Progesterone elevation does not compromise pregnancy rates in high responders: A pooled analysis of in vitro fertilization patients treated with recombinant follicle-stimulating hormone/gonadotropin-releasing hormone antagonist in six trials

Fertility and Sterility

Volumn 100, Issue 6, 2013, Pages

  Griesinger, Georg ^a   Mannaerts, Bernadette ^b   Andersen, Claus Yding ^c   Witjes, Han ^b   Kolibianakis, Efstratios M ^d   Gordon, Keith ^e  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b PSCS   (Netherlands)

^c Mental Health Services CPH   (Denmark)

^d ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^e MERCK RESEARCH LABORATORIES   (United States)

Author keywords

controlled ovarian stimulation; GnRH antagonist; progesterone; Puregon; rFSH

Indexed keywords

GANIRELIX; PROGESTERONE; RECOMBINANT FOLLITROPIN; BIOLOGICAL MARKER; FOLLITROPIN; GONADORELIN;

ADULT; ARTICLE; CORRELATIONAL STUDY; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; FOLLICULAR PHASE; HORMONE DETERMINATION; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; OOCYTE MATURATION; PREGNANCY RATE; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; RETROSPECTIVE STUDY; TREATMENT RESPONSE; ADOLESCENT; ANTAGONISTS AND INHIBITORS; BLOOD; CLINICAL TRIAL (TOPIC); INFERTILITY, FEMALE; INTERNATIONAL COOPERATION; META ANALYSIS; OVULATION INDUCTION; PREGNANCY; PREGNANCY OUTCOME; PREVALENCE; PROGNOSIS; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; BIOLOGICAL MARKERS; CLINICAL TRIALS AS TOPIC; FEMALE; FERTILIZATION IN VITRO; FOLLICLE STIMULATING HORMONE; FOLLICULAR PHASE; GONADOTROPIN-RELEASING HORMONE; HUMANS; INFERTILITY, FEMALE; INTERNATIONALITY; OVULATION INDUCTION; PREGNANCY; PREGNANCY OUTCOME; PREVALENCE; PROGESTERONE; PROGNOSIS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84888440796     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2013.08.045     Document Type: Article

References (28)

1. F. Ubaldi, M. Camus, J. Smitz, H.C. Bennink, S.A. Van, and P. Devroey Premature luteinization in in vitro fertilization cycles using gonadotropin-releasing hormone agonist (GnRH-a) and recombinant follicle-stimulating hormone (FSH) and GnRH-a and urinary FSH Fertil Steril 66 1996 275 280
2. D. Kyrou, M. Al-Azemi, E.G. Papanikolaou, P. Donoso, K. Tziomalos, and P. Devroey The relationship of premature progesterone rise with serum estradiol levels and number of follicles in GnRH antagonist/recombinant FSH-stimulated cycles Eur J Obstet Gynecol Reprod Biol 162 2012 165 168
3. C. Yding Andersen, L. Bungum, A. Nyboe Andersen, and P. Humaidan Preovulatory progesterone concentration associates significantly to follicle number and LH concentration but not to pregnancy rate Reprod Biomed Online 23 2011 187 195
4. E. Bosch, I. Valencia, E. Escudero, J. Crespo, C. Simon, and J. Remohi Premature luteinization during gonadotropin-releasing hormone antagonist cycles and its relationship with in vitro fertilization outcome Fertil Steril 80 2003 1444 1449
5. M.C. Edelstein, H.J. Seltman, B.J. Cox, S.M. Robinson, R.A. Shaw, and S.J. Muasher Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing hormone agonist suppression are not predictive of pregnancy outcome Fertil Steril 54 1990 853 857
6. K.M. Silverberg, W.N. Burns, D.L. Olive, R.M. Riehl, and R.S. Schenken Serum progesterone levels predict success of in vitro fertilization/embryo transfer in patients stimulated with leuprolide acetate and human menopausal gonadotropins J Clin Endocrinol Metab 73 1991 797 803
7. L.L. Thuesen, A. Loft, A.N. Egeberg, J. Smitz, J.H. Petersen, and A. Nyboe Andersen A randomized controlled dose-response pilot study of addition of hCG to recombinant FSH during controlled ovarian stimulation for in vitro fertilization Hum Reprod 27 2012 3074 3084
8. I. Van Vaerenbergh, H.M. Fatemi, C. Blockeel, L. Van Lommel, P. In't Veld, and F. Schuit Progesterone rise on hCG day in GnRH antagonist/rFSH stimulated cycles affects endometrial gene expression Reprod Biomed Online 22 2011 263 271
9. E. Bosch, E. Labarta, J. Crespo, C. Simon, J. Remohi, and J. Jenkins Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles Hum Reprod 25 2010 2092 2100
10. E.M. Kolibianakis, C.A. Venetis, J. Bontis, and B.C. Tarlatzis Significantly lower pregnancy rates in the presence of progesterone elevation in patients treated with GnRH antagonists and gonadotrophins: a systematic review and meta-analysis Curr Pharm Biotechnol 13 2012 464 470
11. R. Huang, C. Fang, S. Xu, Y. Yi, and X. Liang Premature progesterone rise negatively correlated with live birth rate in IVF cycles with GnRH agonist: an analysis of 2,566 cycles Fertil Steril 98 2012 664 670
12. R. Ochsenkühn, A. Arzberger, V. von Schönfeldt, J. Gallwas, N. Rogenhofer, and A. Crispin Subtle progesterone rise on the day of human chorionic gonadotropin administration is associated with lower live birth rates in women undergoing assisted reproductive technology: a retrospective study with 2,555 fresh embryo transfers Fertil Steril 98 2012 347 354
13. B. Xu, Z. Li, H. Zhang, L. Jin, Y. Li, and J. Ai Serum progesterone level effects on the outcome of in vitro fertilization in patients with different ovarian response: an analysis of more than 10,000 cycles Fertil Steril 97 2012 1321 1327
14. C.C. Huang, Y.R. Lien, H.F. Chen, M.J. Chen, C.J. Shieh, and Y.L. Yao The duration of pre-ovulatory serum progesterone elevation before hCG administration affects the outcome of IVF/ICSI cycles Hum Reprod 27 2012 2036 2045
15. European Orgalutran Study Group, G. Borm, and B. Mannaerts Treatment with the gonadotrophin-releasing hormone antagonist ganirelix in women undergoing ovarian stimulation with recombinant follicle stimulating hormone is effective, safe and convenient: results of a controlled, randomized, multicentre trial Hum Reprod 15 2000 1490 1498
16. European Middle East Orgalutran Study Group Comparable clinical outcome using the GnRH antagonist ganirelix or a long protocol of the GnRH agonist triptorelin for the prevention of premature LH surges in women undergoing ovarian stimulation Hum Reprod 16 2001 644 651
17. North American Ganirelix Study Group Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation Fertil Steril 75 2001 38 45
18. P. Devroey, R. Boostanfar, N.P. Koper, B.M. Mannaerts, P.C. Ijzerman-Boon, and B.C. Fauser A double-blind, noninferiority RCT comparing corifollitropin alfa and recombinant FSH during the first seven days of ovarian stimulation using a GnRH antagonist protocol Hum Reprod 24 2009 3063 3072
19. Corifollitropin alfa Ensure Study Group Corifollitropin alfa for ovarian stimulation in IVF: a randomized trial in lower-body-weight women Reprod Biomed Online 21 2010 66 76
20. A. Nyboe Andersen, H. Witjes, K. Gordon, and B. Mannaerts Predictive factors of ovarian response and clinical outcome after IVF/ICSI following a rFSH/GnRH antagonist protocol with or without oral contraceptive pre-treatment Hum Reprod 26 2011 3413 3423
21. M.A. Melo, M. Meseguer, N. Garrido, E. Bosch, A. Pellicer, and J. Remohi The significance of premature luteinization in an oocyte-donation programme Hum Reprod 21 2006 1503 1507
22. A.J. Polotsky, J.L. Daif, S. Jindal, H.J. Lieman, N. Santoro, and L. Pal Serum progesterone on the day of human chorionic gonadotropin administration predicts clinical pregnancy of sibling frozen embryos Fertil Steril 92 2009 1880 1885
23. A.L. Schneyer, T. Fujiwara, J. Fox, C.K. Welt, J. Adams, and G.M. Messerlian Dynamic changes in the intrafollicular inhibin/activin/follistatin axis during human follicular development: relationship to circulating hormone concentrations J Clin Endocrinol Metab 85 2000 3319 3330
24. B.S. Shapiro, S.T. Daneshmand, F.C. Garner, M. Aguirre, C. Hudson, and S. Thomas Embryo cryopreservation rescues cycles with premature luteinization Fertil Steril 93 2010 636 641
25. E.B. Kiliçdag, B. Haydardedeoglu, T. Cok, S.O. Hacivelioglu, and T. Bagis Premature progesterone elevation impairs implantation and live birth rates in GnRH-agonist IVF/ICSI cycles Arch Gynecol Obstet 281 2010 747 752
26. E.G. Papanikolaou, G. Pados, G. Grimbizis, E. Bili, L. Kyriazi, and N.P. Polyzos GnRH-agonist versus GnRH-antagonist IVF cycles: is the reproductive outcome affected by the incidence of progesterone elevation on the day of HCG triggering? A randomized prospective study Hum Reprod 27 2012 1822 1828
27. C.R. Givens, E.D. Schriock, P.V. Dandekar, and M.C. Martin Elevated serum progesterone levels on the day of human chorionic gonadotropin administration do not predict outcome in assisted reproduction cycles Fertil Steril 62 1994 1011 1017
28. J.C. Huang, K.V. Jackson, M.D. Hornstein, and E.S. Ginsburg The effect of elevated serum progesterone during ovulation induction in in vitro fertilization-embryo transfer J Assist Reprod Genet 13 1996 617 624