Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling

Journal of the American Chemical Society

Volumn 137, Issue 24, 2015, Pages 7929-7934

  Chou, Danny Hung Chieh ^a,c,g   Vetere, Amedeo ^a   Choudhary, Amit ^a,d,h   Scully, Stephen S ^a,i   Schenone, Monica ^a   Tang, Alicia ^a   Gomez, Rachel ^a   Burns, Sean M ^a   Lundh, Morten ^a   Vital, Tamara ^a   Comer, Eamon ^a   Faloon, Patrick W ^a,j   Dančík, Vlado ^a   Ciarlo, Christie ^a   Paulk, Joshiawa ^a   Dai, Mingji ^a,k   Reddy, Clark ^a   Sun, Hanshi ^e   Young, Matthew ^f   Donato, Nicholas ^e   Jaffe, Jacob ^a   Clemons, Paul A ^a   Palmer, Michelle ^a   Carr, Steven A ^a   Schreiber, Stuart L ^a,b,c   Wagner, Bridget K ^a   more..

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c HARVARD UNIVERSITY   (United States)

^d HARVARD UNIVERSITY   (United States)

^e UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

^f UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^g UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^h BRIGHAM AND WOMEN S HOSPITAL   (United States)

ⁱ BIND Therapeutics   (United States)

^j BIOGEN   (United States)

^k PURDUE UNIVERSITY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BIRDS; CELL DEATH; CELLS; CYTOLOGY; ENZYME ACTIVITY; ENZYMES; MOBILE SECURITY; MOLECULES; SIGNALING;

MECHANISM OF ACTION; PANCREATIC BETA CELLS; PATHWAY INHIBITORS; PHENOTYPIC SCREENING; QUANTITATIVE PROTEOMIC ANALYSIS; SIGNAL TRANSDUCERS; SIGNALING PATHWAYS; SITE DIRECTED MUTAGENESIS;

CELL SIGNALING;

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; BRD 0476; CASPASE 3; CXCL9 CHEMOKINE; CYTOPROTECTIVE AGENT; DEUBIQUITINASE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 1BETA; JANUS KINASE 2; JANUS KINASE 2 INHIBITOR; RANTES; STAT1 PROTEIN; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN SPECIFIC PEPTIDASE 9X; UNCLASSIFIED DRUG; PROTECTIVE AGENT; UBIQUITIN THIOLESTERASE; USP9X PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURFACE; CELL SURVIVAL; CHEMICAL GENETICS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; DNA END JOINING REPAIR; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PHENOTYPE; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEOMICS; QUANTITATIVE ANALYSIS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; UBIQUITINATION; ANIMAL; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; IMMUNOLOGY; PHOSPHORYLATION; RAT;

ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; HUMANS; INSULIN-SECRETING CELLS; INTERFERON-GAMMA; JANUS KINASE 2; PHOSPHORYLATION; PROTECTIVE AGENTS; RATS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; UBIQUITIN THIOLESTERASE; UBIQUITINATION;

EID: 84933059724     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b04284     Document Type: Article

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