Altered one-carbon metabolism in posttraumatic stress disorder

Journal of Affective Disorders

Volumn 184, Issue , 2015, Pages 277-285

  De Vries, Giel Jan ^a   Lok, Anja ^a,b   Mocking, Roel ^a   Assies, Johanna ^a   Schene, Aart ^a,c,d   Olff, Miranda ^a,b  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b ARQ PSYCHOTRAUMA EXPERT GROUP   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d RADBOUD UNIVERSITY   (Netherlands)

Author keywords

Homocysteine; HPA axis; One carbon metabolism; PTSD

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; HYDROCORTISONE; PRASTERONE; PRASTERONE SULFATE; PYRIDOXINE;

ADULT; ARTICLE; CARBON METABOLISM; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; DEPRESSION; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; MIDDLE AGED; NUTRITIONAL ASSESSMENT; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; BLOOD; CASE CONTROL STUDY; COMPLICATION; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; PSYCHOTRAUMA; RISK FACTOR;

ADULT; CASE-CONTROL STUDIES; DEHYDROEPIANDROSTERONE; DEPRESSION; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MIDDLE AGED; PITUITARY-ADRENAL SYSTEM; PSYCHOLOGICAL TRAUMA; RISK FACTORS; STRESS DISORDERS, POST-TRAUMATIC; VITAMIN B 12; VITAMIN B 6;

EID: 84933509695     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2015.05.062     Document Type: Article

References (91)

1. N. Ahmadi, F. Hajsadeghi, H.B. Mirshkarlo, M. Budoff, R. Yehuda, and R. Ebrahimi Post-traumatic stress disorder, coronary atherosclerosis, and mortality Am. J. Cardiol. 108 1 2011 29 33
2. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders fourth edition: DSM-IV-TR 2000 American Psychiatric Association Washington, DC
3. J. Assies, R.J. Mocking, A. Lok, H.G. Ruhe, F. Pouwer, and A.H. Schene Effects of oxidative stress on fatty acid- and one-carbon-metabolism in psychiatric and cardiovascular disease comorbidity Acta Psychiatr. Scand. 130 3 2014 163 180
4. R.C. Austin, S.R. Lentz, and G.H. Werstuck Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease Cell Death Differ. 11 Suppl. 1 2004 S56 S64
5. L.E. Bautista, I.A. Arenas, A. Penuela, and L.X. Martinez Total plasma homocysteine level and risk of cardiovascular disease: a meta-analysis of prospective cohort studies J. Clin. Epidemiol. 55 9 2002 882 887
6. A.T. Beck, and A. Beamesderfer Assessment of depression: the depression inventory Mod. Probl. Pharmacopsychiatry 7 0 1974 151 169
7. I. Bjelland, G.S. Tell, S.E. Vollset, H. Refsum, and P.M. Ueland Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study Arch. Gen. Psychiatry 60 6 2003 618 626
8. M.M. Black Micronutrient deficiencies and cognitive functioning J. Nutr. 133 11 Suppl. 2 2003 3927S 3931S
9. P.H. Black, and L.D. Garbutt Stress, inflammation and cardiovascular disease J. Psychosom. Res. 52 1 2002 1 23
10. J.A. Boscarino A prospective study of PTSD and early-age heart disease mortality among Vietnam veterans: implications for surveillance and prevention Psychosom. Med. 70 6 2008 668 676
11. J.A. Boscarino Post-traumatic stress disorder and cardiovascular disease link: time to identify specific pathways and interventions Am. J. Cardiol. 108 7 2011 1052 1053
12. T. Bottiglieri Homocysteine and folate metabolism in depression Prog. Neuropsychopharmacol. Biol. Psychiatry 29 7 2005 1103 1112
13. D.J. Brotman, S.H. Golden, and I.S. Wittstein The cardiovascular toll of stress Lancet 370 9592 2007 1089 1100
14. R. Castro, I. Rivera, E.A. Struys, E.E. Jansen, P. Ravasco, M.E. Camilo, H.J. Blom, C. Jakobs, and dA.I. Tavares Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease Clin. Chem. 49 8 2003 1292 1296
15. R. Clarke, J. Halsey, D. Bennett, and S. Lewington Homocysteine and vascular disease: review of published results of the homocysteine-lowering trials J. Inherit. Metab. Dis. 34 1 2011 83 91
16. M. Creamer, R. Bell, and S. Failla Psychometric properties of the impact of event scale-revised Behav. Res. Ther. 41 12 2003 1489 1496
17. N.F. Crum-Cianflone, M.E. Bagnell, E. Schaller, E.J. Boyko, B. Smith, C. Maynard, C.S. Ulmer, M. Vernalis, and T.C. Smith Impact of combat deployment and posttraumatic stress disorder on newly reported coronary heart disease among us active duty and reserve forces Circulation 129 18 2014 1813 1820
18. M.J. Dauncey New insights into nutrition and cognitive neuroscience Proc. Nutr. Soc. 68 4 2009 408 415
19. M.J. Dauncey Recent advances in nutrition, genes and brain health Proc. Nutr. Soc. 71 4 2012 581 591
20. J. Davidson, R. Smith, and H. Kudler Validity and reliability of the DSM-III criteria for posttraumatic stress disorder. Experience with a structured interview J. Nerv. Ment. Dis. 177 6 1989 336 341
21. A. De Bree, W.M. Verschuren, D. Kromhout, L.A. Kluijtmans, and H.J. Blom Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease Pharmacol. Rev. 54 4 2002 599 618
22. G.J. de Vries, and M. Olff The lifetime prevalence of traumatic events and posttraumatic stress disorder in The Netherlands J. Trauma Stress 22 4 2009 259 267
23. A. Dietrich-Muszalska, J. Malinowska, B. Olas, R. Glowacki, E. Bald, B. Wachowicz, and J. Rabe-Jablonska The oxidative stress may be induced by the elevated homocysteine in schizophrenic patients Neurochem. Res. 37 5 2012 1057 1062
24. L.J. Dominguez, A. Galioto, A. Pineo, A. Ferlisi, M. Ciaccio, E. Putignano, M. Belvedere, G. Costanza, and M. Barbagallo Age, homocysteine, and oxidative stress: relation to hypertension and type 2 diabetes mellitus J. Am. Coll. Nutr. 29 1 2010 1 6
25. A. Faggiano, D. Melis, R. Alfieri, M.M. De, M. Filippella, F. Milone, G. Lombardi, A. Colao, and R. Pivonello Sulfur amino acids in Cushing's Disease: insight in homocysteine and taurine levels in patients with active and cured disease J. Clin. Endocrinol. Metab. 90 12 2005 6616 6622
26. J.D. Finkelstein The metabolism of homocysteine: pathways and regulation Eur. J. Pediatr. 157 Suppl. 2 1998 S40 S44
27. J.D. Finkelstein, and B. Harris Methionine metabolism in mammals: synthesis of S-adenosylhomocysteine in rat tissues Arch. Biochem. Biophys. 159 1 1973 160 165
28. J.D. Finkelstein, W. Kyle, and B.J. Harris Methionine metabolism in mammals. Regulation of homocysteine methyltransferases in rat tissue Arch. Biochem. Biophys. 146 1 1971 84 92
29. J.D. Finkelstein, and J.J. Martin Homocysteine Int. J. Biochem. Cell Biol. 32 4 2000 385 389
30. M.B. First, R.L. Spitzer, M. Gibbon, and J.B.W. Williams Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV) 1996 American Psychiatric Press, Inc. Washington, DC
31. E. Fries, J. Hesse, J. Hellhammer, and D.H. Hellhammer A new view on hypocortisolism Psychoneuroendocrinology 30 10 2005 1010 1016
32. S. Friso, and S.W. Choi Gene-nutrient interactions and DNA methylation J. Nutr. 132 8 Suppl. 2002 2382S 2387S
33. M. Gerardi, B.O. Rothbaum, M.C. Astin, and M. Kelley Cortisol response following exposure treatment for ptsd in rape victims J. Aggress. Maltreat. Trauma 19 4 2010 349 356
34. S. Gillette-Guyonnet, M. Secher, and B. Vellas Nutrition and neurodegeneration: epidemiological evidence and challenges for future research Br. J. Clin. Pharmacol. 75 3 2013 738 755
35. A.G. Gocan, D. Bachg, A.E. Schindler, and U.D. Rohr Balancing steroidal hormone cascade in treatment-resistant veteran soldiers with PTSD using a fermented soy product (FSWW08): a pilot study Horm. Mol. Biol. Clin. Investig. 10 3 2012 301 314
36. G.J. Hankey, and J.W. Eikelboom Homocysteine and vascular disease Lancet 354 9176 1999 407 413
37. A.R. Henderson The bootstrap: a technique for data-driven statistics. Using computer-intensive analyses to explore experimental data Clin. Chim. Acta 359 1-2 2005 1 26
38. H. Hendriksen, B. Olivier, and R.S. Oosting From non-pharmacological treatments for post-traumatic stress disorder to novel therapeutic targets Eur. J. Pharmacol. 732 2014 139 158
39. P.I. Holm, S. Hustad, P.M. Ueland, S.E. Vollset, T. Grotmol, and J. Schneede Modulation of the homocysteine-betaine relationship by methylenetetrahydrofolate reductase 677C->t genotypes and B-vitamin status in a large-scale epidemiological study J. Clin. Endocrinol. Metab. 92 4 2007 1535 1541
40. R.L. Jacobs, L.M. Stead, M.E. Brosnan, and J.T. Brosnan Hyperglucagonemia in rats results in decreased plasma homocysteine and increased flux through the transsulfuration pathway in liver J. Biol. Chem. 276 47 2001 43740 43747
41. H. Jakubowski The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease J. Physiol. Pharmacol. 59 Suppl. 9 2008 155 167
42. T. Jendricko, A. Vidovic, M. Grubisic-Ilic, Z. Romic, Z. Kovacic, and D. Kozaric-Kovacic Homocysteine and serum lipids concentration in male war veterans with posttraumatic stress disorder Prog. Neuropsychopharmacol. Biol. Psychiatry 33 1 2009 134 140
43. Y. Jiang, T. Sun, J. Xiong, J. Cao, G. Li, and S. Wang Hyperhomocysteinemia-mediated DNA hypomethylation and its potential epigenetic role in rats Acta Biochim. Biophys. Sin. (Shanghai) 39 9 2007 657 667
44. H.T. Jordan, S.A. Miller-Archie, J.E. Cone, A. Morabia, and S.D. Stellman Heart disease among adults exposed to the September 11, 2001 World Trade Center disaster: results from the World Trade Center Health Registry Prev. Med. 53 6 2011 370 376
45. A. Kale, N. Naphade, S. Sapkale, M. Kamaraju, A. Pillai, S. Joshi, and S. Mahadik Reduced folic acid, vitamin B12 and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: implications for altered one-carbon metabolism Psychiatry Res. 175 1-2 2010 47 53
46. J.L. Kibler, M. Tursich, M. Ma, L. Malcolm, and R. Greenbarg Metabolic, autonomic and immune markers for cardiovascular disease in posttraumatic stress disorder World J. Cardiol. 6 6 2014 455 461
47. J.M. Kim, R. Stewart, S.W. Kim, S.J. Yang, I.S. Shin, and J.S. Yoon Predictive value of folate, vitamin B12 and homocysteine levels in late-life depression Br. J. Psychiatry 192 4 2008 268 274
48. L.D. Kubzansky, K.C. Koenen, C. Jones, and W.W. Eaton A prospective study of posttraumatic stress disorder symptoms and coronary heart disease in women Health Psychol. 28 1 2009 125 130
49. L.D. Kubzansky, K.C. Koenen, A. Spiro III, P.S. Vokonas, and D. Sparrow Prospective study of posttraumatic stress disorder symptoms and coronary heart disease in the normative aging study Arch. Gen. Psychiatry 64 1 2007 109 116
50. S.E. Lakhan, and K.F. Vieira Nutritional therapies for mental disorders Nutr. J. 7 2008 2 10.1186/1475-2891-7-2
51. J. Levine, Z. Stahl, B.A. Sela, S. Gavendo, V. Ruderman, and R.H. Belmaker Elevated homocysteine levels in young male patients with schizophrenia Am. J. Psychiatry 159 10 2002 1790 1792
52. J. Levine, I. Timinsky, T. Vishne, T. Dwolatzky, S. Roitman, Z. Kaplan, M. Kotler, B.A. Sela, and B. Spivak Elevated serum homocysteine levels in male patients with PTSD Depress. Anxiety. 25 11 2008 E154 E157
53. A.A. Mangoni, and S.H. Jackson Homocysteine and cardiovascular disease: current evidence and future prospects Am. J. Med. 112 7 2002 556 565
54. D.A. Marshall, E.M. Walizer, and M.N. Vernalis Achievement of heart health characteristics through participation in an intensive lifestyle change program (Coronary Artery Disease Reversal Study) J. Cardiopulm. Rehabil. Prev 29 2 2009 84 94
55. B.S. McEwen Protective and damaging effects of stress mediators N. Engl. J. Med. 338 3 1998 171 179. 10.1056/NEJM199801153380307
56. B.S. McEwen, and E. Stellar Stress and the individual. Mechanisms leading to disease Arch. Intern. Med. 153 18 1993 2093 2101
57. A.C. McFarlane The long-term costs of traumatic stress: intertwined physical and psychological consequences World Psychiatry 9 1 2010 3 10
58. J. McGrath, A. Brown, and C.D. St Prevention and schizophrenia - the role of dietary factors Schizophr. Bull. 37 2 2011 272 283
59. T. Michelakos, A.A. Kousoulis, K. Katsiardanis, N. Dessypris, A. Anastasiou, K.P. Katsiardani, P. Kanavidis, C. Stefanadis, F.C. Papadopoulos, and E.T. Petridou Serum folate and B12 levels in association with cognitive impairment among seniors: results from the VELESTINO study in Greece and meta-analysis J. Aging Health 25 4 2013 589 616
60. E.S. Mitchell, N. Conus, and J. Kaput B vitamin polymorphisms and behavior: evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder and cognitive decline Neurosci. Biobehav. Rev. 47 2014 307 320
61. S.J. Moat Plasma total homocysteine: instigator or indicator of cardiovascular disease? Ann. Clin. Biochem. 45 Pt 4 2008 345 348
62. J. Moller, G.M. Nielsen, K.C. Tvedegaard, N.T. Andersen, and P.E. Jorgensen A meta-analysis of cerebrovascular disease and hyperhomocysteinaemia Scand. J. Clin. Lab Invest. 60 6 2000 491 499
63. L. Mosca, E. Barrett-Connor, and N.K. Wenger Sex/gender differences in cardiovascular disease prevention: what a difference a decade makes Circulation 124 19 2011 2145 2154
64. J.W. Muntjewerff, R.S. Kahn, H.J. Blom, and H.M. den Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis Mol. Psychiatry 11 2 2006 143 149
65. M. Olff, G.J. de Vries, Y. Guzelcan, J. Assies, and B.P. Gersons Changes in cortisol and DHEA plasma levels after psychotherapy for PTSD Psychoneuroendocrinology 32 6 2007 619 626
66. M. Olff, Y. Guzelcan, G.J. de Vries, J. Assies, and B.P. Gersons HPA- and HPT-axis alterations in chronic posttraumatic stress disorder Psychoneuroendocrinology 31 10 2006 1220 1230
67. M. Olff, W. Langeland, N. Draijer, and B.P. Gersons Gender differences in posttraumatic stress disorder Psychol. Bull. 133 2 2007 183 204
68. F. Pan, G. Chang, S. Lee, and M. Tang Induction of methionine adenosyltranferase in rat liver by corticosteroids Proc. Soc. Exp. Biol. Med. 128 2 1968 611 616
69. E.I. Park, and T.A. Garrow Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteine methyltransferase gene expression and organization of the human gene J. Biol. Chem. 274 12 1999 7816 7824
70. N. Parletta, C.M. Milte, and B.J. Meyer Nutritional modulation of cognitive function and mental health J. Nutr. Biochem. 24 5 2013 725 743
71. R.P. Patrick, and B.N. Ames Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar, schizophrenia, and impulsive behavior FASEB J. 29 2015 2207 2222 10.1096/fj.14-268342
72. H.Y. Peng, C.F. Man, J. Xu, and Y. Fan Elevated homocysteine levels and risk of cardiovascular and all-cause mortality: a meta-analysis of prospective studies J. Zhejiang Univ. Sci. B 16 1 2015 78 86
73. A.F. Perna, D. Ingrosso, and N.G. De Santo Homocysteine and oxidative stress Amino Acids 25 3-4 2003 409 417
74. E. Reynolds Vitamin B12, folic acid, and the nervous system Lancet Neurol. 5 11 2006 949 960
75. E.H. Reynolds Folic acid, ageing, depression, and dementia BMJ 324 7352 2002 1512 1515
76. R.S. Richards, E.U. Nwose, and P. Bwititi Biochemical basis of circadian rhythms and diseases: with emphasis on post-traumatic stress disorder Med. Hypotheses 77 4 2011 605 609
77. P.R. Rosenbaum, and D.B. Rubin The central role of the propensity score in observational studies for causal effects Biometrika 70 1 1983 41 55
78. J.A. Rusiecki, L. Chen, V. Srikantan, L. Zhang, L. Yan, M.L. Polin, and A. Baccarelli DNA methylation in repetitive elements and post-traumatic stress disorder: a case-control study of US military service members Epigenomics 4 1 2012 29 40
79. J.F. Scherrer, T. Chrusciel, A. Zeringue, L.D. Garfield, P.J. Hauptman, P.J. Lustman, K.E. Freedland, R.M. Carney, K.K. Bucholz, R. Owen, and W.R. True Anxiety disorders increase risk for incident myocardial infarction in depressed and nondepressed Veterans Administration patients Am. Heart J. 159 5 2010 772 779
80. K.M. Scott, J.P. de, J. Alonso, M.C. Viana, Z. Liu, S. O'Neill, S. Aguilar-Gaxiola, R. Bruffaerts, J.M. Caldas-de-Almeida, D.J. Stein, G.G. de, S.E. Florescu, C. Hu, N.I. Taib, J.P. Lepine, D. Levinson, H. Matschinger, M.E. Medina-Mora, M. Piazza, J.A. Posada-Villa, H. Uda, B.J. Wojtyniak, C.C. Lim, and R.C. Kessler Associations between DSM-IV mental disorders and subsequent heart disease onset: beyond depression Int. J. Cardiol. 168 6 2013 5293 5299
81. L.G. Sylvia, A.T. Peters, T. Deckersbach, and A.A. Nierenberg Nutrient-based therapies for bipolar disorder: a systematic review Psychother. Psychosom. 82 1 2013 10 19
82. M. Terzolo, B. Allasino, S. Bosio, E. Brusa, F. Daffara, M. Ventura, E. Aroasio, G. Sacchetto, G. Reimondo, A. Angeli, and C. Camaschella Hyperhomocysteinemia in patients with Cushing's syndrome J. Clin. Endocrinol. Metab. 89 8 2004 3745 3751
83. The Homocysteine Studies Collaboration Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis JAMA 288 16 2002 2015 2022
84. F. Thompson, and A. Subar Dietary assessment methodology A. Coulston, C. Boushey, M. Ferruzzi, Nutrition in the Prevention and Treatment of Disease 2013 Academic Press London 5 46
85. P.M. Ueland, P.I. Holm, and S. Hustad Betaine: a key modulator of one-carbon metabolism and homocysteine status Clin. Chem. Lab Med. 43 10 2005 1069 1075
86. V. Vaccarino, J. Goldberg, C. Rooks, A.J. Shah, E. Veledar, T.L. Faber, J.R. Votaw, C.W. Forsberg, and J.D. Bremner Post-traumatic stress disorder and incidence of coronary heart disease: a twin study J. Am. Coll. Cardiol. 62 11 2013 970 978
87. C.G. Victora, L. Adair, C. Fall, P.C. Hallal, R. Martorell, L. Richter, and H.S. Sachdev Maternal and child undernutrition: consequences for adult health and human capital Lancet 371 9609 2008 340 357
88. P.P. Vitaliano, J.M. Scanlan, J. Zhang, M.V. Savage, I.B. Hirsch, and I.C. Siegler A path model of chronic stress, the metabolic syndrome, and coronary heart disease Psychosom. Med. 64 3 2002 418 435
89. Voedingscentrum, 2006. NEVO-tabel: Nederlands Voedingsstoffenbestand/Stichting Nederlands Voedingsstoffenbestand. Den Haag, Voedingscentrum
90. D.S. Wald, M. Law, and J.K. Morris Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis BMJ 325 7374 2002 1202
91. R. Yehuda, L.M. Bierer, C. Sarapas, I. Makotkine, R. Andrew, and J.R. Seckl Cortisol metabolic predictors of response to psychotherapy for symptoms of PTSD in survivors of the World Trade Center attacks on September 11, 2001 Psychoneuroendocrinology 34 9 2009 1304 1313