Apolipoprotein E serum concentration and polymorphism in six European countries: The ApoEurope Project

Atherosclerosis

Volumn 152, Issue 2, 2000, Pages 475-488

  Schiele, F ^a   De Bacquer, D ^b   Vincent Viry, M ^a   Beisiegel, U ^c   Ehnholm, C ^d   Evans, A ^e   Kafatos, A ^f   Martins, M C ^g   Sans, S ^h   Sass, C ^a   Visvikis, S ^a,i   De Backer, G ^b   Siest, G ^a,i  

^a Centre de Medecine Preventive   (France)

^b GHENT UNIVERSITY   (Belgium)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^e QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^f UNIVERSITY OF CRETE   (Greece)

^g NATIONAL INSTITUTE OF HEALTH DR RICARDO JORGE   (Portugal)

^h INSTITUT CATALÀ DE LA SALUT   (Spain)

ⁱ UNIVERSITÉ DE LORRAINE   (France)

Author keywords

Apolipoprotein E concentration; Apolipoprotein E polymorphism; Cardiovascular risk; Epidemiology; Multicentre study

Indexed keywords

APOLIPOPROTEIN E;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CLINICAL TRIAL; EPIDEMIOLOGY; EUROPE; FEMALE; FINLAND; FRANCE; GENETIC POLYMORPHISM; GENOTYPE; GEOGRAPHIC AND GEOLOGICAL PHENOMENA; GREECE; HUMAN; HUMAN EXPERIMENT; LIPOPROTEIN BLOOD LEVEL; MALE; MULTICENTER STUDY; NORMAL HUMAN; PORTUGAL; PRIORITY JOURNAL; SPAIN; UNITED KINGDOM;

ADULT; AGING; APOLIPOPROTEINS E; EUROPE; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 0033816319     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(99)00501-8     Document Type: Article

References (50)

1. Siest G., Pillot T., Régis-Bailly A., Leininger-Muller B., Steinmetz J., Galteau M.M., Visvikis S. Apolipoprotein E: An important gene and protein to be followed in laboratory medicine. Clin. Chem. 41:1995;1068-1086.
2. Lambert JC, Pasquier F, Cottel D, Frigard B, Amouyel P, Chartier-Harlin MC. A new polymorphism in the apo E promoter associated with risk of developing Alzheimer's disease, Hum Mol Genet 1998;740:533-40.
3. Town T., Paris D., Fallin D., Duara R., Barker W., Gold M., Crawford F., Mullan M. The -491 A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known Apo E polymorphism. Neurosci. Lett. 252:1998;95-98.
4. Eggertsen G., Tegelman R., Ericsson S., Angelin B., Berglund L. Apolipoprotein E polymorphism in a healthy Swedish population: variation of allele frequency with age and relation to serum lipid concentrations. Clin. Chem. 39:1993;2125-2129.
5. Stengard J.H., Zerba K.E., Pekkanen J., Ehnholm C., Nissinen A., Sing C.F. Apolipoprotein E polymorphism predicts death from Coronary Heart Disease in a longitudinal study of elderly Finnish men. Circulation. 91:1995;265-269.
6. Stengard J.H., Pekkanen J., Ehnholm C., Nissinen A., Sing C.F. Genotypes with the apolipoprotein ε-4 allele are predictors of coronary heart disease mortality in a longitudinal study of elderly Finnish men aged 65-84 years. Hum. Genet. 97:1996;677-684.
7. Dallongeville J., Lussier-Cacan S., Davignon J. Modulation of plasma triglyceride levels by apo E phenotype: a meta-analysis. J. Lipid. Res. 33:1992;447-454.
8. Slooter A.J., de Knijff P., Hofman A., Cruts M., Breteler M.M., Van Broeckhoven C., Havekes L.M., van Duijn C.M. Serum apolipoprotein E level is not increased in Alzheimer's disease: the Rotterdam study. Neurosci. Lett. 248:1998;21-24.
9. Taddei K., Clarnette R., Gandy S.E., Martins R.N. Increased plasma apolipoprotein E (apo E) levels in Alzheimer's disease. Neurosci. Lett. 223:1997;29-32.
10. Salomaa V.V., Rasi V.P., Vahtera E.M., Pekkanen J., Pursiainen M., Jauhiainen M., Vartiainen E., Ehnholm C.P., Myllylä G. Haemostatic factors and lipoprotein (a) in three geographical areas in Finland: the Finrisk haemostasis study. J. Cardiovasc. Risk. 1:1994;241-248.
11. Woodside J.V., Yarnell J.W.G., McMaster D., Young I.S., Harmon D.L., McCrum E.E., Patterson C.C., Gey K.F., Whitehead S., Evans A. Effect of B-group vitamins and antioxidant vitamins on hyperhomocysteinemia: a double-blind, randomized, factorial-design, controlled trial. Am. J. Clin. Nutr. 67:1998;858-866.
12. Siest G., Visvikis S., Herbeth B., et al. Objectives, design and recruitment of a familial and longitudinal cohort for studying gene-environment interactions in the field of cardiovascular risk: the Stanislas Cohort. Clin. Chem. Lab. Med. 36:1998;35-42.
13. Rodes A., Sans S., Balana L.L., Paluzie G., Aguilera R., Balaguer-Vintro I. Recruitment methods and differences in early, late and non-respondents in the first MONICA-Catalonia population survey. Rev. Epidemiol. Santé Publ. 38:1990;447-453.
14. WHO MONICA Project principal investigators: The world health organization MONICA Project (Monitoring Trends and Determinants in Cardiovascular disease) : a major international collaboration, J Clin Epidemiol 1988;41:105-114.
15. Keil U., Kuulasmaa K. WHO MONICA Project: risk factors. Int. J. Epidemiol. 18 (3 Suppl. 1):1989;S46-S55.
16. Noma A., Hata Y., Goto Y. Quantitation of serum apolipoprotein A-I, A-II, B, C-II, C-III and E in healthy Japanese by turbidimetric immunoassay: reference values, and age- sex-related differences. Clin. Chim. Acta. 199:1991;147-158.
17. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells, Nucl. Acids Res 1988;16:1215.
18. Visvikis S., Schlenk A., Maurice M. DNA extraction and stability for epidemiological studies. Clin. Chem. Lab. Med. 36:1998;551-555.
19. Hixson J.E., Vernier D.T. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J. Lipid Res. 31:1990;545-548.
20. Havekes L.M., De Knijff P., Beisiegel U., Havinga J., Smit M., Klasen E. A rapid micromethod for apolipoprotein E phenotyping directly in serum. J. Lipid Res. 28:1987;455-463.
21. Braeckman L., De Bacquer D., Rosseneu M., De Backer G. Apolipoprotein E polymorphism in middle-aged Belgian men: phenotype distribution and relation to serum lipids and lipoproteins. Atherosclerosis. 120:1996;67-73.
22. Boer JMA, Ehnholm C, Menzel HJ, Havekes LM, Rosseneu M, SJ O'Reilly D, Tiret L, for the EARS group. Interactions between lifestyle-related factors and the apo E polymorphism on plasma lipids and apolipoproteins, the EARS study, Arterioscler Thromb Vasc Biol 1997;17:1675-1681.
23. Alsayed N., Rebourcet R., Chapman J. Concentrations of apoprotein CII, CIII, and E in total serum and in apoprotein B-containing lipoproteins, determined by a new enzyme-linked immunosorbent assay. Clin. Chem. 36:1990;2047-2052.
24. Kottke B.A., Moll P.P., Michels V.V., Weidman W.H. Levels of lipids, lipoproteins and apolipoproteins in a defined population. Mayo Clin. Proc. 66:1991;1198-1208.
25. Krassnoff P., Pisani T., Long S. Quantitative assay for the determination of apo E in serum and plasma. J. Clin. Ligand assay. 19:1996;172-176.
26. Evans K., Laker M.F. Intra-individual factors affecting lipid, lipoprotein and apolipoprotein measurement: a review. Ann. Clin. Biochem. 32:1995;261-280.
27. Cooper G.R., Smith S.J., Myers G.L., Sampson E.J., Magid E. Biological variability in the concentration of serum lipids: sources, meta-analysis, estimation, and minimization by relative range measurements. JIFCC. 7:1995;23-28.
28. Regis-Bailly A., Visvikis S., Steinmetz J., Fournier B., Gueguen R., Siest G. Effects of apo B and apo E gene polymorphisms on lipid and apolipoprotein concentrations after a test meal. Clin. Chim. Acta. 253:1996;127-143.
29. Annuzzi G., Holmquist L., Carlson L.A. Concentrations of apolipoproteins B, C-I, C-II, C-III, E and lipids in serum and serum lipoproteins of normal subjects during alimentary lipaemia. Scand. J. Clin. Lab. Invest. 49:1989;73-81.
30. Miller M., Bachorik P.S., Cloey T.A. Normal variation of plasma lipoprotein: postural effects on plasma concentrations of lipids, lipoproteins, and apolipoprotein. Clin. Chem. 38:1992;569-574.
31. Boerwinkle E., Visvikis S., Welsh D., Steinmetz J., Hanash S.M., Sing C.F. The use of measured genotype information in the analysis of quantitative phenotypes in man. II. The role of the apolipoprotein E polymorphism in determining levels, variability, and covariability of cholesterol, betalipoprotein, and triglycerides in a sample of unrelated individuals. Am. J. Med. Genet. 27:1987;567-582.
32. Hanis C.L., Hewett-Emmett D., Douglas T.C., Bertin T.K., Schull W.J. Effects of the apolipoprotein E polymorphism on levels of lipids, lipoproteins, and apolipoproteins among Mexican-Americans in Starr County, Texas. Arterioscler. Thromb. 11:1991;362-370.
33. Vincent-Viry M., Schiele F., Gueguen R., Bohnet K., Visvikis S., Siest G. Biological variations and genetic reference values for apolipoprotein E serum concentrations: results from the STANISLAS cohort study. Clin. Chem. 44:1998;957-965.
34. Farrer L.A., Cupples L.A., Haines J.L., Hyman B., Kukull W.A., Mayeux R., Myers R.H., Pericak-Vance M.A., Risch N., van Duijn C.M. Effects of age, sex and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. J. Am. Med. Assoc. 278:1997;1349-1356.
35. Gao S., Hendrie H.C., Hall K.S., Hui S. The relationships between age, sex and the incidence of dementia and Alzheimer disease. A meta-analysis. Arch. Gen. Psych. 55:1998;809-815.
36. Lehtimäki T., Moilanen T., Viikari J., Akerblom H.K., Ehnholm C., Rönnemaa T., Marniemi J., Dahlen G., Nikkari T. Apolipoprotein E phenotypes in Finnish youths: a cross-sectional and 6-year follow-up study. Arteriosclerosis. 31:1990;487-495.
37. Gerdes L.U., Klausen J.C., Sihm I., Faergeman O. Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world. Genet. Epidemiol. 9:1992;155-167.
38. Ehnholm C., Lukka M., Kuusi T., Nikkilä E., Utermann G. Apolipoprotein E polymorphism in a Finnish population: gene frequencies and relation to lipoprotein concentrations. J. Lipid Res. 27:1986;227-235.
39. Tiret L, de Knijff P, Menzel HJ, Ehnholm C, Nicaud V, Havekes LM for the EARS group. Apo E polymorphism and predisposition to coronary heart disease in youths of different European populations, the EARS study, Arterioscler Thromb 1994;14:1617-1624.
40. Corbo R.M., Scacchi R., Mureddu L., Mulas G., Alfano G. Apolipoprotein E polymorphism in Italy investigated in native plasma by a simple polyacrylamide gel isoelectric focusing technique. Comparison with frequency data of other European populations. Ann. Hum. Genet. 59:1995;197-209.
41. Corti M.C., Barbato G.M., Baggio G. Lipoprotein alterations and atherosclerosis in the elderly. Curr. Opin. Lipidol. 8:1997;236-241.
42. Luc G., Bard J.M., Arveiler D., et al. Impact of apolipoprotein E polymorphism on lipoproteins and risk of myocardial infarction. The ECTIM study. Arterioscler. Thromb. 14:1994;1412-1419.
43. Couderc R., Bailleul S. L'apolipoproteine E et ses allèles chez le sujet sain et au cours de l'athérosclérose. Ann. Biol. Clin. 56:1998;651-659.
44. Howard B.V., Gidding S.S., Liu K. Association of E phenotype with plasma lipoproteins in African-American and White young adults. The CARDIA study. Am. J. Epidemiol. 148:1998;859-868.
45. Sing C.F., Davignon J. Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am. J. Hum. Genet. 37:1985;268-285.
46. Reilly S.L., Ferrell R.E., Sing C.F. The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, MN. III. Correlations and covariances. Am. J. Hum. Genet. 55:1994;1001-1008.
47. Bohnet K., Pillot T., Visvikis S., Sabolovic N., Siest G. Apolipoprotein (apo) E genotype and apo E concentration determine binding of normal very low density lipoproteins to Hep G2 cell surface receptors. J. Lipid Res. 37:1996;1316-1324.
48. Mahley R.W., Huang Y. Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond. Curr. Opin. Lipidol. 10:1999;207-217.
49. Jarvik G.P., Goode E.L., Austin M.A., Auwerx J., Deeb S., Schellenberg G.D., Reed T. Evidence that the apolipoprotein E-genotype effects on lipid levels can change with age in males: a longitudinal analysis. Am. J. Hum. Genet. 61:1997;171-181.
50. Scacchi R., Gambina G., Ruggeri M., Martini M.C., Ferrari G., Silvestri M., Schiavon R., Corbo R.M. Plasma levels of apolipoprotein E and genetic markers in elderly patients with Alzheimer's disease. Neurosci. Lett. 259:1999;33-36.