T1ρ magnetic resonance imaging and discography pressure as novel biomarkers for disc degeneration and low back pain

Spine

Volumn 36, Issue 25, 2011, Pages 2190-2196

  Borthakur, Arijitt ^a   Maurer, Philip M ^b   Fenty, Matthew ^a   Wang, Chenyang ^a   Berger, Rachelle ^a   Yoder, Jonathon ^c   Balderston, Richard A ^b   Elliott, Dawn M ^c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b 3B Orthopaedics ^*  (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

discography; magnetic resonance imaging; T1rho

Indexed keywords

BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISKOGRAPHY; FEMALE; HUMAN; INFORMED CONSENT; INTERVERTEBRAL DISK DEGENERATION; LOW BACK PAIN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROGNOSIS; QUANTITATIVE ANALYSIS; RECEIVER OPERATING CHARACTERISTIC; INTERVERTEBRAL DISK; LUMBAR VERTEBRA; METHODOLOGY; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PRESSURE; PROSPECTIVE STUDY; RADIOGRAPHY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

ADULT; AGED; FEMALE; HUMANS; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; LOW BACK PAIN; LUMBAR VERTEBRAE; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PRESSURE; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 81855163358     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e31820287bf     Document Type: Article

References (36)

1. Wipf J, Deyo R. Low back pain. Med Clin North Am 1995; 79 : 231-46.
2. Adams M, Roughley P. What is intervertebral disc degeneration, and what causes it? Spine 2006; 31 : 2151-61.
3. Carragee EJ, Hannibal M. Diagnostic evaluation of low back pain. Orthop Clin North Am 2004; 35 : 7-16.
4. Buckwalter JA. Aging and degeneration of the human intervertebral disc. Spine 1995; 20 : 1307-14.
5. Pearce RH, Grimmer BJ, Adams ME. Degeneration and the chemical composition of the human lumbar intervertebral disc. J Orthop Res 1987; 5 : 198-205.
6. Antoniou J, Goudsouzian NM, Heathfield TF, et al. The human lumbar endplate. Evidence of changes in biosynthesis and denaturation of the extracellular matrix with growth, maturation, aging, and degeneration. Spine 1996; 21 : 1153-61.
7. Urban JP, McMullin JF. Swelling pressure of the lumbar intervertebral discs: Influence of age, spinal level, composition, and degeneration. Spine 1988; 13 : 179-87.
8. Johannessen W, Elliott DM. Effects of degeneration on the biphasic material properties of human nucleus pulposus in confined compression. Spine 2005; 30 : E724-9.
9. Cloyd J, Malhotra N, Weng L, et al. Material properties in unconfined compression of human nucleus pulposus, injectable hyaluronic acid-based hydrogels, and tissue engineering scaffolds. Eur Spine J 2007; 16 : 1892-8.
10. Marchand F, Ahmed AM. Investigation of the laminate structure of lumbar disc anulus fibrosus. Spine 1990; 15 : 402-10.
11. Andersson GB. What are the age-related changes in the spine? Baillieres Clin Rheumatol 1998; 12 : 161-73.
12. Kirkaldy-Willis WH, Wedge JH, Yong-Hing K, et al. Pathology and pathogenesis of lumbar spondylosis and stenosis. Spine 1978; 3 : 319-28.
13. Modic MT. Degenerative disc disease and back pain. Magn Reson Imaging Clin N Am 1999; 7 : 481-91.
14. Tehranzadeh J. Discography 2000. Radiol Clin North Am 1998; 36 : 463-95.
15. Carragee EJ, Alamin TF, Carragee JM. Low-pressure positive discography in subjects asymptomatic of significant low back pain illness. Spine 2006; 31 : 505-9.
16. Morgan S, Saifuddin A. MRI of the lumbar intervertebral disc. Clin Radiol 1999; 54 : 703-23.
17. Gunzburg R, Fraser RD, Moore R, et al. An experimental study comparing percutaneous discectomy with chemonucleolysis. Spine 1993; 18 : 218-26.
18. Urban JP, Winlove CP. Pathophysiology of the intervertebral disc and the challenges for MRI. J Magn Reson Imaging 2007; 25 : 419-32.
19. Pfirrmann CW, Metzdorf A, Zanetti M, et al. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine 2001; 26 : 1873-8.
20. Li X, Han ET, Ma CB, et al. In vivo 3T spiral imaging based multislice T(1rho) mapping of knee cartilage in osteoarthritis. Magn Reson Med 2005; 54 : 929-36.
21. Lozano J, Li X, Link TM, et al. Detection of posttraumatic cartilage injury using quantitative T1rho magnetic resonance imaging. A report of two cases with arthroscopic findings. J Bone Joint Surg Am 2006; 88 : 1349-52.
22. Borthakur A, Mellon E, Niyogi S, et al. Sodium and T1rho MRI for molecular and diagnostic imaging of articular cartilage. NMR Biomed 2006; 19 : 781-821.
23. Regatte RR, Akella SV, Borthakur A, et al. Proteoglycan depletioninduced changes in transverse relaxation maps of cartilage: Comparison of T2 and T1rho. Acad Radiol 2002; 9 : 1388-94.
24. Johannessen W, Auerbach JD, Wheaton AJ, et al. Assessment of human disc degeneration and proteoglycan content using T1rhoweighted magnetic resonance imaging. Spine 2006; 31 : 1253-7.
25. Nguyen AM, Johannessen W, Yoder JH, et al. Noninvasive quantification of human nucleus pulposus pressure with use of T1rhoweighted magnetic resonance imaging. J Bone Joint Surg Am 2008; 90 : 796-802.
26. Auerbach JD, Johannessen W, Borthakur A, et al. In vivo quantifi-cation of human lumbar disc degeneration using T(1rho)-weighted magnetic resonance imaging. Eur Spine J 2006; 15 : 338-44.
27. Witschey W, Borthakur A, Elliott M, et al. T1rho-prepared balanced gradient echo for rapid 3D T1rho MRI. J Magn Reson Imaging 2008; 28 : 744-54.
28. Ishihara H, Warensjo K, Roberts S, et al. Proteoglycan synthesis in the intervertebral disk nucleus: The role of extracellular osmolality. Am J Physiol 1997; 272 : C1499-506.
29. Bashir A, Gray ML, Burstein D. Gd-DTPA2-as a measure of cartilage degradation. Magn Reson Med 1996; 36 : 665-73.
30. Bashir A, Gray ML, Hartke J, et al. Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI. Magn Reson Med 1999; 41 : 857-65.
31. Burstein D, Velyvis J, Scott KT, et al. Protocol issues for delayed Gd(DTPA)(2-)-enhanced MRI (dGEMRIC) for clinical evaluation of articular cartilage. Magn Reson Med 2001; 45 : 36-41.
32. Ibrahim MA, Jesmanowicz A, Hyde JS, et al. Contrast enhancement of normal intervertebral disks: Time and dose dependence. AJNR Am J Neuroradiol 1994; 15 : 419-23.
33. Rajasekaran S, Babu JN, Arun R, et al. ISSLS prize winner: A study of diffusion in human lumbar discs: A serial magnetic resonance imaging study documenting the influence of the endplate on diffusion in normaland degenerate discs. Spine 2004; 29 : 2654-67.
34. Reddy R, Insko EK, Noyszewski EA, et al. Sodium MRI of human articular cartilage in vivo. Magn Reson Med 1998; 39 : 697-701.
35. Shapiro EM, Borthakur A, Gougoutas A, et al. 23Na MRI accurately measures fixed charge density in articular cartilage. Magn Reson Med 2002; 47 : 284-91.
36. Wheaton AJ, Borthakur A, Dodge GR, et al. Sodium magnetic resonance imaging of proteoglycan depletion in an in vivo model of osteoarthritis. Acad Radiol 2004; 11 : 21-8.