Milestones in periodontal research and the remaining critical issues

Journal of Periodontal Research

Volumn 34, Issue 7, 1999, Pages 331-339

  Page, Roy C ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Disease prevalence; Inflammatory mediators; Microbiology; Risk factors; Therapy; Tissue destruction

Indexed keywords

ADULT; ARTICLE; DENTAL RESEARCH; HISTORY; HUMAN; PERIODONTAL DISEASE; PERIODONTICS; PERIODONTITIS; PREVALENCE;

ADULT; DENTAL RESEARCH; HISTORY, 20TH CENTURY; HUMANS; PERIODONTAL DISEASES; PERIODONTICS; PERIODONTITIS; PREVALENCE;

EID: 0033202463     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.1999.tb02262.x     Document Type: Article

References (67)

1. Brown JL, Loe H. Prevalence, extent, severity and progression of periodontal disease. Periodontol 2000 1993; 2:57-71.
2. Brown JL, Oliver RC, Loe H. Evaluating periodontal status of U.S. employed adults. J Am Dent Assoc 1990;121: 226-232.
3. Halazonetis TD, Haffajee AD, Socransky SS. Relationship of clinical parameters to attachment loss in subsets of subjects with destructive periodontal disease. J Clin Periodontol 1989;16:563-568.
4. Jenkins WMM, MacFarlane TW, Gilmour WH. Longitudinal study of untreated periodontitis. Clinical findings. J Clin Periodontol 1988;15:324-330.
5. Lindhe J, Haffajee AD, Socransky SS. Progression of periodontal disease in adult subjects in the absence of periodontal therapy. J Clin Periodontol 1983;10:433-442.
6. Yoneyama T, Okamoto H, Lindhe J, Socransky SS, Haffajee AD. Probing depth, attachment loss and gingival recession. Findings from a clinical examination in Ushikus, Japan. J Clin Periodontol 1988;15:581-591.
7. Abdellatif HM, Burt BA. An epidemiological investigation into the relative importance of age and oral hygiene status as determinants of periodontitis. J Dent Res 1987;66:13-18.
8. Axelsson P, Lindhe J, Nyström B. On the prevention of caries and periodontal disease. Results of a 15-year longitudinal study in adults. J Clin Periodontol 1991;18:182-189.
9. Baelum V, Fejerskov O, Karring T. Oral hygiene, gingivitis and periodontal breakdown in adult Tanzanians. J Periodont Res 1986;21:221-232.
10. Reddy J, Africa CS, Parker JR. Darkfield microscopy of subgingival plaque of an urban black population with poor oral hygiene. J Clin Periodontol 1986;13:578-582.
11. Macdonald JB, Gibbons RJ, Socransky SS. Bacterial mechanisms in periodontal disease. Ann NY Acad Sci 1960;85:467-478.
12. Socransky SS, Gibbons RJ, Dale AC, Bortnick L, Rosenthal E, Macdonald JB. The microbiota of the gingival crevice area of man I. Total microscopic and viable counts and counts of specific organisms. Arch Oral Biol 1963;8:275-280.
13. Jordan HN, Keyes PH. Aerobic, Gram-positive filamentous bacteria as etiologic agents of experimental periodontal disease in hamsters. Arch Oral Biol 1964;9:401-414.
14. Keyes PH, Jordan HN. Periodontal lesions in the Syrian hamster. III. Findings related to an infectious and transmissible component. Arch Oral Biol 1964;9:377-400.
15. Loe H, Theilade E, Jensen SB. Experimental gingivitis in man. J Periodontol 1965;36:177-187.
16. Ellison SA. Oral bacteria and periodontal disease. J Dent Res 1970;49:198-202.
17. Genco RJ, Evans RT, Ellison SA. Dental research in microbiology with emphasis on periodontal disease. J Am Dent Assoc 1969;78:1016-1036.
18. Keyes PH. Are periodontal pathoses caused by bacterial infections on cervicoradicular surfaces of teeth? J Dent Res 1970;49:223-228.
19. Socransky SS. Relationship of bacteria to the etiology of periodontal disease. J Dent Res 1970;49:203-222.
20. Loesche WJ. Chemotherapy of dental plaque infections. Oral Sci Rev 1976;9:65-107.
21. Loesche WJ. Possibilities for treating periodontal disease as specific anaerobic infections. J Can Dent Assoc Symp 1984;25:467-472.
22. Newman MG, Socransky SS, Savitt ED, Propas DA, Crawford A. Studies of the microbiology of periodontosis. J Periodontol 1976;47:373-379.
23. Slots J. The predominant cultivable organisms in juvenile periodontitis. Scand J Dent Res 1976;84:1-10.
24. Tanner ARC, Haffer C, Bratthall GT, Visconti RA, Socransky SS. A study of the bacteria associated with advancing periodontitis in man. J Clin Periodontol 1979; 6:278-307.
25. Hugenholtz P, Goebel BM, Pace NR. Impact of culture-independent studies on the emerging phylogenetic view of bacterial diversity. J Bacteriol 1998;180:4765-4774.
26. Choi BK, Paster BJ, Dewhirst FE, Gobel UB. Diversity of cultivable and uncultivable oral spirochetes from a patient with severe destructive periodontitis. Infect Immun 1994; 62:1889-1895.
27. Haffajee AD, Socransky SS. Microbial etiologic agents of destructive periodontal diseases. Periodontol 2000 1994;5: 78-111.
28. Socransky SS, Haffajee AD. Microbial mechanisms in the pathogenesis of destructive periodontal disease: a critical assessment. J Periodont Res 1991;26:195-211.
29. Dahlin G, Manji F, Baelum V, Fejerskou O. Black pigmented Bacteroides species and Actinobacillus actinomycetemcomitans in subgingival plaque of adult Kenyans. J Clin Periodontol 1989;16:305-310.
30. McNabb H, Mombelli AS, Gmur R, Mathey-Din S, Lang NP. Periodontal pathogens in the shallow pockets of immigrants from developing countries. Oral Microbiol Immunol 1992;7:267-272.
31. Loos BG, Dyer DS, Whittam TS, Selander RK. Genetic structure of populations of Porphyromonas gingivalis associated with periodontitis and other oral infections. Infect Immun 1993;61:204-212.
32. Menard C, Mouton C. Clonal diversity of the taxon Porphyromonas gingivalis assessed by random amplified polymorphic DNA fingerprinting. Infect Immun 1995;63: 2522-2531.
33. Teanpaisan R, Douglas CWI, Eley AR, Walsh TF. Clonality of Porphyromonas gingivalis, Prevotella intermedia and Prevotella nigrescens isolated from periodontally diseased and healthy sites. J Periodont Res 1996;31: 232-237.
34. Ali RW, Martin L, Haffajee AD, Socransky SS. Detection of identical ribotypes of Porphyromonas gingivalis in patients residing in the United States, Sudan, Romania and Norway. Oral Microbiol Imunol 1997;12:106-111.
35. Alaluusua S, Saarela M, Jousimies-Somer H, Asikainen S. Ribotyping show intrafamilial similarity in Actinobacillus actinomycetemcomitans isolates. Oral Microbiol Immunol 1993;8:225-229.
36. DiRienzo JM, Slots J. Genetic approach to the study of epidemiology and pathogenesis of Actinobacillus actinomycetemcomitans in localized juvenile periodontitis. Arch Oral Biol 1990;35(suppl):79S-84S.
37. Petit MDA, Van Steenbergen TJM, DeGraaff J, Van der Velden U. Actinobacillus actinomycetyemcomitans in families of adult periodontitis patients. J Periodont Res 1993;28:335-345.
38. Petit MDA, Van Steenbergen TJM, Scholte LMH, Van der Velden U, DeGraaf J. Epidemiology and transmission of Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans among children and their family members. J Clin Periodontol 1993;20:641-650.
39. Saarela M, von Troil-Linden B, Torkko H et al. Transmission of oral bacterial species between spouses. Oral Microbiol Immunol 1993;8:349-354.
40. Van Steenbergen TJ, Petit MD, Scholte LH, Van der Velden U, DeGraaff J. Transmission of Porphyromonas gingivalis between spouses. J Clin Periodontol 1993;20: 278-307.
41. Tinoco EMB, Sivakumar M, Preus HR. The distribution and transmission of Actinobacillus actinomycetemcomitans in families with localized juvenile periodontitis. J Clin Periodontol 1998;25:99-105.
42. Van Winkelhoff AJ, Laine ML, Timmerman MF et al. Prevalence and serotyping of Porphyromonas gingivalis in an Indonesian population. J Clin Periodontol 1999;26: 301-305.
43. Barua PK, Dyer DW, Neiders ME. Effect of iron limitation on Bacteroides gingivalis. Oral Microbiol 1990;5:263-268.
44. Bramanti TE, Holt SC, Ebersole JL, Van Dyke TE. Regulation of Porphyromonas gingivalis virulence: hemin limitation effects on the outer membrane protein (OMP) expression and biologic activity. J Periodont Res 1993;28: 464-466.
45. McKee AS, McDermid AS, Baskerville A, Dowsett AB, Ellwoood DC. Effects of hemin on the physiology and virulence of Bacteroides gingivalis W50. Infect Immun 1986;52:394-355.
46. Costerton JW, Lewandowski Z, DeBeer D et al. Biofilms, the customized microniche. J Bacteriol 1994;176:2137-2142.
47. Ivanyi L, Lehner T. Stimulation of lymphocyte transformation by bacterial antigens in patients with periodontal disease. Archs Oral Biol 1970;15:1089-1096.
48. Lavine WS, Stolman J, Maderazo EG, Ward P, Cogen RC. Defective neutrophil chemotaxis in patients with early onset periodontitis. J Dent Res 1976;55:B212.
49. Gemmell E, Marshall RI, Seymour GJ. Cytokines and prostaglandins in immune homeostasis and tissue destruction in periodontal disease. Periodontol 2000 1997;14: 112-143.
50. Page RC. The role of inflammatory mediators in the pathogenesis of periodontal disease. J Periodont Res 1991; 26:230-242.
51. Birkedal-Hansen H. Role of matrix metalloproteinases in human periodontal disease. J Periodontol 1993;64:474-484.
52. Reynolds JJ, Meikle MC. Mechanisms of connective tissue matrix destruction in periodontitis. Periodontol 2000 1997;14:144-157.
53. Michalowicz BS, Aeppli D, Virag JG et al. Periodontal findings in adult twins. J Periodontol 1991;62:293-299.
54. Schwanz Z, Goultshin J, Dean DD, Boyan BD. Mechanisms of alveolar bone destruction in periodontitis. Periodontol 2000 1997;14:158-172.
55. Hart TC, Kornman KS. Genetic factors in the pathogenesis of periodontitis. Periodontol 2000 1997;14:202-215.
56. Page RC, Beck JD. Risk assessment for periodontal diseases. Int Dent J 1997;47:61-87.
57. Mouton C, Hammond PG, Slots J, Genco RJ. Serum antibodies to oral Bacteroides asaccharolyticus (Bacteroides gingivalis): relationship to age and periodontal disease. Infect Immun 1981;31:182-192.
58. Kornman KS, Crane A, Wang HY et al. The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol 1997;24:72-77.
59. Page RC, Offenbacher S, Schroeder HE, Seymour GJ, Kornman K. Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions. Periodontol 2000 1997;14:216-248.
60. Marshall-Day CD, Stephens RG, Quigley LF Jr. Periodontal disease: prevalence and incidence. J Periodontol 1955; 26:185-203.
61. Page RC, Kornman KS. Pathogenesis of human periodontitis: an introduction. Periodontol 2000 1997;14:9-11.
62. 2 secretion as a determinant of periodontal disease expression. J Periodontol 1993;64:432-444.
63. Page RC. The pathobiology of periodontal diseases may affect systemic diseases: inversion of a paradigm. Ann Periodontol 1998;3:108-120.
64. Consensus report on periodontal diseases: pathogenesis and microbial factors. Ann Periodontol 1996;1:926-932.
65. Lindhe J, Hamp S-E, Loe H. Plaque induced periodontal disease in beagle dogs. 4-year clinical, roentgenographical and histometrical study. J Periodont Res 1975;10:243-255.
66. Salvi GE, Lawrence HP, Offenbacher S, Beck JD. Influence of risk factor on pathogenesis of periodontitis. Periodontol 2000 1997;14:173-201.
67. Spratt DA, Weightman AJ, Wade WG. Diversity of oral assaccharolytic Eubacterium species in periodontitis identification of novel phylotypes representing uncultivated taxa. Oral Microbiol Immunol 1999;14:56-59.