Design and conduct of Xtreme Everest 2: An observational cohort study of Sherpa and lowlander responses to graduated hypobaric hypoxia

F1000Research

Volumn 4, Issue , 2015, Pages

  Martin, Daniel ^a   Gilbert Kawai, Edward ^a   Sheperdigian, Adam ^a   Adams, Thomas ^a   Mitchell, Kay ^a,b,c   Feelisch, Martin ^b,c   Murray, Andrew ^a,d   Peters, Mark ^a,e   Gilbert Kawai, Grace ^a   Montgomery, Hugh ^a   Levett, Denny ^a   Kumar, Rajendra ^a,f   Mythen, Michael ^a   Grocott, Michael ^a,b,c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^c University Hospital Southampton NHS Foundation Trust   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f Nepal Health Research Council   (Nepal)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE;

ALTITUDE; ALTITUDE ACCLIMATIZATION; ARTICLE; BLOOD FLOW; COHORT ANALYSIS; CONTROLLED STUDY; EPIGENETICS; EXERCISE; HUMAN; HYPOBARIC HYPOXIA; HYPOBARISM; HYPOXIA; LABORATORY TEST; METABOLISM; MICROCIRCULATORY BLOOD FLOW; NEPAL; NITRIC OXIDE METABOLISM; OBSERVATIONAL STUDY; OXYGENATION; UNITED KINGDOM;

EID: 84931275088     PISSN: 20461402     EISSN: 1759796X     Source Type: Journal    
DOI: 10.12688/f1000research.6297.1     Document Type: Article

References (30)

1. Grocott M Montgomery H Vercueil A: High-altitude physiology and pathophysiology: implications and relevance for intensive care medicine. Crit Care. 2007;11(1):203. 17291330 10.1186/cc5142 2151873
2. Protti A Singer M: Bench-to-bedside review: potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure. Crit Care. 2006;10(5):228. 16953900 10.1186/cc5014 1751057
3. JD Y: Hypoxemia and mortality in the ICU. Yearbook of Intensive Care and Emergency Medicine. 2000;2000:239-246. 10.1007/978-3-662-13455-9_21
4. Kilgannon JH Jones AE Shapiro NI: Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA. 2010;303(21):2165-2171. 20516417 10.1001/jama.2010.707
5. Ronning OM Guldvog B: Should stroke victims routinely receive supplemental oxygen? A quasi-randomized controlled trial. Stroke. 1999;30(10):2033-2037. 10512903 10.1161/01.STR.30.10.2033
6. Ince C Sinaasappel M: Microcirculatory oxygenation and shunting in sepsis and shock. Crit Care Med. 1999;27(7):1369-1377. 10446833
7. den Uil CA Klijn E Lagrand WK: The microcirculation in health and critical disease. Prog Cardiovasc Dis. 2008;51(2):161-170. 18774014 10.1016/j.pcad.2008.07.002
8. Carre JE Orban JC Re L: Survival in critical illness is associated with early activation of mitochondrial biogenesis. Am J Respir Crit Care Med. 2010;182(6):745-751. 20538956 10.1164/rccm.201003-0326OC 2949402
9. Hollenberg SM Cinel I: Bench-to-bedside review: nitric oxide in critical illness--update 2008. Crit Care. 2009;13(4):218. 19664175 10.1186/cc7706 2750127
10. Martin DS Grocott MP: Oxygen therapy in critical illness: precise control of arterial oxygenation and permissive hypoxemia. Crit Care Med. 2013;41(2):423-432. 23263574 10.1097/CCM.0b013e31826a44f6
11. Grocott MP Martin DS Wilson MH: Caudwell Xtreme Everest expedition. High Alt Med Biol. 2010;11(2):133-137. 20586597 10.1089/ham.2009.1093
12. Levett DZ Martin DS Wilson MH: Design and conduct of Caudwell Xtreme Everest: an observational cohort study of variation in human adaptation to progressive environmental hypoxia. BMC Med Res Methodol. 2010;10:98. 20964858 10.1186/1471-2288-10-98 2988011
13. Angus DC Mira JP Vincent JL: Improving clinical trials in the critically ill. Crit Care Med. 2010;38(2):527-532. 19851096 10.1097/CCM.0b013e3181c0259d
14. Opal SM Patrozou E: Translational research in the development of novel sepsis therapeutics: logical deductive reasoning or mission impossible? Crit Care Med. 2009;37(1 Suppl):S10-S15. 19104207 10.1097/CCM.0b013e3181921497
15. Grocott M Richardson A Montgomery H: Caudwell Xtreme Everest: a field study of human adaptation to hypoxia. Crit Care. 2007;11(4):151. 17672886 10.1186/cc5921 2206524
16. Martin DS Goedhart P Vercueil A: Changes in sublingual microcirculatory flow index and vessel density on ascent to altitude. Exp Physiol. 2010;95(8):880-891. 20418348 10.1113/expphysiol.2009.051656
17. Martin DS Ince C Goedhart P: Abnormal blood flow in the sublingual microcirculation at high altitude. Eur J Appl Physiol. 2009;106(3):473-478. 19333616 10.1007/s00421-009-1023-8 2688617
18. Martin DS Levett DZ Mythen M: Changes in skeletal muscle oxygenation during exercise measured by near-infrared spectroscopy on ascent to altitude. Crit Care. 2009;13(Suppl 5):S7. 19951391 10.1186/cc8005 2786109
19. Levett DZ Fernandez BO Riley HL: The role of nitrogen oxides in human adaptation to hypoxia. Sci Rep. 2011;1:109. 22355626 10.1038/srep00109 3219423
20. Edwards LM Murray AJ Tyler DJ: The effect of high-altitude on human skeletal muscle energetics: 31P-MRS results from the Caudwell Xtreme Everest expedition. PLoS One. 2010;5(5):e10681. 20502713 10.1371/journal.pone.0010681 2873292
21. Holloway CJ Montgomery HE Murray AJ: Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp. FASEB J. 2011;25(2):792-796. 20978235 10.1096/fj.10-172999
22. Levett DZ Radford EJ Menassa DA: Acclimatization of skeletal muscle mitochondria to high-altitude hypoxia during an ascent of Everest. FASEB J. 2012;26(4):1431-1441. 22186874 10.1096/fj.11-197772
23. Martin DS Gilbert-Kawai E Levett DZh: Xtreme Everest 2: unlocking the secrets of the Sherpa phenotype? Extrem Physiol Med. 2013;2(1):30. 24229457 10.1186/2046-7648-2-30 3853703
24. Aldenderfer MS: Moving up in the world; archaeologists seek to understand how and when people came to occupy the Andean and Tibetan plateaus. Am Sci. 2003;91(6):542-550. 10.1511/2003.6.542
25. Bigham A Bauchet M Pinto D: Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. PLoS Genet. 2010;6(9):e1001116. 20838600 10.1371/journal.pgen.1001116 2936536
26. Malacrida S Katsuyama Y Droma Y: Association between human polymorphic DNA markers and hypoxia adaptation in Sherpa detected by a preliminary genome scan. Ann Hum Genet. 2007;71(Pt 5):630-638. 17359493 10.1111/j.1469-1809.2007.00358.x
27. Peng Y Yang Z Zhang H: Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas. Mol Biol Evol. 2011;28(2):1075-1081. 21030426 10.1093/molbev/msq290
28. Xu S Li S Yang Y: A genome-wide search for signals of high-altitude adaptation in Tibetans. Mol Biol Evol. 2011;28(2):1003-1011. 20961960 10.1093/molbev/msq277
29. Yi X Liang Y Huerta-Sanchez E: Sequencing of 50 human exomes reveals adaptation to high altitude. Science. 2010;329(5987):75-78. 20595611 10.1126/science.1190371 3711608
30. ATS/ACCP Statement on cardiopulmonary exercise testing. American Thoracic Society; American College of Chest Physicians. Am J Respir Crit Care Med. 2003;167(2):211-277. 12524257 10.1164/rccm.167.2.211