Tormentic acid, a triterpenoid saponin, isolated from Rosa rugosa, inhibited LPS-induced iNOS, COX-2, and TNF-α expression through inactivation of the nuclear factor-κb pathway in RAW 264.7 macrophages

International Immunopharmacology

Volumn 11, Issue 4, 2011, Pages 504-510

  An, Hyo Jin ^a   Kim, In Tae ^a   Park, Hee Juhn ^b   Kim, Hyung Min ^a   Choi, Jung Hye ^a,c   Lee, Kyung Tae ^a,c  

^a Kyung Hee University   (South Korea)

^b Sangji University   (South Korea)

^c Kyung Hee University Hospital   (South Korea)

Author keywords

Nitric oxide; Nuclear factor B (NF B); Raw 264.7 cells; Rosa rugosa; Tormentic acid

Indexed keywords

CYCLOOXYGENASE 2; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; PROSTAGLANDIN E2; TORMENTIC ACID; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DNA BINDING; DOWN REGULATION; DRUG MECHANISM; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; ENZYME SYNTHESIS; GENE EXPRESSION; IMMUNOREGULATION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ROSA RUGOSA; ROSACEAE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORETIC MOBILITY SHIFT ASSAY; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MOLECULAR STRUCTURE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PLANT ROOTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; ROSACEAE; SAPONINS; SIGNAL TRANSDUCTION; TRITERPENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79952735309     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2011.01.002     Document Type: Article

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