-
1
-
-
42149107502
-
Genetic Aspects of Alzheimer Disease
-
Bird, D. T. Genetic Aspects of Alzheimer Disease. Genet. Med. 10, 231–239 (2008).
-
(2008)
Genet. Med
, vol.10
, pp. 231-239
-
-
Bird, D.T.1
-
2
-
-
0035826782
-
Practice parameter: Diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology
-
Knopman, D. S. et al. Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 56, 1143–1153 (2001).
-
(2001)
Neurology
, vol.56
, pp. 1143-1153
-
-
Knopman, D.S.1
-
3
-
-
75649135280
-
Neuropathology of Alzheimer’s disease
-
Perl, D. P. Neuropathology of Alzheimer’s disease. Mt. Sinai. J. Med. 77, 32–42 (2010).
-
(2010)
Mt. Sinai. J. Med
, vol.77
, pp. 32-42
-
-
Perl, D.P.1
-
4
-
-
38449115010
-
Economic considerations in the management of Alzheimer’s disease
-
Zhu, C. W. & Sano, M. Economic considerations in the management of Alzheimer’s disease. Clin. Interv. Aging 1, 143–154 (2006).
-
(2006)
Clin. Interv. Aging
, vol.1
, pp. 143-154
-
-
Zhu, C.W.1
Sano, M.2
-
5
-
-
0028982103
-
The toxicity in vitro of beta-amyloid protein
-
Iversen, L. L. The toxicity in vitro of beta-amyloid protein. Biochem. J. 311, 1–16 (1995).
-
(1995)
Biochem. J
, vol.311
, pp. 1-16
-
-
Iversen, L.L.1
-
6
-
-
33750082374
-
Early diagnostics and therapeutics for Alzheimer’s disease-how early can we get there?
-
Monien, B. H., Apostolova, L. G. & Bitan, G. Early diagnostics and therapeutics for Alzheimer’s disease-how early can we get there? Expert. Rev. Neurother. 6, 1293–1306 (2006).
-
(2006)
Expert. Rev. Neurother
, vol.6
, pp. 1293-1306
-
-
Monien, B.H.1
Apostolova, L.G.2
Bitan, G.3
-
7
-
-
68449090629
-
Update on amyloid imaging: From healthy aging to Alzheimer’s disease
-
Wolk, D. A. & Klunk, W. Update on amyloid imaging: from healthy aging to Alzheimer’s disease. Curr. Neurol. Neurosci. Rep. 9, 345–352 (2009).
-
(2009)
Curr. Neurol. Neurosci. Rep
, vol.9
, pp. 345-352
-
-
Wolk, D.A.1
Klunk, W.2
-
8
-
-
38949108762
-
Diagnosis and treatment of dementia: Introduction. Introducing a series based on the Third Canadian Consensus Conference on the Diagnosis and Treatment of Dementia
-
Chertkow, H. Diagnosis and treatment of dementia: Introduction. Introducing a series based on the Third Canadian Consensus Conference on the Diagnosis and Treatment of Dementia. Canadian Medical Association 178, 316–321 (2008).
-
(2008)
Canadian Medical Association
, vol.178
, pp. 316-321
-
-
Chertkow, H.1
-
9
-
-
0042023711
-
Alzheimer Disease in the US Population, Prevalence Estimates Using the 2000 Census
-
Hebert, L. E. Scherr, P. A., Bienias, J. L., Bennett, D. A. & Evans, D. A. Alzheimer Disease in the US Population, Prevalence Estimates Using the 2000 Census. Arch Neurol. 60, 1119–1122 (2003).
-
(2003)
Arch Neurol
, vol.60
, pp. 1119-1122
-
-
Hebert, L.E.1
Scherr, P.A.2
Bienias, J.L.3
Bennett, D.A.4
Evans, D.A.5
-
10
-
-
77949336151
-
Alzheimer’s disease facts and figures
-
Alzheimer’s Association. Alzheimer’s disease facts and figures. Alzheimer’s and Dement. 6, 158–194 (2010).
-
(2010)
Alzheimer’s and Dement
, vol.6
, pp. 158-194
-
-
-
11
-
-
0028296884
-
Canadian study of health and aging: Study methods and prevalence of dementia
-
Canadian study of health and aging: study methods and prevalence of dementia. CMAJ 150, 899–913 (1994).
-
(1994)
CMAJ
, vol.150
, pp. 899-913
-
-
-
12
-
-
57349130740
-
Diagnosis and treatment of dementia: 6. Management of severe Alzheimer disease
-
Herrmann, N. & Gauthier, S. Diagnosis and treatment of dementia: 6. Management of severe Alzheimer disease. CMAJ 179, 1279–1287 (2008).
-
(2008)
CMAJ
, vol.179
, pp. 1279-1287
-
-
Herrmann, N.1
Gauthier, S.2
-
13
-
-
40549134510
-
A prospective, double-blind, community-controlled comparison of three doses of galantamine in the treatment of mild to moderate Alzheimer’s disease in a Korean population
-
Suh, G. H. et al. A prospective, double-blind, community-controlled comparison of three doses of galantamine in the treatment of mild to moderate Alzheimer’s disease in a Korean population. J. Korean. Med. Sci. 23, 10–17 (2008).
-
(2008)
J. Korean. Med. Sci
, vol.23
, pp. 10-17
-
-
Suh, G.H.1
-
14
-
-
80052814305
-
Clinical characteristics of a nationwide hospital-based registry of mild-to-moderate Alzheimer’s disease patients in Korea: A CREDOS (Clinical Research Center for Dementia of South Korea) study
-
Park, H. K. et al. Clinical characteristics of a nationwide hospital-based registry of mild-to-moderate Alzheimer’s disease patients in Korea: a CREDOS (Clinical Research Center for Dementia of South Korea) study. J. Korean Med. Sci. 26, 1219–1222 (2011).
-
(2011)
J. Korean Med. Sci
, vol.26
, pp. 1219-1222
-
-
Park, H.K.1
-
16
-
-
0035066332
-
Alzheimer’s Disease: Genes, Proteins, and Therapy
-
Selkoe, D. J. Alzheimer’s Disease: Genes, Proteins, and Therapy. Physiol. Rev. 81, 741–766 (2001).
-
(2001)
Physiol. Rev
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
17
-
-
0003717728
-
-
Bethesda, MD: National Institute on Aging
-
National Institute on Aging. Progress Report on Alzheimer’s Disease. Bethesda, MD: National Institute on Aging (1998).
-
(1998)
Progress Report on Alzheimer’s Disease
-
-
-
18
-
-
0034861814
-
Prevalence, costs, and treatment of Alzheimer’s disease and related dementia: A managed care perspective
-
Rice, D. P. et al. Prevalence, costs, and treatment of Alzheimer’s disease and related dementia: a managed care perspective. Am. J. Manag. Care 7, 809–818 (2001).
-
(2001)
Am. J. Manag. Care
, vol.7
, pp. 809-818
-
-
Rice, D.P.1
-
19
-
-
33748995923
-
Longitudinal study of effects of patient characteristics on direct costs in Alzheimer disease
-
Zhu, C. W. et al. Longitudinal study of effects of patient characteristics on direct costs in Alzheimer disease. Neurology 67, 998–1005 (2006).
-
(2006)
Neurology
, vol.67
, pp. 998-1005
-
-
Zhu, C.W.1
-
20
-
-
54349119997
-
Diagnosis and treatment of dementia: 4. Approach to management of mild to moderate dementia
-
Hogan, D. B. et al. Diagnosis and treatment of dementia: 4. Approach to management of mild to moderate dementia. CMAJ 179, 787–793 (2008).
-
(2008)
CMAJ
, vol.179
, pp. 787-793
-
-
Hogan, D.B.1
-
21
-
-
43549124541
-
Diagnosis and treatment of dementia: 3. Mild cognitive impairment and cognitive impairment without dementia
-
Chertkow, H. et al. Diagnosis and treatment of dementia: 3. Mild cognitive impairment and cognitive impairment without dementia. CMAJ 178, 1273–1285 (2008).
-
(2008)
CMAJ
, vol.178
, pp. 1273-1285
-
-
Chertkow, H.1
-
22
-
-
33646035489
-
Mild cognitive impairment
-
Gauthier, S. et al. Mild cognitive impairment. Lancet 367, 1262–1270 (2006).
-
(2006)
Lancet
, vol.367
, pp. 1262-1270
-
-
Gauthier, S.1
-
23
-
-
1642329138
-
Amnestic MCI or prodromal Alzheimer’s disease?
-
Dubois, B. & Albert, M. L. Amnestic MCI or prodromal Alzheimer’s disease? Lancet Neurol. 3, 246–248 (2004).
-
(2004)
Lancet Neurol
, vol.3
, pp. 246-248
-
-
Dubois, B.1
Albert, M.L.2
-
24
-
-
0036045136
-
Is mild cognitive impairment bridging the gap between normal aging and Alzheimer’s disease
-
Smith, G. Is mild cognitive impairment bridging the gap between normal aging and Alzheimer’s disease? J. Neural. Transm. Suppl. 62, 97–104 (2002).
-
(2002)
J. Neural. Transm. Suppl
, vol.62
, pp. 97-104
-
-
Smith, G.1
-
25
-
-
67349195578
-
Early identification and treatment of Alzheimer’s disease: Social and fiscal outcomes
-
Weimer, D. L. & Sager, M. A. Early identification and treatment of Alzheimer’s disease: Social and fiscal outcomes. Alzheimers Dement. 5, 215–226 (2009).
-
(2009)
Alzheimers Dement
, vol.5
, pp. 215-226
-
-
Weimer, D.L.1
Sager, M.A.2
-
26
-
-
0034706426
-
The Detection of Dementia in the Primary Care Setting
-
Valcour, V. G., Masaki, K. H., Curb, J. D. & Blanchette, P. L. The Detection of Dementia in the Primary Care Setting. Arch InterMed. 160, 2964–2968 (2000).
-
(2000)
Arch Intermed
, vol.160
, pp. 2964-2968
-
-
Valcour, V.G.1
Masaki, K.H.2
Curb, J.D.3
Blanchette, P.L.4
-
27
-
-
68349145968
-
Predictors of progression of cognitive decline in Alzheimer’s disease: The role of vascular and sociodemographic factors
-
Musicco, M. et al. Predictors of progression of cognitive decline in Alzheimer’s disease: the role of vascular and sociodemographic factors. J. Neurol. 256, 1288–1295 (2009).
-
(2009)
J. Neurol
, vol.256
, pp. 1288-1295
-
-
Musicco, M.1
-
28
-
-
0028456711
-
Is it really Alzheimer’s?
-
Spooner, M. A. Is it really Alzheimer’s? Can. Fam. Physician 40, 1141–1145 (1994).
-
(1994)
Can. Fam. Physician
, vol.40
, pp. 1141-1145
-
-
Spooner, M.A.1
-
29
-
-
33746932485
-
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
-
Desikan, R. S. et al. An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage 31, 968–980 (2006).
-
(2006)
Neuroimage
, vol.31
, pp. 968-980
-
-
Desikan, R.S.1
-
30
-
-
67650833343
-
Mapping Brain β-Amyloid
-
Jagust, W. Mapping Brain β-Amyloid. Curr. Opin. Neurol. 22, 356–361 (2010).
-
(2010)
Curr. Opin. Neurol
, vol.22
, pp. 356-361
-
-
Jagust, W.1
-
31
-
-
77649092874
-
Amyloid-beta42 oligomer structures from fibrils: A systematic molecular dynamics study
-
Horn, A. H. & Sticht, H. Amyloid-beta42 oligomer structures from fibrils: a systematic molecular dynamics study. J. Phys. Chem. B. 114, 2219–2226 (2010).
-
(2010)
J. Phys. Chem. B
, vol.114
, pp. 2219-2226
-
-
Horn, A.H.1
Sticht, H.2
-
32
-
-
26844435756
-
Molecular Dynamics Simulations of Alzheimer’s β-Amyloid Protofilaments
-
Buchete, N. V., Tycko, R. & Humme, G. Molecular Dynamics Simulations of Alzheimer’s β-Amyloid Protofilaments. J. Mol. Biol. 353, 804–821 (2005).
-
(2005)
J. Mol. Biol
, vol.353
, pp. 804-821
-
-
Buchete, N.V.1
Tycko, R.2
Humme, G.3
-
33
-
-
0034718157
-
Alzheimer’s amyloid fibrils: Structure and assembly
-
Serpell, L. C. Alzheimer’s amyloid fibrils: structure and assembly. Biochim. Biophys. Acta. 1502, 16–30 (2000).
-
(2000)
Biochim. Biophys. Acta
, vol.1502
, pp. 16-30
-
-
Serpell, L.C.1
-
34
-
-
77952515576
-
An Overview of APP Processing Enzymes and Products
-
Chow, V. W., Mattson, M. P., Wong, P. C. & Gleichmann, M. An Overview of APP Processing Enzymes and Products. Neuromolecular. Med. 12, 1–12 (2009).
-
(2009)
Neuromolecular. Med
, vol.12
, pp. 1-12
-
-
Chow, V.W.1
Mattson, M.P.2
Wong, P.C.3
Gleichmann, M.4
-
35
-
-
33646787103
-
Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer’s disease: Prospects, limitations and strategies
-
Evin, G., Sernee, M. F. & Masters, C. L. Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer’s disease: prospects, limitations and strategies. CNS Drugs 20, 351–372 (2006).
-
(2006)
CNS Drugs
, vol.20
, pp. 351-372
-
-
Evin, G.1
Sernee, M.F.2
Masters, C.L.3
-
36
-
-
4344630985
-
BACE1: The beta-secretase enzyme in Alzheimer’s disease
-
Vassar, R. BACE1: the beta-secretase enzyme in Alzheimer’s disease. J. Mol. Neurosci. 23, 105–114 (2004).
-
(2004)
J. Mol. Neurosci
, vol.23
, pp. 105-114
-
-
Vassar, R.1
-
37
-
-
4344673143
-
Biomarkers of Alzheimer Disease in Plasma
-
Irizarry, M. C. Biomarkers of Alzheimer Disease in Plasma. NeuroRx. 1, 226–234 (2004).
-
(2004)
Neurorx
, vol.1
, pp. 226-234
-
-
Irizarry, M.C.1
-
38
-
-
4544266973
-
CSF biomarkers for mild cognitive impairment
-
Blennow, K. CSF biomarkers for mild cognitive impairment. J. Int. Med. 256, 224–234 (2004).
-
(2004)
J. Int. Med
, vol.256
, pp. 224-234
-
-
Blennow, K.1
-
39
-
-
41649087542
-
Diagnosis and treatment of dementia: 2. Diagnosis
-
Feldman, H. H. et al. Diagnosis and treatment of dementia: 2. Diagnosis. CMAJ 178, 825–836 (2008).
-
(2008)
CMAJ
, vol.178
, pp. 825-836
-
-
Feldman, H.H.1
-
40
-
-
0037411512
-
Biological markers for therapeutic trials in Alzheimer’s disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer’s disease. Biological markers for therapeutic trials in Alzheimer’s disease
-
Frank, R. A. et al. Biological markers for therapeutic trials in Alzheimer’s disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer’s disease. Biological markers for therapeutic trials in Alzheimer’s disease. Neurobiol. Aging 24, 521–536 (2003).
-
(2003)
Neurobiol. Aging
, vol.24
, pp. 521-536
-
-
Frank, R.A.1
-
41
-
-
33748634913
-
Mild cognitive impairment: An opportunity to identify patients at high risk for progression to Alzheimer’s disease
-
Levey, A., Lah, J., Goldstein, F., Steenland, K. & Bliwise, D. Mild cognitive impairment: an opportunity to identify patients at high risk for progression to Alzheimer’s disease. Clin Ther. 28, 991–1001 (2006).
-
(2006)
Clin Ther
, vol.28
, pp. 991-1001
-
-
Levey, A.1
Lah, J.2
Goldstein, F.3
Steenland, K.4
Bliwise, D.5
-
42
-
-
72049130805
-
Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade
-
Jack, C. R. et al. Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade. Lancet Neurol. 9, 119 (2010).
-
(2010)
Lancet Neurol
, vol.9
-
-
Jack, C.R.1
-
43
-
-
40949105521
-
Diagnosis and treatment of dementia: 1. Risk assessment and primary prevention of Alzheimer disease
-
Patterson, C. et al. Diagnosis and treatment of dementia: 1. Risk assessment and primary prevention of Alzheimer disease. CMAJ 178, 548–556 (2008).
-
(2008)
CMAJ
, vol.178
, pp. 548-556
-
-
Patterson, C.1
-
44
-
-
77956355612
-
Requiring an amyloid-beta1-42 biomarker for prodromal Alzheimer’s disease or mild cognitive impairment does not lead to more efficient clinical trials
-
Schneider, L. S., Kennedy, R. E. & Cutter, G. R. Requiring an amyloid-beta1-42 biomarker for prodromal Alzheimer’s disease or mild cognitive impairment does not lead to more efficient clinical trials. Alzheimers Dement. 6, 367–377 (2010).
-
(2010)
Alzheimers Dement
, vol.6
, pp. 367-377
-
-
Schneider, L.S.1
Kennedy, R.E.2
Cutter, G.R.3
-
45
-
-
0032033832
-
Consensus report of the Working Group on: Molecular and biochemical markers of Alzheimer’s disease
-
(1998)
-
The Ronald and Nancy Reagan Research Institute of the Alzheimer’s Association and the National Institute on Aging Working Group. 1998, Consensus report of the Working Group on: Molecular and biochemical markers of Alzheimer’s disease. Neurobiol. Aging 19, 109–116 (1998).
-
(1998)
Neurobiol. Aging
, vol.19
, pp. 109-116
-
-
-
46
-
-
69149100749
-
Proteomic Analysis of Alzheimer’s Disease Cerebrospinal Fluid from Neuropathologically Diagnosed Subjects
-
Maarouf, C. L. et al. Proteomic Analysis of Alzheimer’s Disease Cerebrospinal Fluid from Neuropathologically Diagnosed Subjects. Curr. Alzheimer Res. 6, 399–406 (2009).
-
(2009)
Curr. Alzheimer Res
, vol.6
, pp. 399-406
-
-
Maarouf, C.L.1
-
47
-
-
0141767139
-
Proteomics in Alzheimer’s disease: Insights into potential mechanisms of neurodegeneration
-
Butterfield, D. A., Boyd-Kimball, D. & Castegna, A. Proteomics in Alzheimer’s disease: insights into potential mechanisms of neurodegeneration. J. Neurochem. 86, 1313–1327 (2003).
-
(2003)
J. Neurochem
, vol.86
, pp. 1313-1327
-
-
Butterfield, D.A.1
Boyd-Kimball, D.2
Castegna, A.3
-
48
-
-
54449097885
-
Proteomics of Human Neurodegenerative Diseases
-
Zhang, J., Keene, C. D., Pan, C., Montine, K. S. & Montine, T. J. Proteomics of Human Neurodegenerative Diseases. J. Neuropathol. Exp. Neurol. 67, 923–932 (2008).
-
(2008)
J. Neuropathol. Exp. Neurol
, vol.67
, pp. 923-932
-
-
Zhang, J.1
Keene, C.D.2
Pan, C.3
Montine, K.S.4
Montine, T.J.5
-
49
-
-
67649544381
-
Biomarker Discovery in Neurodegenerative Diseases: A Proteomic Approach
-
Shi, M., Caudle, W. M. & Zhang, J. Biomarker Discovery in Neurodegenerative Diseases: A Proteomic Approach. Neurobiol. Dis. 35, 157–164 (2009).
-
(2009)
Neurobiol. Dis
, vol.35
, pp. 157-164
-
-
Shi, M.1
Caudle, W.M.2
Zhang, J.3
-
50
-
-
0029278675
-
Matrix-Assisted Laser Desorption Ionization Mass Spectrometry: Applications in Peptide and Protein Characterization
-
Zaluzec, E. J., Gage, D. A. & Watson, J. T. Matrix-Assisted Laser Desorption Ionization Mass Spectrometry: Applications in Peptide and Protein Characterization. Protein Expr. Purif. 6, 109–123 (2002).
-
(2002)
Protein Expr. Purif
, vol.6
, pp. 109-123
-
-
Zaluzec, E.J.1
Gage, D.A.2
Watson, J.T.3
-
51
-
-
69849106821
-
Capillary electrophoresis-mass spectrometry as a powerful tool in biomarker discovery and clinical diagnosis: An update of recent developments
-
Mischak, H. et al. Capillary electrophoresis-mass spectrometry as a powerful tool in biomarker discovery and clinical diagnosis: an update of recent developments. Mass Spectrom. Rev. 28, 703–724 (2009).
-
(2009)
Mass Spectrom. Rev
, vol.28
, pp. 703-724
-
-
Mischak, H.1
-
52
-
-
43249084924
-
MRI characterization of brain structure and function in Mild Cognitiven Impairment: A review
-
Ries, M. L. et al. MRI characterization of brain structure and function in Mild Cognitiven Impairment: A review. J. Am. Geriatr. Soc. 56, 920–934 (2008).
-
(2008)
J. Am. Geriatr. Soc
, vol.56
, pp. 920-934
-
-
Ries, M.L.1
-
53
-
-
31544443575
-
The Alzheimer’s Disease Neuroimaging Initiative
-
Mueller, S. G. et al. The Alzheimer’s Disease Neuroimaging Initiative. Neuroimaging Clin. N. Am. 15, 869–877 (2008).
-
(2008)
Neuroimaging Clin. N. Am
, vol.15
, pp. 869-877
-
-
Mueller, S.G.1
-
54
-
-
0033793378
-
Visual rating and volumetry of the medial temporal lobe on magnetic resonance imaging indementia: A comparative study
-
Wahlund, L. O., Julin, P., Johansson, S. E. & Scheltens, P. Visual rating and volumetry of the medial temporal lobe on magnetic resonance imaging indementia: a comparative study. J. Neurol. Neurosurg. Psychiatry 69, 630–635 (2000).
-
(2000)
J. Neurol. Neurosurg. Psychiatry
, vol.69
, pp. 630-635
-
-
Wahlund, L.O.1
Julin, P.2
Johansson, S.E.3
Scheltens, P.4
-
55
-
-
33846048774
-
Qualitative estimates of medial temporal atrophy as a predictor of progression from mild cognitive impairment to dementia. Arch
-
DeCarli, C. et al. Qualitative estimates of medial temporal atrophy as a predictor of progression from mild cognitive impairment to dementia. Arch. Neurol. 1, 108–115 (2007).
-
(2007)
Neurol
, vol.1
, pp. 108-115
-
-
Decarli, C.1
-
56
-
-
58149395966
-
Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease
-
Duara, R. et al. Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease. Neurology 71, 1986–1992 (2008).
-
(2008)
Neurology
, vol.71
, pp. 1986-1992
-
-
Duara, R.1
-
57
-
-
77950829087
-
A 10-year follow-up of hippocampal volume on magnetic resonancen imaging in early dementia and cognitive decline
-
den Heijer, T. et al. A 10-year follow-up of hippocampal volume on magnetic resonancen imaging in early dementia and cognitive decline. Brain 133, 1163–1172 (2010).
-
(2010)
Brain
, vol.133
, pp. 1163-1172
-
-
Den Heijer, T.1
-
58
-
-
0034127931
-
Use of structural magnetic resonance imaging to predict who will get Alzheimer’s disease
-
Killiany, R. J. et al. Use of structural magnetic resonance imaging to predict who will get Alzheimer’s disease. Ann. Neurol. 47, 430–439 (2000).
-
(2000)
Ann. Neurol
, vol.47
, pp. 430-439
-
-
Killiany, R.J.1
-
59
-
-
0037007045
-
Mapping the evolution of regional atrophy in Alzheimer’s disease: Unbiased analysis of fluid-registered serial MRI
-
Scahill, R. I., Schott, J. M., Stevens, J. M., Rossor, M. N. & Fox, N. C. Mapping the evolution of regional atrophy in Alzheimer’s disease: unbiased analysis of fluid-registered serial MRI. Proc. Natl. Acad. Sci. USA 99, 4703–4707 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 4703-4707
-
-
Scahill, R.I.1
Schott, J.M.2
Stevens, J.M.3
Rossor, M.N.4
Fox, N.C.5
-
60
-
-
0034801730
-
Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer’s disease
-
Du, A. T. et al. Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer’s disease. J. Neurol. Neurosurg. Psychiatry 71, 441–447 (2001).
-
(2001)
J. Neurol. Neurosurg. Psychiatry
, vol.71
, pp. 441-447
-
-
Du, A.T.1
-
61
-
-
44649105053
-
T1rho MRI of Alzheimer’s disease
-
Borthakur, A., Sochor, M., Davatzikos, C., Trojanowski, J. Q. & Clark, C. M. T1rho MRI of Alzheimer’s disease. Neuroimage 41, 1199–1205 (2008).
-
(2008)
Neuroimage
, vol.41
, pp. 1199-1205
-
-
Borthakur, A.1
Sochor, M.2
Davatzikos, C.3
Trojanowski, J.Q.4
Clark, C.M.5
-
62
-
-
79953030333
-
T (1ρ) MRI in Alzheimer’s disease: Detection of pathological changes in medial temporal lobe
-
Haris et al. T (1ρ) MRI in Alzheimer’s disease: detection of pathological changes in medial temporal lobe.J. Neuroimaging 21, 86–90 (2011).
-
(2011)
J. Neuroimaging
, vol.21
, pp. 86-90
-
-
-
63
-
-
0034126959
-
PET: The merging of biology and imaging into molecular imaging
-
Phelps, M. E. PET: the merging of biology and imaging into molecular imaging. J. Nucl. Med. 41, 661–681 (2000).
-
(2000)
J. Nucl. Med
, vol.41
, pp. 661-681
-
-
Phelps, M.E.1
-
64
-
-
68449090629
-
Update on Amyloid Imaging: From Healthy Aging to Alzheimer’s Disease
-
Wolk, D. A. & Klunk, W. E. Update on Amyloid Imaging: From Healthy Aging to Alzheimer’s Disease. Curr. Neurol. Neurosci. Rep. 9, 345–352 (2009).
-
(2009)
Curr. Neurol. Neurosci. Rep
, vol.9
, pp. 345-352
-
-
Wolk, D.A.1
Klunk, W.E.2
-
65
-
-
10744232413
-
Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B
-
Klunk, W. E. et al. Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B. Ann. Neurol. 55, 306–319 (2004).
-
(2004)
Ann. Neurol
, vol.55
, pp. 306-319
-
-
Klunk, W.E.1
-
66
-
-
34248579112
-
2-(2-[2-Dimethylaminothiazol-5-yl] ethenyl)-6-(2-[fluoro]ethoxy) benzoxazole: A novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer’s disease patients
-
Kudo, Y. et al. 2-(2-[2-Dimethylaminothiazol-5-yl] ethenyl)-6-(2-[fluoro]ethoxy) benzoxazole: a novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer’s disease patients. J. Nucl. Med. 48, 553–561 (2007).
-
(2007)
J. Nucl. Med
, vol.48
, pp. 553-561
-
-
Kudo, Y.1
-
67
-
-
15944366880
-
In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET
-
Verhoeff, N. P. et al. In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET. Am. J. Geriatr. Psychiatry 12, 584–595 (2004).
-
(2004)
Am. J. Geriatr. Psychiatry
, vol.12
, pp. 584-595
-
-
Verhoeff, N.P.1
-
68
-
-
84903202261
-
Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease
-
Shoghi-Jadid, K. et al. Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease. Am. J. Geriatr. Psychiatry 10, 24–35 (2002).
-
(2002)
Am. J. Geriatr. Psychiatry
, vol.10
, pp. 24-35
-
-
Shoghi-Jadid, K.1
-
69
-
-
33845707784
-
PET of brain amyloid and tau in mild cognitive impairment
-
Small, G. W. et al. PET of brain amyloid and tau in mild cognitive impairment. N. Engl. J. Med. 355, 2652–2663 (2006).
-
(2006)
N. Engl. J. Med
, vol.355
, pp. 2652-2663
-
-
Small, G.W.1
-
70
-
-
38149081191
-
Imaging of amyloid β in Alzheimer’s disease with 18F-BAY94-9172, a novel PET tracer: Proof of mechanism
-
Rowe, C. C. et al. Imaging of amyloid β in Alzheimer’s disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism. Lancet Neurol. 7, 129–135 (2008).
-
(2008)
Lancet Neurol
, vol.7
, pp. 129-135
-
-
Rowe, C.C.1
-
71
-
-
0036235195
-
Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer’s Disease Treatment Studies
-
Alexander, G. E., Chen, K., Pietrini, P., Rapoport, S. I. & Reiman, E. M. Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer’s Disease Treatment Studies. Am. J. Psychiatry 159, 738–745 (2002).
-
(2002)
Am. J. Psychiatry
, vol.159
, pp. 738-745
-
-
Alexander, G.E.1
Chen, K.2
Pietrini, P.3
Rapoport, S.I.4
Reiman, E.M.5
-
72
-
-
69549089908
-
Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer’s disease
-
Waragai, M. et al. Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer’s disease. J. Neurol. Sci. 285, 100–108 (2004).
-
(2004)
J. Neurol. Sci
, vol.285
, pp. 100-108
-
-
Waragai, M.1
-
73
-
-
84855364400
-
Effectiveness and Safety of 18FFDG PET in the Evaluation of Dementia: A Review of the Recent Literature
-
Bohnen, N. I., Djang, D. S., Herholz, K., Anzai, Y. & Minoshima, S. Effectiveness and Safety of 18FFDG PET in the Evaluation of Dementia: A Review of the Recent Literature. J. Nucl. Med. 53, 59–71 (2011).
-
(2011)
J. Nucl. Med
, vol.53
, pp. 59-71
-
-
Bohnen, N.I.1
Djang, D.S.2
Herholz, K.3
Anzai, Y.4
Minoshima, S.5
-
74
-
-
77953937194
-
In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18FAV-45 (Florbetapir [corrected] F 18)
-
Wong, D. F. et al. In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18FAV-45 (florbetapir [corrected] F 18). J. Nucl. Med. 51, 913–920 (2010).
-
(2010)
J. Nucl. Med
, vol.51
, pp. 913-920
-
-
Wong, D.F.1
-
75
-
-
68249141258
-
Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease
-
Nelissen, N. et al. Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease. J. Nucl. Med. 50, 1251–1259 (2009).
-
(2009)
J. Nucl. Med
, vol.50
, pp. 1251-1259
-
-
Nelissen, N.1
-
76
-
-
40849093600
-
Genome-wide association studies in Alzheimer disease
-
Waring, S. C. & Rosenberg, R. N. Genome-wide association studies in Alzheimer disease. Arch. Neurol.65, 329–334 (2008).
-
(2008)
Arch. Neurol
, vol.65
, pp. 329-334
-
-
Waring, S.C.1
Rosenberg, R.N.2
-
77
-
-
0343247789
-
Preferential deposition of amyloid β protein (Aβ) in the form Aβ40 in Alzheimer’s disease is associated with a gene dosage effect of the apolipoprotein
-
Mann, D. et al. Preferential deposition of amyloid β protein (Aβ) in the form Aβ40 in Alzheimer’s disease is associated with a gene dosage effect of the apolipoprotein E E4 allele. Neurosci. Lett. 221, 81–84 (1997).
-
(1997)
E E4 Allele. Neurosci. Lett
, vol.221
, pp. 81-84
-
-
Mann, D.1
-
78
-
-
74949100133
-
Epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging
-
Thambisetty, M., Beason-Held, L., An, L. Y., Kraut, M. A. & Resnick, S. M. APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging. Arch. Neurol. 67, 93–98 (2010).
-
(2010)
Arch. Neurol
, vol.67
, pp. 93-98
-
-
Thambisetty, M.1
Beason-Held, L.2
An, L.Y.3
Kraut, M.A.4
Resnick, S.5
-
79
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer’s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s disease
-
Scheuner, D. et al. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer’s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s disease. Nat. Med. 2, 864–870 (1996).
-
(1996)
Nat. Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
-
80
-
-
77950605681
-
Editorial to biomarkers of Alzheimers disease and dementia in cerebrospinal fluid and blood.Exp
-
Humpel, C. Editorial to biomarkers of Alzheimers disease and dementia in cerebrospinal fluid and blood.Exp. Gerontol. 45, 1 (2010).
-
(2010)
Gerontol
, vol.45
-
-
Humpel, C.1
-
81
-
-
0029819924
-
Abnormal Pattern of Platelet APP Isoforms in Alzheimer Disease and Down Syndrome.Arch
-
Di Luca, M. et al. Abnormal Pattern of Platelet APP Isoforms in Alzheimer Disease and Down Syndrome.Arch. Neurol. 53, 1162–1166 (1996).
-
(1996)
Neurol
, vol.53
, pp. 1162-1166
-
-
Di Luca, M.1
-
82
-
-
4243215848
-
Apolipoprotein E isoformdependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer’s disease
-
Holtzman, D. M. et al. Apolipoprotein E isoformdependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer’s disease. Proc. Natl. Acad. Sci. USA 97, 2892–2897 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 2892-2897
-
-
Holtzman, D.M.1
-
83
-
-
29444460533
-
Apolipoprotein (Apo) E4 enhances amyloid β peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target
-
Ye, S. et al. Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target. Proc. Natl. Acad. Sci. USA 102, 18700–18705 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 18700-18705
-
-
Ye, S.1
-
84
-
-
4143091289
-
Apolipoprotein E: Diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer’s disease
-
Huang, Y., Weisgraber, K. H., Mucke, L. & Mahley, R. W. Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer’s disease. J. Mol. Neurosci. 23, 189–204 (2004).
-
(2004)
J. Mol. Neurosci
, vol.23
, pp. 189-204
-
-
Huang, Y.1
Weisgraber, K.H.2
Mucke, L.3
Mahley, R.W.4
-
85
-
-
0035902514
-
Apolipoprotein E fragments present in Alzheimer’s disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons
-
Huang, Y. et al. Apolipoprotein E fragments present in Alzheimer’s disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons. PNAS 98, 8838–8843 (2001).
-
(2001)
PNAS
, vol.98
, pp. 8838-8843
-
-
Huang, Y.1
-
86
-
-
39549091493
-
Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons
-
Brodbeck, J. et al. Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons. PNAS 105, 1343–1346 (2007).
-
(2007)
PNAS
, vol.105
, pp. 1343-1346
-
-
Brodbeck, J.1
-
87
-
-
0033564771
-
Expression of Human Apolipoprotein E3 or E4 in the Brains of Apoe-/- Mice: Isoform-Specific Effects on Neurodegeneration
-
Buttini, M. et al. Expression of Human Apolipoprotein E3 or E4 in the Brains of Apoe-/- Mice: Isoform-Specific Effects on Neurodegeneration. J. Neurosci. 19, 4867–4880 (1999).
-
(1999)
J. Neurosci
, vol.19
, pp. 4867-4880
-
-
Buttini, M.1
-
88
-
-
42649084052
-
The role of interleukin-1 in neuroinflammation and Alzheimer disease: An evolving perspective
-
Shaftel, S. S., Griffin, W. S. & O’Banion, M. K. The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective. J. Neuroinflammation 5, 7 (2008).
-
(2008)
J. Neuroinflammation
, vol.5
-
-
Shaftel, S.S.1
Griffin, W.S.2
O’Banion, M.K.3
-
89
-
-
71249159664
-
Increased serum IL-1beta level in Alzheimer’s disease and mild cognitive impairment
-
Forlenza, O. V. et al. Increased serum IL-1beta level in Alzheimer’s disease and mild cognitive impairment. Dement. Geriatr. Cogn. Disord. 28, 507–512 (2009).
-
(2009)
Dement. Geriatr. Cogn. Disord
, vol.28
, pp. 507-512
-
-
Forlenza, O.V.1
-
90
-
-
0033966340
-
Increased plasma levels of interleukin-1, interleukin-6 and α-1-antichymotrypsin in patients with Alzheimer’s disease: Peripheral inflammation or signals from the brain
-
Licastro, F. et al. Increased plasma levels of interleukin-1, interleukin-6 and α-1-antichymotrypsin in patients with Alzheimer’s disease: peripheral inflammation or signals from the brain? J. Neuroimmunol. 103, 97–102 (2000).
-
(2000)
J. Neuroimmunol
, vol.103
, pp. 97-102
-
-
Licastro, F.1
-
91
-
-
0027161033
-
Interleukin-6 and aging: Blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction
-
Ershler, W. B. et al. Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction. Lymphokine Cytokine Res. 12, 225–230 (1993).
-
(1993)
Lymphokine Cytokine Res
, vol.12
, pp. 225-230
-
-
Ershler, W.B.1
-
92
-
-
77955883396
-
Cytokine polymorphisms and Alzheimer disease: Possible associations
-
Ribizzi, G., Fiordoro, S., Barocci, S., Ferrari, E. & Megna, M. Cytokine polymorphisms and Alzheimer disease: possible associations. Neurol. Sci. 31, 321–325 (2010).
-
(2010)
Neurol. Sci
, vol.31
, pp. 321-325
-
-
Ribizzi, G.1
Fiordoro, S.2
Barocci, S.3
Ferrari, E.4
Megna, M.5
-
93
-
-
0037085011
-
Alzheimer’s disease and oxygen radicals: New insights. Biochem
-
Praticò, D. Alzheimer’s disease and oxygen radicals: new insights. Biochem. Pharmacol. 63, 563–567 (2001).
-
(2001)
Pharmacol
, vol.63
, pp. 563-567
-
-
Praticò, D.1
-
94
-
-
0032902974
-
Oxidative alterations in Alzheimer’s disease
-
Markesbery, W. R. & Carney, J. M. Oxidative alterations in Alzheimer’s disease. Brain Pathol. 9, 133–146 (1999).
-
(1999)
Brain Pathol
, vol.9
, pp. 133-146
-
-
Markesbery, W.R.1
Carney, J.M.2
-
95
-
-
38449123153
-
Effects of antioxidant supplementation on the aging process
-
Fusco, D., Colloca, G., Lo Monaco, M. R. and Cesari, M. Effects of antioxidant supplementation on the aging process. Clin. Interv. Aging 2, 377–387 (2007).
-
(2007)
Clin. Interv. Aging
, vol.2
, pp. 377-387
-
-
Fusco, D.1
Colloca, G.2
Lo Monaco, M.R.3
Cesari, M.4
-
96
-
-
0032921546
-
Plasma chain-breaking antioxidants in Alzheimer’s disease, vascular dementia and Parkinson’s disease
-
Foy, C. J., Passmore, A. P., Vahidassr, M. D., Young, I. S. & Lawson, J. T. Plasma chain-breaking antioxidants in Alzheimer’s disease, vascular dementia and Parkinson’s disease. QJM 92, 39–45 (1999).
-
(1999)
QJM
, vol.92
, pp. 39-45
-
-
Foy, C.J.1
Passmore, A.P.2
Vahidassr, M.D.3
Young, I.S.4
Lawson, J.T.5
-
97
-
-
39249084075
-
Cholesterol retention in Alzheimer’s brain is responsible for high β- and γ-secretase activities and Aβ production
-
Xiong, H. et al. Cholesterol retention in Alzheimer’s brain is responsible for high β- and γ-secretase activities and Aβ production. Neurobiol. Dis. 29, 422–437 (2008).
-
(2008)
Neurobiol. Dis
, vol.29
, pp. 422-437
-
-
Xiong, H.1
-
98
-
-
0035826795
-
A fluid connection: Cholesterol and Aβ
-
Wolozin, B. A fluid connection: Cholesterol and Aβ. Proc. Natl. Acad. Sci. USA 98, 5371–5373 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 5371-5373
-
-
Wolozin, B.1
-
99
-
-
33644911218
-
Cholesterol, APOE genotype, and Alzheimer disease
-
Hall, K. et al. 2006, Cholesterol, APOE genotype, and Alzheimer disease. Neurology 66, 223–227 (2006).
-
(2006)
Neurology
, vol.66
, Issue.2006
, pp. 223-227
-
-
Hall, K.1
-
100
-
-
0033816319
-
Apolipoprotein E serum concentration and polymorphism in six European countries: The Apo Europe Project
-
Schiele, F. et al. Apolipoprotein E serum concentration and polymorphism in six European countries: the Apo Europe Project. Atherosclerosis 152, 475–488 (2000).
-
(2000)
Atherosclerosis
, vol.152
, pp. 475-488
-
-
Schiele, F.1
-
101
-
-
35448970996
-
Molecular Targeting of Proteins by l-Homocysteine: Mechanistic Implications for Vascular Disease
-
Glushchenko, A. V. & Jacobsen, D. W. Molecular Targeting of Proteins by l-Homocysteine: Mechanistic Implications for Vascular Disease. Antioxid. Redox. Signal 9, 1883–1898 (2007).
-
(2007)
Antioxid. Redox. Signal
, vol.9
, pp. 1883-1898
-
-
Glushchenko, A.V.1
Jacobsen, D.W.2
-
102
-
-
77952994380
-
The influence of vascular disease on cognitive performance in the preclinical and early phases of Alzheimer’s disease
-
Laukka, E. J., Fratiglioni, L. & Bäckman, L. The influence of vascular disease on cognitive performance in the preclinical and early phases of Alzheimer’s disease. Dement. Geriatr. Cogn. Disord. 29, 498–503 (2010).
-
(2010)
Dement. Geriatr. Cogn. Disord
, vol.29
, pp. 498-503
-
-
Laukka, E.J.1
Fratiglioni, L.2
Bäckman, L.3
-
103
-
-
78049483245
-
Predictive value of platelet activation for the rate of cognitive decline in Alzheimer’s disease patients
-
Stellos, K. et al. Predictive value of platelet activation for the rate of cognitive decline in Alzheimer’s disease patients. J. Cereb. Blood Flow Metab. 30, 1–4 (2010).
-
(2010)
J. Cereb. Blood Flow Metab
, vol.30
, pp. 1-4
-
-
Stellos, K.1
-
104
-
-
73049103818
-
Platelet-bound P-selectin expression in patients with coronary artery disease: Impact on clinical presentation and myocardial necrosis, and effect of diabetes mellitus and anti-platelet medication
-
Stellos, K., Bigalke, B., Stakos, D., Henkelmann, N. & Gawaz, M. Platelet-bound P-selectin expression in patients with coronary artery disease: impact on clinical presentation and myocardial necrosis, and effect of diabetes mellitus and anti-platelet medication. J. Thromb. Haemost. 8, 205–207 (2010).
-
(2010)
J. Thromb. Haemost
, vol.8
, pp. 205-207
-
-
Stellos, K.1
Bigalke, B.2
Stakos, D.3
Henkelmann, N.4
Gawaz, M.5
-
105
-
-
70349499185
-
Plasma biomarkers for mild cognitive impairment and Alzheimer’s disease
-
Song, F., Poljak, A., Smythe, G. A. & Sachdev, P. Plasma biomarkers for mild cognitive impairment and Alzheimer’s disease, Brain Research Reviews 61, 69–80 (2009).
-
(2009)
Brain Research Reviews
, vol.61
, pp. 69-80
-
-
Song, F.1
Poljak, A.2
Smythe, G.A.3
Sachdev, P.4
-
106
-
-
33745959062
-
Plasma Abeta (1–40) and Abeta (1–42) and the risk of dementia: A prospective case-cohort study
-
van Oijen, M., Hofman, A., Soares, H. D., Koudstaal, P. J. & Breteler, M. M. Plasma Abeta (1–40) and Abeta (1–42) and the risk of dementia: a prospective case-cohort study. Lancet Neurol. 5, 655–660 (2006).
-
(2006)
Lancet Neurol
, vol.5
, pp. 655-660
-
-
Van Oijen, M.1
Hofman, A.2
Soares, H.D.3
Koudstaal, P.J.4
Breteler, M.M.5
-
107
-
-
31044443590
-
Circulating biomarkers of cognitive decline and dementia
-
(2006)
-
Solfrizzi, V. et al. 2006, Circulating biomarkers of cognitive decline and dementia. Clin. Chim. Acta 364, 91–112 (2006).
-
(2006)
Clin. Chim. Acta
, vol.364
, pp. 91-112
-
-
Solfrizzi, V.1
-
108
-
-
60349119623
-
Magnetic Resonance Imaging Improves Cerebrospinal Fluid Biomarkers in the Early Detection of Alzheimer’s Disease
-
Brys, M. et al. Magnetic Resonance Imaging Improves Cerebrospinal Fluid Biomarkers in the Early Detection of Alzheimer’s Disease. J. Alzheimers Dis. 16, 351–362 (2009).
-
(2009)
J. Alzheimers Dis
, vol.16
, pp. 351-362
-
-
Brys, M.1
-
109
-
-
77956028825
-
Confounding Factors Influencing Amyloid Beta Concentration in Cerebrospinal Fluid
-
pii: 986310
-
Bjerke, M. et al. Confounding Factors Influencing Amyloid Beta Concentration in Cerebrospinal Fluid. Int. J. Alzheimer Dis. pii: 986310 (2010).
-
(2010)
Int. J. Alzheimer Dis
-
-
Bjerke, M.1
-
110
-
-
3142622923
-
Do statins slow down Alzheimer’s disease? A review
-
Caballero, J. & Nahata, M. Do statins slow down Alzheimer’s disease? A review. J. Clin. Pharm. Ther.29, 209–213 (2004).
-
(2004)
J. Clin. Pharm. Ther
, vol.29
, pp. 209-213
-
-
Caballero, J.1
Nahata, M.2
-
111
-
-
77957267776
-
Correlations between soluble α/β forms of amyloid precursor protein and Aβ38, 40, and 42 in humancerebrospinal fluid
-
Gabelle, A. et al. Correlations between soluble α/β forms of amyloid precursor protein and Aβ38, 40, and 42 in humancerebrospinal fluid. Brain Res. 1357, 175–183 (2010).
-
(2010)
Brain Res
, vol.1357
, pp. 175-183
-
-
Gabelle, A.1
-
112
-
-
7444253126
-
Cerebrospinal Fluid Protein Biomarkers for Alzheimer’s Disease
-
Blennow, K. Cerebrospinal Fluid Protein Biomarkers for Alzheimer’s Disease. NeuroRx. 1, 213–225 (2004).
-
(2004)
Neurorx
, vol.1
, pp. 213-225
-
-
Blennow, K.1
-
113
-
-
0034027642
-
Age-dependent change in the levels of Abeta40 and Abeta42 in cerebrospinal fluid from control subjects, and a decrease in the ratio of Abeta42 to Abeta40 level in cerebrospinal fluid from Alzheimer’s disease patients
-
Fukuyama, R. et al. Age-dependent change in the levels of Abeta40 and Abeta42 in cerebrospinal fluid from control subjects, and a decrease in the ratio of Abeta42 to Abeta40 level in cerebrospinal fluid from Alzheimer’s disease patients. Eur. Neurol. 43, 155–160 (2000).
-
(2000)
Eur. Neurol
, vol.43
, pp. 155-160
-
-
Fukuyama, R.1
-
114
-
-
77449126153
-
Extracellular chaperones modulate the effects of Alzheimer’s patient cerebrospinal fluid on Aβ1-42 toxicity and uptake
-
Yerbury, J. J. & Wilson, M. R. Extracellular chaperones modulate the effects of Alzheimer’s patient cerebrospinal fluid on Aβ1-42 toxicity and uptake. Cell Stress Chaperones 15, 115–121 (2009).
-
(2009)
Cell Stress Chaperones
, vol.15
, pp. 115-121
-
-
Yerbury, J.J.1
Wilson, M.R.2
-
115
-
-
67649531853
-
Biomarkers of Alzheimer’s Disease. Neurobiol
-
Craig-Schapiro, R., Fagan, A. M. & Holtzman, D. M. Biomarkers of Alzheimer’s Disease. Neurobiol. Dis.35, 128–140 (2009).
-
(2009)
Dis
, vol.35
, pp. 128-140
-
-
Craig-Schapiro, R.1
Fagan, A.M.2
Holtzman, D.M.3
-
116
-
-
34347407998
-
Fibrinogen gamma-A chain precursor in CSF: A candidate biomarker for Alzheimer’s disease
-
Lee, J. W. et al. Fibrinogen gamma-A chain precursor in CSF: a candidate biomarker for Alzheimer’s disease. BMC Neurol. 7, 14 (2007).
-
(2007)
BMC Neurol
, vol.7
-
-
Lee, J.W.1
-
117
-
-
42049083159
-
Both plasmaretinol-binding protein and haptoglobin precursor allele 1 in CSF: Candidate biomarkers for the progression of normal to mild cognitive impairment to Alzheimer’s disease
-
Jung, S. M. et al. Both plasmaretinol-binding protein and haptoglobin precursor allele 1 in CSF: Candidate biomarkers for the progression of normal to mild cognitive impairment to Alzheimer’s disease. Neurosci. Lett.436, 153–157 (2008).
-
(2008)
Neurosci. Lett
, vol.436
, pp. 153-157
-
-
Jung, S.M.1
-
118
-
-
0037040525
-
Elevated levels of phosphorylated neurofilament proteins incerebrospinal fluid of Alzheimer disease patients
-
Hu, Y. Y. et al. Elevated levels of phosphorylated neurofilament proteins incerebrospinal fluid of Alzheimer disease patients. Neurosci. Lett. 320, 156–160 (2002).
-
(2002)
Neurosci. Lett
, vol.320
, pp. 156-160
-
-
Hu, Y.Y.1
-
119
-
-
0028363163
-
Ubiquitin in cerebrospinal fluid in Alzheimer’s disease and vascular dementia
-
Blennow, K., Davidsson, P., Wallin, A., Gottfries, C. G. & Svennerholm, L. Ubiquitin in cerebrospinal fluid in Alzheimer’s disease and vascular dementia. Int. Psychogeriatr. 6, 13–22 (1994).
-
(1994)
Int. Psychogeriatr
, vol.6
, pp. 13-22
-
-
Blennow, K.1
Davidsson, P.2
Wallin, A.3
Gottfries, C.G.4
Svennerholm, L.5
-
120
-
-
0033762711
-
Increased 8, 12-iso-iPF (2α) -VI in Alzheimer’s disease: Correlation of a noninvasive index of lipid peroxidation with disease severity
-
Praticò, D. et al. Increased 8, 12-iso-iPF (2α) -VI in Alzheimer’s disease: Correlation of a noninvasive index of lipid peroxidation with disease severity. Ann. Neurol. 48, 809–812 (2000).
-
(2000)
Ann. Neurol
, vol.48
, pp. 809-812
-
-
Praticò, D.1
-
121
-
-
0035907290
-
Amyloid Precursor Protein and Amyloid β Peptide in Human Platelets
-
Skovronsky, D. M., Lee, V. M. Y. & Praticò, D. Amyloid Precursor Protein and Amyloid β Peptide in Human Platelets. J. Biol. Chem. 276, 17036–17043 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 17036-17043
-
-
Skovronsky, D.M.1
Lee, V.2
Praticò, D.3
-
122
-
-
77955953955
-
Biomarkers for Alzheimer’s Disease Diagnosis
-
pii: 606802
-
Anoop, A., Singh, P. K., Jacob, R. S. & Maji, S. K. CSF Biomarkers for Alzheimer’s Disease Diagnosis. Int. J. Alzheimers Dis. pii: 606802 (2010).
-
(2010)
Int. J. Alzheimers Dis
-
-
Anoop, A.1
Singh, P.K.2
Jacob, R.S.3
Maji, S.4
-
123
-
-
67650225313
-
CSF biomarkers, impairment of cerebral hemodynamics and degree of cognitive decline in Alzheimer’s and mixed dementia
-
Stefani, A. et al. CSF biomarkers, impairment of cerebral hemodynamics and degree of cognitive decline in Alzheimer’s and mixed dementia. J. Neurol. Sci. 283, 109–115 (2009).
-
(2009)
J. Neurol. Sci
, vol.283
, pp. 109-115
-
-
Stefani, A.1
-
124
-
-
77949425172
-
Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer’s disease
-
Fagan, A. M. et al. Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer’s disease. EMBO Mol. Med. 1, 371–380 (2009).
-
(2009)
EMBO Mol. Med
, vol.1
, pp. 371-380
-
-
Fagan, A.M.1
-
125
-
-
43249106998
-
CSF biomarkers in frontotemporal lobar degeneration with known pathology
-
Bian, H. et al. CSF biomarkers in frontotemporal lobar degeneration with known pathology. Neurology 70, 1827–1835 (2008).
-
(2008)
Neurology
, vol.70
, pp. 1827-1835
-
-
Bian, H.1
-
126
-
-
7444271086
-
Cerebrospinal fluid β-amyloid1-42 and tau in control subjects at risk for Alzheimer’s disease: The effect of APOE ε4 allele
-
Sunderland, T. et al. Cerebrospinal fluid β-amyloid1-42 and tau in control subjects at risk for Alzheimer’s disease: The effect of APOE ε4 allele. Biol. Psychiatry 56, 670–676 (2004).
-
(2004)
Biol. Psychiatry
, vol.56
, pp. 670-676
-
-
Sunderland, T.1
-
127
-
-
33750612372
-
Proteomics in Clinical Trials and Practice
-
Azad, N. S. et al. Proteomics in Clinical Trials and Practice. Proteomics 5, 1819–1829 (2006).
-
(2006)
Proteomics
, vol.5
, pp. 1819-1829
-
-
Azad, N.S.1
-
128
-
-
77954835300
-
High-molecular-weight beta-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients
-
Fukumoto, H. et al. High-molecular-weight beta-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients. FASEB J. 24, 2716–2726 (2010).
-
(2010)
FASEB J
, vol.24
, pp. 2716-2726
-
-
Fukumoto, H.1
-
129
-
-
68049131389
-
Abeta oligomers and fibrillar aggregates induce different apoptotic pathways in
-
Picone, P. et al. Abeta oligomers and fibrillar aggregates induce different apoptotic pathways in LAN5 neuroblastoma cell cultures. Biophys. J. 96, 4200–4211 (2009).
-
(2009)
LAN5 Neuroblastoma Cell Cultures. Biophys. J
, vol.96
, pp. 4200-4211
-
-
Picone, P.1
-
131
-
-
72049120104
-
Prediction and Prevention (?) of Alzheimer’s Disease
-
Petersen, R. C. Prediction and Prevention (?) of Alzheimer’s Disease. Lancet Neurol. 9, 4–5 (2010).
-
(2010)
Lancet Neurol
, vol.9
, pp. 4-5
-
-
Petersen, R.C.1
-
132
-
-
34548258322
-
Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models
-
Cheng, I. H. et al. Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. J. Biol. Chem. 282, 23818–23128 (2007).
-
(2007)
J. Biol. Chem
, vol.282
, pp. 23128-23818
-
-
Cheng, I.H.1
-
133
-
-
38949208262
-
Plaque-bearing mice with reduced levels of oligomeric amyloid-beta assemblies have intact memory function
-
Lesné, S., Kotilinek, L. & Ashe, K. H. Plaque-bearing mice with reduced levels of oligomeric amyloid-beta assemblies have intact memory function. Neuroscience 151, 745–749 (2007).
-
(2007)
Neuroscience
, vol.151
, pp. 745-749
-
-
Lesné, S.1
Kotilinek, L.2
Ashe, K.H.3
-
134
-
-
79961000597
-
Characterization of oligomer formation of amyloid-beta peptide using a split-luciferase complementation assay
-
Hashimoto, T., Adams, K. W., Fan, Z., McLean, P. J. & Hyman, B. T. Characterization of oligomer formation of amyloid-beta peptide using a split-luciferase complementation assay. J. Biol. Chem. 286, 27081–27091 (2011).
-
(2011)
J. Biol. Chem
, vol.286
, pp. 27081-27091
-
-
Hashimoto, T.1
Adams, K.W.2
Fan, Z.3
McLean, P.J.4
Hyman, B.T.5
-
135
-
-
12944312683
-
Simultaneous measurement of betaamyloid (1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology
-
Olsson, A. et al. Simultaneous measurement of betaamyloid (1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology. Clin. Chem. 51, 336–345 (2005).
-
(2005)
Clin. Chem
, vol.51
, pp. 336-345
-
-
Olsson, A.1
-
136
-
-
84856021758
-
Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity
-
Bao, F. et al. Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity. Neurobiol. Aging 33, 825.e1-1 (2011).
-
(2011)
Neurobiol. Aging
, vol.33
, Issue.825
, pp. e1-e1
-
-
Bao, F.1
-
137
-
-
78449245429
-
A strategy for designing a peptide probe for detection of β-amyloid oligomers
-
Hu, Y. et al. A strategy for designing a peptide probe for detection of β-amyloid oligomers. Chembiochem 11, 2409–2418 (2010).
-
(2010)
Chembiochem
, vol.11
, pp. 2409-2418
-
-
Hu, Y.1
-
138
-
-
79960298697
-
Sequestration of toxic oligomers by HspB1 as a cytoprotective mechanism
-
Ojha, J., Masilamoni, G., Dunlap, D., Udoff, R. A. & Cashikar, A. G. Sequestration of toxic oligomers by HspB1 as a cytoprotective mechanism. Mol. Cell Biol. 31, 3146–3157 (2011).
-
(2011)
Mol. Cell Biol
, vol.31
, pp. 3146-3157
-
-
Ojha, J.1
Masilamoni, G.2
Dunlap, D.3
Udoff, R.A.4
Cashikar, A.G.5
-
139
-
-
0346023035
-
Association of a salivary acetylcholinesterase with Alzheimer’s disease and response to cholinesterase inhibitors
-
Sayer, R., Law, E., Connelly, P. J. & Breen, K. C. Association of a salivary acetylcholinesterase with Alzheimer’s disease and response to cholinesterase inhibitors. Clin. Biochem. 37, 98–104 (2004).
-
(2004)
Clin. Biochem
, vol.37
, pp. 98-104
-
-
Sayer, R.1
Law, E.2
Connelly, P.J.3
Breen, K.C.4
-
140
-
-
78049326706
-
Saliva levels of Abeta1-42 as potential biomarker of Alzheimer’s disease: A pilot study
-
Bermejo-Pareja, F., Antequera, D., Vargas, T., Molina, J. A. & Carro, E. Saliva levels of Abeta1-42 as potential biomarker of Alzheimer’s disease: a pilot study. BMC Neurol. 10, 108 (2010).
-
(2010)
BMC Neurol
, vol.10
-
-
Bermejo-Pareja, F.1
Antequera, D.2
Vargas, T.3
Molina, J.A.4
Carro, E.5
-
142
-
-
70350061949
-
Multimodal techniques for diagnosis and prognosis of Alzheimer’s disease
-
Perrin, R. J., Fagan, A. M. & Holtzman, D. M. Multimodal techniques for diagnosis and prognosis of Alzheimer’s disease. Nature 461, 916–922 (2009)
-
(2009)
Nature
, vol.461
, pp. 916-922
-
-
Perrin, R.J.1
Fagan, A.M.2
Holtzman, D.M.3
|