메뉴 건너뛰기




Volumn 35, Issue 6, 2015, Pages 1374-1381

Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase β, and Not Via CD40 and IκB Kinase α

Author keywords

atherosclerosis; atherothrombosis; blood platelets; CD40; CD40 ligand; signal transduction; signaling pathways; thrombosis

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; COLLAGEN; CONVULXIN; GLYCOPROTEIN VI; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE BETA; THROMBIN; UNCLASSIFIED DRUG; I KAPPA B KINASE;

EID: 84933042246     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.305127     Document Type: Article
Times cited : (30)

References (46)
  • 1
    • 0036851876 scopus 로고    scopus 로고
    • Platelets in atherothrombosis
    • Ruggeri ZM. Platelets in atherothrombosis. Nat Med. 2002;8:1227-1234. doi: 10.1038/nm1102-1227.
    • (2002) Nat Med , vol.8 , pp. 1227-1234
    • Ruggeri, Z.M.1
  • 2
    • 20444407316 scopus 로고    scopus 로고
    • Contribution of platelet glycoprotein VI to the thrombogenic effect of collagens in fibrous atherosclerotic lesions
    • Cosemans JM, Kuijpers MJ, Lecut C, Loubele ST, Heeneman S, Jandrot-Perrus M, Heemskerk JW. Contribution of platelet glycoprotein VI to the thrombogenic effect of collagens in fibrous atherosclerotic lesions. Atherosclerosis. 2005;181:19-27. doi: 10.1016/j. atherosclerosis.2004.12.037.
    • (2005) Atherosclerosis , vol.181 , pp. 19-27
    • Cosemans, J.M.1    Kuijpers, M.J.2    Lecut, C.3    Loubele, S.T.4    Heeneman, S.5    Jandrot-Perrus, M.6    Heemskerk, J.W.7
  • 6
    • 0037877918 scopus 로고    scopus 로고
    • CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation
    • Inwald DP, McDowall A, Peters MJ, Callard RE, Klein NJ. CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation. Circ Res. 2003;92:1041-1048. doi: 10.1161/01. RES.0000070111.98158.6C.
    • (2003) Circ Res , vol.92 , pp. 1041-1048
    • Inwald, D.P.1    McDowall, A.2    Peters, M.J.3    Callard, R.E.4    Klein, N.J.5
  • 8
    • 84867754221 scopus 로고    scopus 로고
    • The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways
    • Burkhart JM, Vaudel M, Gambaryan S, Radau S, Walter U, Martens L, Geiger J, Sickmann A, Zahedi RP. The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways. Blood. 2012;120:e73-e82. doi: 10.1182/blood-2012-04-416594.
    • (2012) Blood , vol.120 , pp. e73-e82
    • Burkhart, J.M.1    Vaudel, M.2    Gambaryan, S.3    Radau, S.4    Walter, U.5    Martens, L.6    Geiger, J.7    Sickmann, A.8    Zahedi, R.P.9
  • 9
    • 77954482405 scopus 로고    scopus 로고
    • CD40 ligand shedding is regulated by interaction between matrix metalloproteinase-2 and platelet integrin alpha(IIb)beta(3)
    • Choi WS, Jeon OH, Kim DS. CD40 ligand shedding is regulated by interaction between matrix metalloproteinase-2 and platelet integrin alpha(IIb)beta(3). J Thromb Haemost. 2010;8:1364-1371. doi: 10.1111/j.1538-7836.2010.03837.x.
    • (2010) J Thromb Haemost , vol.8 , pp. 1364-1371
    • Choi, W.S.1    Jeon, O.H.2    Kim, D.S.3
  • 10
    • 84880420104 scopus 로고    scopus 로고
    • Platelet shedding of CD40L is regulated by matrix metalloproteinase-9 in abdominal sepsis
    • Rahman M, Zhang S, Chew M, Syk I, Jeppsson B, Thorlacius H. Platelet shedding of CD40L is regulated by matrix metalloproteinase-9 in abdominal sepsis. J Thromb Haemost. 2013;11:1385-1398. doi: 10.1111/jth.12273.
    • (2013) J Thromb Haemost , vol.11 , pp. 1385-1398
    • Rahman, M.1    Zhang, S.2    Chew, M.3    Syk, I.4    Jeppsson, B.5    Thorlacius, H.6
  • 13
    • 2642608661 scopus 로고    scopus 로고
    • Reduction of atherosclerosis in mice by inhibition of CD40 signalling
    • Mach F, Schönbeck U, Sukhova GK, Atkinson E, Libby P. Reduction of atherosclerosis in mice by inhibition of CD40 signalling. Nature. 1998;394:200-203. doi: 10.1038/28204.
    • (1998) Nature , vol.394 , pp. 200-203
    • Mach, F.1    Schönbeck, U.2    Sukhova, G.K.3    Atkinson, E.4    Libby, P.5
  • 14
    • 77149136451 scopus 로고    scopus 로고
    • Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile
    • Lutgens E, Lievens D, Beckers L, et al. Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile. J Exp Med. 2010;207:391-404. doi: 10.1084/jem.20091293.
    • (2010) J Exp Med , vol.207 , pp. 391-404
    • Lutgens, E.1    Lievens, D.2    Beckers, L.3
  • 16
    • 47149094263 scopus 로고    scopus 로고
    • The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling
    • Donners MM, Beckers L, Lievens D, et al. The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling. Blood. 2008;111:4596-4604. doi: 10.1182/blood-2007-05-088906.
    • (2008) Blood , vol.111 , pp. 4596-4604
    • Donners, M.M.1    Beckers, L.2    Lievens, D.3
  • 17
    • 78549272749 scopus 로고    scopus 로고
    • Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis
    • Lievens D, Zernecke A, Seijkens T, et al. Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis. Blood. 2010;116:4317-4327. doi: 10.1182/blood-2010-01-261206.
    • (2010) Blood , vol.116 , pp. 4317-4327
    • Lievens, D.1    Zernecke, A.2    Seijkens, T.3
  • 18
    • 78650420516 scopus 로고    scopus 로고
    • Enhanced levels of soluble CD40 ligand exacerbate platelet aggregation and thrombus formation through a CD40-dependent tumor necrosis factor receptor-associated factor-2/Rac1/p38 mitogen-activated protein kinase signaling pathway
    • Yacoub D, Hachem A, Théorêt JF, Gillis MA, Mourad W, Merhi Y. Enhanced levels of soluble CD40 ligand exacerbate platelet aggregation and thrombus formation through a CD40-dependent tumor necrosis factor receptor-associated factor-2/Rac1/p38 mitogen-activated protein kinase signaling pathway. Arterioscler Thromb Vasc Biol. 2010;30:2424-2433. doi: 10.1161/ATVBAHA.110.216143.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 2424-2433
    • Yacoub, D.1    Hachem, A.2    Théorêt, J.F.3    Gillis, M.A.4    Mourad, W.5    Merhi, Y.6
  • 19
  • 22
    • 0142091359 scopus 로고    scopus 로고
    • Soluble CD40 ligand induces beta3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signaling
    • Prasad KS, Andre P, He M, Bao M, Manganello J, Phillips DR. Soluble CD40 ligand induces beta3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signaling. Proc Natl Acad Sci U S A. 2003;100:12367-12371. doi: 10.1073/pnas.2032886100.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 12367-12371
    • Prasad, K.S.1    Andre, P.2    He, M.3    Bao, M.4    Manganello, J.5    Phillips, D.R.6
  • 27
    • 21044454703 scopus 로고    scopus 로고
    • PI 3-kinase p110beta: A new target for antithrombotic therapy
    • Jackson SP, Schoenwaelder SM, Goncalves I, et al. PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med. 2005;11:507-514. doi: 10.1038/nm1232.
    • (2005) Nat Med , vol.11 , pp. 507-514
    • Jackson, S.P.1    Schoenwaelder, S.M.2    Goncalves, I.3
  • 28
    • 4444260266 scopus 로고    scopus 로고
    • Platelet adhesion signalling and the regulation of thrombus formation
    • Gibbins JM. Platelet adhesion signalling and the regulation of thrombus formation. J Cell Sci. 2004;117:3415-3425. doi: 10.1242/jcs.01325.
    • (2004) J Cell Sci , vol.117 , pp. 3415-3425
    • Gibbins, J.M.1
  • 30
    • 70349251723 scopus 로고    scopus 로고
    • Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM-and integrin-mediated signaling in platelets
    • Canobbio I, Stefanini L, Cipolla L, Ciraolo E, Gruppi C, Balduini C, Hirsch E, Torti M. Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM-and integrin-mediated signaling in platelets. Blood. 2009;114:2193-2196. doi: 10.1182/blood-2009-03-208074.
    • (2009) Blood , vol.114 , pp. 2193-2196
    • Canobbio, I.1    Stefanini, L.2    Cipolla, L.3    Ciraolo, E.4    Gruppi, C.5    Balduini, C.6    Hirsch, E.7    Torti, M.8
  • 31
    • 77950423041 scopus 로고    scopus 로고
    • Deletion of the p110beta isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo
    • Martin V, Guillermet-Guibert J, Chicanne G, Cabou C, Jandrot-Perrus M, Plantavid M, Vanhaesebroeck B, Payrastre B, Gratacap MP. Deletion of the p110beta isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo. Blood. 2010;115:2008-2013. doi: 10.1182/blood-2009-04-217224.
    • (2010) Blood , vol.115 , pp. 2008-2013
    • Martin, V.1    Guillermet-Guibert, J.2    Chicanne, G.3    Cabou, C.4    Jandrot-Perrus, M.5    Plantavid, M.6    Vanhaesebroeck, B.7    Payrastre, B.8    Gratacap, M.P.9
  • 32
    • 73449084397 scopus 로고    scopus 로고
    • A noble function of BAY 11-7082: Inhibition of platelet aggregation mediated by an elevated cAMP-induced VASP, and decreased ERK2/JNK1 phosphorylations
    • Lee HS, Kim SD, Lee WM, Endale M, Kamruzzaman SM, Oh WJ, Cho JY, Kim SK, Cho HJ, Park HJ, Rhee MH. A noble function of BAY 11-7082: Inhibition of platelet aggregation mediated by an elevated cAMP-induced VASP, and decreased ERK2/JNK1 phosphorylations. Eur J Pharmacol. 2010;627:85-91. doi: 10.1016/j.ejphar.2009.11.005.
    • (2010) Eur J Pharmacol , vol.627 , pp. 85-91
    • Lee, H.S.1    Kim, S.D.2    Lee, W.M.3    Endale, M.4    Kamruzzaman, S.M.5    Oh, W.J.6    Cho, J.Y.7    Kim, S.K.8    Cho, H.J.9    Park, H.J.10    Rhee, M.H.11
  • 33
    • 80051987703 scopus 로고    scopus 로고
    • Crosstalk in NF-?B signaling pathways
    • Oeckinghaus A, Hayden MS, Ghosh S. Crosstalk in NF-?B signaling pathways. Nat Immunol. 2011;12:695-708. doi: 10.1038/ni.2065.
    • (2011) Nat Immunol , vol.12 , pp. 695-708
    • Oeckinghaus, A.1    Hayden, M.S.2    Ghosh, S.3
  • 34
    • 78650920066 scopus 로고    scopus 로고
    • Non-canonical NF-?B signaling pathway
    • Sun SC. Non-canonical NF-?B signaling pathway. Cell Res. 2011;21:71-85. doi: 10.1038/cr.2010.177.
    • (2011) Cell Res , vol.21 , pp. 71-85
    • Sun, S.C.1
  • 35
    • 0035861314 scopus 로고    scopus 로고
    • IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development
    • Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV, Karin M. IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell. 2001;107:763-775.
    • (2001) Cell , vol.107 , pp. 763-775
    • Cao, Y.1    Bonizzi, G.2    Seagroves, T.N.3    Greten, F.R.4    Johnson, R.5    Schmidt, E.V.6    Karin, M.7
  • 36
    • 77953694980 scopus 로고    scopus 로고
    • Therapeutic interventions targeting CD40L (CD154) and CD40: The opportunities and challenges
    • In:Grewal IS, Ed. Berlin, Germany: Landes Biosciences and Springer;
    • Law CL, Gewal IS. Therapeutic interventions targeting CD40L (CD154) and CD40: the opportunities and challenges. In:Grewal IS, ed. Therapeutics of the TNF Superfamily. Berlin, Germany: Landes Biosciences and Springer 2009:8-36
    • (2009) Therapeutics of the TNF Superfamily , pp. 8-8
    • Law, C.L.1    Gewal, I.S.2
  • 37
    • 34547112554 scopus 로고    scopus 로고
    • CD40-40L signaling in vascular inflammation
    • Chakrabarti S, Blair P, Freedman JE. CD40-40L signaling in vascular inflammation. J Biol Chem. 2007;282:18307-18317. doi: 10.1074/jbc. M700211200.
    • (2007) J Biol Chem , vol.282 , pp. 18307-18317
    • Chakrabarti, S.1    Blair, P.2    Freedman, J.E.3
  • 38
    • 70350447306 scopus 로고    scopus 로고
    • The multifunctionality of CD40L and its receptor CD40 in atherosclerosis
    • Lievens D, Eijgelaar WJ, Biessen EA, Daemen MJ, Lutgens E. The multifunctionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 2009;102:206-214. doi: 10.1160/TH09-01-0029.
    • (2009) Thromb Haemost , vol.102 , pp. 206-214
    • Lievens, D.1    Eijgelaar, W.J.2    Biessen, E.A.3    Daemen, M.J.4    Lutgens, E.5
  • 42
    • 77449106039 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces
    • Schoenwaelder SM, Ono A, Nesbitt WS, Lim J, Jarman K, Jackson SP. Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces. J Biol Chem. 2010;285:2886-2896. doi: 10.1074/jbc.M109.029132.
    • (2010) J Biol Chem , vol.285 , pp. 2886-2896
    • Schoenwaelder, S.M.1    Ono, A.2    Nesbitt, W.S.3    Lim, J.4    Jarman, K.5    Jackson, S.P.6
  • 46
    • 4444283150 scopus 로고    scopus 로고
    • Release of soluble CD40 ligand after platelet activation: Studies on the solubilization phase
    • Otterdal K, Pedersen TM, Solum NO. Release of soluble CD40 ligand after platelet activation: studies on the solubilization phase. Thromb Res. 2004;114:167-177. doi: 10.1016/j.thromres.2004.05.007.
    • (2004) Thromb Res , vol.114 , pp. 167-177
    • Otterdal, K.1    Pedersen, T.M.2    Solum, N.O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.