Synthesis, characterization, and preclinical validation of a PET radiopharmaceutical for interrogating Aβ (β-amyloid) plaques in Alzheimer’s disease

EJNMMI Research

Volumn 5, Issue 1, 2015, Pages

  Sundaram, Guruswami SM ^a,b   Dhavale, Dhruva ^d   Prior, Julie L ^a,b   Sivapackiam, Jothilingam ^a,b   Laforest, Richard ^b   Kotzbauer, Paul ^d   Sharma, Vijay ^a,b,c,d  

^a Molecular Imaging Center   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Department of Biomedical Engineering ^*  (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer s disease; PET imaging; Radiopharmaceuticals; amyloid (A )

Indexed keywords

5 (2 (6 (2 [18F] FLUOROETHOXY) BENZO[D]THIAZOL 2 YL)VINYL) N,N DIMETHYLPYRIDIN 2 AMINE; AMYLOID BETA PROTEIN; PRESENILIN 1; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BLOOD BRAIN BARRIER; CARBON NUCLEAR MAGNETIC RESONANCE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG SYNTHESIS; FEMALE; FLUORINE NUCLEAR MAGNETIC RESONANCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TRANSGENIC MOUSE;

EID: 84932648805     PISSN: None     EISSN: 2191219X     Source Type: Journal    
DOI: 10.1186/s13550-015-0112-4     Document Type: Article

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