Next generation sequencing and its applications in forensic genetics

Forensic Science International: Genetics

Volumn 18, Issue , 2015, Pages 78-89

  Børsting, Claus ^a   Morling, Niels ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Forensic genetics; Next generation sequencing; Review; Single molecule sequencing

Indexed keywords

ARTICLE; DNA SEQUENCE; DNA SYNTHESIS; FORENSIC GENETICS; GENE EXPRESSION; HIGH THROUGHPUT SEQUENCING; HUMAN; INDEL MUTATION; NEXT GENERATION SEQUENCING; PRIORITY JOURNAL; PYROSEQUENCING; RNA SEQUENCE; SIGNAL DETECTION; POLYMERASE CHAIN REACTION; PROCEDURES; SINGLE NUCLEOTIDE POLYMORPHISM; TRENDS;

MICROSATELLITE DNA;

FORENSIC GENETICS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MICROSATELLITE REPEATS; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA;

EID: 84932127543     PISSN: 18724973     EISSN: 18780326     Source Type: Journal    
DOI: 10.1016/j.fsigen.2015.02.002     Document Type: Article

References (94)

1. R. Higuchi, C.H. von Beroldingen, G.F. Sensabaugh, and H.A. Erlich DNA typing from single hairs Nature 332 1988 543 546
2. C. Ginther, L. Issel-Tarver, and M.C. King Identifying individuals by sequencing mitochondrial DNA from teeth Nat. Genet. 2 1992 135 138
3. K.M. Sullivan, R. Hopgood, and P. Gill Identification of human remains by amplification and automated sequencing of mitochondrial DNA Int. J. Legal Med. 105 1992 83 86
4. W. Parson, A. Brandstatter, A. Alonso, N. Brandt, B. Brinkmann, A. Carracedo, D. Corach, O. Froment, I. Furac, T. Grzybowski, K. Hedberg, C. Keyser-Tracqui, T. Kupiec, S. Lutz-Bonengel, B. Mevag, R. Ploski, H. Schmitter, P. Schneider, D. Syndercombe-Court, E. Sorensen, H. Thew, G. Tully, and R. Scheithauer The EDNAP mitochondrial DNA population database (EMPOP) collaborative exercises: organisation, results and perspectives Forensic Sci. Int. 139 2004 215 226
5. W. Parson, and H.J. Bandelt Extended guidelines for mtDNA typing of population data in forensic science Forensic Sci. Int. Genet. 1 2007 13 19
6. F. Sanger, S. Nicklen, and A.R. Coulson DNA sequencing with chain-terminating inhibitors Proc. Natl. Acad. Sci. U. S. A. 74 1977 5463 5467
7. K.R. Mitchelson The use of capillary electrophoresis for DNA polymorphism analysis Mol. Biotechnol. 24 2003 41 68
8. C. Børsting, and N. Morling Single nucleotide polymorphisms J.A. Siegel, S. Pekka, Encyclopedia of Forensic Sciences 2013 Elsevier Maryland, USA 233 239
9. C. Børsting, E. Rockenbauer, and N. Morling Validation of a single nucleotide polymorphism (SNP) typing assay with 49 SNPs for forensic genetic testing in a laboratory accredited according to the ISO 17025 standard Forensic Sci. Int. Genet. 4 2009 34 42
10. C. Børsting, M. Mikkelsen, and N. Morling Kinship analysis with diallelic SNPs - experiences with the SNPforID Multiplex in an ISO17025 accreditated laboratory Transfus. Med. Hemother. 39 2012 195 201
11. S. Walsh, A. Lindenbergh, S.B. Zuniga, T. Sijen, P. de Knijff, M. Kayser, and K.N. Ballantyne Developmental validation of the IrisPlex system: determination of blue and brown iris colour for forensic intelligence Forensic Sci. Int. Genet. 5 2011 464 471
12. S. Walsh, L. Chaitanya, L. Clarisse, L. Wirken, J. Draus-Barini, L. Kovatsi, H. Maeda, T. Ishikawa, T. Sijen, P. de Knijff, W. Branicki, F. Liu, and M. Kayser Developmental validation of the HIrisPlex system: DNA-based eye and hair colour prediction for forensic and anthropological usage Forensic Sci. Int. Genet. 9 2014 150 161
13. C. Phillips, A. Salas, J.J. Sanchez, M. Fondevila, A. Gomez-Tato, J. Alvarez-Dios, M. Calaza, M.C. de Cal, D. Ballard, M.V. Lareu, A. Carracedo, and S.N. Consortium Inferring ancestral origin using a single multiplex assay of ancestry-informative marker SNPs Forensic Sci. Int. Genet. 1 2007 273 280
14. C. Phillips, L. Prieto, M. Fondevila, A. Salas, A. Gomez-Tato, J. Alvarez-Dios, A. Alonso, A. Blanco-Verea, M. Brion, M. Montesino, A. Carracedo, and M.V. Lareu Ancestry analysis in the 11-M Madrid bomb attack investigation PLoS One 4 2009 e6583
15. M. Ronaghi, S. Karamohamed, B. Pettersson, M. Uhlen, and P. Nyren Real-time DNA sequencing using detection of pyrophosphate release Anal. Biochem. 242 1996 84 89
16. H. Andreasson, A. Asp, A. Alderborn, U. Gyllensten, and M. Allen Mitochondrial sequence analysis for forensic identification using pyrosequencing technology Biotechniques 32 2002 124-126, 128, 130-133
17. H. Andreasson, M. Nilsson, B. Budowle, S. Frisk, and M. Allen Quantification of mtDNA mixtures in forensic evidence material using pyrosequencing Int. J. Legal Med. 120 2006 383 390
18. A.M. Divne, H. Edlund, and M. Allen Forensic analysis of autosomal STR markers using pyrosequencing Forensic Sci. Int. Genet. 4 2010 122 129
19. M. Margulies, M. Egholm, W.E. Altman, S. Attiya, J.S. Bader, L.A. Bemben, J. Berka, M.S. Braverman, Y.J. Chen, Z. Chen, S.B. Dewell, L. Du, J.M. Fierro, X.V. Gomes, B.C. Godwin, W. He, S. Helgesen, C.H. Ho, G.P. Irzyk, S.C. Jando, M.L. Alenquer, T.P. Jarvie, K.B. Jirage, J.B. Kim, J.R. Knight, J.R. Lanza, J.H. Leamon, S.M. Lefkowitz, M. Lei, J. Li, K.L. Lohman, H. Lu, V.B. Makhijani, K.E. McDade, M.P. McKenna, E.W. Myers, E. Nickerson, J.R. Nobile, R. Plant, B.P. Puc, M.T. Ronan, G.T. Roth, G.J. Sarkis, J.F. Simons, J.W. Simpson, M. Srinivasan, K.R. Tartaro, A. Tomasz, K.A. Vogt, G.A. Volkmer, S.H. Wang, Y. Wang, M.P. Weiner, P. Yu, R.F. Begley, and J.M. Rothberg Genome sequencing in microfabricated high-density picolitre reactors Nature 437 2005 376 380
20. D.A. Wheeler, M. Srinivasan, M. Egholm, Y. Shen, L. Chen, A. McGuire, W. He, Y.J. Chen, V. Makhijani, G.T. Roth, X. Gomes, K. Tartaro, F. Niazi, C.L. Turcotte, G.P. Irzyk, J.R. Lupski, C. Chinault, X.Z. Song, Y. Liu, Y. Yuan, L. Nazareth, X. Qin, D.M. Muzny, M. Margulies, G.M. Weinstock, R.A. Gibbs, and J.M. Rothberg The complete genome of an individual by massively parallel DNA sequencing Nature 452 2008 872 876
21. K.V. Voelkerding, S.A. Dames, and J.D. Durtschi Next-generation sequencing: from basic research to diagnostics Clin. Chem. 55 2009 641 658
22. I. Braslavsky, B. Hebert, E. Kartalov, and S.R. Quake Sequence information can be obtained from single DNA molecules Proc. Natl. Acad. Sci. U. S. A. 100 2003 3960 3964
23. T.D. Harris, P.R. Buzby, H. Babcock, E. Beer, J. Bowers, I. Braslavsky, M. Causey, J. Colonell, J. Dimeo, J.W. Efcavitch, E. Giladi, J. Gill, J. Healy, M. Jarosz, D. Lapen, K. Moulton, S.R. Quake, K. Steinmann, E. Thayer, A. Tyurina, R. Ward, H. Weiss, and Z. Xie Single-molecule DNA sequencing of a viral genome Science 320 2008 106 109
24. E.R. Mardis Next-generation DNA sequencing methods Annu. Rev. Genomics Hum. Genet. 9 2008 387 402
25. M.L. Metzker Sequencing technologies - the next generation Nat. Rev. Genet. 11 2010 31 46
26. J. Korlach, K.P. Bjornson, B.P. Chaudhuri, R.L. Cicero, B.A. Flusberg, J.J. Gray, D. Holden, R. Saxena, J. Wegener, and S.W. Turner Real-time DNA sequencing from single polymerase molecules Methods Enzymol. 472 2010 431 455
27. R. Nielsen, J.S. Paul, A. Albrechtsen, and Y.S. Song Genotype and SNP calling from next-generation sequencing data Nat. Rev. Genet. 12 2011 443 451
28. A. Altmann, P. Weber, D. Bader, M. Preuss, E.B. Binder, and B. Muller-Myhsok A beginners guide to SNP calling from high-throughput DNA-sequencing data Hum. Genet. 131 2012 1541 1554
29. F. Ozsolak Third-generation sequencing techniques and applications to drug discovery Expert Opin. Drug Discov. 7 2012 231 243
30. F. Haque, J. Li, H.C. Wu, X.J. Liang, and P. Guo Solid-state and biological nanopore for real-time sensing of single chemical and sequencing of DNA Nano Today 8 2013 56 74
31. D. Goldman, and K. Domschke Making sense of deep sequencing Int. J. Neuropsychopharmacol. 2014 1 9
32. N. Cloonan, and S.M. Grimmond Transcriptome content and dynamics at single-nucleotide resolution Genome Biol. 9 2008 234
33. M. Yano, T. Ohtsuka, and H. Okano RNA-binding protein research with transcriptome-wide technologies in neural development Cell Tissue Res. 359 2014 135 144
34. L. Mamanova, A.J. Coffey, C.E. Scott, I. Kozarewa, E.H. Turner, A. Kumar, E. Howard, J. Shendure, and D.J. Turner Target-enrichment strategies for next-generation sequencing Nat. Methods 7 2010 111 118
35. X. Liu, J. Wang, and L. Chen Whole-exome sequencing reveals recurrent somatic mutation networks in cancer Cancer Lett. 340 2013 270 276
36. I.S. Hagemann, C.E. Cottrell, and C.M. Lockwood Design of targeted capture-based, next generation sequencing tests for precision cancer therapy Cancer Genet. 206 2013 420 431
37. D. Dressman, H. Yan, G. Traverso, K.W. Kinzler, and B. Vogelstein Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations Proc. Natl. Acad. Sci. U. S. A. 100 2003 8817 8822
38. M. Fedurco, A. Romieu, S. Williams, I. Lawrence, and G. Turcatti BTA a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies Nucleic Acids Res. 34 2006 e22
39. P.M. Lundquist, C.F. Zhong, P. Zhao, A.B. Tomaney, P.S. Peluso, J. Dixon, B. Bettman, Y. Lacroix, D.P. Kwo, E. McCullough, M. Maxham, K. Hester, P. McNitt, D.M. Grey, C. Henriquez, M. Foquet, S.W. Turner, and D. Zaccarin Parallel confocal detection of single molecules in real time Opt. Lett. 33 2008 1026 1028
40. J. Eid, A. Fehr, J. Gray, K. Luong, J. Lyle, G. Otto, P. Peluso, D. Rank, P. Baybayan, B. Bettman, A. Bibillo, K. Bjornson, B. Chaudhuri, F. Christians, R. Cicero, S. Clark, R. Dalal, A. Dewinter, J. Dixon, M. Foquet, A. Gaertner, P. Hardenbol, C. Heiner, K. Hester, D. Holden, G. Kearns, X. Kong, R. Kuse, Y. Lacroix, S. Lin, P. Lundquist, C. Ma, P. Marks, M. Maxham, D. Murphy, I. Park, T. Pham, M. Phillips, J. Roy, R. Sebra, G. Shen, J. Sorenson, A. Tomaney, K. Travers, M. Trulson, J. Vieceli, J. Wegener, D. Wu, A. Yang, D. Zaccarin, P. Zhao, F. Zhong, J. Korlach, and S. Turner Real-time DNA sequencing from single polymerase molecules Science 323 2009 133 138
41. D.H. Stoloff, and M. Wanunu Recent trends in nanopores for biotechnology Curr. Opin. Biotechnol. 24 2013 699 704
42. L. Liang, Q. Wang, H. Agren, and Y. Tu Computational studies of DNA sequencing with solid-state nanopores: key issues and future prospects Front. Chem. 2 2014 1 4
43. A.S. Mikheyev, and M.M. Tin A first look at the Oxford Nanopore MinION sequencer Mol. Ecol. Resour. 14 2014 1097 1102
44. C.S. Chin, D.H. Alexander, P. Marks, A.A. Klammer, J. Drake, C. Heiner, A. Clum, A. Copeland, J. Huddleston, E.E. Eichler, S.W. Turner, and J. Korlach Nonhybrid, finished microbial genome assemblies from long-read SMRT sequencing data Nat. Methods 10 2013 563 569
45. J. Huddleston, S. Ranade, M. Malig, F. Antonacci, M. Chaisson, L. Hon, P.H. Sudmant, T.A. Graves, C. Alkan, M.Y. Dennis, R.K. Wilson, S.W. Turner, J. Korlach, and E.E. Eichler Reconstructing complex regions of genomes using long-read sequencing technology Genome Res. 24 2014 688 696
46. B.A. Flusberg, D.R. Webster, J.H. Lee, K.J. Travers, E.C. Olivares, T.A. Clark, J. Korlach, and S.W. Turner Direct detection of DNA methylation during single-molecule, real-time sequencing Nat. Methods 7 2010 461 465
47. E.V. Wallace, D. Stoddart, A.J. Heron, E. Mikhailova, G. Maglia, T.J. Donohoe, and H. Bayley Identification of epigenetic DNA modifications with a protein nanopore Chem. Commun. (Camb.) 46 2010 8195 8197
48. T.A. Clark, I.A. Murray, R.D. Morgan, A.O. Kislyuk, K.E. Spittle, M. Boitano, A. Fomenkov, R.J. Roberts, and J. Korlach Characterization of DNA methyltransferase specificities using single-molecule, real-time DNA sequencing Nucleic Acids Res. 40 2012 e29
49. J. Schreiber, Z.L. Wescoe, R. Abu-Shumays, J.T. Vivian, B. Baatar, K. Karplus, and M. Akeson Error rates for nanopore discrimination among cytosine, methylcytosine, and hydroxymethylcytosine along individual DNA strands Proc. Natl. Acad. Sci. U. S. A. 110 2013 18910 18915
50. M. Nothnagel, A. Herrmann, A. Wolf, S. Schreiber, M. Platzer, R. Siebert, M. Krawczak, and J. Hampe Technology-specific error signatures in the 1000 Genomes Project data Hum. Genet. 130 2011 505 516
51. H.Y. Lam, M.J. Clark, R. Chen, R. Chen, G. Natsoulis, M. O'Huallachain, F.E. Dewey, L. Habegger, E.A. Ashley, M.B. Gerstein, A.J. Butte, H.P. Ji, and M. Snyder Performance comparison of whole-genome sequencing platforms Nat. Biotechnol. 30 2012 78 82
52. A. Ratan, W. Miller, J. Guillory, J. Stinson, S. Seshagiri, and S.C. Schuster Comparison of sequencing platforms for single nucleotide variant calls in a human sample PLoS One 8 2013 e55089
53. N. Rieber, M. Zapatka, B. Lasitschka, D. Jones, P. Northcott, B. Hutter, N. Jager, M. Kool, M. Taylor, P. Lichter, S. Pfister, S. Wolf, B. Brors, and R. Eils Coverage bias and sensitivity of variant calling for four whole-genome sequencing technologies PLoS One 8 2013 e66621
54. H.L. Rehm Disease-targeted sequencing: a cornerstone in the clinic Nat. Rev. Genet. 14 2013 295 300
55. C. Beadling, T.L. Neff, M.C. Heinrich, K. Rhodes, M. Thornton, J. Leamon, M. Andersen, and C.L. Corless Combining highly multiplexed PCR with semiconductor-based sequencing for rapid cancer genotyping J. Mol. Diagn. 15 2013 171 176
56. S.Q. Wong, J. Li, A.Y. Tan, R. Vedururu, J.M. Pang, H. Do, J. Ellul, K. Doig, A. Bell, G.A. MacArthur, S.B. Fox, D.M. Thomas, A. Fellowes, J.P. Parisot, A. Dobrovic, and C. Cohort Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing BMC Med. Genomics 7 2014 23
57. L. Castera, S. Krieger, A. Rousselin, A. Legros, J.J. Baumann, O. Bruet, B. Brault, R. Fouillet, N. Goardon, O. Letac, S. Baert-Desurmont, J. Tinat, O. Bera, C. Dugast, P. Berthet, F. Polycarpe, V. Layet, A. Hardouin, T. Frebourg, and D. Vaur Next-generation sequencing for the diagnosis of hereditary breast and ovarian cancer using genomic capture targeting multiple candidate genes Eur. J. Hum. Genet. 22 2014 1305 1311
58. G. Millat, V. Chanavat, and R. Rousson Evaluation of a new high-throughput next-generation sequencing method based on a custom AmpliSeq Library and Ion Torrent PGM Sequencing for the rapid detection of genetic variations in long QT syndrome Mol. Diagn. Ther. 18 2014 533 539
59. J. Tarabeux, B. Zeitouni, V. Moncoutier, H. Tenreiro, K. Abidallah, S. Lair, P. Legoix-Ne, Q. Leroy, E. Rouleau, L. Golmard, E. Barillot, M.H. Stern, T. Rio-Frio, D. Stoppa-Lyonnet, and C. Houdayer Streamlined ion torrent PGM-based diagnostics: BRCA1 and BRCA2 genes as a model Eur. J. Hum. Genet. 22 2014 535 541
60. G.J. Tsongalis, J.D. Peterson, F.B. de Abreu, C.D. Tunkey, T.L. Gallagher, L.D. Strausbaugh, W.A. Wells, and C.I. Amos Routine use of the Ion Torrent AmpliSeq cancer hotspot panel for identification of clinically actionable somatic mutations Clin. Chem. Lab. Med. 52 2014 707 714
61. T.J. Treangen, and S.L. Salzberg Repetitive DNA and next-generation sequencing: computational challenges and solutions Nat. Rev. Genet. 13 2012 36 46
62. S.L. Fordyce, M.C. Avila-Arcos, E. Rockenbauer, C. Børsting, R. Frank-Hansen, F.T. Petersen, E. Willerslev, A.J. Hansen, N. Morling, and M.T. Gilbert High-throughput sequencing of core STR loci for forensic genetic investigations using the Roche Genome Sequencer FLX platform Biotechniques 51 2011 127 133
63. C. Van Neste, F. Van Nieuwerburgh, D. Van Hoofstat, and D. Deforce Forensic STR analysis using massive parallel sequencing Forensic Sci. Int. Genet. 6 2012 810 818
64. E. Rockenbauer, S. Hansen, M. Mikkelsen, C. Børsting, and N. Morling Characterization of mutations and sequence variants in the D21S11 locus by next generation sequencing Forensic Sci. Int. Genet. 8 2014 68 72
65. S. Dalsgaard, E. Rockenbauer, A. Buchard, H.S. Mogensen, R. Frank-Hansen, C. Børsting, and N. Morling Non-uniform phenotyping of D12S391 resolved by second generation sequencing Forensic Sci. Int. Genet. 8 2014 195 199
66. C. Gelardi, E. Rockenbauer, S. Dalsgaard, C. Børsting, and N. Morling Second generation sequencing of three STRs D3S1358, D12S391 and D21S11 in Danes and a new nomenclature for sequenced STR alleles Forensic Sci. Int. Genet. 12 2014 38 41
67. C. Tomas, H.S. Mogensen, S.L. Friis, C. Hallenberg, M.C. Stene, and N. Morling Concordance study and population frequencies for 16 autosomal STRs analyzed with PowerPlex(R) ESI 17 and AmpFlSTR(R) NGM SElect in Somalis, Danes and Greenlanders Forensic Sci. Int. Genet. 11 2014 e18 e21
68. A.A. Westen, T. Kraaijenbrink, E.A. Robles de Medina, J. Harteveld, P. Willemse, S.B. Zuniga, K.J. van der Gaag, N.E. Weiler, J. Warnaar, M. Kayser, T. Sijen, and P. de Knijff Comparing six commercial autosomal STR kits in a large Dutch population sample Forensic Sci. Int. Genet. 10 2014 55 63
69. M. Scheible, O. Loreille, R. Just, and J. Irwin Short tandem repeat typing on the 454 platform: strategies and considerations for targeted sequencing of common forensic markers Forensic Sci. Int. Genet. 12 2014 107 119
70. S.Y. Anvar, K.J. van der Gaag, J.W. van der Heijden, M.H. Veltrop, R.H. Vossen, R.H. de Leeuw, C. Breukel, H.P. Buermans, J.S. Verbeek, P. de Knijff, J.T. den Dunnen, and J.F. Laros TSSV: a tool for characterization of complex allelic variants in pure and mixed genomes Bioinformatics 30 2014 1651 1659
71. D.M. Bornman, M.E. Hester, J.M. Schuetter, M.D. Kasoji, A. Minard-Smith, C.A. Barden, S.C. Nelson, G.D. Godbold, C.H. Baker, B. Yang, J.E. Walther, I.E. Tornes, P.S. Yan, B. Rodriguez, R. Bundschuh, M.L. Dickens, B.A. Young, and S.A. Faith Short-read, high-throughput sequencing technology for STR genotyping Biotechniques 1-6 2012 10.2144/000113857
72. D.H. Warshauer, D. Lin, K. Hari, R. Jain, C. Davis, B. Larue, J.L. King, and B. Budowle STRait Razor: a length-based forensic STR allele-calling tool for use with second generation sequencing data Forensic Sci. Int. Genet. 7 2013 409 417
73. C. Van Neste, M. Vandewoestyne, W. Van Criekinge, D. Deforce, and F. Van Nieuwerburgh My-Forensic-Loci-queries (MyFLq) framework for analysis of forensic STR data generated by massive parallel sequencing Forensic Sci. Int. Genet. 9 2014 1 8
74. S.L. Fordyce, H.S. Mogensen, C. Borsting, R.E. Lagace, C.W. Chang, N. Rajagopalan, and N. Morling Second-generation sequencing of forensic STRs using the Ion Torrent HID STR 10-plex and the Ion PGM Forensic Sci. Int. Genet. 14 2015 132 140
75. S. Dalsgaard, E. Rockenbauer, C. Gelardi, C. Børsting, S.L. Fordyce, and N. Morling Characterization of mutations and sequence variations in complex STR loci by second generation sequencing Forensic Sci. Int. Genet. Suppl. 4 2013 e218 e219
76. C. Børsting, S.L. Fordyce, J. Olofsson, H.S. Mogensen, and N. Morling Evaluation of the Ion Torrent HID SNP 169-plex: a SNP typing assay developed for human identification by second generation sequencing Forensic Sci. Int. Genet. 12 2014 144 154
77. S.B. Seo, J.L. King, D.H. Warshauer, C.P. Davis, J. Ge, and B. Budowle Single nucleotide polymorphism typing with massively parallel sequencing for human identification Int. J. Legal Med. 127 2013 1079 1086
78. J.J. Sanchez, C. Phillips, C. Børsting, K. Balogh, M. Bogus, M. Fondevila, C.D. Harrison, E. Musgrave-Brown, A. Salas, D. Syndercombe-Court, P.M. Schneider, A. Carracedo, and N. Morling A multiplex assay with 52 single nucleotide polymorphisms for human identification Electrophoresis 27 2006 1713 1724
79. A.J. Pakstis, W.C. Speed, R. Fang, F.C. Hyland, M.R. Furtado, J.R. Kidd, and K.K. Kidd SNPs for a universal individual identification panel Hum. Genet. 127 2010 315 324
80. R. Nassir, R. Kosoy, C. Tian, P.A. White, L.M. Butler, G. Silva, R. Kittles, M.E. Alarcon-Riquelme, P.K. Gregersen, J.W. Belmont, F.M. De La Vega, and M.F. Seldin An ancestry informative marker set for determining continental origin: validation and extension using human genome diversity panels BMC Genet. 10 2009 39
81. C.M. Nievergelt, A.X. Maihofer, T. Shekhtman, O. Libiger, X. Wang, K.K. Kidd, and J.R. Kidd Inference of human continental origin and admixture proportions using a highly discriminative ancestry informative 41-SNP panel Investig. Genet. 4 2013 13
82. S. Walsh, F. Liu, A. Wollstein, L. Kovatsi, A. Ralf, A. Kosiniak-Kamysz, W. Branicki, and M. Kayser The HIrisPlex system for simultaneous prediction of hair and eye colour from DNA Forensic Sci. Int. Genet. 7 2013 98 115
83. L. Poulsen, S.L. Friis, C. Hallenberg, B.T. Simonsen, and N. Morling A report of the 2009-2011 paternity and relationship testing workshops of the English Speaking Working Group of the International Society for Forensic Genetics Forensic Sci. Int. Genet. 9 2014 e1 e-2
84. A.R. Thomsen, C. Hallenberg, B.T. Simonsen, R.B. Langkjaer, and N. Morling A report of the 2002-2008 paternity testing workshops of the English Speaking Working Group of the International Society for Forensic Genetics Forensic Sci. Int. Genet. 3 2009 214 221
85. D.W. Gjertson, C.H. Brenner, M.P. Baur, A. Carracedo, F. Guidet, J.A. Luque, R. Lessig, W.R. Mayr, V.L. Pascali, M. Prinz, P.M. Schneider, and N. Morling ISFG: recommendations on biostatistics in paternity testing Forensic Sci. Int. Genet. 1 2007 223 231
86. C.L. Hertz, L. Ferrero-Miliani, R. Frank-Hansen, N. Morling, and H. Bundgaard A comparison of genetic findings in sudden cardiac death victims and cardiac patients: the importance of phenotypic classification Europace 2014 10.1093/europace/euu210
87. L.E. Visser, R.H. van Schaik, M. van Vliet, P.H. Trienekens, P.A. De Smet, A.G. Vulto, A. Hofman, C.M. van Duijn, and B.H. Stricker Allelic variants of cytochrome P450 2C9 modify the interaction between nonsteroidal anti-inflammatory drugs and coumarin anticoagulants Clin. Pharmacol. Ther. 77 2005 479 485
88. D. Sullivan, J.K. Pinsonneault, A.C. Papp, H. Zhu, S. Lemeshow, D.C. Mash, and W. Sadee Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction Transl. Psychiatry 3 2013 e222
89. M.J. Cox, W.O. Cookson, and M.F. Moffatt Sequencing the human microbiome in health and disease Hum. Mol. Genet. 22 2013 R88 R94
90. M.E. Quinones-Mateu, S. Avila, G. Reyes-Teran, and M.A. Martinez Deep sequencing: becoming a critical tool in clinical virology J. Clin. Virol. 61 2014 9 19
91. K.G. Frey, J.E. Herrera-Galeano, C.L. Redden, T.V. Luu, S.L. Servetas, A.J. Mateczun, V.P. Mokashi, and K.A. Bishop-Lilly Comparison of three next-generation sequencing platforms for metagenomic sequencing and identification of pathogens in blood BMC Genomics 15 2014 96
92. S.G. Tringe, and E.M. Rubin Metagenomics: DNA sequencing of environmental samples Nat. Rev. Genet. 6 2005 805 814
93. S. Giampaoli, A. Berti, R.M. Di Maggio, E. Pilli, A. Valentini, F. Valeriani, G. Gianfranceschi, F. Barni, L. Ripani, and V. Romano Spica The environmental biological signature: NGS profiling for forensic comparison of soils Forensic Sci. Int. 240 2014 41 47
94. J.M. Young, L.S. Weyrich, and A. Cooper Forensic soil DNA analysis using high-throughput sequencing: a comparison of four molecular markers Forensic Sci. Int. Genet. 13 2014 176 184