메뉴 건너뛰기




Volumn 5, Issue 1, 2015, Pages

Synthesis, characterization, and preclinical validation of a PET radiopharmaceutical for interrogating Aβ (β-amyloid) plaques in Alzheimer’s disease

Author keywords

Alzheimer s disease; PET imaging; Radiopharmaceuticals; amyloid (A )

Indexed keywords

5 (2 (6 (2 [18F] FLUOROETHOXY) BENZO[D]THIAZOL 2 YL)VINYL) N,N DIMETHYLPYRIDIN 2 AMINE; AMYLOID BETA PROTEIN; PRESENILIN 1; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

EID: 84932648805     PISSN: None     EISSN: 2191219X     Source Type: Journal    
DOI: 10.1186/s13550-015-0112-4     Document Type: Article
Times cited : (6)

References (49)
  • 2
    • 84875354777 scopus 로고    scopus 로고
    • 2013 Alzheimer’s disease facts and figures
    • 10.1016/j.jalz.2013.02.003
    • Thies W, Bleiler L. 2013 Alzheimer’s disease facts and figures. Alzheimers Dement. 2013;9:208–45. doi:10.1016/j.jalz.2013.02.003.
    • (2013) Alzheimers Dement. , vol.9 , pp. 208-245
    • Thies, W.1    Bleiler, L.2
  • 3
    • 79956125839 scopus 로고    scopus 로고
    • Biomarkers in Alzheimer’s disease drug development
    • COI: 1:CAS:528:DC%2BC3MXmtVyjsr0%3D, PID: 21550318, 10.1016/j.jalz.2010.06.004
    • Cummings JL. Biomarkers in Alzheimer’s disease drug development. Alzheimers Dement. 2011;7:e13–44. doi:10.1016/j.jalz.2010.06.004.
    • (2011) Alzheimers Dement. , vol.7 , pp. e13-e44
    • Cummings, J.L.1
  • 4
    • 82755193805 scopus 로고    scopus 로고
    • Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-transgene expression
    • COI: 1:CAS:528:DC%2BC3MXhsFygtbjJ, PID: 21601614, 10.1016/j.pneurobio.2011.05.004
    • Teipel SJ, Buchert R, Thome J, Hampel H, Pahnke J. Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-transgene expression. Prog Neurobiol. 2011;95:547–56. doi:10.1016/j.pneurobio.2011.05.004.
    • (2011) Prog Neurobiol. , vol.95 , pp. 547-556
    • Teipel, S.J.1    Buchert, R.2    Thome, J.3    Hampel, H.4    Pahnke, J.5
  • 5
    • 79952793175 scopus 로고    scopus 로고
    • Amyloid beta (Abeta) and phospho-tau (p-tau) as diagnostic biomarkers in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3MXms1Wnu7w%3D, PID: 21342022, 10.1515/CCLM.2011.087
    • Prvulovic D, Hampel H. Amyloid beta (Abeta) and phospho-tau (p-tau) as diagnostic biomarkers in Alzheimer’s disease. Clin Chem Lab Med. 2011;49:367–74. doi:10.1515/CCLM.2011.087.
    • (2011) Clin Chem Lab Med. , vol.49 , pp. 367-374
    • Prvulovic, D.1    Hampel, H.2
  • 6
    • 82755161905 scopus 로고    scopus 로고
    • Biomarkers for Alzheimer’s disease therapeutic trials
    • COI: 1:CAS:528:DC%2BC3MXhsFygtbjK, PID: 21130138, 10.1016/j.pneurobio.2010.11.005
    • Hampel H, Wilcock G, Andrieu S, Aisen P, Blennow K, Broich K, et al. Biomarkers for Alzheimer’s disease therapeutic trials. Prog Neurobiol. 2011;95:579–93. doi:10.1016/j.pneurobio.2010.11.005.
    • (2011) Prog Neurobiol. , vol.95 , pp. 579-593
    • Hampel, H.1    Wilcock, G.2    Andrieu, S.3    Aisen, P.4    Blennow, K.5    Broich, K.6
  • 7
    • 67349184808 scopus 로고    scopus 로고
    • Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease
    • PID: 19376612, 10.1016/j.neurobiolaging.2009.04.002
    • Price JL, McKeel Jr DW, Buckles VD, Roe CM, Xiong C, Grundman M, et al. Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiol Aging. 2009;30:1026–36. doi:10.1016/j.neurobiolaging.2009.04.002.
    • (2009) Neurobiol Aging. , vol.30 , pp. 1026-1036
    • Price, J.L.1    McKeel, D.W.2    Buckles, V.D.3    Roe, C.M.4    Xiong, C.5    Grundman, M.6
  • 8
    • 10744232413 scopus 로고    scopus 로고
    • Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B
    • COI: 1:CAS:528:DC%2BD2cXisFKntb8%3D, PID: 14991808
    • Klunk W, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt D, et al. Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B. Ann Neurol. 2004;55:306–19.
    • (2004) Ann Neurol. , vol.55 , pp. 306-319
    • Klunk, W.1    Engler, H.2    Nordberg, A.3    Wang, Y.4    Blomqvist, G.5    Holt, D.6
  • 9
    • 4644283049 scopus 로고    scopus 로고
    • PET imaging of amyloid in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD2cXnvFKjtL4%3D, PID: 15324720
    • Nordberg A. PET imaging of amyloid in Alzheimer’s disease. Lancet Neurol. 2004;3:519–27.
    • (2004) Lancet Neurol. , vol.3 , pp. 519-527
    • Nordberg, A.1
  • 11
    • 70350716476 scopus 로고    scopus 로고
    • Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain
    • COI: 1:CAS:528:DC%2BD1MXhsVyqs7rK, PID: 19837759, 10.2967/jnumed.109.065284
    • Choi SR, Golding G, Zhuang Z, Zhang W, Lim N, Hefti F, et al. Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain. J Nucl Med. 2009;50:1887–94. doi:10.2967/jnumed.109.065284.
    • (2009) J Nucl Med. , vol.50 , pp. 1887-1894
    • Choi, S.R.1    Golding, G.2    Zhuang, Z.3    Zhang, W.4    Lim, N.5    Hefti, F.6
  • 12
    • 84877041796 scopus 로고    scopus 로고
    • Head-to-head comparison of 11C-PiB and 18F-AZD4694 (NAV4694) for beta-amyloid imaging in aging and dementia
    • COI: 1:CAS:528:DC%2BC3sXpvFeisbg%3D, PID: 23575995, 10.2967/jnumed.112.114785
    • Rowe CC, Pejoska S, Mulligan RS, Jones G, Chan JG, Svensson S, et al. Head-to-head comparison of 11C-PiB and 18F-AZD4694 (NAV4694) for beta-amyloid imaging in aging and dementia. J Nucl Med. 2013;54:880–6. doi:10.2967/jnumed.112.114785.
    • (2013) J Nucl Med. , vol.54 , pp. 880-886
    • Rowe, C.C.1    Pejoska, S.2    Mulligan, R.S.3    Jones, G.4    Chan, J.G.5    Svensson, S.6
  • 13
    • 84858607421 scopus 로고    scopus 로고
    • Clinical validation of 18F-AZD4694, an amyloid-beta-specific PET radioligand
    • COI: 1:CAS:528:DC%2BC38XlvVGhurk%3D, PID: 22323782, 10.2967/jnumed.111.094029
    • Cselenyi Z, Jonhagen ME, Forsberg A, Halldin C, Julin P, Schou M, et al. Clinical validation of 18F-AZD4694, an amyloid-beta-specific PET radioligand. J Nucl Med. 2012;53:415–24. doi:10.2967/jnumed.111.094029.
    • (2012) J Nucl Med. , vol.53 , pp. 415-424
    • Cselenyi, Z.1    Jonhagen, M.E.2    Forsberg, A.3    Halldin, C.4    Julin, P.5    Schou, M.6
  • 14
    • 84862529821 scopus 로고    scopus 로고
    • Correlation of early-phase 18F-florbetapir (AV-45/Amyvid) PET images to FDG images: preliminary studies
    • COI: 1:CAS:528:DC%2BC38XkvFymur8%3D, PID: 22270508, 10.1007/s00259-011-2051-2
    • Hsiao IT, Huang CC, Hsieh CJ, Hsu WC, Wey SP, Yen TC, et al. Correlation of early-phase 18F-florbetapir (AV-45/Amyvid) PET images to FDG images: preliminary studies. Eur J Nucl Med Mol Imaging. 2012;39:613–20. doi:10.1007/s00259-011-2051-2.
    • (2012) Eur J Nucl Med Mol Imaging. , vol.39 , pp. 613-620
    • Hsiao, I.T.1    Huang, C.C.2    Hsieh, C.J.3    Hsu, W.C.4    Wey, S.P.5    Yen, T.C.6
  • 15
    • 66149104129 scopus 로고    scopus 로고
    • Whole-body biodistribution and radiation dosimetry of 18F-GE067: a radioligand for in vivo brain amyloid imaging
    • COI: 1:CAS:528:DC%2BD1MXmtV2hsrk%3D, PID: 19372469, 10.2967/jnumed.108.060756
    • Koole M, Lewis DM, Buckley C, Nelissen N, Vandenbulcke M, Brooks DJ, et al. Whole-body biodistribution and radiation dosimetry of 18F-GE067: a radioligand for in vivo brain amyloid imaging. J Nucl Med. 2009;50:818–22. doi:10.2967/jnumed.108.060756.
    • (2009) J Nucl Med. , vol.50 , pp. 818-822
    • Koole, M.1    Lewis, D.M.2    Buckley, C.3    Nelissen, N.4    Vandenbulcke, M.5    Brooks, D.J.6
  • 16
    • 68249141258 scopus 로고    scopus 로고
    • Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease
    • COI: 1:CAS:528:DC%2BD1MXhtVymtrrJ, PID: 19617318, 10.2967/jnumed.109.063305
    • Nelissen N, Van Laere K, Thurfjell L, Owenius R, Vandenbulcke M, Koole M, et al. Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease. J Nucl Med. 2009;50:1251–9. doi:10.2967/jnumed.109.063305.
    • (2009) J Nucl Med. , vol.50 , pp. 1251-1259
    • Nelissen, N.1    Van Laere, K.2    Thurfjell, L.3    Owenius, R.4    Vandenbulcke, M.5    Koole, M.6
  • 17
    • 38149081191 scopus 로고    scopus 로고
    • Imaging of amyloid beta in Alzheimer’s disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism
    • COI: 1:CAS:528:DC%2BD1cXis1WmsLw%3D, PID: 18191617, 10.1016/S1474-4422(08)70001-2
    • Rowe CC, Ackerman U, Browne W, Mulligan R, Pike KL, O’Keefe G, et al. Imaging of amyloid beta in Alzheimer’s disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism. Lancet Neurol. 2008;7:129–35. doi:10.1016/S1474-4422(08)70001-2.
    • (2008) Lancet Neurol , vol.7 , pp. 129-135
    • Rowe, C.C.1    Ackerman, U.2    Browne, W.3    Mulligan, R.4    Pike, K.L.5    O’Keefe, G.6
  • 18
    • 80051688987 scopus 로고    scopus 로고
    • Amyloid imaging with (18)F-florbetaben in Alzheimer disease and other dementias
    • PID: 21764791, 10.2967/jnumed.111.089730
    • Villemagne VL, Ong K, Mulligan RS, Holl G, Pejoska S, Jones G, et al. Amyloid imaging with (18)F-florbetaben in Alzheimer disease and other dementias. J Nucl Med. 2011;52:1210–7. doi:10.2967/jnumed.111.089730.
    • (2011) J Nucl Med. , vol.52 , pp. 1210-1217
    • Villemagne, V.L.1    Ong, K.2    Mulligan, R.S.3    Holl, G.4    Pejoska, S.5    Jones, G.6
  • 19
    • 84877106494 scopus 로고    scopus 로고
    • PET quantification of 18F-florbetaben binding to beta-amyloid deposits in human brains
    • COI: 1:CAS:528:DC%2BC3sXosFCnsL4%3D, PID: 23471310, 10.2967/jnumed.112.107185
    • Becker GA, Ichise M, Barthel H, Luthardt J, Patt M, Seese A, et al. PET quantification of 18F-florbetaben binding to beta-amyloid deposits in human brains. J Nucl Med. 2013;54:723–31. doi:10.2967/jnumed.112.107185.
    • (2013) J Nucl Med. , vol.54 , pp. 723-731
    • Becker, G.A.1    Ichise, M.2    Barthel, H.3    Luthardt, J.4    Patt, M.5    Seese, A.6
  • 20
    • 77953937194 scopus 로고    scopus 로고
    • In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18)
    • COI: 1:CAS:528:DC%2BC3cXosl2ksb4%3D, PID: 20501908, 10.2967/jnumed.109.069088
    • Wong DF, Rosenberg PB, Zhou Y, Kumar A, Raymont V, Ravert HT, et al. In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18). J Nucl Med. 2010;51:913–20. doi:10.2967/jnumed.109.069088.
    • (2010) J Nucl Med. , vol.51 , pp. 913-920
    • Wong, D.F.1    Rosenberg, P.B.2    Zhou, Y.3    Kumar, A.4    Raymont, V.5    Ravert, H.T.6
  • 21
    • 84879980176 scopus 로고    scopus 로고
    • Amyloid tracers detect multiple binding sites in Alzheimer’s disease brain tissue
    • PID: 23757761, 10.1093/brain/awt142
    • Ni R, Gillberg PG, Bergfors A, Marutle A, Nordberg A. Amyloid tracers detect multiple binding sites in Alzheimer’s disease brain tissue. Brain. 2013;136:2217–27. doi:10.1093/brain/awt142.
    • (2013) Brain. , vol.136 , pp. 2217-2227
    • Ni, R.1    Gillberg, P.G.2    Bergfors, A.3    Marutle, A.4    Nordberg, A.5
  • 22
    • 14844303913 scopus 로고    scopus 로고
    • Evidence for presence of three distinct binding sites for thioflavin T class of Alzheimer’s disease PET imaging agents on b-amyloid peptide fibrils
    • COI: 1:CAS:528:DC%2BD2MXhs1yisLY%3D, PID: 15615711
    • Lockhart A, Ye L, Judd D, Meritt A, Lowe P, Morgenstern J, et al. Evidence for presence of three distinct binding sites for thioflavin T class of Alzheimer’s disease PET imaging agents on b-amyloid peptide fibrils. J Biol Chem. 2005;280:7677–84.
    • (2005) J Biol Chem. , vol.280 , pp. 7677-7684
    • Lockhart, A.1    Ye, L.2    Judd, D.3    Meritt, A.4    Lowe, P.5    Morgenstern, J.6
  • 23
    • 84904568939 scopus 로고    scopus 로고
    • Characterization of a brain permeant fluorescent molecule and visualization of Aβ parenchymal plaques, using real-time multiphoton imaging in transgenic mice
    • COI: 1:CAS:528:DC%2BC2cXhtFajsbjL, PID: 25003699
    • Sundaram GSM, Garai K, Rath NP, Yan P, Cirrito JR, Cairns N, et al. Characterization of a brain permeant fluorescent molecule and visualization of Aβ parenchymal plaques, using real-time multiphoton imaging in transgenic mice. Org Lett. 2014;16:3640–3.
    • (2014) Org Lett. , vol.16 , pp. 3640-3643
    • Sundaram, G.S.M.1    Garai, K.2    Rath, N.P.3    Yan, P.4    Cirrito, J.R.5    Cairns, N.6
  • 24
    • 84994347306 scopus 로고    scopus 로고
    • Design and synthesis of a novel PET probe for early detection of Alzheimer’s disease
    • Sundaram GSM, Cairns N, Lee J-M, Sharma V. Design and synthesis of a novel PET probe for early detection of Alzheimer’s disease. J Nucl Med. 2014;55:137.
    • (2014) J Nucl Med. , vol.55 , pp. 137
    • Sundaram, G.S.M.1    Cairns, N.2    Lee, J.-M.3    Sharma, V.4
  • 25
    • 2542457758 scopus 로고    scopus 로고
    • Synthesis of [18F]Fluorocholine analogues as potential imaging agents for PET studies
    • COI: 1:CAS:528:DC%2BD2cXktFyhsbk%3D
    • Yu K, Park J, Yang S. Synthesis of [18F]Fluorocholine analogues as potential imaging agents for PET studies. Bull Korean Chem Soc. 2004;25:506–10.
    • (2004) Bull Korean Chem Soc. , vol.25 , pp. 506-510
    • Yu, K.1    Park, J.2    Yang, S.3
  • 26
    • 84873564460 scopus 로고    scopus 로고
    • Binding of the radioligand SIL23 to alpha-synuclein fibrils in Parkinson disease brain tissue establishes feasibility and screening approaches for developing a Parkinson disease imaging agent
    • COI: 1:CAS:528:DC%2BC3sXivFGqs74%3D, PID: 23405108, 10.1371/journal.pone.0055031
    • Bagchi DP, Yu L, Perlmutter JS, Xu J, Mach RH, Tu Z, et al. Binding of the radioligand SIL23 to alpha-synuclein fibrils in Parkinson disease brain tissue establishes feasibility and screening approaches for developing a Parkinson disease imaging agent. PLoS One. 2013;8:e55031. doi:10.1371/journal.pone.0055031.
    • (2013) PLoS One. , vol.8 , pp. e55031
    • Bagchi, D.P.1    Yu, L.2    Perlmutter, J.S.3    Xu, J.4    Mach, R.H.5    Tu, Z.6
  • 27
    • 77956698237 scopus 로고    scopus 로고
    • Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer’s disease research
    • COI: 1:CAS:528:DC%2BC3cXnsFSktL8%3D, PID: 20539293, 10.1038/nprot.2010.72
    • Jan A, Hartley DM, Lashuel HA. Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer’s disease research. Nat Protoc. 2010;5:1186–209. doi:10.1038/nprot.2010.72.
    • (2010) Nat Protoc. , vol.5 , pp. 1186-1209
    • Jan, A.1    Hartley, D.M.2    Lashuel, H.A.3
  • 28
    • 27944471285 scopus 로고    scopus 로고
    • Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer’s disease brain but not in transgenic mouse brain
    • COI: 1:CAS:528:DC%2BD2MXht1Kqsb%2FP, PID: 16291932
    • Klunk WE, Lopresti BJ, Ikonomovic MD, Lefterov IM, Koldamova RP, Abrahamson EE, et al. Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer’s disease brain but not in transgenic mouse brain. J Neurosci. 2005;25:10598–606.
    • (2005) J Neurosci. , vol.25 , pp. 10598-10606
    • Klunk, W.E.1    Lopresti, B.J.2    Ikonomovic, M.D.3    Lefterov, I.M.4    Koldamova, R.P.5    Abrahamson, E.E.6
  • 29
    • 84887416188 scopus 로고    scopus 로고
    • [(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer’s disease
    • PID: 23411393, 10.1016/j.jalz.2012.11.008
    • Xia CF, Arteaga J, Chen G, Gangadharmath U, Gomez LF, Kasi D, et al. [(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer’s disease. Alzheimers Dement. 2013;9:666–76. doi:10.1016/j.jalz.2012.11.008.
    • (2013) Alzheimers Dement , vol.9 , pp. 666-676
    • Xia, C.F.1    Arteaga, J.2    Chen, G.3    Gangadharmath, U.4    Gomez, L.F.5    Kasi, D.6
  • 30
    • 84859064398 scopus 로고    scopus 로고
    • Bidirectional relationship between functional connectivity and amyloid-beta deposition in mouse brain
    • COI: 1:CAS:528:DC%2BC38Xlt1ehtL0%3D, PID: 22457485, 10.1523/JNEUROSCI.5845-11.2012
    • Bero AW, Bauer AQ, Stewart FR, White BR, Cirrito JR, Raichle ME, et al. Bidirectional relationship between functional connectivity and amyloid-beta deposition in mouse brain. J Neurosci. 2012;32:4334–40. doi:10.1523/JNEUROSCI.5845-11.2012.
    • (2012) J Neurosci. , vol.32 , pp. 4334-4340
    • Bero, A.W.1    Bauer, A.Q.2    Stewart, F.R.3    White, B.R.4    Cirrito, J.R.5    Raichle, M.E.6
  • 31
    • 84876569513 scopus 로고    scopus 로고
    • Blocking the interaction between apolipoprotein E and Abeta reduces intraneuronal accumulation of Abeta and inhibits synaptic degeneration
    • COI: 1:CAS:528:DC%2BC3sXmtlCrurc%3D, PID: 23499462, 10.1016/j.ajpath.2013.01.034
    • Kuszczyk MA, Sanchez S, Pankiewicz J, Kim J, Duszczyk M, Guridi M, et al. Blocking the interaction between apolipoprotein E and Abeta reduces intraneuronal accumulation of Abeta and inhibits synaptic degeneration. Am J Pathol. 2013;182:1750–68. doi:10.1016/j.ajpath.2013.01.034.
    • (2013) Am J Pathol. , vol.182 , pp. 1750-1768
    • Kuszczyk, M.A.1    Sanchez, S.2    Pankiewicz, J.3    Kim, J.4    Duszczyk, M.5    Guridi, M.6
  • 32
    • 77953578223 scopus 로고    scopus 로고
    • Synthesis, molecular structure, and validation of metalloprobes for assessment of MDR1 P-glycoprotein-mediated functional transport
    • COI: 1:CAS:528:DC%2BC3cXnsVWhuro%3D, PID: 20505882
    • Sivapackiam J, Harpstrite SE, Prior JL, Gu H, Rath NP, Sharma V. Synthesis, molecular structure, and validation of metalloprobes for assessment of MDR1 P-glycoprotein-mediated functional transport. Dalton Trans. 2010;39:5842–50.
    • (2010) Dalton Trans. , vol.39 , pp. 5842-5850
    • Sivapackiam, J.1    Harpstrite, S.E.2    Prior, J.L.3    Gu, H.4    Rath, N.P.5    Sharma, V.6
  • 33
    • 70349967829 scopus 로고    scopus 로고
    • Efficient and economical access to substituted benzothiazoles: copper-catalyzed coupling of 2-haloanilides with metal sulfides and subsequent condensation
    • COI: 1:CAS:528:DC%2BD1MXmsVSis7k%3D, PID: 19425042, 10.1002/anie.200900486
    • Ma D, Xie S, Xue P, Zhang X, Dong J, Jiang Y. Efficient and economical access to substituted benzothiazoles: copper-catalyzed coupling of 2-haloanilides with metal sulfides and subsequent condensation. Angew Chem Int Ed Engl. 2009;48:4222–5. doi:10.1002/anie.200900486.
    • (2009) Angew Chem Int Ed Engl. , vol.48 , pp. 4222-4225
    • Ma, D.1    Xie, S.2    Xue, P.3    Zhang, X.4    Dong, J.5    Jiang, Y.6
  • 34
    • 0038792263 scopus 로고    scopus 로고
    • Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents
    • COI: 1:CAS:528:DC%2BD3sXjvFOiurg%3D, PID: 12801237
    • Mathis C, Wang Y, Holt D, Huang G, Debnath M, Klunk W. Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. J Med Chem. 2003;46:2740–54.
    • (2003) J Med Chem. , vol.46 , pp. 2740-2754
    • Mathis, C.1    Wang, Y.2    Holt, D.3    Huang, G.4    Debnath, M.5    Klunk, W.6
  • 36
    • 84932646364 scopus 로고    scopus 로고
    • ID: 3473704. 2014.
    • http://www.accessdata.fda.gov/…/204677s000lb/search/Reference ID: 3473704. 2014.
  • 37
    • 84868317595 scopus 로고    scopus 로고
    • Preclinical characterization of a novel class of 18F-labeled PET tracers for amyloid-beta
    • COI: 1:CAS:528:DC%2BC3sXnslWhsw%3D%3D, PID: 23008501, 10.2967/jnumed.112.104810
    • Brockschnieder D, Schmitt-Willich H, Heinrich T, Varrone A, Gulyas B, Toth M, et al. Preclinical characterization of a novel class of 18F-labeled PET tracers for amyloid-beta. J Nucl Med. 2012;53:1794–801. doi:10.2967/jnumed.112.104810.
    • (2012) J Nucl Med. , vol.53 , pp. 1794-1801
    • Brockschnieder, D.1    Schmitt-Willich, H.2    Heinrich, T.3    Varrone, A.4    Gulyas, B.5    Toth, M.6
  • 38
    • 84869021291 scopus 로고    scopus 로고
    • Development of positron emission tomography beta-amyloid plaque imaging agents
    • PID: 23026364, 10.1053/j.semnuclmed.2012.07.001
    • Mathis CA, Mason NS, Lopresti BJ, Klunk WE. Development of positron emission tomography beta-amyloid plaque imaging agents. Semin Nucl Med. 2012;42:423–32. doi:10.1053/j.semnuclmed.2012.07.001.
    • (2012) Semin Nucl Med. , vol.42 , pp. 423-432
    • Mathis, C.A.1    Mason, N.S.2    Lopresti, B.J.3    Klunk, W.E.4
  • 39
    • 0021020662 scopus 로고
    • Relationship between lipophilicity and brain extraction of C-11 labeled radiopharmaceuticals
    • COI: 1:CAS:528:DyaL2cXhvFynsg%3D%3D
    • Dischino D, Welch M, Kilbourn M, Raichle M. Relationship between lipophilicity and brain extraction of C-11 labeled radiopharmaceuticals. J Nucl Med. 1983;24:1030–8.
    • (1983) J Nucl Med. , vol.24 , pp. 1030-1038
    • Dischino, D.1    Welch, M.2    Kilbourn, M.3    Raichle, M.4
  • 40
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Aß elevation, and amyloid plaques in transgenic mice
    • COI: 1:CAS:528:DyaK28XmtVyns7c%3D, PID: 8810256
    • Hsiao K, Chapman P, Nilsen S, Eckman S, Harigaya Y, Younkin S, et al. Correlative memory deficits, Aß elevation, and amyloid plaques in transgenic mice. Science. 1996;274:99–102.
    • (1996) Science. , vol.274 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, S.4    Harigaya, Y.5    Younkin, S.6
  • 41
    • 0032886415 scopus 로고    scopus 로고
    • Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes
    • COI: 1:CAS:528:DyaK1MXltFShsbo%3D, PID: 10448051, 10.1006/nbdi.1999.0243
    • McGowan E, Sanders S, Iwatsubo T, Takeuchi A, Saido T, Zehr C, et al. Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes. Neurobiol Dis. 1999;6:231–44. doi:10.1006/nbdi.1999.0243.
    • (1999) Neurobiol Dis. , vol.6 , pp. 231-244
    • McGowan, E.1    Sanders, S.2    Iwatsubo, T.3    Takeuchi, A.4    Saido, T.5    Zehr, C.6
  • 42
    • 0031914718 scopus 로고    scopus 로고
    • Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
    • COI: 1:CAS:528:DyaK1cXjt1OhsA%3D%3D, PID: 9427614
    • Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med. 1998;4:97–100.
    • (1998) Nat Med. , vol.4 , pp. 97-100
    • Holcomb, L.1    Gordon, M.N.2    McGowan, E.3    Yu, X.4    Benkovic, S.5    Jantzen, P.6
  • 43
    • 2542584749 scopus 로고    scopus 로고
    • Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice
    • COI: 1:CAS:528:DC%2BD2cXlsVCktbc%3D, PID: 15174014, 10.1002/ana.20101
    • Trinchese F, Liu S, Battaglia F, Walter S, Mathews PM, Arancio O. Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice. Ann Neurol. 2004;55:801–14. doi:10.1002/ana.20101.
    • (2004) Ann Neurol. , vol.55 , pp. 801-814
    • Trinchese, F.1    Liu, S.2    Battaglia, F.3    Walter, S.4    Mathews, P.M.5    Arancio, O.6
  • 44
    • 84881392145 scopus 로고    scopus 로고
    • Longitudinal amyloid imaging in mouse brain with 11C-PIB: comparison of APP23, Tg2576, and APPswe-PS1dE9 mouse models of Alzheimer disease
    • COI: 1:CAS:528:DC%2BC3sXhsVejsr%2FO, PID: 23833271, 10.2967/jnumed.112.110163
    • Snellman A, Lopez-Picon FR, Rokka J, Salmona M, Forloni G, Scheinin M, et al. Longitudinal amyloid imaging in mouse brain with 11C-PIB: comparison of APP23, Tg2576, and APPswe-PS1dE9 mouse models of Alzheimer disease. J Nucl Med. 2013;54:1434–41. doi:10.2967/jnumed.112.110163.
    • (2013) J Nucl Med. , vol.54 , pp. 1434-1441
    • Snellman, A.1    Lopez-Picon, F.R.2    Rokka, J.3    Salmona, M.4    Forloni, G.5    Scheinin, M.6
  • 45
    • 84879911625 scopus 로고    scopus 로고
    • Longitudinal assessment of cerebral beta-amyloid deposition in mice overexpressing Swedish mutant beta-amyloid precursor protein using 18F-florbetaben PET
    • COI: 1:CAS:528:DC%2BC3sXht1WitrrF, PID: 23729696, 10.2967/jnumed.112.114660
    • Rominger A, Brendel M, Burgold S, Keppler K, Baumann K, Xiong G, et al. Longitudinal assessment of cerebral beta-amyloid deposition in mice overexpressing Swedish mutant beta-amyloid precursor protein using 18F-florbetaben PET. J Nucl Med. 2013;54:1127–34. doi:10.2967/jnumed.112.114660.
    • (2013) J Nucl Med. , vol.54 , pp. 1127-1134
    • Rominger, A.1    Brendel, M.2    Burgold, S.3    Keppler, K.4    Baumann, K.5    Xiong, G.6
  • 46
    • 84857959777 scopus 로고    scopus 로고
    • Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC38XktlSktr0%3D, PID: 22427802, 10.1371/journal.pone.0031310
    • Manook A, Yousefi BH, Willuweit A, Platzer S, Reder S, Voss A, et al. Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer’s disease. PLoS One. 2012;7:e31310. doi:10.1371/journal.pone.0031310.
    • (2012) PLoS One. , vol.7 , pp. e31310
    • Manook, A.1    Yousefi, B.H.2    Willuweit, A.3    Platzer, S.4    Reder, S.5    Voss, A.6
  • 47
    • 84867356027 scopus 로고    scopus 로고
    • Vaccine development to treat Alzheimer’s disease neuropathology in APP/PS1 transgenic mice
    • PID: 23024882, 10.1155/2012/376138
    • Carrera I, Etcheverria I, Fernandez-Novoa L, Lombardi V, Cacabelos R, Vigo C. Vaccine development to treat Alzheimer’s disease neuropathology in APP/PS1 transgenic mice. Int J Alzheimers Dis. 2012;2012:376138. doi:10.1155/2012/376138.
    • (2012) Int J Alzheimers Dis. , vol.2012 , pp. 376138
    • Carrera, I.1    Etcheverria, I.2    Fernandez-Novoa, L.3    Lombardi, V.4    Cacabelos, R.5    Vigo, C.6
  • 48
    • 84868319492 scopus 로고    scopus 로고
    • Intravenous delivery of targeted liposomes to amyloid-beta pathology in APP/PSEN1 transgenic mice
    • COI: 1:CAS:528:DC%2BC38XhslWjsLnF, PID: 23119043, 10.1371/journal.pone.0048515
    • Tanifum EA, Dasgupta I, Srivastava M, Bhavane RC, Sun L, Berridge J, et al. Intravenous delivery of targeted liposomes to amyloid-beta pathology in APP/PSEN1 transgenic mice. PLoS One. 2012;7:e48515. doi:10.1371/journal.pone.0048515.
    • (2012) PLoS One. , vol.7 , pp. e48515
    • Tanifum, E.A.1    Dasgupta, I.2    Srivastava, M.3    Bhavane, R.C.4    Sun, L.5    Berridge, J.6
  • 49
    • 35348821915 scopus 로고    scopus 로고
    • Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer’s disease enabled by positron emission tomography
    • COI: 1:CAS:528:DC%2BD2sXht1Wnsb7J, PID: 17928437, 10.1523/JNEUROSCI.0673-07.2007
    • Maeda J, Ji B, Irie T, Tomiyama T, Maruyama M, Okauchi T, et al. Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer’s disease enabled by positron emission tomography. J Neurosci. 2007;27:10957–68. doi:10.1523/JNEUROSCI.0673-07.2007.
    • (2007) J Neurosci. , vol.27 , pp. 10957-10968
    • Maeda, J.1    Ji, B.2    Irie, T.3    Tomiyama, T.4    Maruyama, M.5    Okauchi, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.