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Volumn 38, Issue 2, 2010, Pages 527-532

Improving clinical trials in the critically ill

Author keywords

Intensive care; New technologies

Indexed keywords

CLINICAL RESEARCH; CLINICAL TRIAL; CONSENSUS DEVELOPMENT; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; HEALTH CARE QUALITY; HUMAN; INTENSIVE CARE; OUTCOME ASSESSMENT; PRACTICE GUIDELINE; PRIORITY JOURNAL; REVIEW;

EID: 74949085894     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181c0259d     Document Type: Article
Times cited : (50)

References (29)
  • 1
    • 41649116334 scopus 로고    scopus 로고
    • Multicenter randomized controlled trials evaluating mortality in intensive care: Doomed to fail?
    • Ospina-Tascon G, Luiz Buchele G, Vincent JL: Multicenter randomized controlled trials evaluating mortality in intensive care: Doomed to fail? Crit Care Med 2008 36 1311-1322
    • (2008) Crit Care Med , vol.36 , pp. 1311-1322
    • Ospina-Tascon, G.1    Luiz Buchele, G.2    Vincent, J.L.3
  • 2
    • 33846677129 scopus 로고    scopus 로고
    • Comparison of treatment effects between animal experiments and clinical trials: Systematic review
    • Perel P, Roberts I, Sena E, et al: Comparison of treatment effects between animal experiments and clinical trials: systematic review. BMJ 2007; 334:197
    • (2007) BMJ , vol.334 , pp. 197
    • Perel, P.1    Roberts, I.2    Sena, E.3
  • 3
    • 60849101889 scopus 로고    scopus 로고
    • Myocardial transcriptional profiles in a mu-rine model of sepsis: Evidence for the importance of age
    • Checchia PA, Schierding W, Polpitiya A, et al: Myocardial transcriptional profiles in a mu-rine model of sepsis: Evidence for the importance of age. Pediatr Crit Care Med 2008; 9:530-535
    • (2008) Pediatr Crit Care Med , vol.9 , pp. 530-535
    • Checchia, P.A.1    Schierding, W.2    Polpitiya, A.3
  • 4
    • 37749005803 scopus 로고    scopus 로고
    • Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection
    • Lutterloh EC, Opal SM, Pittman DD, et al: Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection. Crit Care 2007; 11:R122
    • (2007) Crit Care , vol.11
    • Lutterloh, E.C.1    Opal, S.M.2    Pittman, D.D.3
  • 5
    • 38549154462 scopus 로고    scopus 로고
    • Acute phase response impairs host defense against Pseudomonas aeruginosa pneumonia in mice
    • Renckens R, van Westerloo DJ, Roelofs JJ, et al: Acute phase response impairs host defense against Pseudomonas aeruginosa pneumonia in mice. Crit Care Med 2008; 36: 580-587
    • (2008) Crit Care Med , vol.36 , pp. 580-587
    • Renckens, R.1    Van Westerloo, D.J.2    Roelofs, J.J.3
  • 6
    • 0142186310 scopus 로고    scopus 로고
    • Reduction of cardiovascular disorders by preventive perioperative antihistamine administration in general surgery: Are the drugs interchangeable?
    • Celik I, Stinner B, Lorenz W, et al: [Reduction of cardiovascular disorders by preventive perioperative antihistamine administration in general surgery: Are the drugs interchangeable?]. Langenbecks Arch Chir Suppl Kongressbd 1998; 115:731-735
    • (1998) Langenbecks Arch Chir Suppl Kongressbd , vol.115 , pp. 731-735
    • Celik, I.1    Stinner, B.2    Lorenz, W.3
  • 7
    • 38349114229 scopus 로고    scopus 로고
    • Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions
    • Kircher MF, Grimm J, Swirski FK, et al: Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions. Circulation 2008; 117:388-395
    • (2008) Circulation , vol.117 , pp. 388-395
    • Kircher, M.F.1    Grimm, J.2    Swirski, F.K.3
  • 8
    • 27144509163 scopus 로고    scopus 로고
    • A network-based analysis of systemic inflammation in humans
    • Calvano SE, Xiao W, Richards DR, et al: A network-based analysis of systemic inflammation in humans. Nature 2005; 437: 1032-1037
    • (2005) Nature , vol.437 , pp. 1032-1037
    • Calvano, S.E.1    Xiao, W.2    Richards, D.R.3
  • 9
    • 33947193958 scopus 로고    scopus 로고
    • Evidence-based modeling of critical illness: An initial consensus from the Society for Complexity in Acute Illness
    • Vodovotz Y, Clermont G, Hunt CA, et al: Evidence-based modeling of critical illness: an initial consensus from the Society for Complexity in Acute Illness. J Crit Care 2007; 22:77-84
    • (2007) J Crit Care , vol.22 , pp. 77-84
    • Vodovotz, Y.1    Clermont, G.2    Hunt, C.A.3
  • 11
    • 4043056616 scopus 로고    scopus 로고
    • In silico design of clinical trials: A method coming of age
    • Clermont G, Bartels J, Kumar R, et al: In silico design of clinical trials: A method coming of age. Crit Care Med 2004; 32: 2061-2070
    • (2004) Crit Care Med , vol.32 , pp. 2061-2070
    • Clermont, G.1    Bartels, J.2    Kumar, R.3
  • 12
    • 1342265610 scopus 로고    scopus 로고
    • Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: Cluster-randomised, single-blinded intervention trial
    • Christ-Crain M, Jaccard-Stolz D, Bingisser R, et al: Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: Cluster-randomised, single-blinded intervention trial. Lancet 2004; 363:600-607
    • (2004) Lancet , vol.363 , pp. 600-607
    • Christ-Crain, M.1    Jaccard-Stolz, D.2    Bingisser, R.3
  • 13
    • 33745471090 scopus 로고    scopus 로고
    • Procalcitonin-guidance of antibiotic therapy in community-acquired pneumonia: A randomized trial
    • Christ-Crain M, Stolz D, Bingisser R, et al: Procalcitonin-guidance of antibiotic therapy in community-acquired pneumonia: A randomized trial. Am J Respir Crit Care Med 2006; 174:84-93
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 84-93
    • Christ-Crain, M.1    Stolz, D.2    Bingisser, R.3
  • 14
    • 40649087642 scopus 로고    scopus 로고
    • Use of procalcitonin to shorten antibiotic treatment duration in septic patients: A randomized trial
    • Nobre V, Harbarth S, Graf JD, et al: Use of procalcitonin to shorten antibiotic treatment duration in septic patients: A randomized trial. Am J Respir Crit Care Med 2008; 177: 498-505
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 498-505
    • Nobre, V.1    Harbarth, S.2    Graf, J.D.3
  • 15
    • 0037126332 scopus 로고    scopus 로고
    • Public use of automated external defibrilla-tors
    • Caffrey SL, Willoughby PJ, Pepe PE, et al: Public use of automated external defibrilla-tors. N Engl J Med 2002; 347:1242-1247
    • (2002) N Engl J Med , vol.347 , pp. 1242-1247
    • Caffrey, S.L.1    Willoughby, P.J.2    Pepe, P.E.3
  • 16
    • 20444443626 scopus 로고    scopus 로고
    • Introduction of the medical emergency team (MET) system: A cluster-randomised controlled trial
    • Hillman K, Chen J, Cretikos M, et al: Introduction of the medical emergency team (MET) system: A cluster-randomised controlled trial. Lancet 2005; 365:2091-2097
    • (2005) Lancet , vol.365 , pp. 2091-2097
    • Hillman, K.1    Chen, J.2    Cretikos, M.3
  • 17
    • 54049152446 scopus 로고    scopus 로고
    • Bench-to-bedside review: The evaluation of complex interventions in critical care
    • Delaney A, Angus DC, Bellomo R, et al: Bench-to-bedside review: The evaluation of complex interventions in critical care. Crit Care 2008; 12:210
    • (2008) Crit Care , vol.12 , pp. 210
    • Delaney, A.1    Angus, D.C.2    Bellomo, R.3
  • 18
    • 39049146102 scopus 로고    scopus 로고
    • Testing protocols in the intensive care unit: Complex trials of complex interventions for complex patients
    • Chiche JD, Angus DC: Testing protocols in the intensive care unit: Complex trials of complex interventions for complex patients. JAMA 2008; 299:693-695
    • (2008) JAMA , vol.299 , pp. 693-695
    • Chiche, J.D.1    Angus, D.C.2
  • 19
    • 0343360868 scopus 로고    scopus 로고
    • A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care
    • Hebert PC, Wells G, Blajchman MA, et al: A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 1999; 340:409-417
    • (1999) N Engl J Med , vol.340 , pp. 409-417
    • Hebert, P.C.1    Wells, G.2    Blajchman, M.A.3
  • 20
    • 34249288679 scopus 로고    scopus 로고
    • Randomization in clinical trials of titrated therapies: Unintended consequences of using fixed treatment protocols
    • Deans KJ, Minneci PC, Suffredini AF, et al: Randomization in clinical trials of titrated therapies: Unintended consequences of using fixed treatment protocols. Crit Care Med 2007; 35:1509-1516
    • (2007) Crit Care Med , vol.35 , pp. 1509-1516
    • Deans, K.J.1    Minneci, P.C.2    Suffredini, A.F.3
  • 21
    • 10644277923 scopus 로고    scopus 로고
    • Sources of variability on the estimate of treatment effect in the PROWESS trial: Implications for the design and conduct of future studies in severe sepsis
    • Macias WL, Vallet B, Bernard GR, et al: Sources of variability on the estimate of treatment effect in the PROWESS trial: Implications for the design and conduct of future studies in severe sepsis. Crit Care Med 2004; 32:2385-2391
    • (2004) Crit Care Med , vol.32 , pp. 2385-2391
    • MacIas, W.L.1    Vallet, B.2    Bernard, G.R.3
  • 22
    • 0018750520 scopus 로고
    • A new design for randomized clinical trials
    • Zelen M: A new design for randomized clinical trials. N Engl J Med 1979; 300: 1242-1245
    • (1979) N Engl J Med , vol.300 , pp. 1242-1245
    • Zelen, M.1
  • 23
    • 0036742352 scopus 로고    scopus 로고
    • Studying communication about end-of-life care during the ICU family conference: Development of a framework
    • Curtis JR, Engelberg RA, Wenrich MD, et al: Studying communication about end-of-life care during the ICU family conference: development of a framework. J Crit Care 2002; 17:147-160
    • (2002) J Crit Care , vol.17 , pp. 147-160
    • Curtis, J.R.1    Engelberg, R.A.2    Wenrich, M.D.3
  • 24
    • 33846657370 scopus 로고    scopus 로고
    • A communication strategy and brochure for relatives of patients dying in the ICU
    • Lautrette A, Darmon M, Megarbane B, et al: A communication strategy and brochure for relatives of patients dying in the ICU. N Engl J Med 2007; 356:469-478
    • (2007) N Engl J Med , vol.356 , pp. 469-478
    • Lautrette, A.1    Darmon, M.2    Megarbane, B.3
  • 25
    • 6844236394 scopus 로고    scopus 로고
    • A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation
    • Cook D, Guyatt G, Marshall J, et al: A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. N Engl J Med 1998; 338:791-797
    • (1998) N Engl J Med , vol.338 , pp. 791-797
    • Cook, D.1    Guyatt, G.2    Marshall, J.3
  • 26
    • 0034509672 scopus 로고    scopus 로고
    • Low-dose dopamine in patients with early renal dysfunction: A placebo-controlled randomised trial
    • Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group
    • Bellomo R, Chapman M, Finfer S, et al: Low-dose dopamine in patients with early renal dysfunction: A placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Lancet 2000; 356:2139-2143
    • (2000) Lancet , vol.356 , pp. 2139-2143
    • Bellomo, R.1    Chapman, M.2    Finfer, S.3
  • 27
    • 0037413466 scopus 로고    scopus 로고
    • A randomized, controlled trial of the use of pulmonary-artery catheters in high-risk surgical patients
    • Sandham JD, Hull RD, Brant RF, et al: A randomized, controlled trial of the use of pulmonary-artery catheters in high-risk surgical patients. N Engl J Med 2003; 348:5-14
    • (2003) N Engl J Med , vol.348 , pp. 5-14
    • Sandham, J.D.1    Hull, R.D.2    Brant, R.F.3
  • 29
    • 31344461826 scopus 로고    scopus 로고
    • Sepsis in European intensive care units: Results of the SOAP study
    • Vincent JL, Sakr Y, Sprung CL, et al: Sepsis in European intensive care units: Results of the SOAP study. Crit Care Med 2006; 34: 344-353
    • (2006) Crit Care Med , vol.34 , pp. 344-353
    • Vincent, J.L.1    Sakr, Y.2    Sprung, C.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.