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Volumn 10, Issue 7, 2015, Pages 1232-1239

Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design

(5) Holvey, Rhian S a Valkov, Eugene b Neal, David a Stewart, Murray b Abell, Chris a

a UNIVERSITY OF CAMBRIDGE (United Kingdom)

b MRC LABORATORY OF MOLECULAR BIOLOGY (United Kingdom)

Author keywords

cancer; fragment based ligand design; nuclear transporters; protein protein interactions; structure guided ligand design

Indexed keywords

CARRIER PROTEIN; KARYOPHERIN ALPHA; LIGAND; PROTEIN TPX2; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; MOLECULAR LIBRARY; NUCLEAR PROTEIN; PROTEIN BINDING; TPX2 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; CRYSTALLOGRAPHY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTEIN TARGETING; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HUMAN; MOLECULAR LIBRARY; MOLECULAR MODEL; PHARMACOLOGY;

ALPHA KARYOPHERINS; BINDING SITES; CELL CYCLE PROTEINS; HUMANS; LIGANDS; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEAR PROTEINS; PROTEIN BINDING; SMALL MOLECULE LIBRARIES;

EID: 84933500980 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201500014 Document Type: Article

Times cited : (10)

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