CCN2 suppresses catabolic effects of interleukin-1β through α5β1 and αVβ3 Integrins in nucleus pulposus cells: Implications in intervertebral disc degeneration

Journal of Biological Chemistry

Volumn 289, Issue 11, 2014, Pages 7374-7387

  Tran, Cassie M ^a   Schoepflin, Zachary R ^a   Markova, Dessislava Z ^a   Kepler, Christopher K ^a   Anderson, D Greg ^a   Shapiro, Irving M ^a   Risbud, Makarand V ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CYTOLOGY; GLYCOPROTEINS; PROTEINS;

BASAL EXPRESSION; INDUCTIVE EFFECTS; INFLAMMATORY CYTOKINES; INTER-VERTEBRAL DISC DEGENERATION; NEGATIVE FEEDBACK LOOP; PEPTIDE INHIBITORS; PROLYL HYDROXYLASE; PROTEIN EXPRESSIONS;

GENE EXPRESSION;

AGGRECANASE 2; CARISOPRODOL; CONNECTIVE TISSUE GROWTH FACTOR; ECHISTATIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTEGRIN RECEPTOR; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE 3; STROMELYSIN; SYNDECAN 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 5; VITRONECTIN RECEPTOR;

ARTICLE; BINDING SITE; CATABOLISM; CELL CULTURE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; INTERVERTEBRAL DISK DEGENERATION; NEGATIVE FEEDBACK; NUCLEUS PULPOSUS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MICROARRAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

CARTILAGE BIOLOGY; CHONDROCYTES; CYTOKINE; EXTRACELLULAR MATRIX PROTEINS; INTEGRINS;

ANIMALS; CHONDROCYTES; CONNECTIVE TISSUE GROWTH FACTOR; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GENE SILENCING; HEK293 CELLS; HUMANS; INFLAMMATION; INTEGRIN ALPHA5BETA1; INTEGRIN ALPHAVBETA3; INTERLEUKIN-1BETA; INTERVERTEBRAL DISC DEGENERATION; MUTAGENESIS, SITE-DIRECTED; NF-KAPPA B; PROMOTER REGIONS, GENETIC; RATS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84896263428     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.526111     Document Type: Article

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