The effect of high-altitude on human skeletal muscle energetics: 31P-MRS results from the caudwell xtreme everest expedition

PLoS ONE

Volumn 5, Issue 5, 2010, Pages

  Edwards, Lindsay M ^a,b   Murray, Andrew J ^a   Tyler, Damian J ^a,b   Kemp, Graham J ^c   Holloway, Cameron J ^b   Robbins, Peter A ^a   Neubauer, Stefan ^b   Levett, Denny ^d   Montgomery, Hugh E ^d,e   Grocott, Mike P ^d   Clarke, Kieran ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; PHOSPHORUS 31;

ADULT; ALTITUDE; ALTITUDE ACCLIMATIZATION; ALTITUDE DISEASE; ARTICLE; CONTROLLED STUDY; ENERGY TRANSFER; EXERCISE RECOVERY; HUMAN; HUMAN EXPERIMENT; HYDROLYSIS; HYPOBARISM; MALE; MOUNTAINEERING; MUSCLE ATROPHY; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PHOSPHATE METABOLISM; SKELETAL MUSCLE; STEADY STATE; TRAVEL; ENERGY METABOLISM; EXERCISE; KINETICS; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

ADULT; ALTITUDE; ENERGY METABOLISM; EXERCISE; EXPEDITIONS; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; MOUNTAINEERING; MUSCLE, SKELETAL; PHOSPHOCREATINE; YOUNG ADULT;

EID: 77956275584     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010681     Document Type: Article

References (51)

1. Reynafarje B (1962) Myoglobin content and enzymatic activity of muscle and altitude adaptation. J Appl Physiol 17: 301-305.
2. Hochachka PW, Stanley C, Merkt J, Sumar-Kalinowski J (1983) Metabolic meaning of elevated levels of oxidative enzymes in high altitude adapted animals: an interpretive hypothesis. Respir Physiol 52: 303-313.
3. Lynn EG, Lu Z, Minerbi D, Sack MN (2007) The regulation, control, and consequences of mitochondrial oxygen utilization and disposition in the heart and skeletal muscle during hypoxia. Antioxid Redox Signal 9: 1353-1361.
4. Hoppeler H, Vogt M (2001) Muscle tissue adaptations to hypoxia. J Exp Biol 204: 3133-3139.
5. Rosser BW, Hochachka PW (1993) Metabolic capacity of muscle fibers from high-altitude natives. Eur J Appl Physiol Occup Physiol 67: 513-517.
6. Green H, Roy B, Grant S, Otto C, Pipe A, et al. (2000) Human skeletal muscle exercise metabolism following an expedition to Mount Denali. Am J Physiol Regul Integr Comp Physiol 279: R1872-1879.
7. Semenza GL, Roth PH, Fang HM, Wang GL (1994) Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 269: 23757-23763.
8. Hochachka PW (2001) Molecular/metabolic defense and rescue mechanisms for surviving oxygen lack: from genes to pathways. In: Hornbein T, Schoene R, eds. High Altitude, An Exploration of Human Adaptation. New York: Marcel Dekker. pp 131-138.
9. Lundby C, Calbet JA, Sander M, van Hall G, Mazzeo RS, et al. (2007) Exercise economy does not change after acclimatization to moderate to very high altitude. Scand J Med Sci Sports 17: 281-291.
10. Hahn AG, Gore CJ (2001) The effect of altitude on cycling performance: a challenge to traditional concepts. Sports Med 31: 533-557.
11. Grocott M, Richardson A, Montgomery H, Mythen M (2007) Caudwell Xtreme Everest: a field study of human adaptation to hypoxia. Crit Care 11: 151.
12. Naressi A, Couturier C, Castang I, de Beer R, Graveron-Demilly D (2001) Javabased graphical user interface for MRUI, a software package for quantitation of in vivo/medical magnetic resonance spectroscopy signals. Comput Biol Med 31:269-286.
13. Vanhamme L, van den Boogaart A, Van Huffel S (1997) Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J Magn Reson 129: 35-43.
14. Kemp GJ, Meyerspeer M, Moser E (2007) Absolute quantification of phosphorus metabolite concentrations in human muscle in vivo by 31P MRS: a quantitative review. NMR Biomed 20: 555-565.
15. Golding EM, Teague WE, Dobson GP (1995) Adjustment of K' to varying pH and pMg for the creatine kinase, adenylate kinase and ATP hydrolysis equilibria permitting quantitative bioenergetic assessment. J Exp Biol 198: 1775-1782.
16. Jeneson JAL, Wiseman RW, Kushmerick MJ (1997) Non-invasive quantitative 31P MRS assay of mitochondrial function in skeletal muscle in situ. Molecular and Cellular Biochemistry 174: 17-22.
17. Braun M (1941) Differential Equations and their Applications. New York: Springer.
18. Vandenborne K, Walter G, Leigh JS, Goelman G (1993) pH heterogeneity during exercise in localized spectra from single human muscles. Am J Physiol Cell Physiol 265: C1332-1339.
19. Short KR, Nair KS (2001) Does aging adversely affect muscle mitochondrial function? Exerc Sport Sci Rev 29: 118-123.
20. Cymerman A, Reeves JT, Sutton JR, Rock PB, Groves BM, et al. (1989) Operation Everest II: maximal oxygen uptake at extreme altitude. J Appl Physiol 66: 2446-2453.
21. Coyle EF, Martin WH, 3rd, Sinacore DR, Joyner MJ, Hagberg JM, et al. (1984) Time course of loss of adaptations after stopping prolonged intense endurance training. J Appl Physiol 57: 1857-1864.
22. West JB, Boyer SJ, Graber DJ, Hackett PH, Maret KH, et al. (1983) Maximal exercise at extreme altitudes on Mount Everest. J Appl Physiol 55: 688-698.
23. Consolazio CF, Johnson HL, Krzywicki HJ, Daws TA (1972) Metabolic aspects of acute altitude exposure (4,300 meters) in adequately nourished humans. Am J Clin Nutr 25: 23-29.
24. Consolazio CF, Matoush L, Johnson HL, Daws TA (1968) Protein and water balances of young adults during prolonged exposure to high altitude (4,300 m). Am J Clin Nutr 21: 154-161.
25. Rose MS, Houston CS, Fulco CS, Coates G, Sutton JR, et al. (1988) Operation Everest. II: Nutrition and body composition. J Appl Physiol 65: 2545-2551.
26. Boyer SJ, Blume FD (1984) Weight loss and changes in body composition at high altitude. J Appl Physiol 57: 1580-1585.
27. Shukla V, Singh SN, Vats P, Singh VK, Singh SB, et al. (2005) Ghrelin and leptin levels of sojourners and acclimatized lowlanders at high altitude. Nutr Neurosci 8: 161-165.
28. Hannon JP, Klain GJ, Sudman DM, Sullivan FJ (1976) Nutritional aspects of high-altitude exposure in women. Am J Clin Nutr 29: 604-613.
29. Guilland JC, Klepping J (1985) Nutritional alterations at high altitude in man. Eur J Appl Physiol Occup Physiol 54: 517-523.
30. Westerterp KR (2001) Limits to sustainable human metabolic rate. J Exp Biol 204: 3183-3187.
31. Westerterp KR, Kayser B (2006) Body mass regulation at altitude. Eur J Gastroenterol Hepatol 18: 1-3.
32. Butterfield GE, Gates J, Fleming S, Brooks GA, Sutton JR, et al. (1992) Increased energy intake minimizes weight loss in men at high altitude. J Appl Physiol 72: 1741-1748.
33. Netzer NC, Chytra R, Kupper T (2008) Low intense physical exercise in normobaric hypoxia leads to more weight loss in obese people than low intense physical exercise in normobaric sham hypoxia. Sleep Breath 12: 129-134.
34. Gill MB, Pugh LG (1964) Basal Metabolism and Respiration in Men Living at 5,800 M (19,000 Ft). J Appl Physiol 19: 949-954.
35. Grover RF (1963) Basal Oxygen Uptake of Man at High Altitude. J Appl Physiol 18: 909-912.
36. Hannon JP, Sudman DM (1973) Basal metabolic and cardiovascular function of women during altitude acclimatization. J Appl Physiol 34: 471-477.
37. Kellogg RH, Pace N, Archibald ER, Vaughan BE (1957) Respiratory response to inspired CO2 during acclimatization to an altitude of 12, 470 feet. J Appl Physiol 11: 65-71.
38. Stock MJ, Norgan NG, Ferro-Luzzi A, Evans E (1978) Effect of altitude on dietary-induced thermogenesis at rest and during light exercise in man. J Appl Physiol 45: 345-349.
39. Mawson JT, Braun B, Rock PB, Moore LG, Mazzeo R, et al. (2000) Women at altitude: energy requirement at 4,300 m. J Appl Physiol 88: 272-281.
40. Mathew L, Purkayastha SS, Gupta JS, Malhotra MS (1976) Body temperature and basal metabolic changes during acclimatization to altitude (3,500 m) in man. Indian J Physiol Pharmacol 20: 197-202.
41. Armellini F, Zamboni M, Robbi R, Todesco T, Bissoli L, et al. (1997) The effects of high altitude trekking on body composition and resting metabolic rate. Horm Metab Res 29: 458-461.
42. Lundby C, Steensberg A (2004) Interleukin-6 response to exercise during acute and chronic hypoxia. Eur J Appl Physiol 91: 88-93.
43. Klausen B, Toubro S, Astrup A (1997) Age and sex effects on energy expenditure. Am J Clin Nutr 65: 895-907.
44. Mazzeo RS, Donovan D, Fleshner M, Butterfield GE, Zamudio S, et al. (2001) Interleukin-6 response to exercise and high-altitude exposure: influence of alphaadrenergic blockade. J Appl Physiol 91: 2143-2149.
45. Barton BE (2001) IL-6-like cytokines and cancer cachexia: consequences of chronic inflammation. Immunol Res 23: 41-58.
46. Barton BE, Murphy TF (2001) Cancer cachexia is mediated in part by the induction of IL-6-like cytokines from the spleen. Cytokine 16: 251-257.
47. Tisdale MJ (2001) Loss of skeletal muscle in cancer: biochemical mechanisms. Front Biosci 6: D164-174.
48. Korzeniewski B, Zoladz JA (2005) Some factors determining the PCr recovery overshoot in skeletal muscle. Biophysical Chemistry 116: 129-136.
49. Korzeniewski B (2003) Regulation of oxidative phosphorylation in different muscles and various experimental conditions. Biochem J 375: 799-804.
50. Allen DG, Westerblad H (2001) Role of phosphate and calcium stores in muscle fatigue. J Physiol 536: 657-665.
51. Polgreen KE, Kemp GJ, Leighton B, Radda GK (1994) Modulation of Pi transport in skeletal muscle by insulin and IGF-1. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1223: 279-284.