Estimating the net effect of progesterone elevation on the day of hCG on live birth rates after IVF: A cohort analysis of 3296 IVF cycles

Human Reproduction

Volumn 30, Issue 3, 2015, Pages 684-691

  Venetis, Christos A ^a   Kolibianakis, Efstratios M ^b   Bosdou, Julia K ^b   Lainas, George T ^c   Sfontouris, Ioannis A ^c   Tarlatzis, Basil C ^b   Lainas, Tryfon G ^c  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^c IVF Unit   (Greece)

Author keywords

hCG; ICSI outcome; IVF; Ovarian stimulation; Pregnancy; Progesterone

Indexed keywords

ESTRADIOL; FOLLITROPIN; GONADORELIN AGONIST; GONADORELIN DERIVATIVE; LUTEINIZING HORMONE; PROGESTERONE; RECOMBINANT CHORIONIC GONADOTROPIN; RECOMBINANT FOLLITROPIN; CHORIONIC GONADOTROPIN;

ARTICLE; BODY MASS; CLINICAL PRACTICE; COHORT ANALYSIS; EMBRYO TRANSFER; ESTRADIOL BLOOD LEVEL; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; LIVE BIRTH; LUTEINIZING HORMONE BLOOD LEVEL; OOCYTE MATURATION; PREGNANCY RATE; PROGESTERONE BLOOD LEVEL; RETROSPECTIVE STUDY; BLOOD; COMPARATIVE STUDY; FEMALE; MULTIVARIATE ANALYSIS; PREGNANCY; RISK; STATISTICAL ANALYSIS;

CHORIONIC GONADOTROPIN; DATA INTERPRETATION, STATISTICAL; FEMALE; FERTILIZATION IN VITRO; HUMANS; LIVE BIRTH; MULTIVARIATE ANALYSIS; ODDS RATIO; PREGNANCY; PREGNANCY RATE; PROGESTERONE; RETROSPECTIVE STUDIES;

EID: 84931271816     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/deu362     Document Type: Article

References (35)

1. Baczkowski T, Kurzawa R, Glabowski W. Methods of embryo scoring in in vitro fertilization. Reprod Biol 2004;4:5-22.
2. Bosch E, Labarta E, Crespo J, Simon C, Remohi J, Jenkins J, Pellicer A. Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod 2010;25:2092-2100.
3. Check JH, Lurie D, Askari HA, Hoover L, Lauer C. The range of subtle rise in serum progesterone levels following controlled ovarian hyperstimulation associated with lower in vitro fertilization pregnancy rates is determined by the source of manufacturer. Eur J Obstet Gynecol Reprod Biol 1993; 52:205-209.
4. Edelstein MC, Seltman HJ, Cox BJ, Robinson SM, Shaw RA, Muasher SJ. Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing hormone agonist suppression are not predictive of pregnancy outcome. Fertil Steril 1990; 54:853-857.
5. Fanchin R, Righini C, Olivennes F, de Ziegler D, Selva J, Frydman R. Premature progesterone elevation does not alteroocyte qualityininvitro fertilization. Fertil Steril 1996;65:1178-1183.
6. Fanchin R, Righini C, Olivennes F, Ferreira AL, de Ziegler D, Frydman R. Consequences of premature progesterone elevation on the outcome of in vitro fertilization: insights into a controversy. Fertil Steril 1997; 68:799-805.
7. Gardner DK, Schoolcraft WB. Culture and transfer of human blastocysts. Curr Opin Obstet Gynecol 1999;11:307-311.
8. Gardner DK, Lane M, Stevens J, Schlenker T, Schoolcraft WB. Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertil Steril 2000;73:1155-1158.
9. Glujovsky D, Blake D, Farquhar C, Bardach A. Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology. Cochrane Database Syst Rev 2012;7:CD002118.
10. Griesinger G, Mannaerts B, Andersen CY, Witjes H, Kolibianakis EM, Gordon K. Progesterone elevation does not compromise pregnancy rates in high responders: a pooled analysis of in vitro fertilization patients treated with recombinant follicle-stimulating hormone/gonadotropin-releasing hormone antagonist in six trials. Fertil Steril 2013;100: 1622-1628 e1621-1623.
11. Grimes DA, Schulz KF. Bias and causal associationsin observational research. Lancet 2002;359:248-252.
12. Harrell FE. Regression Modeling Strategies: with Applications to Linear Models, Logistic Regression, and Survival Analysis. Berlin: Springer, 2001.
13. Hosmer DW Jr, Lemeshow S. Applied Logistic Regression. New Jersey, NJ: John Wiley & Sons, 2004.
14. Huang CC, Lien YR, Chen HF, Chen MJ, Shieh CJ, Yao YL, Chang CH, Chen SU, Yang YS. The duration of pre-ovulatory serum progesterone elevation before hCG administration affects the outcome of IVF/ICSI cycles. Hum Reprod 2012a;27:2036-2045.
15. Huang R, Fang C, Xu S, Yi Y, Liang X. Premature progesterone rise negatively correlated withlive birth rateinIVF cycles with Gn RH agonist:ananalysis of 2566 cycles. Fertil Steril 2012b;98:664-670.
16. Jaccard J, Turrisi R. Interaction Effects in Multiple Regression, 2nd edn, Thousand Oaks, CA: Sage, 2003.
17. Kolibianakis EM, Venetis CA, Bontis J, Tarlatzis BC. Significantly lower pregnancy rates in the presence of progesterone elevation in patients treated with Gn RH antagonists and gonadotrophins: a systematic review and meta-analysis. Curr Pharm Biotechnol 2012;13:464-470.
18. Kyrou D, Al-Azemi M, Papanikolaou EG, Donoso P, Tziomalos K, Devroey P, Fatemi HM. The relationship of premature progesterone rise with serum estradiol levels and number of follicles in Gn RH antagonist/recombinant FSH-stimulated cycles. Eur J Obstet Gynecol Reprod Biol 2012;162:165-168.
19. Miller KF, Behnke EJ, Arciaga RL, Goldberg JM, Chin NW, Awadalla SG. The significance of elevated progesterone at the time of administration of human chorionic gonadotropin may be related to luteal support. J Assist Reprod Genet 1996;13:698-701.
20. Ochsenkühn R, Arzberger A, von Schönfeldt V, Gallwas J, Rogenhofer N, Crispin A, Thaler CJ, Noss U. Subtle progesterone rise on the day of human chorionic gonadotropin administration is associated with lower live birth rates in women undergoing assisted reproductive technology: a retrospective study with 2555 fresh embryo transfers. Fertil Steril 2012; 98:347-354.
21. Pandian Z, Marjoribanks J, Ozturk O, Serour G, Bhattacharya S. Number of embryos for transfer following in vitro fertilisation or intra-cytoplasmic sperm injection. Cochrane Database Syst Rev 2013;7:CD003416.
22. Papanikolaou EG, Kolibianakis EM, Tournaye H, Venetis CA, Fatemi H, Tarlatzis B, Devroey P. Live birth rates after transfer of equal number of blastocysts or cleavage-stage embryos in IVF. A systematic review and meta-analysis. Hum Reprod 2008;23:91-99.
23. Rogers W. Regression standard errors in clustered samples. Stata Technical Bull 1993;13:19-23.
24. Rothman KJ, Greenland S. Causation and causal inference in epidemiology. Am J Public Health 2005;95(Suppl 1):S144-S150.
25. Rothman KJ, Greenland S, Lash TL. Modern Epidemiology. Philadelphia, PA: Lippincott Williams & Wilkins, 2008.
26. Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Embryo cryopreservation rescues cycles with premature luteinization. Fertil Steril 2010;93:636-641.
27. Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responders. Fertil Steril 2011;96:344-348.
28. Sunkara SK, Rittenberg V, Raine-Fenning N, Bhattacharya S, Zamora J, Coomarasamy A. Association between the number of eggs and live birth in IVF treatment: an analysis of 400 135 treatment cycles. Hum Reprod 2011;26:1768-1774.
29. Templeton A, Morris JK, Parslow W. Factors that affect outcome of in-vitro fertilisation treatment. Lancet 1996;348:1402-1406.
30. Venetis CA, Kolibianakis EM, Papanikolaou E, Bontis J, Devroey P, Tarlatzis BC. Is progesterone elevation on the day of human chorionic gonadotrophin administration associated with the probability of pregnancy in in vitro fertilization? A systematic review and meta-analysis. Hum Reprod Update 2007;13:343-355.
31. Venetis CA, Kolibianakis EM, Bosdou JK, Tarlatzis BC. Progesterone elevation and probabilityofpregnancy after IVF:asystematic review and meta-analysis of over 60 000 cycles. Hum Reprod Update 2013;19:433-457.
32. Wang Z. Two post-estimation commands for assessing confounding effects in epidemiological studies. Stata J 2007;7:183-196.
33. Williams RL. A note on robust variance estimation for cluster-correlated data. Biometrics 2000;56:645-646.
34. Xu B, Li Z, Zhang H, Jin L, Li Y, Ai J, Zhu G. Serum progesterone level effects on the outcome of in vitro fertilization in patients with different ovarian response: an analysis of more than 10 000 cycles. Fertil Steril 2012; 97:1321-1327. e1324.
35. Yding Andersen C, Bungum L, Nyboe Andersen A, Humaidan P. Preovulatory progesterone concentration associates significantly to follicle number and LH concentration but not to pregnancy rate. Reprod Biomed Online 2011; 23:187-195.