Differential Regulation of Gene Expression of Alveolar Epithelial Cell Markers in Human Lung Adenocarcinoma-Derived A549 Clones

Stem Cells International

Volumn 2015, Issue , 2015, Pages

  Kondo, Hiroshi ^a   Miyoshi, Keiko ^a   Sakiyama, Shoji ^a   Tangoku, Akira ^a   Noma, Takafumi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

8 BROMO CYCLIC AMP; AQUAPORIN 5; CELL MARKER; DEXAMETHASONE; ISOBUTYLMETHYLXANTHINE; KERATINOCYTE GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; SURFACTANT PROTEIN B; SURFACTANT PROTEIN C; THYROID TRANSCRIPTION FACTOR 1;

A549 CELL LINE; ARTICLE; CELL CLONING; CELL DIFFERENTIATION; CELL SUBPOPULATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ADENOCARCINOMA; LUNG ALVEOLUS EPITHELIUM CELL; PLASTICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 84934273618     PISSN: None     EISSN: 16879678     Source Type: Journal    
DOI: 10.1155/2015/165867     Document Type: Article

References (71)

1. T. G. Liou, S. M. Raman, and B. C. Cahill, "Lung transplantation for chronic obstructive pulmonary disease", Transplant Research and Risk Management, vol. 2013, no. 5, pp. 1-20, 2013.
2. D. Siniscalco, N. Sullo, S. Maione, F. Rossi, and B. D'Agostino, "Stem cell therapy: the great promise in lung disease", Therapeutic Advances in Respiratory Disease, vol. 2, no. 3, pp. 173-177, 2008.
3. A. Tzouvelekis, G. Laurent, and D. Bouros, "Stem cell therapy in chronic obstructive pulmonary disease. Seeking the prometheus effect", Current Drug Targets, vol. 14, no. 2, pp. 246-252, 2013.
4. M. Ghaedi, E. A. Calle, J. J. Mendez et al., "Human i PS cell-derived alveolar epithelium repopulates lung extracellular matrix", The Journal of Clinical Investigation, vol. 123, no. 11, pp. 4950-4962, 2013.
5. S. X. L. Huang, M. N. Islam, J. O'Neill et al., "Efficient generation of lung and airway epithelial cells from human pluripotent stem cells", Nature Biotechnology, vol. 32, no. 1, pp. 84-91, 2014.
6. M. C. Williams, "Alveolar type I cells: molecular phenotype and development", Annual Review of Physiology, vol. 65, pp. 669-695, 2003.
7. K. Dahlin, E. M. Mager, L. Allen et al., "Identification of genes differentially expressed in rat alveolar type I cells", American Journal of Respiratory Cell and Molecular Biology, vol. 31, no. 3, pp. 309-316, 2004.
8. S. M. Kreda, M. C. Gynn, D. A. Fenstermacher, R. C. Boucher, and S. E. Gabriel, "Expression and localization of epithelial aquaporins in the adult human lung", American Journal of Respiratory Cell and Molecular Biology, vol. 24, no. 3, pp. 224-234, 2001.
9. L. De Maio, W. Tseng, Z. Balverde et al., "Characterization of mouse alveolar epithelial cell monolayers", American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 296, no. 6, pp. L1051-L1058, 2009.
10. G. R. Newman, L. Campbell, C. von Ruhland, B. Jasani, and M. Gumbleton, "Caveolin and its cellular and subcellular immunolocalisation in lung alveolar epithelium: implications for alveolar epithelial type I cell function", Cell and Tissue Research, vol. 295, no. 1, pp. 111-120, 1999.
11. N. Demling, C. Ehrhardt, M. Kasper, M. Laue, L. Knels, and E. P. Rieber, "Promotion of cell adherence and spreading: a novel function of RAGE, the highly selective differentiationmarker of human alveolar epithelial type I cells", Cell and Tissue Research, vol. 323, no. 3, pp. 475-488, 2006.
12. J. R. Rock and B. L. M. Hogan, "Epithelial progenitor cells in lung development, maintenance, repair, and disease", Annual Review of Cell and Developmental Biology, vol. 27, pp. 493-512, 2011.
13. H. Fehrenbach, "Alveolar epithelial type II cell: defender of the alveolus revisited", Respiratory Research, vol. 2, no. 3, pp. 475-488, 2006.
14. F. Possmayer, "A proposed nomenclature for pulmonary surfactant-associated proteins", American Review of Respiratory Disease, vol. 138, no. 4, pp. 990-998, 1988.
15. Y. Kuroki and D. R. Voelker, "Pulmonary surfactant proteins", The Journal of Biological Chemistry, vol. 269, no. 42, pp. 25943-25946, 1994.
16. T. Yamaguchi, Y. Hosono, K. Yanagisawa, and T. Takahashi, "NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression", Cancer Cell, vol. 23, no. 6, pp. 718-723, 2013.
17. V. Boggaram, "Thyroid transcription factor-1 (TTF-1/Nkx2.1/TITF1) gene regulation in the lung", Clinical Science, vol. 116, no. 1, pp. 27-35, 2009.
18. R. J. Bohinski, R. Di Lauro, and J. A. Whitsett, "The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis", Molecular and Cellular Biology, vol. 14, no. 9, pp. 5671-5681, 1994.
19. S. E. Kelly, C. J. Bachurski, M. S. Burhans, and S. W. Glasser, "Transcription of the lung-specific surfactant protein C gene is mediated by thyroid transcription factor 1", The Journal of Biological Chemistry, vol. 271, no. 12, pp. 6881-6888, 1996.
20. J. V. Degiulio, C. D. Kaufman, and D. A. Dean, "The SPC promoter facilitates alveolar type II epithelial cell-specific plasmid nuclear import and gene expression", Gene Therapy, vol. 17, no. 4, pp. 541-549, 2010.
21. 2", The American Journal of Pathology, vol. 70, no. 2, pp. 175-198, 1973.
22. B. D. Uhal, "Cell cycle kinetics in the alveolar epithelium", The American Journal of Physiology, vol. 272, no. 6, part 1, pp. L1031-L1045, 1997.
23. L. B. Ware and M. A. Matthay, "The acute respiratory distress syndrome", The New England Journal of Medicine, vol. 342, no. 18, pp. 1334-1349, 2000.
24. G. R. Clegg, C. Tyrrell, S. R. McKechnie, M. F. Beers, D. Harrison, and M. C. McElroy, "Coexpression of RTI40 with alveolar epithelial type II cell proteins in lungs following injury: identification of alveolar intermediate cell types", American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 289, no. 3, pp. L382-L390, 2005.
25. T. J. Desai, D. G. Brownfield, and M. A. Krasnow, "Alveolar progenitor and stem cells in lung development, renewal and cancer", Nature, vol. 507, no. 7491, pp. 190-194, 2014.
26. C. E. Barkauskas, M. J. Cronce, C. R. Rackley et al., "Type 2 alveolar cells are stem cells in adult lung", The Journal of Clinical Investigation, vol. 123, no. 7, pp. 3025-3036, 2013.
27. D. M. Valenzuela and J. Groffen, "Four human carcinoma cell lines with novel mutations in position 12 of c-K-ras oncogene", Nucleic Acids Research, vol. 14, no. 2, pp. 843-852, 1986.
28. M. Krypuy, G. M. Newnham, D. M. Thomas, M. Conron, and A. Dobrovic, "High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer", BMC Cancer, vol. 6, article 295, 2006.
29. J. Amann, S. Kalyankrishna, P. P. Massion et al., "Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer", Cancer Research, vol. 65, no. 1, pp. 226-235, 2005.
30. M. Lieber, B. Smith, A. Szakal, W. Nelson-Rees, and G. Todaro, "A continuous tumor cell line from a human lung carcinoma with properties of type II alveolar epithelial cells", International Journal of Cancer, vol. 17, no. 1, pp. 62-70, 1976.
31. V. Kolla, L. W. Gonzales, J. Gonzales et al., "Thyroid transcription factor in differentiating type II cells: regulation, isoforms, and target genes", American Journal of Respiratory Cell and Molecular Biology, vol. 36, no. 2, pp. 213-225, 2007.
32. I. R. Witherden, E. J. V. Bon, P. Goldstraw, C. Ratcliffe, U. Pastorino, and T. D. Tetley, "Primary human alveolar type II epithelial cell chemokine release: effects of cigarette smoke and neutrophil elastase", American Journal of Respiratory Cell and Molecular Biology, vol. 30, no. 4, pp. 500-509, 2004.
33. M. V. Croce, A. G. Colussi, M. R. Price, and A. Segal-Eiras, "Identification and characterization of different subpopulations in a human lung adenocarcinoma cell line (A549)", Pathology & Oncology Research, vol. 5, no. 3, pp. 197-204, 1999.
34. Z. Rucka, P. Vanhara, I. Koutna et al., "Differential effects of insulin and dexamethasone on pulmonary surfactant-associated genes and proteins in A549 and H441 cells and lung tissue", International Journal of Molecular Medicine, vol. 32, no. 1, pp. 211-218, 2013.
35. R. E. Scott, C.-Y. Tzen, M. M. Witte, S. Blatti, and H. Wang, "Regulation of differentiation, proliferation and cancer suppressor activity", The International Journal of Developmental Biology, vol. 37, no. 1, pp. 67-74, 1993.
36. G. L. Semenza, "Targeting HIF-1 for cancer therapy", Nature Reviews Cancer, vol. 3, no. 10, pp. 721-732, 2003.
37. Q. Ke and M. Costa, "Hypoxia-inducible factor-1 (HIF-1)", Molecular Pharmacology, vol. 70, no. 5, pp. 1469-1480, 2006.
38. D. T. Dang, F. Chen, L. B. Gardner et al., "Hypoxiainducible factor-1α promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts", Cancer Research, vol. 66, no. 3, pp. 1684-1693, 2006.
39. J. Brognard and P. A. Dennis, "Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by smallmolecules or dominant negativemutants", Cell Death and Differentiation, vol. 9, no. 9, pp. 893-904, 2002.
40. J. Niu, Q. Mo, H. Wang, M. Li, J. Cui, and Z. Li, "Invasion inhibition by a MEK inhibitor correlates with the actin-based cytoskeleton in lung cancer A549 cells", Biochemical and Biophysical Research Communications, vol. 422, no. 1, pp. 80-84, 2012.
41. T. A. Longmire, L. Ikonomou, F. Hawkins et al., "Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells", Cell Stem Cell, vol. 10, no. 4, pp. 398-411, 2012.
42. S. Gotoh, I. Ito, T. Nagasaki et al., "Generation of alveolar epithelial spheroids via isolated progenitor cells from human pluripotent stem cells", Stem Cell Reports, vol. 3, no. 3, pp. 394-403, 2014.
43. L. W. Gonzales, S. H. Guttentag, K. C. Wade, A. D. Postle, and P. L. Ballard, "Differentiation of human pulmonary type II cells in vitro by glucocorticoid plus c AMP", American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 283, no. 5, pp. L940-L951, 2002.
44. P. L. Ballard, J. W. Lee, X. Fang et al., "Regulated gene expression in cultured type II cells of adult human lung", American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 299, no. 1, pp. L36-L50, 2010.
45. C. D. Foster, L. S. Varghese, R. B. Skalina, L. W. Gonzales, and S. H. Guttentag, "In vitro transdifferentiation of human fetal type II cells toward a type I-like cell", Pediatric Research, vol. 61, no. 4, pp. 404-409, 2007.
46. K. A. Foster, C. G. Oster, M. M. Mayer, M. L. Avery, and K. L. Audus, "Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism", Experimental Cell Research, vol. 243, no. 2, pp. 359-366, 1998.
47. M. E. Winkler, C. Mauritz, S. Groos et al., "Serum-free differentiation of murine embryonic stem cells into alveolar type II epithelial cells", Cloning and Stem Cells, vol. 10, no. 1, pp. 49-64, 2008.
48. R. S. Herbst, J. V. Heymach, and S. M. Lippman, "Molecular origins of cancer: lung cancer", The New England Journal of Medicine, vol. 359, no. 13, pp. 1367-1380, 2008.
49. M. F. Favata, K. Y. Horiuchi, E. J. Manos et al., "Identification of a novel inhibitor ofmitogen-activated protein kinase kinase", The Journal of Biological Chemistry, vol. 273, no. 29, pp. 18623-18632, 1998.
50. D. T. Dudley, L. Pang, S. J. Decker, A. J. Bridges, and A. R. Saltiel, "A synthetic inhibitor of the mitogen-activated protein kinase cascade", Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 17, pp. 7686-7689, 1995.
51. C. Lauand, P. Rezende-Teixeira, B. A. Cortez, E. L. D. O. Niero, and G. M. Machado-Santelli, "Independent of Erb B1 gene copy number, EGF stimulates migration but is not associated with cell proliferation in non-small cell lung cancer", Cancer Cell International, vol. 13, no. 1, article 38, 2013.
52. P. W. Cook, P. A. Mattox, W. W. Keeble et al., "A heparin sulfateregulated human keratinocyte autocrine factor is similar or identical to amphiregulin", Molecular and Cellular Biology, vol. 11, no. 5, pp. 2547-2557, 1991.
53. K. Hashimoto, S. Higashiyama, H. Asada et al., "Heparinbinding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes", The Journal of Biological Chemistry, vol. 269, no. 31, pp. 20060-20066, 1994.
54. R. C. Harris, E. Chung, and R. J. Coffey, "EGF receptor ligands", Experimental Cell Research, vol. 284, no. 1, pp. 2-13, 2003.
55. E. Kakiashvili, Q. Dan, M. Vandermeer et al., "The epidermal growth factor receptor mediates tumor necrosis factor-α-induced activation of the ERK/GEF-H1/Rho A pathway in tubular epithelium", The Journal of Biological Chemistry, vol. 286, no. 11, pp. 9268-9279, 2011.
56. O. Warburg, "On the origin of cancer cells", Science, vol. 123, no. 3191, pp. 309-314, 1956.
57. N. D. Amoêdo, M. F. Rodrigues, P. Pezzuto et al., "Energy metabolism in H460 lung cancer cells: effects of histone deacetylase inhibitors", PLoS ONE, vol. 6, no. 7, Article ID e22264, 2011.
58. K. Sugahara, J. S. Rubin, R. J. Mason, E. L. Aronsen, and J. M. Shannon, "Keratinocyte growth factor increases m RNAs for SP-A and SP-B in adult rat alveolar type II cells in culture", American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 269, no. 3, part 2, pp. L344-L350, 1995.
59. N. Chelly, O.-B. Mouhieddine-Gueddiche, A.-M. Barlier-Mur, B. Chailley-Heu, and J. R. Bourbon, "Keratinocyte growth factor enhances maturation of fetal rat lung type II cells", American Journal of Respiratory Cell and Molecular Biology, vol. 20, no. 3, pp. 423-432, 1999.
60. Z. Borok, R. L. Lubman, S. I. Danto et al., "Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin 5", American Journal of Respiratory Cell and Molecular Biology, vol. 18, no. 4, pp. 554-561, 1998.
61. S. Schmeckebier, C. Mauritz, K. Katsirntaki et al., "Keratinocyte growth factor and dexamethasone plus elevated c AMP levels synergistically support pluripotent stemcell differentiation into alveolar epithelial type II cells", Tissue Engineering Part A, vol. 19, no. 7-8, pp. 938-951, 2013.
62. W. Zhou, M. Choi, D. Margineantu et al., "HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESCto-Epi SC/h ESC transition", The EMBOJournal, vol. 31, no. 9, pp. 2103-2116, 2012.
63. L. Zhao, M. Yee, and M. A. O'Reilly, "Transdifferentiation of alveolar epithelial type II to type I cells is controlled by opposing TGF-β and BMP signaling", American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 305, no. 6, pp. L409-L418, 2013.
64. M. C. Ghosh, V. Gorantla, P. S. Makena et al., "Insulin-like growth factor-I stimulates differentiation of ATII cells to ATIlike cells through activation of Wnt5a", American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 305, no. 3, pp. L222-L228, 2013.
65. N. O. Bianchi, "Y chromosome structural and functional changes in human malignant diseases", Mutation Research, vol. 682, no. 1, pp. 21-27, 2009.
66. S. Vijayakumar, D. Garcia, C. H. Hensel et al., "The human Y chromosome suppresses the tumorigenicity of PC-3, a human prostate cancer cell line, in athymic nude mice", Genes Chromosomes & Cancer, vol. 44, no. 4, pp. 365-372, 2005.
67. S. Vijayakumar, D. C. Hall, X. T. Reveles et al., "Detection of recurrent copy number loss at Yp11.2 involving TSPY gene cluster in prostate cancer using array-based comparative genomic hybridization", Cancer Research, vol. 66, no. 8, pp. 4055-4064, 2006.
68. L. A. Forsberg, C. Rasi, N. Malmqvist et al., "Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer", Nature Genetics, vol. 46, no. 6, pp. 624-628, 2014.
69. K. Kemper, P. L. de Goeje, D. S. Peeper, and R. van Amerongen, "Phenotype switching: tumor cell plasticity as a resistance mechanism and target for therapy", Cancer Research, vol. 74, no. 21, pp. 5937-5941, 2014.
70. G. J. Riely, J. Marks, and W. Pao, "KRASmutations in non-small cell lung cancer", Proceedings of the American Thoracic Society, vol. 6, no. 2, pp. 201-205, 2009.
71. M. D. Siegelin and A. C. Borczuk, "Epidermal growth factor receptor mutations in lung adenocarcinoma", Laboratory Investigation, vol. 94, no. 2, pp. 129-137, 2014.