer Res. 2002;62:5645–5650.
-
(2002)
Cancer Res
, vol.62
, pp. 5645-5650
-
-
Kenerson, H.L.1
Aicher, L.D.2
True, L.D.3
-
7
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
COI: 1:CAS:528:DC%2BD38XkvFKltLs%3D, PID: 12094235
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer. 2002;2:489–501.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
8
-
-
4344602002
-
The biology and clinical relevance of the PTEN tumor suppressor pathway
-
COI: 1:CAS:528:DC%2BD2cXpsVWktbk%3D, PID: 15254063
-
Sansal I, Sellers WR. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol. 2004;22:2954–2963.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2954-2963
-
-
Sansal, I.1
Sellers, W.R.2
-
9
-
-
11244297916
-
Dysregulation of the TSC-mTOR pathway in human disease
-
COI: 1:CAS:528:DC%2BD2cXhtFChsL3M, PID: 15624019
-
Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet. 2005;37:19–24.
-
(2005)
Nat Genet
, vol.37
, pp. 19-24
-
-
Inoki, K.1
Corradetti, M.N.2
Guan, K.L.3
-
10
-
-
2942724235
-
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
-
COI: 1:CAS:528:DC%2BD2cXksVais7w%3D, PID: 15156201
-
Majumder PK, Febbo PG, Bikoff R, et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med. 2004;10:594–601.
-
(2004)
Nat Med
, vol.10
, pp. 594-601
-
-
Majumder, P.K.1
Febbo, P.G.2
Bikoff, R.3
-
11
-
-
18144399578
-
mTOR-targeted therapy of cancer with rapamycin derivatives
-
COI: 1:STN:280:DC%2BD2M7kvVWmsQ%3D%3D, PID: 15728109
-
Vignot S, Faivre S, Aguirre D, et al. mTOR-targeted therapy of cancer with rapamycin derivatives. Ann Oncol. 2005;16:525–537.
-
(2005)
Ann Oncol
, vol.16
, pp. 525-537
-
-
Vignot, S.1
Faivre, S.2
Aguirre, D.3
-
12
-
-
33750072949
-
mTOR and cancer therapy
-
COI: 1:CAS:528:DC%2BD28XhtVOlsrrN, PID: 17041628
-
Easton JB, Houghton PJ. mTOR and cancer therapy. Oncogene. 2006;25:6436–6446.
-
(2006)
Oncogene
, vol.25
, pp. 6436-6446
-
-
Easton, J.B.1
Houghton, P.J.2
-
13
-
-
50049125036
-
Abberrant Rheb-mediated mTOR1 activation and Pten haploinsufficiency are cooperative oncogenic events
-
COI: 1:CAS:528:DC%2BD1cXhtVehtr3M, PID: 18708577
-
Nardella C, Chen Z, Salmena L, et al. Abberrant Rheb-mediated mTOR1 activation and Pten haploinsufficiency are cooperative oncogenic events. Genes Dev. 2008;22:2172–2177.
-
(2008)
Genes Dev
, vol.22
, pp. 2172-2177
-
-
Nardella, C.1
Chen, Z.2
Salmena, L.3
-
14
-
-
77951026717
-
Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis
-
Lu ZH, Shvartsman MB, Lee AY, et al. Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis. Cancer Res. 2010;70:3287–3298.
-
(2010)
Cancer Res
, vol.70
, pp. 3287-3298
-
-
Lu, Z.H.1
Shvartsman, M.B.2
Lee, A.Y.3
-
15
-
-
0034901515
-
Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition
-
COI: 1:CAS:528:DC%2BD3MXltV2hsL4%3D, PID: 11410517
-
Dudkin L, Dilling MB, Cheshire PJ, et al. Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition. Clin Cancer Res. 2001;7:1758–1764.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1758-1764
-
-
Dudkin, L.1
Dilling, M.B.2
Cheshire, P.J.3
-
16
-
-
33750858427
-
Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways
-
COI: 1:CAS:528:DC%2BD28XhtFyqtLzE, PID: 16715128
-
Liu L, Li F, Cardelli JA, et al. Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Oncogene. 2006;25:7029–7040.
-
(2006)
Oncogene
, vol.25
, pp. 7029-7040
-
-
Liu, L.1
Li, F.2
Cardelli, J.A.3
-
17
-
-
33745307617
-
Ras, PI(3)K and mTOR signaling controls tumour cell growth
-
COI: 1:CAS:528:DC%2BD28XkvVyrsr8%3D, PID: 16724053
-
Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signaling controls tumour cell growth. Nature. 2006;441:424–430.
-
(2006)
Nature
, vol.441
, pp. 424-430
-
-
Shaw, R.J.1
Cantley, L.C.2
-
18
-
-
58249085318
-
Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer
-
COI: 1:CAS:528:DC%2BD1MXhvVKrsbw%3D, PID: 19047305
-
Wolpin BM, Hezel AF, Abrams T, et al. Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer. J Clin Oncol. 2009;27:193–198.
-
(2009)
J Clin Oncol
, vol.27
, pp. 193-198
-
-
Wolpin, B.M.1
Hezel, A.F.2
Abrams, T.3
-
19
-
-
2342559981
-
The TOR pathway: a target for cancer therapy
-
COI: 1:CAS:528:DC%2BD2cXjsFSlu7Y%3D, PID: 15122205
-
Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer. 2004;4:335–348.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 335-348
-
-
Bjornsti, M.A.1
Houghton, P.J.2
-
20
-
-
13844312400
-
Phosphorylation and regulation of AKT/PKB by the rictor-mTOR complex
-
COI: 1:CAS:528:DC%2BD2MXhtlSrtbY%3D, PID: 15718470
-
Sarbassov DD, Guertin DA, Ali SM, et al. Phosphorylation and regulation of AKT/PKB by the rictor-mTOR complex. Science. 2005;307:1098–1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
-
21
-
-
11144236505
-
mTOR and p70 S6 kinase expression in primary liver neoplasms
-
COI: 1:CAS:528:DC%2BD2cXhtFGjs73J, PID: 15623621
-
Sahin F, Kannangai R, Adegbola O, et al. mTOR and p70 S6 kinase expression in primary liver neoplasms. Clin Cancer Res. 2004;10:8421–8425.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 8421-8425
-
-
Sahin, F.1
Kannangai, R.2
Adegbola, O.3
-
22
-
-
16344392137
-
Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth
-
COI: 1:CAS:528:DC%2BD2MXjslCrs7c%3D, PID: 15770715
-
Schumacher G, Oidtmann M, Rueggeberg A, et al. Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth. World J Gastroenterol. 2005;11:1420–1425.
-
(2005)
World J Gastroenterol
, vol.11
, pp. 1420-1425
-
-
Schumacher, G.1
Oidtmann, M.2
Rueggeberg, A.3
-
23
-
-
33947501692
-
Mammalian target of rapamycin pathway in hepatocellular carcinomas of patients undergoing liver transplantation
-
COI: 1:CAS:528:DC%2BD2sXjs1Gmurs%3D, PID: 17318075
-
Sieghart W, Fuereder T, Schmid K, et al. Mammalian target of rapamycin pathway in hepatocellular carcinomas of patients undergoing liver transplantation. Transplantation. 2007;83:425–432.
-
(2007)
Transplantation
, vol.83
, pp. 425-432
-
-
Sieghart, W.1
Fuereder, T.2
Schmid, K.3
-
24
-
-
34047118033
-
Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma
-
COI: 1:CAS:528:DC%2BD2sXjvFamtb0%3D, PID: 17321636
-
Semela D, Piguet AC, Kolev M, et al. Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma. J Hepatol. 2007;46:840–848.
-
(2007)
J Hepatol
, vol.46
, pp. 840-848
-
-
Semela, D.1
Piguet, A.C.2
Kolev, M.3
-
25
-
-
57349087153
-
Pivotal role of mTOR signaling in hepatocellular carcinoma
-
COI: 1:CAS:528:DC%2BD1MXht1ertr0%3D, PID: 18929564
-
Villanueva A, Chiang DY, Newell P, et al. Pivotal role of mTOR signaling in hepatocellular carcinoma. Gastroenterology. 2008;135:1972–1983.
-
(2008)
Gastroenterology
, vol.135
, pp. 1972-1983
-
-
Villanueva, A.1
Chiang, D.Y.2
Newell, P.3
-
26
-
-
0034474498
-
The Brisbane 2000 terminology of liver anatomy and resection. Terminology Committee of the International Hepato-Pancreato-Biliary Association
-
Strasberg SM, Belghiti J, Clavien PA. The Brisbane 2000 terminology of liver anatomy and resection. Terminology Committee of the International Hepato-Pancreato-Biliary Association. HPB. 2000;2:333–339.
-
(2000)
HPB
, vol.2
, pp. 333-339
-
-
Strasberg, S.M.1
Belghiti, J.2
Clavien, P.A.3
-
28
-
-
0027447928
-
Simple technique for detecting RNA viruses by PCR in single sections of wax embedded tissue
-
COI: 1:STN:280:DyaK3s3hs12lsw%3D%3D, PID: 8385159
-
Woodall CJ, Watt NJ, Clements GB. Simple technique for detecting RNA viruses by PCR in single sections of wax embedded tissue. J Clin Pathol. 1993;46:276–277.
-
(1993)
J Clin Pathol
, vol.46
, pp. 276-277
-
-
Woodall, C.J.1
Watt, N.J.2
Clements, G.B.3
-
29
-
-
0034146097
-
Telomerase reverse transcriptase expression is increased early in the Barrett’s metaplasia, dysplasia, adenocarcinoma sequence
-
COI: 1:STN:280:DC%2BD3c7jvFKktA%3D%3D, PID: 10675236
-
Lord RV, Salonga D, Danenberg KD, et al. Telomerase reverse transcriptase expression is increased early in the Barrett’s metaplasia, dysplasia, adenocarcinoma sequence. J Gastrointest Surg. 2000;4:135–142.
-
(2000)
J Gastrointest Surg
, vol.4
, pp. 135-142
-
-
Lord, R.V.1
Salonga, D.2
Danenberg, K.D.3
-
30
-
-
0029964835
-
A novel method for real time quantitative RT-PCR
-
COI: 1:CAS:528:DyaK28XmsVWru7s%3D, PID: 8908519
-
Gibson UE, Heid CA, Williams PM. A novel method for real time quantitative RT-PCR. Genome Res. 1996;6:995–1001.
-
(1996)
Genome Res
, vol.6
, pp. 995-1001
-
-
Gibson, U.E.1
Heid, C.A.2
Williams, P.M.3
-
31
-
-
0029957181
-
Real time quantitative PCR
-
COI: 1:CAS:528:DyaK28XmsVWru7w%3D, PID: 8908518
-
Heid CA, Stevens J, Livak KJ, et al. Real time quantitative PCR. Genome Res. 1996;6:986–994.
-
(1996)
Genome Res
, vol.6
, pp. 986-994
-
-
Heid, C.A.1
Stevens, J.2
Livak, K.J.3
-
32
-
-
0033565625
-
Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes
-
COI: 1:CAS:528:DyaK1MXks1Omsbs%3D, PID: 10416617
-
Kornmann M, Danenberg KD, Arber N, et al. Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes. Cancer Res. 1999;59:3505–3511.
-
(1999)
Cancer Res
, vol.59
, pp. 3505-3511
-
-
Kornmann, M.1
Danenberg, K.D.2
Arber, N.3
-
33
-
-
0030824603
-
Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: evidence for autocrine and paracrine actions
-
COI: 1:CAS:528:DyaK2sXmsFCitrY%3D, PID: 9333017
-
Kornmann M, Ishiwata T, Beger HG, et al. Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: evidence for autocrine and paracrine actions. Oncogene. 1997;15:1417–1424.
-
(1997)
Oncogene
, vol.15
, pp. 1417-1424
-
-
Kornmann, M.1
Ishiwata, T.2
Beger, H.G.3
-
35
-
-
78649826428
-
Updates of mTOR inhibitors
-
COI: 1:CAS:528:DC%2BC3cXhs1art7jM, PID: 20812900
-
Zhou H, Luo Y, Huang S. Updates of mTOR inhibitors. Anticancer Agents Med Chem. 2010;10:571–581.
-
(2010)
Anticancer Agents Med Chem
, vol.10
, pp. 571-581
-
-
Zhou, H.1
Luo, Y.2
Huang, S.3
-
36
-
-
84887228819
-
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
-
COI: 1:CAS:528:DC%2BC3sXhs1yhsb7O, PID: 24161930
-
Liu P, Gan W, Inuzuka H, et al. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol. 2013;15:1340–1350.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 1340-1350
-
-
Liu, P.1
Gan, W.2
Inuzuka, H.3
-
37
-
-
79958696694
-
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
-
COI: 1:CAS:528:DC%2BC3MXntVGltLs%3D, PID: 21659604
-
Hsu PP, Kang SA, Rameseder J, et al. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science. 2011;332:1317–1322.
-
(2011)
Science
, vol.332
, pp. 1317-1322
-
-
Hsu, P.P.1
Kang, S.A.2
Rameseder, J.3
-
38
-
-
79958696336
-
Quantitative phosphoproteomic analysis identifies the adaptor protein Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
-
COI: 1:CAS:528:DC%2BC3MXntVGltLg%3D, PID: 21659605
-
Yu Y, Yoon SO, Poulogiannis G, et al. Quantitative phosphoproteomic analysis identifies the adaptor protein Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science. 2011;332:1322–1326.
-
(2011)
Science
, vol.332
, pp. 1322-1326
-
-
Yu, Y.1
Yoon, S.O.2
Poulogiannis, G.3
-
39
-
-
4544220704
-
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
-
COI: 1:CAS:528:DC%2BD2cXntlGks7g%3D, PID: 15306821
-
Um SH, Frigerio F, Watanabe M, et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature. 2004;431:200–205.
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
Frigerio, F.2
Watanabe, M.3
-
40
-
-
34548324283
-
Epithelial cell adhesion molecule. More than a carcinoma marker and adhesion molecule
-
COI: 1:CAS:528:DC%2BD2sXpsFaitLg%3D, PID: 17600130
-
Trzpis M, McLaughlin PMJ, Leij LMFH, et al. Epithelial cell adhesion molecule. More than a carcinoma marker and adhesion molecule. Am J Pathol. 2007;171:386–395.
-
(2007)
Am J Pathol
, vol.171
, pp. 386-395
-
-
Trzpis, M.1
McLaughlin, P.M.J.2
Leij, L.M.F.H.3
-
41
-
-
30644472381
-
Frequent high-level expression of the immunotherapeutic target EpCAM in colon, stomach, prostate and lung cancers
-
COI: 1:CAS:528:DC%2BD28XisVGgug%3D%3D, PID: 16404366
-
Went P, Vasei M, Bubendorf L, et al. Frequent high-level expression of the immunotherapeutic target EpCAM in colon, stomach, prostate and lung cancers. Br J Cancer. 2006;94:128–135.
-
(2006)
Br J Cancer
, vol.94
, pp. 128-135
-
-
Went, P.1
Vasei, M.2
Bubendorf, L.3
-
42
-
-
78751603857
-
Gene expression signature of the gross morphology in hepatocellular carcinoma
-
PID: 21233610
-
Murakata A, Tanaka S, Mogushi K, et al. Gene expression signature of the gross morphology in hepatocellular carcinoma. Ann Surg. 2011;253:94–100.
-
(2011)
Ann Surg
, vol.253
, pp. 94-100
-
-
Murakata, A.1
Tanaka, S.2
Mogushi, K.3
-
43
-
-
84898989382
-
Hepatocellular carcinoma: reasons for phase III failure and novel perspectives on trial design
-
COI: 1:CAS:528:DC%2BC2cXmtl2msL4%3D, PID: 24589894
-
Llovet JM, Hernandez-Gea V. Hepatocellular carcinoma: reasons for phase III failure and novel perspectives on trial design. Clin Cancer Res. 2014;20:2072–2079.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 2072-2079
-
-
Llovet, J.M.1
Hernandez-Gea, V.2
|