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Volumn 56, Issue 5, 2015, Pages 1450-1459

Significance of 5,10-methylenetetrahydrofolate reductase gene variants in acute lymphoblastic leukemia in Indian population: An experimental, computational and meta-analysis

Author keywords

Acute lymphoblastic leukemia; in silico analysis; Indian population; Meta analysis; MTHFR gene polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); MICRORNA; 3' UNTRANSLATED REGION; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MTHFR PROTEIN, HUMAN;

EID: 84932183754     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2014.953154     Document Type: Article
Times cited : (11)

References (51)
  • 1
    • 44049092643 scopus 로고    scopus 로고
    • Homocysteine, vitamin B12 and folate status in pediatric acute lymphoblastic leukemia
    • Sadananda Adiga MN, Chandy S, Ramaswamy G, et al. Homocysteine, vitamin B12 and folate status in pediatric acute lymphoblastic leukemia. Indian J Pediatr 2008; 75: 235-238.
    • (2008) Indian J Pediatr , vol.75 , pp. 235-238
    • Sadananda Adiga, M.N.1    Chandy, S.2    Ramaswamy, G.3
  • 2
    • 0032845227 scopus 로고    scopus 로고
    • Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
    • James SJ, Pogribna M, Pogribny IP, et al. Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome. Am J Clin Nutr 1999;70:495-501.
    • (1999) Am J Clin Nutr , vol.70 , pp. 495-501
    • James, S.J.1    Pogribna, M.2    Pogribny, I.P.3
  • 3
    • 0035479285 scopus 로고    scopus 로고
    • Abnormal folate metabolism and genetic polymorphism of the folate pathway in a child with Down syndrome and neural tube defect
    • Al-Gazali LI, Padmanabhan R, Melnyk S, et al. Abnormal folate metabolism and genetic polymorphism of the folate pathway in a child with Down syndrome and neural tube defect. Am J Med Genet 2001;103:128-132.
    • (2001) Am J Med Genet , vol.103 , pp. 128-132
    • Al-Gazali, L.I.1    Padmanabhan, R.2    Melnyk, S.3
  • 4
    • 0033607241 scopus 로고    scopus 로고
    • Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults
    • Skibola CF, Smith MT, Kane E, et al. Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci USA 1999;96:12810-12815.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12810-12815
    • Skibola, C.F.1    Smith, M.T.2    Kane, E.3
  • 5
    • 0031687887 scopus 로고    scopus 로고
    • A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
    • Weisberg I, Tran P, Christensen B, et al. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 1998;64:169-172.
    • (1998) Mol Genet Metab , vol.64 , pp. 169-172
    • Weisberg, I.1    Tran, P.2    Christensen, B.3
  • 6
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-113.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 7
    • 0036707812 scopus 로고    scopus 로고
    • Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms
    • Tran P, Leclerc D, Chan M, et al. Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms. Mamm Genome 2002;13:483-492.
    • (2002) Mamm Genome , vol.13 , pp. 483-492
    • Tran, P.1    Leclerc, D.2    Chan, M.3
  • 8
    • 0033005239 scopus 로고    scopus 로고
    • The role of the 5'untranslated region of an mRNA in translation regulation during development
    • van der Velden AW, Tomas AA. The role of the 5'untranslated region of an mRNA in translation regulation during development. Int J Biochem Cell Biol 1999;31:87-106.
    • (1999) Int J Biochem Cell Biol , vol.31 , pp. 87-106
    • Van Der Velden, A.W.1    Tomas, A.A.2
  • 9
    • 84884704672 scopus 로고    scopus 로고
    • The human MTHFR rs4846049 polymorphism increases coronary heart disease risk through modifying miRNA binding
    • Wu C, Gong Y, Sun A, et al. The human MTHFR rs4846049 polymorphism increases coronary heart disease risk through modifying miRNA binding. Nutr Metab Cardiovasc Dis 2013;23:693-698.
    • (2013) Nutr Metab Cardiovasc Dis , vol.23 , pp. 693-698
    • Wu, C.1    Gong, Y.2    Sun, A.3
  • 10
    • 0015228022 scopus 로고
    • Mammalian methylenetetrahydrofolate reductase. Partial purif cation, properties, and inhibition by S-adenosylmethionine
    • Kutzbach C, Stokstad EL. Mammalian methylenetetrahydrofolate reductase. Partial purif cation, properties, and inhibition by S-adenosylmethionine. Biochim Biophys Acta 1971;250:459-477.
    • (1971) Biochim Biophys Acta , vol.250 , pp. 459-477
    • Kutzbach, C.1    Stokstad, E.L.2
  • 11
    • 23044461104 scopus 로고    scopus 로고
    • Regulation of human methylenetetrahydrofolate reductase by phosphorylation
    • Yamada K, Strahler JR, Andrews PC, et al. Regulation of human methylenetetrahydrofolate reductase by phosphorylation. Proc Natl Acad Sci USA 2005;102:10454-10459.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 10454-10459
    • Yamada, K.1    Strahler, J.R.2    Andrews, P.C.3
  • 12
    • 84885190937 scopus 로고    scopus 로고
    • The Effects of non-synonymous single nucleotide polymorphisms (nsSNPs) on protein-protein interactions
    • Yates CM, Sternberg MJ. The Effects of non-synonymous single nucleotide polymorphisms (nsSNPs) on protein-protein interactions. J Mol Biol 2013;425:3949-3963.
    • (2013) J Mol Biol , vol.425 , pp. 3949-3963
    • Yates, C.M.1    Sternberg, M.J.2
  • 13
    • 27644478284 scopus 로고    scopus 로고
    • The distribution of SNPs in human gene regulatory regions
    • Guo Y, Jamison DC. The distribution of SNPs in human gene regulatory regions. BMC Genomics 2005;6:140.
    • (2005) BMC Genomics , vol.6 , pp. 140
    • Guo, Y.1    Jamison, D.C.2
  • 14
    • 84874637732 scopus 로고    scopus 로고
    • The impact of 3 ′ UTR variants on dif erential expression of candidate cancer susceptibility genes
    • Skeeles LE, Fleming JL, Mahler KL, et al. The impact of 3 ′ UTR variants on dif erential expression of candidate cancer susceptibility genes. PLoS One 2013;8:e58609.
    • (2013) PLoS One , vol.8 , pp. e58609
    • Skeeles, L.E.1    Fleming, J.L.2    Mahler, K.L.3
  • 15
    • 84866084186 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms can create alternative polyadenylation signals and af ect gene expression through loss of microRNA-regulation
    • T omas LF, Saetrom P. Single nucleotide polymorphisms can create alternative polyadenylation signals and af ect gene expression through loss of microRNA-regulation. PLoS Comput Biol 2012; 8: e1002621.
    • (2012) PLoS Comput Biol , vol.8 , pp. e1002621
    • Tomas, L.F.1    Saetrom, P.2
  • 16
    • 84869404521 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism C677T is a protective factor for pediatric acute lymphoblastic leukemia in the Chinese population: A meta-analysis
    • Wang H, Meng L, Zhao L, et al. Methylenetetrahydrofolate reductase polymorphism C677T is a protective factor for pediatric acute lymphoblastic leukemia in the Chinese population: a meta-analysis. Genet Test Mol Biomarkers 2012;16:1401-1407.
    • (2012) Genet Test Mol Biomarkers , vol.16 , pp. 1401-1407
    • Wang, H.1    Meng, L.2    Zhao, L.3
  • 17
    • 33750090420 scopus 로고    scopus 로고
    • A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia
    • Zintzaras E, Koufakis T, Ziakas PD, et al. A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia. Eur J Epidemiol 2006;21:501-510.
    • (2006) Eur J Epidemiol , vol.21 , pp. 501-510
    • Zintzaras, E.1    Koufakis, T.2    Ziakas, P.D.3
  • 18
    • 33750497230 scopus 로고    scopus 로고
    • 5, 10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: A meta-analysis
    • Pereira TV, Rudnicki M, Pereira AC, et al. 5, 10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 2006;15:1956-1963.
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 1956-1963
    • Pereira, T.V.1    Rudnicki, M.2    Pereira, A.C.3
  • 19
    • 80053212404 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms and acute lymphoblastic leukemia risk: A meta-analysis based on 28 case-control studies
    • Tong N, Sheng X, Wang M, et al. Methylenetetrahydrofolate reductase gene polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis based on 28 case-control studies. Leuk Lymphoma 2011;52:1949-1960.
    • (2011) Leuk Lymphoma , vol.52 , pp. 1949-1960
    • Tong, N.1    Sheng, X.2    Wang, M.3
  • 20
    • 84865620566 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia-evidence from an updated meta-analysis including 35 studies
    • Wang H, Wang J, Zhao L, et al. Methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia-evidence from an updated meta-analysis including 35 studies. BMC Med Genet 2012;13:77.
    • (2012) BMC Med Genet , vol.13 , pp. 77
    • Wang, H.1    Wang, J.2    Zhao, L.3
  • 21
    • 84858798304 scopus 로고    scopus 로고
    • Variants of the MTHFR gene and susceptibility to acute lymphoblastic leukemia in children: A synthesis of genetic association studies
    • Zintzaras E, Doxani C, Rodopoulou P, et al. Variants of the MTHFR gene and susceptibility to acute lymphoblastic leukemia in children: a synthesis of genetic association studies. Cancer Epidemiol 2012;36:169-176.
    • (2012) Cancer Epidemiol , vol.36 , pp. 169-176
    • Zintzaras, E.1    Doxani, C.2    Rodopoulou, P.3
  • 22
    • 84862496495 scopus 로고    scopus 로고
    • Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in North India
    • Nikbakht M, Malek Zadeh K, Kumar Jha A, et al. Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in North India. Exp Oncol 2012;34:43-48.
    • (2012) Exp Oncol , vol.34 , pp. 43-48
    • Nikbakht, M.1    Malek Zadeh, K.2    Kumar Jha, A.3
  • 23
    • 77951771318 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms: Association with risk for pediatric acute lymphoblastic leukemia in north Indians
    • Sood S, Das R, Trehan A, et al. Methylenetetrahydrofolate reductase gene polymorphisms: association with risk for pediatric acute lymphoblastic leukemia in north Indians. Leuk Lymphoma 2010;51:928-932.
    • (2010) Leuk Lymphoma , vol.51 , pp. 928-932
    • Sood, S.1    Das, R.2    Trehan, A.3
  • 24
    • 34250899593 scopus 로고    scopus 로고
    • Multiplex PCR-based reverse line blot hybridization assay (mPCR/RLB)-a practical epidemiological and diagnostic tool
    • Kong F, Gilbert GL. Multiplex PCR-based reverse line blot hybridization assay (mPCR/RLB)-a practical epidemiological and diagnostic tool. Nat Protoc 2006;1:2668-2680.
    • (2006) Nat Protoc , vol.1 , pp. 2668-2680
    • Kong, F.1    Gilbert, G.L.2
  • 25
    • 0346966836 scopus 로고    scopus 로고
    • Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia
    • Krajinovic M, Lamothe S, Labuda D, et al. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood 2004;103:252-257.
    • (2004) Blood , vol.103 , pp. 252-257
    • Krajinovic, M.1    Lamothe, S.2    Labuda, D.3
  • 26
    • 12744274510 scopus 로고    scopus 로고
    • Heterogeneity testing in meta-analysis of genome searches
    • Zintzaras E, Ioannidis JP. Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol 2005;28:123-137.
    • (2005) Genet Epidemiol , vol.28 , pp. 123-137
    • Zintzaras, E.1    Ioannidis, J.P.2
  • 27
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • Higgins JP, T ompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002 15;21:1539-1558.
    • (2002) Stat Med , vol.15 , Issue.21 , pp. 1539-1558
    • Higgins, J.P.1    Tompson, S.G.2
  • 28
    • 0041876133 scopus 로고    scopus 로고
    • Measuring inconsistency in meta-analyses
    • Higgins JP, T ompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-560
    • (2003) BMJ , vol.327 , pp. 557-560
    • Higgins, J.P.1    Tompson, S.G.2    Deeks, J.J.3
  • 29
    • 32544442291 scopus 로고    scopus 로고
    • Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations
    • Trikalinos TA, Salanti G, Khoury MJ, et al. Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations. Am J Epidemiol 2006;163:300-309.
    • (2006) Am J Epidemiol , vol.163 , pp. 300-309
    • Trikalinos, T.A.1    Salanti, G.2    Khoury, M.J.3
  • 30
    • 79952058159 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase gene polymorphisms and essential hypertension in Han Chinese
    • Wang HG, Wang JL, Chang P, et al. Endothelial nitric oxide synthase gene polymorphisms and essential hypertension in Han Chinese. Genet Mol Res 2010; 9: 1896-1907.
    • (2010) Genet Mol Res , vol.9 , pp. 1896-1907
    • Wang, H.G.1    Wang, J.L.2    Chang, P.3
  • 32
    • 84892432033 scopus 로고    scopus 로고
    • Genetic association of KCNJ10 rs1130183 with seizure susceptibility and computational analysis of deleterious non-synonymous SNPs of KCNJ10 gene
    • Phani NM, Acharya S, Xavy S, et al. Genetic association of KCNJ10 rs1130183 with seizure susceptibility and computational analysis of deleterious non-synonymous SNPs of KCNJ10 gene. Gene 2014;536:247-253.
    • (2014) Gene , vol.536 , pp. 247-253
    • Phani, N.M.1    Acharya, S.2    Xavy, S.3
  • 33
    • 84891471650 scopus 로고    scopus 로고
    • Structural and functional analysis of human SOD1 in amyotrophic lateral sclerosis
    • Moreira LG, Pereira LC, Drummond PR, et al. Structural and functional analysis of human SOD1 in amyotrophic lateral sclerosis. PLoS One 2013;8:e81979.
    • (2013) PLoS One , vol.8 , pp. e81979
    • Moreira, L.G.1    Pereira, L.C.2    Drummond, P.R.3
  • 34
    • 84857691987 scopus 로고    scopus 로고
    • Genome-wide identif cation of SNPs in microRNA genes and the SNP Effects on microRNA target binding and biogenesis
    • Gong J, Tong Y, Zhang HM, et al. Genome-wide identif cation of SNPs in microRNA genes and the SNP Effects on microRNA target binding and biogenesis. Hum Mutat 2012;33:254-263.
    • (2012) Hum Mutat , vol.33 , pp. 254-263
    • Gong, J.1    Tong, Y.2    Zhang, H.M.3
  • 35
    • 84869884324 scopus 로고    scopus 로고
    • MirSNP, a database of polymorphisms altering miRNA target sites, identif es miRNA-related SNPs in GWAS SNPs and eQTLs
    • Liu C, Zhang F, Li T, et al. MirSNP, a database of polymorphisms altering miRNA target sites, identif es miRNA-related SNPs in GWAS SNPs and eQTLs. BMC Genomics 2012;13:661.
    • (2012) BMC Genomics , vol.13 , pp. 661
    • Liu, C.1    Zhang, F.2    Li, T.3
  • 36
    • 84862162057 scopus 로고    scopus 로고
    • PolymiRTS Database 2.0: Linking polymorphisms in microRNA target sites with human diseases and complex traits
    • Database issue)
    • Ziebarth JD, Bhattacharya A, Chen A, et al. PolymiRTS Database 2.0: linking polymorphisms in microRNA target sites with human diseases and complex traits. Nucleic Acids Res 2012; 40(Database issue):D216-D221.
    • (2012) Nucleic Acids Res , vol.40 , pp. D216-D221
    • Ziebarth, J.D.1    Bhattacharya, A.2    Chen, A.3
  • 37
    • 33747697063 scopus 로고    scopus 로고
    • Polymorphisms in the MTHFR gene and their possible association with susceptibility to childhood acute lymphocytic leukemia in an Indian population
    • Reddy H, Jamil K. Polymorphisms in the MTHFR gene and their possible association with susceptibility to childhood acute lymphocytic leukemia in an Indian population. Leuk Lymphoma 2006; 47: 1333-1339.
    • (2006) Leuk Lymphoma , vol.47 , pp. 1333-1339
    • Reddy, H.1    Jamil, K.2
  • 38
    • 75749092993 scopus 로고    scopus 로고
    • M ethylenetetrahydrofolate reductase gene polymorphisms and risk of acute lymphoblastic leukemia in children
    • Sadananda Adiga MN, Chandy S, Ramachandra N, et al. M ethylenetetrahydrofolate reductase gene polymorphisms and risk of acute lymphoblastic leukemia in children. Indian J Cancer 2010; 47:40-45.
    • (2010) Indian J Cancer , vol.47 , pp. 40-45
    • Sadananda Adiga, M.N.1    Chandy, S.2    Ramachandra, N.3
  • 39
    • 84932159725 scopus 로고    scopus 로고
    • MTHFR gene polymorphisms and the risk of acute lymphoblastic leukemia in adults and children: A case control study in India
    • Sazawal S, Chaubey R, Kaur P, et al. MTHFR gene polymorphisms and the risk of acute lymphoblastic leukemia in adults and children: a case control study in India. Indian J Hematol Blood Transfus 2013: 1-7.
    • Indian J Hematol Blood Transfus , vol.2013 , pp. 1-7
    • Sazawal, S.1    Chaubey, R.2    Kaur, P.3
  • 40
    • 84863498117 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T genetic polymorphisms and risk of leukaemia among the North Indian population
    • Hussain SR, Naqvi H, Raza ST, et al. Methylenetetrahydrofolate reductase C677T genetic polymorphisms and risk of leukaemia among the North Indian population. Cancer Epidemiol 2012;36:e227-e231.
    • (2012) Cancer Epidemiol , vol.36 , pp. e227-e231
    • Hussain, S.R.1    Naqvi, H.2    Raza, S.T.3
  • 41
    • 63449123250 scopus 로고    scopus 로고
    • The methylenetetrahydrofolate reductase C677T mutation induces cell-specif c changes in genomic DNA methylation and uracil misincorporation: A possible molecular basis for the site-specif c cancer risk modif cation
    • Sohn KJ, Jang H, Campan M, et al. The methylenetetrahydrofolate reductase C677T mutation induces cell-specif c changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specif c cancer risk modif cation. Int J Cancer 2009;124:1999-2005.
    • (2009) Int J Cancer , vol.124 , pp. 1999-2005
    • Sohn, K.J.1    Jang, H.2    Campan, M.3
  • 42
    • 20144371859 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase 677C-T polymorphism and folate status af ect one-carbon incorporation into human DNA deoxynucleosides
    • Quinlivan EP, Davis SR, Shelnutt KP, et al. Methylenetetrahydrofolate reductase 677C-T polymorphism and folate status af ect one-carbon incorporation into human DNA deoxynucleosides. J Nutr 2005;135:389-396.
    • (2005) J Nutr , vol.135 , pp. 389-396
    • Quinlivan, E.P.1    Davis, S.R.2    Shelnutt, K.P.3
  • 43
    • 77952749179 scopus 로고    scopus 로고
    • Association between the methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia in Serbian children
    • Damnjanovic T, Milicevic R, Novkovic T, et al. Association between the methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia in Serbian children. J Pediatr Hematol Oncol 2010;32:e148-e150.
    • (2010) J Pediatr Hematol Oncol , vol.32 , pp. e148-e150
    • Damnjanovic, T.1    Milicevic, R.2    Novkovic, T.3
  • 44
    • 0035672957 scopus 로고    scopus 로고
    • The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia
    • Franco RF, Simoes BP, Tone LG, et al. The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia. Br J Haematol 2001; 115: 616-618.
    • (2001) Br J Haematol , vol.115 , pp. 616-618
    • Franco, R.F.1    Simoes, B.P.2    Tone, L.G.3
  • 45
    • 77952611948 scopus 로고    scopus 로고
    • Genetic variation in the folate metabolic pathway and risk of pediatric leukemia
    • Lightfoot TJ, Johnston WT, Painter D, et al. Genetic variation in the folate metabolic pathway and risk of pediatric leukemia. Blood. 2010;115:3923-3929.
    • (2010) Blood. , vol.115 , pp. 3923-3929
    • Lightfoot, T.J.1    Johnston, W.T.2    Painter, D.3
  • 46
    • 72249086376 scopus 로고    scopus 로고
    • Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia
    • Koppen IJ, Hermans FJ, Kaspers GJ. Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia. Br J Haematol 2010; 148: 3-14.
    • (2010) Br J Haematol , vol.148 , pp. 3-14
    • Koppen, I.J.1    Hermans, F.J.2    Kaspers, G.J.3
  • 47
    • 33846537961 scopus 로고    scopus 로고
    • Folate metabolic gene polymorphisms and pediatric acute lymphoblastic leukemia: A case-control study
    • Gast A, Bermejo JL, Flohr T, et al. Folate metabolic gene polymorphisms and pediatric acute lymphoblastic leukemia: a case-control study. Leukemia 2007;21:320-325.
    • (2007) Leukemia , vol.21 , pp. 320-325
    • Gast, A.1    Bermejo, J.L.2    Flohr, T.3
  • 48
    • 79960194080 scopus 로고    scopus 로고
    • Bioinformatic and genetic association analysis of microRNA target sites in one-carbon metabolism genes
    • Stone N, Pangilinan F, Molloy AM, et al. Bioinformatic and genetic association analysis of microRNA target sites in one-carbon metabolism genes. PLoS One 2011; 6: e21851.
    • (2011) PLoS One , vol.6 , pp. e21851
    • Stone, N.1    Pangilinan, F.2    Molloy, A.M.3
  • 49
    • 84899480846 scopus 로고    scopus 로고
    • Chemokine receptor CCR6 expression is regulated by miR-518a-5p in colorectal cancer cells
    • Rubie C, Kruse B, Frick VO, et al. Chemokine receptor CCR6 expression is regulated by miR-518a-5p in colorectal cancer cells. J Transl Med 2014;12:48.
    • (2014) J Transl Med , vol.12 , pp. 48
    • Rubie, C.1    Kruse, B.2    Frick, V.O.3
  • 50
    • 84894422455 scopus 로고    scopus 로고
    • Intraindividual somatic variations in MTHFR gene polymorphisms in relation to colon cancer
    • Rai PS, Pai GC, Alvares JF, et al. Intraindividual somatic variations in MTHFR gene polymorphisms in relation to colon cancer. Pharmacogenomics 2014;15:349-359.
    • (2014) Pharmacogenomics , vol.15 , pp. 349-359
    • Rai, P.S.1    Pai, G.C.2    Alvares, J.F.3
  • 51
    • 76749104337 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms and the risk of colorectal carcinoma in a sample of Egyptian individuals
    • ElAwady MK, Karim AM, Hanna LS, et al. Methylenetetrahydrofolate reductase gene polymorphisms and the risk of colorectal carcinoma in a sample of Egyptian individuals. Cancer Biomark 2009;5:233-240.
    • (2009) Cancer Biomark , vol.5 , pp. 233-240
    • Elawady, M.K.1    Karim, A.M.2    Hanna, L.S.3


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