Tormentic acid inhibits LPS-induced inflammatory response in human gingival fibroblasts via inhibition of TLR4-mediated NF-κB and MAPK signalling pathway

Archives of Oral Biology

Volumn 60, Issue 9, 2015, Pages 1327-1332

  Jian, Cong Xiang ^a,b   Li, Ming Zhe ^a   Zheng, Wei Yin ^a   He, Yong ^a   Ren, Yu ^a   Wu, Zhong Min ^a   Fan, Quan Shui ^b   Hu, Yong He ^b   Li, Chen Jun ^a  

^a CHENGDU MILITARY GENERAL HOSPITAL   (China)

^b Chengdu Military Garrison Center for Disease Control and Prevention   (China)

Author keywords

Cytokine; Human gingival fibroblasts; MAPKs; NF B; Tormentic acid

Indexed keywords

PORPHYROMONAS GINGIVALIS; ROSA RUGOSA;

I KAPPA B; I KAPPA B BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; TLR4 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 4; TORMENTIC ACID; TRITERPENE;

CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; GINGIVA; HUMAN; METABOLISM; PORPHYROMONAS GINGIVALIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; GINGIVA; HUMANS; I-KAPPA B PROTEINS; INTERLEUKIN-6; INTERLEUKIN-8; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; NF-KAPPA B; PORPHYROMONAS GINGIVALIS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TRITERPENES;

EID: 84933556356     PISSN: 00039969     EISSN: 18791506     Source Type: Journal    
DOI: 10.1016/j.archoralbio.2015.05.005     Document Type: Article

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