Maleimide conjugates of saxitoxin as covalent inhibitors of voltage-gated sodium channels

Journal of the American Chemical Society

Volumn 135, Issue 29, 2013, Pages 10582-10585

  Parsons, William H ^a,b   Du Bois, J ^a  

^a STANFORD UNIVERSITY   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHANNEL FUNCTIONS; LIVE-CELL IMAGING; NATURALLY OCCURRING; PROTEIN MODIFICATIONS; SECOND GENERATION; SELECTIVE LABELING; SODIUM ION CHANNELS; TOTAL SYNTHESIS;

AMINO ACIDS; METAL IONS; MOLECULAR BIOLOGY; NEURONS; SODIUM; TOXIC MATERIALS;

CHEMICAL REACTIONS;

MALEIMIDE; SAXITOXIN; SUCCINIMIDE; VOLTAGE GATED SODIUM CHANNEL;

ALKYLATION; ARTICLE; CHEMICAL STRUCTURE; HIPPOCAMPUS; PROTEIN MODIFICATION; PROTEOMICS; SODIUM CONDUCTANCE; SYNTHESIS;

ANIMALS; CHO CELLS; CRICETULUS; HUMANS; MALEIMIDES; MODELS, MOLECULAR; NEURONS; RATS; SAXITOXIN; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 84880813914     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja4019644     Document Type: Article

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