Serum folate and B12 levels in association with cognitive impairment among seniors: Results from the VELESTINO study in greece and meta-analysis

Journal of Aging and Health

Volumn 25, Issue 4, 2013, Pages 589-616

  Michelakos, Theodoros ^a   Kousoulis, Antonis A ^a   Katsiardanis, Konstantinos ^a   Dessypris, Nick ^a   Anastasiou, Anastasia ^b   Katsiardani, Kalliopi Penelopi ^a   Kanavidis, Prodromos ^a   Stefanadis, Christodoulos ^a   Papadopoulos, Fotios C ^c   Petridou, Eleni Th ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b Health Centre of Velestino   (Greece)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

aged; B12; cognitive impairment; folate; meta analysis

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID;

AGED; ARTICLE; BLOOD; COGNITIVE DEFECT; CROSS-SECTIONAL STUDY; FEMALE; GREECE; HUMAN; MALE; META ANALYSIS; RISK FACTOR; SOCIOECONOMICS; VERY ELDERLY;

AGED; B12; COGNITIVE IMPAIRMENT; FOLATE; META-ANALYSIS;

AGED; AGED, 80 AND OVER; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; FEMALE; FOLIC ACID; GREECE; HUMANS; MALE; RISK FACTORS; SOCIOECONOMIC FACTORS; VITAMIN B 12;

EID: 84879247236     PISSN: 08982643     EISSN: 15526887     Source Type: Journal    
DOI: 10.1177/0898264313482488     Document Type: Article

References (59)

1. Argyriadou S., Vlachonikolis I., Melisopoulou H., Katachanakis K., Lionis C.. In what extent anemia coexists with cognitive impairment in elderly: A cross-sectional study in Greece. BioMed Central Family Practice. 2001 ; 2: 5
2. Ariogul S., Cankurtaran M., Dagli N., Khalil M., Yavuz B.. Vitamin B12, folate, homocysteine and dementia: Are they really related?. Archives of Gerontology & Geriatrics. 2005 ; 40 (2). 139-146
3. Bernard M. A., Nakonezny P. A., Kashner T. M.. The effect of vitamin B12 deficiency on older veterans and its relationship to health. Journal of American Geriatric Society. 1998 ; 46: 1199-1206
4. Brubacher D., Monsch A. U., Stahelin H. B.. Weight change and cognitive performance. International Journal Obesity Related & Metabolic Disorder. 2004 ; 28: 1163-1167
5. Clarke R., Birks J., Nexo E., Ueland P. M., Schneede J., Scott J., Evans J. G.. Low vitamin B-12 status and risk of cognitive decline in older adults. American Journal of Clinical Nutrition. 2007 ; 86: 1384-1391
6. Clarke R., Sherliker P., Hin H., Molloy A. M., Nexo E., Ueland P. M., Evans J. G.. Folate and vitamin B12 status in relation to cognitive impairment and anaemia in the setting of voluntary fortification in the UK. British Journal of Nutrition. 2008 ; 100: 1054-1059
7. Crum R. M., Anthony J. C., Bassett S. S., Folstein M. F.. Population-based norms for the Mini-Mental State Examination by age and educational level. Journal of American Medical Association. 1993 ; 269: 2386-2391
8. Dimopoulos N., Piperi C., Salonicioti A., Psarra V., Gazi F., Nounopoulos C., Kalofoutis A.. Association of cognitive impairment with plasma levels of folate, vitamin B12 and homocysteine in the elderly. In Vivo. 2006 ; 20 (6B). 895-899
9. Ebly E. M., Schaefer J. P., Campbell N. R., Hogan D. B.. Folate status, vascular disease and cognition in elderly Canadians. Age Ageing. 1998 ; 27: 485-491
10. Farlow M. R.. Should the ApoE genotype be a covariate for clinical trials in Alzheimer disease?. Alzheimers Research & Theory. 2010 ; 2 (3). 15
11. Feng L., Isaac V., Sim S., Ng T. P., Krishnan K. R., Chee M. W.. Associations between elevated homocysteine, cognitive impairment, and reduced white matter volume in healthy old adults. American Journal of Geriatric Psychiatry. 2011 ; 19 :
12. Feng L., Ng T. P., Chuah L., Niti M., Kua E. H.. Homocysteine, folate, and vitamin B-12 and cognitive performance in older Chinese adults: Findings from the Singapore Longitudinal Ageing Study. American Journal of Clinical Nutrition. 2006 ; 84: 1506-1512
13. Ferrea S., Winterer G.. Neuroprotective and neurotoxic effects of nicotine. Pharmacopsychiatry. 2009 ; 42: 255-265
14. Folstein M. F., Folstein S. E., McHugh P. R.. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research. 1975 ; 12 (3). 189-198
15. Ford A. H., Almeida O. P.. Effect of homocysteine lowering treatment on cognitive function: A systematic review and meta-analysis of randomized controlled trials. Journal of Alzheimers Disease. 2012 ; 29 (1). 133-149
16. Fountoulakis K., Tsolaki M., Chantzi H., Kazis A.. Mini-Mental State Examination (MMSE): A validation study in Greece. American Journal of Alzheimer's Disease & Other Dementias. 2000 ; 15: 342-345
17. Fountoulakis K. N., Tsolaki M., Iacovides A., Yesavage J., O'Hara R., Kazis A., Ierodiakonou C.. The validation of the short form of the Geriatric Depression Scale (GDS) in Greece. Aging (Milano). 1999 ; 11: 367-372
18. Hall J. R., O'Bryant S. E., Johnson L. A., Barber R. C.. Depressive symptom clusters and neuropsychological performance in mild Alzheimer's and cognitively normal elderly. Depression Research Treatment. 2011 ; 2011: 396958
19. Hin H., Clarke R., Sherliker P., Atoyebi W., Emmens K., Birks J., Evans J. G.. Clinical relevance of low serum vitamin B12 concentrations in older people: The Banbury B12 study. Age Ageing. 2006 ; 35: 416-422
20. Hinkelmann K., Moritz S., Botzenhardt J., Riedesel K., Wiedemann K., Kellner M., Otte C.. Cognitive impairment in major depression: Association with salivary cortisol. [Research Support, Non-U.S. Gov't]. Biological Psychiatry. 2009 ; 66: 879-885
21. Huang C. Q., Dong B. R., Zhang Y. L., Wu H. M., Liu Q. X.. Association of cognitive impairment with smoking, alcohol consumption, tea consumption, and exercise among Chinese nonagenarians/centenarians. Cognitive Behavioral Neurology. 2009 ; 22 (3). 190-196
22. James B. D., Wilson R. S., Barnes L. L., Bennett D. A.. Late-life social activity and cognitive decline in old age. Journal of International Neuropsychological Society. 2011 ; 17: 998-1005
23. Kerwin D. R., Gaussoin S. A., Chlebowski R. T., Kuller L. H., Vitolins M., Coker L. H., Espeland M. A.. Interaction between body mass index and central adiposity and risk of incident cognitive impairment and dementia: Results from the Women's Health Initiative Memory Study. Journal of the American Geriatrics Society. 2011 ; 59 (1). 107-112
24. Kim H. J., Cho H. K., Kwon Y. H.. Synergistic induction of ER stress by homocysteine and beta-amyloid in SH-SY5Y cells. Journal of Nutritional Biochemistry. 2008 ; 19: 754-761
25. Kobayashi T., Kato S.. Depression-dementia medius: Between depression and the manifestation of dementia symptoms. Psychogeriatrics. 2011 ; 11 (3). 177-182
26. Kruman II, Kumaravel T. S., Lohani A., Pedersen W. A., Cutler R. G., Kruman Y., Mattson M. P.. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. Journal of neuroscience. 2002 ; 22: 1752-1762
27. Lindeman R. D., Romero L. J., Koehler K. M., Liang H. C., LaRue A., Baumgartner R. N., Garry P. J.. Serum vitamin B12, C and folate concentrations in the New Mexico elder health survey: Correlations with cognitive and affective functions. Journal of the American College of Nutrition. 2000 ; 19 (1). 68-76
28. Lipton S. A., Kim W. K., Choi Y. B., Kumar S., D'Emilia D. M., Rayudu P. V., Stamler J. S.. Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proceedings of the National Academy of Sciences of the United States of America. 1997 ; 94: 5923-5928
29. Lonie J. A., Parra-Rodriguez M. A., Tierney K. M., Herrmann L. L., Donaghey C., O'Carroll R. E., Ebmeier K. P.. Predicting outcome in mild cognitive impairment: 4-year follow-up study. British Journal of Psychiatry. 2010 ; 197 (2). 135-140
30. Malouf M., Grimley E. J., Areosa S. A.. Folic acid with or without vitamin B12 for cognition and dementia. Cochrane Database of Systematic Reviews. 2003 ; 4: CD004514
31. Malouf R., Areosa Sastre A.. Vitamin B12 for cognition. Cochrane Database of Systematic Reviews. 2003 ; 3: CD004326
32. Mannino D. M., Mulinare J., Ford E. S., Schwartz J.. Tobacco smoke exposure and decreased serum and red blood cell folate levels: Data from the Third National Health and Nutrition Examination Survey. Nicotine & Tobacco research. 2003 ; 5: 357-362
33. Marengoni A., Cossi S., De Martinis M., Calabrese P. A., Orini S., Grassi V.. Homocysteine and disability in hospitalized geriatric patients. Metabolism. 2004 ; 53: 1016-1020
34. Marques A. H., Silverman M. N., Sternberg E. M.. Glucocorticoid dysregulations and their clinical correlates. From receptors to therapeutics. Annals of the New York Academy of Sciences. 2009 ; 1179: 1-18
35. Mooijaart S. P., Gussekloo J., Frolich M., Jolles J., Stott D. J., Westendorp R. G., de Craen A. J.. Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: The Leiden 85-Plus study. American Journal of Clinical Nutrition. 2005 ; 82: 866-871
36. Morris M. C.. Nutritional determinants of cognitive aging and dementia. The Proceedings of the Nutrition Society. 2012 ; 71 (1). 1-13
37. Morris M. S., Jacques P. F., Rosenberg I. H., Selhub J.. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. American Journal of Clinical Nutrition. 2007 ; 85 (1). 193-200
38. Neafsey E. J., Collins M. A.. Moderate alcohol consumption and cognitive risk. Neuropsychiatric Disease & Treatment. 2011 ; 7: 465-484
39. Ortega R. M., Manas L. R., Andres P., Gaspar M. J., Agudo F. R., Jimenez A., Pascual T.. Functional and psychic deterioration in elderly people may be aggravated by folate deficiency. Journal of nutrition. 1996 ; 126: 1992-1999
40. Perquin M., Schuller A. M., Vaillant M., Diederich N., Bisdorff A., Leners J. C., Lair M. L.. The epidemiology of mild cognitive impairment (MCI) and Alzheimer's disease (AD) in community-living seniors: Protocol of the MemoVie cohort study, Luxembourg. BioMed Central Public Health. 2012 ; 12 (1). 519
41. Pizzolo F., Blom H. J., Choi S. W., Girelli D., Guarini P., Martinelli N., Friso S.. Folic acid effects on s-adenosylmethionine, s- adenosylhomocysteine, and DNA methylation in patients with intermediate hyperhomocysteinemia. Journal of the American College of Nutrition. 2011 ; 30 (1). 11-18
42. Quadri P., Fragiacomo C., Pezzati R., Zanda E., Forloni G., Tettamanti M., Lucca U.. Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia. American Journal of Clinical Nutrition. 2004 ; 80 (1). 114-122
43. Ramos M. I., Allen L. H., Mungas D. M., Jagust W. J., Haan M. N., Green R., Miller J. W.. Low folate status is associated with impaired cognitive function and dementia in the Sacramento Area Latino Study on Aging. American Journal of Clinical Nutrition. 2005 ; 82: 1346-1352
44. Ravaglia G., Forti P., Maioli F., Muscari A., Sacchetti L., Arnone G., Mariani E.. Homocysteine and cognitive function in healthy elderly community dwellers in Italy. American Journal of Clinical Nutrition. 2003 ; 77: 668-673
45. Ravaglia G., Forti P., Maioli F., Vettori C., Grossi G., Bargossi A. M., Cavalli G.. Elevated plasma homocysteine levels in centenarians are not associated with cognitive impairment. Mechanisms of Ageing and Development. 2000 ; 121 (1-3). 251-261
46. Sachdev P. S., Lipnicki D. M., Crawford J., Reppermund S., Kochan N. A., Trollor J. N., Brodaty H.. Risk profiles of subtypes of mild cognitive impairment: The Sydney memory and ageing study. Journal of the American Geriatrics Society. 2011 ; 60: 24-33
47. Sanderson S., Tatt I. D., Higgins J. P.. Tools for assessing quality and susceptibility to bias in observational studies in epidemiology: A systematic review and annotated bibliography. International Journal of Epidemiology. 2007 ; 36: 666-676
48. Selhub J., Morris M. S., Jacques P. F., Rosenberg I. H.. Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency. American Journal of Clinical Nutrition. 2009 ; 89: 702S - 706S
49. Sheikh J. I., Yesavage J. A. Clinical gerontology: A guide to assessment and intervention. Brink T. L., ed. New York, NY: The Haworth Press ; 1986: 165-173.
50. Skarupski K. A., Tangney C., Li H., Ouyang B., Evans D. A., Morris M. C.. Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time. American Journal of Clinical Nutrition. 2010 ; 92: 330-335
51. Stampfer M. J., Kang J. H., Chen J., Cherry R., Grodstein F.. Effects of moderate alcohol consumption on cognitive function in women. The New England Journal of Medicine. 2005 ; 352: 245-253
52. Stang A.. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. European Journal of Epidemiology. 2010 ; 25: 603-605
53. Stephan B. C., Hunter S., Harris D., Llewellyn D. J., Siervo M., Matthews F. E., Brayne C.. The neuropathological profile of mild cognitive impairment (MCI): A systematic review. Molecular Psychiatry. 2011 ; 17: 1056-1076
54. Stewart R., Asonganyi B., Sherwood R.. Plasma homocysteine and cognitive impairment in an older British African-Caribbean population. Journal of the American Geriatrics Society. 2002 ; 50: 1227-1232
55. Stott D. J., Falconer A., Kerr G. D., Murray H. M., Trompet S., Westendorp R. G., Ford I.. Does low to moderate alcohol intake protect against cognitive decline in older people?. Journal of the American Geriatrics Society. 2008 ; 56: 2217-2224
56. Vogiatzoglou A., Refsum H., Johnston C., Smith S. M., Bradley K. M., de Jager C., Smith A. D.. Vitamin B12 status and rate of brain volume loss in community-dwelling elderly. Neurology. 2008 ; 71: 826-832
57. Voisin T., Touchon J., Vellas B.. Mild cognitive impairment: A nosological entity?. Current Opinion in Neurology. 2003 ; 16: S43 - S45
58. Walker J. G., Batterham P. J., Mackinnon A. J., Jorm A. F., Hickie I., Fenech M., Christensen H.. Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline in community-dwelling older adults with depressive symptoms - The Beyond Ageing Project: A randomized controlled trial. American Journal of Clinical Nutrition. 2012 ; 95 (1). 194-203
59. Yesavage J. A. Clinical memory assessment of older adults. Poon L. W., ed. Washington, DC: American Psychological Association ; 1986: 213-217.