Aegeline from Aegle marmelos stimulates glucose transport via Akt and Rac1 signaling, and contributes to a cytoskeletal rearrangement through PI3K/Rac1

European Journal of Pharmacology

Volumn 762, Issue , 2015, Pages 419-429

  Gautam, Sudeep ^a   Ishrat, Nayab ^a   Singh, Rohit ^a   Narender, Tadigoppula ^a   Srivastava, Arvind K ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Aegeline; Aegle marmelos; C2C12 myotubes; Cofilin; Glucose uptake; Insulin resistance

Indexed keywords

2 DEOXY GLUCOSE; AEGELINE; ANTIDIABETIC AGENT; COFILIN; GENISTEIN; GLUCOSE DERIVATIVE; GLUCOSE TRANSPORTER 4; INSULIN RECEPTOR SUBSTRATE 1; P21 ACTIVATED KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAC1 PROTEIN; UNCLASSIFIED DRUG; WORTMANNIN; ACTIN; AMIDE; GLUCOSE; P21 ACTIVATED KINASE;

ACTIN FILAMENT; ACTIN POLYMERIZATION; AEGLE MARMELOS; ARTICLE; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOSKELETAL REARRANGEMENT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; GLUCOSE TRANSPORT; MYOTUBE; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; AEGLE; ANIMAL; CELL LINE; CHEMISTRY; CYTOLOGY; CYTOSKELETON; DOSE RESPONSE; DRUG EFFECTS; HUMAN; INSULIN RESISTANCE; METABOLISM; MOUSE; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN TRANSPORT; SKELETAL MUSCLE; SKELETAL MUSCLE CELL; TIME FACTOR;

ACTIN CYTOSKELETON; ACTINS; AEGLE; AMIDES; ANIMALS; CELL LINE; CYTOSKELETON; DOSE-RESPONSE RELATIONSHIP, DRUG; GENISTEIN; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HUMANS; INSULIN RESISTANCE; MICE; MUSCLE FIBERS, SKELETAL; MUSCLE, SKELETAL; P21-ACTIVATED KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; RAC1 GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84933575578     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.05.021     Document Type: Article

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