Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response

PLoS Pathogens

Volumn 8, Issue 7, 2012, Pages 43-

  Perry, Jeffrey W ^a   Ahmed, Mohammad ^a   Chang, Kyeong Ok ^b   Donato, Nicholas J ^a   Showalter, Hollis D ^c   Wobus, Christiane E ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b KANSAS STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; DEUBIQUITINASE INHIBITOR; ENDONUCLEASE; INOSITOL REQUIRING ENZYME 1; PROTEASOME; UNCLASSIFIED DRUG; WP 1130; X BOX BINDING PROTEIN 1; DEGRASYN; DNA BINDING PROTEIN; ENZYME INHIBITOR; ERN2 PROTEIN, MOUSE; MEMBRANE PROTEIN; NITRILE; PROTEIN SERINE THREONINE KINASE; PYRIDINE DERIVATIVE; REGULATORY FACTOR X TRANSCRIPTION FACTORS; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UBIQUITIN; UBIQUITIN THIOLESTERASE; USP14 PROTEIN, HUMAN; USP14 PROTEIN, MOUSE;

ANTIVIRAL ACTIVITY; ARTICLE; ENCEPHALOMYOCARDITIS VIRUS; ENZYME ACTIVITY; LA CROSSE VIRUS; MACROPHAGE; NONHUMAN; NOROVIRUS INFECTION; PROTEOMICS; RNA VIRUS; SINDBIS VIRUS; UNFOLDED PROTEIN RESPONSE; ANIMAL; CALICIVIRUS INFECTION; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; MOUSE; NOROVIRUS; PATHOGENICITY; PHYSIOLOGY; RNA INTERFERENCE; TUMOR CELL LINE; VIROLOGY; VIRUS REPLICATION;

ENCEPHALOMYOCARDITIS VIRUS; LA CROSSE VIRUS; MURINAE; MURINE NOROVIRUS; NOROVIRUS; NORWALK VIRUS; RNA VIRUSES; SINDBIS VIRUS; VESICULAR STOMATITIS VIRUS;

ANIMALS; ANTIVIRAL AGENTS; CALICIVIRIDAE INFECTIONS; CELL LINE; CELL LINE, TUMOR; DNA-BINDING PROTEINS; ENCEPHALOMYOCARDITIS VIRUS; ENZYME INHIBITORS; HUMANS; LA CROSSE VIRUS; MACROPHAGES; MEMBRANE PROTEINS; MICE; NITRILES; NOROVIRUS; NORWALK VIRUS; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SINDBIS VIRUS; TRANSCRIPTION FACTORS; UBIQUITIN; UBIQUITIN THIOLESTERASE; UNFOLDED PROTEIN RESPONSE; VIRUS REPLICATION;

EID: 84864580657     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002783     Document Type: Article

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