Cardiac response to hypobaric hypoxia: Persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp

FASEB Journal

Volumn 25, Issue 2, 2011, Pages 792-796

  Holloway, Cameron J ^a,b   Montgomery, Hugh E ^c   Murray, Andrew J ^a,b,d   Cochlin, Lowri E ^a,b   Codreanu, Ion ^b   Hopwood, Naomi ^a   Johnson, Andrew W ^a,b   Rider, Oliver J ^b   Levett, Denny Z H ^c   Tyler, Damian J ^a,b   Francis, Jane M ^b   Neubauer, Stefan ^b   Grocott, Michael P W ^c   Clarke, Kieran ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Cardiac energy metabolism; Cardiac function

Indexed keywords

CREATINE KINASE;

ADULT; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY SURFACE; BODY WEIGHT; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENERGY METABOLISM; FEMALE; HEART FUNCTION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE FILLING; HEART LEFT VENTRICLE MASS; HEART MUSCLE ISCHEMIA; HEART RATE; HEART SIZE; HEART VOLUME; HIGH ENERGY PHOSPHATE; HUMAN; HYDRATION; HYPOBARISM; HYPOXIA; MALE; PHOSPHATE METABOLISM; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

ACCLIMATIZATION; ADULT; ALTITUDE; ENERGY METABOLISM; FEMALE; HEART VENTRICLES; HUMANS; MALE; MOUNTAINEERING; MYOCARDIUM; ORGAN SIZE; PHOSPHATES; VENTRICULAR FUNCTION;

EID: 79551649357     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-172999     Document Type: Article

References (19)

1. Murray, A. J. (2009) Metabolic adaptation of skeletal muscle to high altitude hypoxia: how new technologies could resolve the controversies. Genome Med. 1, 117
2. Tian, R., Nascimben, L., Ingwall, J. S., and Lorell, B. H. (1997) Failure to maintain a low ADP concentration impairs diastolic function in hypertrophied rat hearts. Circulation 96, 1313-1319
3. Kjaergaard, J., Snyder, E. M., Hassager, C., Olson, T. P., Oh, J. K., and Johnson, B. D. (2006) The effect of 18 h of simulated high altitude on left ventricular function. Eur. J. Appl. Physiol. 98, 411-418
4. Boussuges, A., Molenat, F., Burnet, H., Cauchy, E., Gardette, B., Sainty, J. M., Jammes, Y., and Richalet, J. P. (2000) Operation Everest III (Comex '97): modifications of cardiac function secondary to altitude-induced hypoxia. An echocardiographic and Doppler study. Am. J. Respir. Crit. Care Med. 161, 264-270
5. Maeder, M. T., and Kaye, D. M. (2009) Heart failure with normal left ventricular ejection fraction. J. Am. Coll. Cardiol. 53, 905-918
6. Giordano, F. J. (2005) Oxygen, oxidative stress, hypoxia, and heart failure. J. Clin. Invest. 115, 500-508
7. Neubauer, S. (2007) The failing heart-an engine out of fuel. N. Engl. J. Med. 356, 1140-1151
8. Tyler, D. J., Emmanuel, Y., Cochlin, L. E., Hudsmith, L. E., Holloway, C. J., Neubauer, S., Clarke, K., and Robson, M. D. (2009) Reproducibility of 31P cardiac magnetic resonance spectroscopy at 3 T. NMR Biomed. 22, 405-413
9. Hudsmith, L. E., Petersen, S. E., Tyler, D. J., Francis, J. M., Cheng, A. S., Clarke, K., Selvanayagam, J. B., Robson, M. D., and Neubauer, S. (2006) Determination of cardiac volumes and mass with FLASH and SSFP cine sequences at 1.5 vs. 3 tesla: a validation study. J. Magn. Reson. Imaging 24, 312-318
10. Grocott, M., Richardson, A., Montgomery, H., and Mythen, M. (2007) Caudwell Xtreme Everest: a field study of human adaptation to hypoxia. Crit. Care 11, 151
11. Howald, H., and Hoppeler, H. (2003) Performing at extreme altitude: muscle cellular and subcellular adaptations. Eur. J. Appl. Physiol. 90, 360-364
12. Hoon, R. S., Balasubramanian, V., Mathew, O. P., Tiwari, S. C., Sharma, S. C., and Chadha, K. S. (1977) Effect of high-altitude exposure for 10 days on stroke volume and cardiac output. J. Appl. Physiol. 42, 722-727
13. Allemann, Y., Sartori, C., Lepori, M., Pierre, S., Melot, C., Naeije, R., Scherrer, U., and Maggiorini, M. (2000) Echocardiographic and invasive measurements of pulmonary artery pressure correlate closely at high altitude. Am. J. Physiol. Heart Circ. Physiol. 279, H2013-H2016
14. Dubowitz, G., and Peacock, A. J. (2007) Pulmonary artery pressure in healthy subjects at 4250 m measured by Doppler echocardiography. Wilderness Environ. Med. 18, 305-311
15. Weiss, R. G., Bottomley, P. A., Hardy, C. J., and Gerstenblith, G. (1990) Regional myocardial metabolism of high-energy phosphates during isometric exercise in patients with coronary artery disease. N. Engl. J. Med. 323, 1593-1600
16. Hochachka, P. W., Clark, C. M., Holden, J. E., Stanley, C., Ugurbil, K., and Menon, R. S. (1996) 31P magnetic resonance spectroscopy of the Sherpa heart: a phosphocreatine/adenosine triphosphate signature of metabolic defense against hypobaric hypoxia. Proc. Natl. Acad. Sci. U. S. A. 93, 1215-1220
17. Portman, M., Standaert, T., and Ning, X.-H. (1996) Developmental changes in ATP utilization during graded hypoxia and reoxygenation in the heart in vivo. Am. J. Physiol. Heart Circ. Physiol. 270, H216-H223
18. Kelly, D. P. (2008) Hypoxic reprogramming. Nat. Genet. 40, 132-134
19. Zhang, H., Bosch-Marce, M., Shimoda, L. A., Tan, Y. S., Baek, J. H., Wesley, J. B., Gonzalez, F. J., and Semenza, G. L. (2008) Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J. Biol. Chem. 283, 10892-10903