Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ

Biochemistry

Volumn 54, Issue 25, 2015, Pages 3911-3920

  Zhang, Min Min ^a   Gajewiak, Joanna ^a   Azam, Layla ^a   Bulaj, Grzegorz ^a   Olivera, Baldomero M ^a   Yoshikami, Doju ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; COVALENT BONDS; ENZYME ACTIVITY; ION EXCHANGE; PEPTIDES; SULFUR COMPOUNDS; TOXIC MATERIALS;

CHANNEL COMPLEX; CYS REPLACEMENT; DISULFIDE BONDS; DITHIOTHREITOL; LEAVING GROUPS; REACTION SCHEMES; THIOL DISULFIDE EXCHANGE; XENOPUS LAEVIS OOCYTES;

SODIUM;

CONOTOXIN; CONOTOXIN GVIIJ; CYSTEINE; PEPTIDE DERIVATIVE; SODIUM CHANNEL NAV1.2; UNCLASSIFIED DRUG; DISULFIDE; SCN2A1 PROTEIN, RAT;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DISULFIDE BOND; ELECTRICITY; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; MOLECULAR PROBE; MOLECULAR WEIGHT; NONHUMAN; OOCYTE; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTION ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SODIUM CURRENT; WILD TYPE; XENOPUS LAEVIS; ANIMAL; CHEMISTRY; GENETICS; KINETICS; METABOLISM; OXIDATION REDUCTION REACTION; RAT;

RATTUS; XENOPUS LAEVIS;

ANIMALS; BINDING SITES; CONOTOXINS; CYSTEINE; DISULFIDES; KINETICS; NAV1.2 VOLTAGE-GATED SODIUM CHANNEL; OOCYTES; OXIDATION-REDUCTION; RATS; XENOPUS LAEVIS;

EID: 84933564453     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b00390     Document Type: Article

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