Study of Antiglycation, Hypoglycemic, and Nephroprotective Activities of the Green Dwarf Variety Coconut Water (Cocos nucifera L.) in Alloxan-Induced Diabetic Rats

Journal of Medicinal Food

Volumn 18, Issue 7, 2015, Pages 802-809

  Pinto, Isabella F D ^a   Silva, Railmara P ^b   Filho, Adriano De B Chaves ^a   Dantas, Lucas S ^a   Bispo, Vanderson S ^a   Matos, Isaac A ^b   Otsuka, Felipe A M ^b   Santos, Aline C ^b   Matos, Humberto Reis ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF SERGIPE   (Brazil)

Author keywords

antihyperglycemic activity; caffeic acid; coconut water; diabetes; nephroprotective activity

Indexed keywords

ACARBOSE; ANTIDIABETIC AGENT; CAFFEIC ACID; GLUCOSE; HEMOGLOBIN A1C; NEPHROPROTECTIVE AGENT; PROTECTIVE AGENT; UNCLASSIFIED DRUG; ALLOXAN; ANTIOXIDANT; CAFFEIC ACID DERIVATIVE; GLYCOSYLATED HEMOGLOBIN; UREA;

ALLOXAN-INDUCED DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; BODY WEIGHT; COCONUT; COCONUT MILK; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; KIDNEY HOMOGENATE; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; RAT; RENAL PROTECTION; ANIMAL; BEVERAGE; BLOOD; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DRUG EFFECTS; HYPERGLYCEMIA; OXIDATIVE STRESS; PHYTOTHERAPY; WISTAR RAT;

ANIMALIA; COCOS NUCIFERA; RATTUS;

ACARBOSE; ALLOXAN; ANIMALS; ANTIOXIDANTS; BEVERAGES; CAFFEIC ACIDS; COCOS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; HEMOGLOBIN A, GLYCOSYLATED; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; MALE; OXIDATIVE STRESS; PHYTOTHERAPY; RATS; RATS, WISTAR; UREA;

EID: 84933498645     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2014.0046     Document Type: Article

References (74)

1. Albert KG, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation 13. Diabet Med 1998;15:539-553.
2. Wild S, Roglic G, Green A, Sicree R, King H: Global prevalence of diabetes. Diabetes Care 2013;27:1047-1053.
3. Tripathi BK, Srivastava AK: Diabetes mellitus: complications and therapeutics. Med Sci Monit 2006;12:130-147.
4. Bonifacio E, Ziegler AG: Advances in the prediction and natural history of type 1 diabetes. Endocrinol Metab Clin North Am 2010;39:513-525.
5. Forsen T, Eriksson J, Tuomilehto J, Reunanen A, Osmond C, Barker D: The fetal and childhood growth of persons who develop type 2 diabetes. Ann Inter Med 2000;133:176-182.
6. Izquierdo A, Medina-Gómez G: Role of lipotoxicity in the development of kidney damage in metabolic syndrome and aging. Dial Transplant 2012;33:89-96.
7. Chan E, Elevitch CR: Cocos Nucifera (Coconut). In: Species Profiles for Pacific Island Agroforestry, Ver. 2.1. (Elevitch DR, ed.). Permanent Agriculture Resources (PAR), Hölualoa, Hawaii, 2006, pp. 1-27.
8. Lopes MA, Larkins BA: Endosperm origin, development and function. Plant Cell 1993;5:1383-1399.
9. Adams W, Bratt DE: Young coconut water for home rehydration in children with mild gastroenteritis. Trop Geogr Med 1992;44:149-153.
10. Saat M, Singh R, Sirisinghe RG, Nawawi M: Rehydration after exercise with young coconut water, carbohydrate-electrolute beverage and plain water. J Physiol Anthropol Appl Human Sci 2002;21:93-104.
11. Borse BB, Rao LJM, Ramalakshmi K, Raghavan B: Chemical composition of volatiles from coconut SAP (neera) and effect of processing. Food Chem 2007;101:877-880.
12. Chumbimuni-Torres KY, Kubota LT: Simultaneous determination of calcium and potassium in coconut water by a flow-injection method with tubular potentiometric sensors. J Food Compos Anal 2006;19:225-230.
13. Jirovetz L, Buchbauer G, Ngassoum MB: Solid-phasemicroextraction-headspace aroma compounds of coconut (Cocos nucifera) milk and meat from Cameroon. Nutrition 2003;27:300-303.
14. Santoso U, Kubo K, Ota T, Tadokoro T, Maekawa A: Nutrient composition of kopyor coconut (Cocos nucifera L.). Food Chem 1996;51:299-304.
15. Santos JLA, Bispo VS, Chaves Filho ABC, et al.: Evaluation of chemical constituents and antioxidant activity of coconut water (Cocus nucifera L.) and caffeic acid in cell culture. Ann Braz Acad Sci 2013;85:59-70.
16. Esquenazi D, Wigg MD, Miranda MMFS, et al.: Antimicrobial and antiviral activities of polyphenolics from Cocos nucifera Linn. (Palmae) husk fiber extract. Res Microbiol 2002;153:647-652.
17. Preetha PP, Devib VG, Rajamohan T: Hypoglycemic and antioxidant potential of coconut water in experimental diabetes. Food Funct 2012;753:753-757.
18. Leong LP, Shui G: An investigation of antioxidant capacity of fruits in Singapore markets. Food Chem 2002;76:69-75.
19. Skrede G, Larsen VB, Aaby K, Jorgensen AS, Birkeland SE: Antioxidative properties of commercial fruit preparations and stability of bilberry and black currant extracts in milk products. J Food Sci 2004;69:351-356.
20. Mantena SK, Badduri SR, Siripurapu KB, Unnikrishnan MK: In vitro evaluation of antioxidant properties of Cocos nucifera Linn. water. Nahrung 2003;47:126-131.
21. Dey G, Chakraborty M, Mitra A: C6-C3 and C6-C1 phenolic metabolites in Cocos nucifera. J Plant Physiol 2005;162:375-381.
22. Dayrit FM, Buenafe OEM, Chainani ET, Vera IMS: Analysis of monoglycerides, diglycerides, sterols, and free fatty acids in coconut (Cocos nucifera L.) oil by 31P NMR spectroscopy. J Agric Food Chem 2008;56:5765-5769.
23. Seneviratne KN, Dissanayake DMS: Variation of phenolic content in coconut oil extracted by two conventional methods. Int J Food Sci Technol 2008;43:597-602.
24. Chakraborty M, Mitra A: The antioxidant and antimicrobial properties of the methanolic extract from Cocos nucifera mesocarp. Food Chem 2008;107:994-999.
25. Kono Y, Kobayashi K, Tagawa S, et al.: Antioxidant activity of polyphenolics in diets: rate constants of reactions of chlorogenic acid and caffeic acid with reactive species of oxygen and nitrogen. Biochim Biophys Acta 1997;1335:335-342.
26. Gülçin I: Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid). Toxicology 2006;217:213-220.
27. Adisakwattana S, Moonsan P, Yibchok-Anun S: Insulin-releasing properties of a series of cinnamic acid derivatives in vitro and in vivo. J Agric Food Chem 2008;56:7838-7844.
28. Chen JH, Shao Y, Huang MT, Chin CK, Ho CT: Inhibitory effect of caffeic acid phenethyl ester on human leukaemia HL-60 cells. Cancer Lett 1996;108:211-214.
29. Hirose M, Takesada Y, Tanaka H, Tamano S, Kato T, Shirai T: Carcinogenicity of antioxidants butylatedhydroxyanisole, caffeic acid, sesamol, 4-methoxyphenol and catechol at low doses, either alone or in combination and modulation of their effects in a rat medium-term multiorgan carcinogenesis model. Carcinogenesis 1997;19:207-212.
30. Scalbert A, Manach C, Morand C, Rémésy C, Jiménez L: Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr 2005;45:287-306.
31. Yamada J, Tomita Y: Antimutagenic activity of caffeic acid and related compounds. Biosci Biotech Bioch 1996;60:328-329.
32. Cheng JT, Liu IM, Tzeng TF, Chen WC, Hayakawa S, Yamamoto T: Release of beta-endorphin by caffeic acid to lower plasma glucose in streptozotocin-induced diabetic rats. Horm Metab Res 2003;35:251-258.
33. Hsu FL, Chen YC, Cheng JT: Caffeic acid as active principle from the fruit of Xanthium strumarium to lower plasma glucose in diabetic rats. Planta Med 2000;66:228-230.
34. Okutan H, Ozcelikb N, Yilmazb HR, Uzb E: Effects of caffeic acid phenethyl ester on lipid peroxidation and antioxidant enzymes in diabetic rat heart. Clin Biochem 2005;38:191-196.
35. Park SH, Min TS: Caffeic acid phenethyl ester ameliorates changes in IGFs secretion and gene expression in streptozotocin-induced diabetic rats. Life Sci 2006;78:1741-1747.
36. Vetrichelva T, Kavimani S, Grupta JK: Effect of rifampicin on trigonella foenumgraecum (Fenugreek)-induced hypoglycemia in rats. Indian J Pharm Sci 1998;60:244-245.
37. Pari L, Saravanan G: Antidiabetic effect of cogent db, a herbal drug in alloxan-induced diabetes mellitus. Comp Biochem Physiol Part C 2002;131:19-25.
38. Hyvarinen A, Nikkila EA: Specific determination of blood glucose with o-toluidine. Clin Chim Acta 1962;7:140-143.
39. Bradford MM: A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:284-254.
40. Kitamura M, Iuchi I: An improved diacetylmonoxime method for the determination of urea in blood and urine. Clin Chem Acta 1959;4:701-706.
41. Jallow DJ, Mitchell JR, Zampaglione N, Gillete R: Brombenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-brombenzene oxide as the hepatic metabolite. Pharmacology 1974;11:151-169.
42. Johnson R, Metcalf PA, Baker JR: Fructosamine: a new approach to the estimation of serum glycosylprotein. Clin Chim Acta 1982;127:87-95.
43. Aebi H: Catalase. In: Methods in Enzymology, Vol. 105 (Packer L, ed.). Academic Press, Florida, 1982, pp. 121-126.
44. Akerboom TP, Sies H: Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples. Methods Enzymol 1981;77:373-382.
45. Brandstrup N, Kirk JE, Bruni C: The hexokinase and phosphoglucoisomerase activities of aortic and pulmonary tissue in individuals of various ages. J Gerontol 1957;12:166-171.
46. Baynes JW, Thorpe SR: Role of oxidative stress in diabetic complications: A new perspective on an old paradigm. Diabetes 1999;48:1-9.
47. Pradera ES, Fernandez E, Calderin O: Coconut water, a clinical and experimental study. Amer J Dis Child 1942;64:977-995.
48. Bahadoran Z, Mirmiran P, Azizi F: Dietary polyphenols as potential nutraceuticals in management of diabetes: a review. J Diabetes Metab Disord 2013;12:43.
49. Sindurani JA, Rajamohan T: Effects of different levels of coconut fiber on blood glucose, serum insulin and minerals in rats. Indian J Physiol Pharmacol 2000;44:97-100.
50. Jung UJ, Lee MK, Park YB, Jeon SM, Choi MS: Antihyperglycemic and antioxidant properties of caffeic acid in db/db mice. J Pharmacol Exp Ther 2006;318:476-483.
51. Ene AC, Nwankwo EA, Samdi LM: Alloxan-induced diabetes in rats and the effects of black caraway (Carumcarvi L.) oil on their body weight. Res J Med Med Sci 2007;2:48-52.
52. Ktari N, Mnafgui K, Nasri R, et al.: Hypoglycemic and hypolipidemic effects of protein hydrolysates from zebra blenny (Salaria basilisca) in alloxan-induced diabetic rats. Food Funct 2013;4:1691-1699.
53. Booth AA, Khalifah RG, Todd P, Hudson BG: In vitro kinetic studies of formation of antigenic advanced glycationend products (AGEs). J Biol Chem 1997;272:5430-5437.
54. Cohen G, Riahi Y, Alpert E, Gruzman A, Sasson S: The roles of hyperglycaemia and oxidative stress in the rise and collapse of the natural protective mechanism against vascular endothelial cell dysfunction in diabetes. Arch Physiol Biochem 2007;113:259-267.
55. Huebschmann AG, Regensteiner JG, Vlassara H, Reusch JE: Diabetes and advanced glycoxidation end products. Diabetes Care 2006;29:1420-1432.
56. Elgawish A, Glomb M, Friedlander M, Monnier VM: Involvement of hydrogen peroxide in collagen cross-linking by high glucose in vitro and in vivo. J Biol Chem 1996;271:12964-12971.
57. Viswanathaswamy AHM, Koit BC, Aparna G, Thippeswamy AHM, Kulkarni RV: Antihyperglycemic and antihyperlipidemic activity of Plectranthusamboinicus on normal and alloxaninduces diabetic rats. Indian J Pharm Sci 2011;73:139-145.
58. Lee EY, Chung CH: The role of glomerular podocytes in diabetic nephropathy. J Korean Diabetes Assoc 2007;31:451-154.
59. Ziyadeh FN, Wolf G: Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy. Curr Diabetes Rev 2008;4:39-45.
60. Dabla PK: Renal function in diabetic nephropathy. World J Diabetes 2010;1:48-56.
61. Evans JL, Goldfine ID, Maddux BA, Grodsky GM: Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 2002;23:599-622.
62. Jacobson JM, Michael JR, Jafri MH, Gurtnerm GH: Antioxidants and antioxidant enzymes protect against pulmonary oxygen toxicity in the rabbit. J Appl Physiol 1990;68:1252-1259.
63. Pompella A, Visvikism A, Paolichi A, De Tat V, Casini AF: The changing faces of glutathione, a cellular protagonist. Biochem Pharmacol 2003;66:1499-1503.
64. Soto CP, Perez BL, Favar LP, Reyes JL: Prevention of alloxan-induced diabetes mellitus in the rat by silymarin. Comp Biochem Phys 1998,119:125-129.
65. Arulselvan P, Subramanian SP: Beneficial effects of Murrayakoenigii leaves on antioxidant defense system and ultra structural changes of pancreatic beta-cells in experimental diabetes in rats. Chem Biol Interacts 2007;165:155-164.
66. Al-Azzawie HF, Alhamdani MS: Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits. Life Sci 2006;78:1371-1377.
67. Daisy P, Suveena S, Cecily Rosimary Latha R: Target level analysis of antioxidant activity of costunolide and eremanthin isolated from Costus speciosus. Asian J Pharma Clin Res 2012;5:32-35.
68. Sepici-Dincel A, Açikqöz S, Cevik C, Sengelen M, Yesilada E: Effects of in vivo antioxidant enzyme activities of myrtle oil in normoglyceamic and alloxan diabetic rabbits. J Ethnopharmacol 2007;110:498-503.
69. Ye G, Donthi RV, Metreveli NS, Epstein PN: Overexpression of hexokinase protects hypoxic and diabetic cardiomyocytes by increasing ATP generation. Cardiovasc Toxicol 2005;5:293-300.
70. Nishikawa T, Edelstein D, Du XL, et al.: Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000;404:787-790.
71. Yong JWH, Ge L, Ng YF, Tan SN: The chemical composition and biological properties of coconut (Cocos nucifera L.). Water Mol 2009;14:5144-5164.
72. Nair PMG, Park SY, Chung JW, Choi J: Transcriptional regulation of glutathione biosynthesis genes, γ-glutamyl-cysteine ligase and glutathione synthetase in response to cadmium and nonylphenol in Chironomus riparius. Enviro Toxicol Phar 2013;36:265-273.
73. Morris D, Khurasany M, Nguyen T, et al.: Glutathione and infection. Biochim Biophys Acta 2013;1830:3329-3349.
74. Hunyadi A, Martins A, Hsieh TJ, Seres A, Zupkó I: Chlorognic Acid and Rutin Play a Major Role in the In Vivo Anti-Diabetic Activity of Morus alba Leaf Extract on type II Diabetic Rats. Plos One 2012;7:506-519.