The duration of pre-ovulatory serum progesterone elevation before hCG administration affects the outcome of IVF/ICSI cycles

Human Reproduction

Volumn 27, Issue 7, 2012, Pages 2036-2045

  Huang, Chu Chun ^a   Lien, Yih Ron ^a   Chen, Hsin Fu ^a   Chen, Mei Jou ^a   Shieh, Chia Jen ^a   Yao, Yi Lin ^a   Chang, Chin Hao ^a   Chen, Shee Uan ^a   Yang, Yu Shih ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

hCG; in vitro fertilization; ovarian stimulation; pregnancy rate; progesterone

Indexed keywords

BUSERELIN ACETATE; CETRORELIX; GANIRELIX; HUMAN MENOPAUSAL GONADOTROPIN; PROGESTERONE; RECOMBINANT CHORIONIC GONADOTROPIN; RECOMBINANT FOLLITROPIN;

ADULT; ARTICLE; BLASTOCYST; CONTROLLED OVARIAN STIMULATION; CORRELATION ANALYSIS; EMBRYO; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; GESTATIONAL AGE; HUMAN; IMMUNOASSAY; MAJOR CLINICAL STUDY; OVARY CYCLE; OVARY HYPERSTIMULATION; PATIENT SELECTION; PREGNANCY; PREGNANCY RATE; PROGESTERONE BLOOD LEVEL; RETROSPECTIVE STUDY;

EID: 84863593390     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/des141     Document Type: Article

References (55)

1. Agarwal SK, Vogel K, Weitsman SR, Magoffin DA. Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulosa and theca cells of the human ovary. J Clin Endocrinol Metab 1999; 84:1072-1076. (Pubitemid 29138245)
2. Al-Azemi M, Kyrou D, Papanikolaou EG, Polyzos NP, Devroey P, Fatemi HM. The relationship between premature progesterone rise with serum estradiol levels and number of follicles in GnRH antagonist/rec-FSH stimulated cycles. In: Abstracts of the 27th Annual Meeting of the European Society of Human Reproduction and Embryology, 2011, P-526.
3. Andersen AN, Devroey P, Arce JC. Clinical outcome following stimulation with highly purified hMG or recombinant FSH in patients undergoing IVF: a randomized assessor-blind controlled trial. Hum Reprod 2006; 21:3217-3227. (Pubitemid 44811626)
4. Andersen YC, Bungum L, Andersen AN, Humaidan P. Preovulatory progesterone concentration associates significantly to follicle number and LH concentration but not to pregnancy rate. Reprod Biomed Online 2011;23:187-195.
5. BenNun I, Ghetler Y, Jaffe R, Siegal A, Kaneti H, Fejgin M. The effect of preovulatory progesterone administration on the endometrial maturation and implantation rate after in vitro fertilisation and embryo transfer. Fertil Steril 1990;53:276-281. (Pubitemid 20076356)
6. Bosch E, Valencia I, Escudero E, Crespo J, Simón C, Remoh́ J, Pellicer A. Premature luteinization during gonadotropin-releasing hormone antagonist cycles and its relationship with in vitro fertilization outcome. Fertil Steril 2003;80:1444-1449. (Pubitemid 37532460)
7. Bosch E, Labarta E, Crespo J, Simón C, Remoh́ J, Jenkins J, Pellicer A. Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod 2010;25:2092-2100.
8. Bourgain C, Devroey P. The endometrium in stimulated cycles for IVF. Hum Reprod Update 2003;9:515-522. (Pubitemid 38072144)
9. Bourgain C, Ubaldi F, Tavaniotou A, Smitz J, Van Steirteghem AC, Devroey P. Endometrial hormone receptors and proliferation index in the periovulatory phase of stimulated embryo transfer cycles in comparison with natural cycles and relation to clinical pregnancy outcome. Fertil Steril 2002;78:237-244. (Pubitemid 34845894)
10. Brannian JD, Zhao Y, McElroy M. Leptin inhibits gonadotropin-stimulated granulosa cell progesterone production by antagonizing insulin action. Hum Reprod 1999;14:1445-1448. (Pubitemid 29265431)
11. Chetkowski RJ, Kiltz RJ, Salyer WR. In premature luteinization, progesterone induces secretory transformation of the endometrium without impairment of embryo viability. Fertil Steril 1997;68: 292-297. (Pubitemid 27342604)
12. Devroey P, Bourgain C, Macklon NS, Fauser BC. Reproductive biology and IVF: ovarian stimulation and endometrial receptivity. Trends Endocrinol Metab 2004;15:84-90. (Pubitemid 38258332)
13. de Ziegler D. Hormonal control of endometrial receptivity. Hum Reprod 1995;10:4-7.
14. Elnashar AM. Progesterone rise on the day of HCG administration (premature luteinization) in IVF: an overdue update. J Assist Reprod Genet 2010;27:149-155.
15. Erel CT, Senturk LM. The impact of body mass index on assisted reproduction. Curr Opin Obstet Gynecol 2009;21:228-235.
16. Fanchin R, Hourvitz A, Olivennes F, Taieb J, Hazout A, Frydman R. Premature progesterone elevation spares blastulation but not pregnancy rates in in vitro fertilization with coculture. Fertil Steril 1997a;68:648-652. (Pubitemid 27454323)
17. Fanchin R, Righini C, Olivennes F, Ferreira AL, de Ziegler D, Frydman R. Consequences of premature progesterone elevation on the outcome of in vitro fertilization: insights into a controversy. Fertil Steril 1997b; 68:799-805. (Pubitemid 27506090)
18. Fanchin R, Righini C, Olivennes F, Taieb J, de Ziegler D, Frydman R. Computerized assessment of endometrial echogenicity: clues to the endometrial effects of premature progesterone elevation. Fertil Steril 1999;71:174-181. (Pubitemid 29042365)
19. Fatemi HM, Popovic-Todorovic B, Papanikolaou E, Donoso P, Devroey P. An update of luteal phase support in stimulated IVF cycles. Hum Reprod Update 2007;13:581-590. (Pubitemid 350018526)
20. Fatemi HM, Doody K, Witjes H, Mannaerts B. A high ovarian response does not compromise the chance of pregnancy. In: Abstracts of the 27th Annual Meeting of the European Society of Human Reproduction and Embryology, 2011, P-510.
21. Fedorcsák P, Dale PO, Storeng R, Ertzeid G, Bjercke S, Oldereid N, Omland AK, Abyholm T, Tanbo T. Impact of overweight and underweight on assisted reproduction treatment. Hum Reprod 2004; 19:2523-2528. (Pubitemid 39481277)
22. Filicori M, Cognigni GE, Pocognoli P, Tabarelli C, Spetolli D, Taraborrelli S, Ciampaglia W. Modulation of folliculogenesis and steroidogenesis in women by graded menotrophin administration. Hum Reprod 2002; 17:2009-2015.
23. Haouzi D, Assou S, Mahmoud K, Tondeur S, Rème T, Hedon B, De Vos J, Hamamah S. Gene expression profile of human endometrial receptivity: comparison between natural and stimulated cycles for the same patients. Hum Reprod 2009;24:1436-1445.
24. Ho CH, Chen SU, Peng FS, Chang CY, Lien YR, Yang YS. Prospective comparison of short and long GnRH agonist protocols using recombinant gonadotrophins for IVF/ICSI treatments. Reprod Biomed Online 2008;16:632-639.
25. Hofmann GE, Bentzien F, Bergh PA, Garrisi GJ, Williams MC, Guzman I, Navot D. Premature luteinization in controlled ovarian hyperstimulation has no adverse effect on oocyte and embryo quality. Fertil Steril 1993; 60:675-679. (Pubitemid 23298514)
26. Horcajadas JA, Ḿnguez P, Dopazo J, Esteban FJ, Doḿnguez F, Giudice LC, Pellicer A, Simón C. Controlled ovarian stimulation induces a functional genomic delay of the endometrium with potential clinical implications. J Clin Endocrinol Metab 2008;93:4500-4510. (Pubitemid 352789553)
27. Howles CM, Macnamee MC, Edwards RG. Progesterone supplementation in the late follicular phase of an in-vitro fertilisation cycle: a 'natural' way to time oocyte recovery? Hum Reprod 1988;3:409-412.
28. Hugues JN, Massé-Laroche E, Reboul-Marty J, Boko O, Meynant C, Cédrin-Durnerin I. Impact of endogenous luteinizing hormone serum levels on progesterone elevation on the day of human chorionic gonadotropin administration. Fertil Steril 2011;96:600-604.
29. Karamouti M, Kollia P, Kallitsaris A, Vamvakopoulos N, Kollios G, Messinis IE. Growth hormone, insulin-like growth factor I, leptin interaction in human cultured lutein granulosa cells steroidogenesis. Fertil Steril 2008;90:1444-1450.
30. Kiliçdag EB, Haydardedeoglu B, Cok T, Hacivelioglu SO, Bagis T. Premature progesterone elevation impairs implantation and live birth rates in GnRH-agonist IVF/ICSI cycles. Arch Gynecol Obstet 2010; 281:747-752.
31. Kolibianakis E, Bourgain C, Albano C, Osmanagaoglu K, Smitz J, Van Steirteghem A, Devroey P. Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin releasing hormone antagonists, and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up. Fertil Steril 2002;78:1025-1029. (Pubitemid 35292504)
32. Kolibianakis E, Bourgain C, Papanikolaou EG, Camus M, Tournaye H, Van Steirteghem AC, Devroey P. Prolongation of follicular phase by delaying hCG administration results in a higher incidence of endometrial advancement on the day of oocyte retrieval in GnRH antagonist cycles. Hum Reprod 2005;20:2453-2456. (Pubitemid 41222492)
33. Kolibianakis EM, Venetis CA, Bontis J, Tarlatzis BC. Significantly lower pregnancy rates in the presence of progesterone elevation in patients treated with GnRH antagonists and gonadotrophins: a systematic review and meta-analysis. Curr Pharm Biotechnol 2012; 13:464-470.
34. Kyrou D, Popovic-Todorovic B, Fatemi HM, Bourgain C, Haentjens P, Van Landuyt L, Devroey P. Does the estradiol level on the day of human chorionic gonadotrophin administration have an impact on pregnancy rates in patients treated with rec-FSH/GnRH antagonist? Hum Reprod 2009;24:2902-2909.
35. Labarta E, Mart́nez-Conejero JA, Alamá P, Horcajadas JA, Pellicer A, Simón C, Bosch E. Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod 2011; 26:1813-1825.
36. Lai TH, Lee FK, Lin TK, Horng SG, Chen SC, Chen YH, Wang PC. An increased serum progesterone-to-estradiol ratio on the day of human chorionic gonadotropin administration does not have a negative impact on clinical pregnancy rate in women with normal ovarian reserve treated with a long gonadotropin releasing hormone agonist protocol. Fertil Steril 2009;92:508-514.
37. Lee TH, Wu MY, Chen HF, Chen SU, Ho HN, Yang YS. Association of a single dose of gonadotropin-releasing hormone antagonist with nitric oxide and embryo quality in in vitro fertilization cycles. Fertil Steril 2006;86:1020-1022.
38. Legro RS, Ary BA, Paulson RJ, Stanczyk FZ, Sauer MV. Premature luteinization as detected by elevated serum progesterone is associated with a higher pregnancy rate in donor oocyte in-vitro fertilization. Hum Reprod 1993;8:1506-1511. (Pubitemid 23265989)
39. Liu Y, Lee KF, Ng EH, Yeung WS, Ho PC. Gene expression profiling of human peri-implantation endometria between natural and stimulated cycles. Fertil Steril 2008;90:2152-2164.
40. Melo MA, Meseguer M, Garrido N, Bosch E, Pellicer A, Remoh́ J. The significance of premature luteinization in an oocyte-donation programme. Hum Reprod 2006;21:1503-1507. (Pubitemid 44445028)
41. Ozçakir HT, Levi R, Tavmergen E, Göker EN. Premature luteinization defined as progesterone estradiol ratio .1 on hCG administration day seems to adversely affect clinical outcome in long gonadotropin-releasing hormone agonist cycles. J Obstet Gynaecol Res 2004;30:100-104. (Pubitemid 38508622)
42. Papanikolaou EG, Bourgain C, Kolibianakis E, Tournaye H, Devroey P. Steroid receptor expression in late follicular phase endometrium in GnRH antagonist IVF cycles is already altered, indicating initiation of early luteal phase transformation in the absence of secretory changes. Hum Reprod 2005;20:1541-1547. (Pubitemid 40852245)
43. Saadat P, Boostanfar R, Slater CC, Tourgeman DE, Stanczyk FZ, Paulson RJ. Accelerated endometrial maturation in the luteal phase of cycles utilizing controlled ovarian hyperstimulation: impact of gonadotropin-releasing hormone agonists versus antagonists. Fertil Steril 2004;82:167-171. (Pubitemid 38968794)
44. Segal S, Glatstein I, McShane P, Hotamisligil S, Ezcurra D, Carson R. Premature luteinization and in vitro fertilization outcome in gonadotropin/gonadotropin-releasing hormone antagonist cycles in women with polycystic ovary syndrome. Fertil Steril 2009; 91:1755-1759.
45. Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Embryo cryopreservation rescues cycles with premature luteinization. Fertil Steril 2010;93:636-641.
46. Silverberg KM, Martin M, Olive DL, Burns WN, Schenken RS. Elevated serum progesterone levels on the day of human chorionic gonadotropin administration in in vitro fertilization cycles do not adversely affect embryo quality. Fertil Steril 1994;61:508-513. (Pubitemid 24083154)
47. Smitz J, Ron-El R, Tarlatzis BC. The use of gonadotrophin releasing hormone agonists for in vitro fertilization and other assisted procreation techniques: experience from three centres. Hum Reprod 1992;7:49-66.
48. Sohn SH, Pensias AS, Emmi AM, Dubey AK, Layman LC, Reindollar RH, DeCherney AH. Administration of progesterone before oocyte retrieval negatively affects the implantation rate. Fertil Steril 1999; 71:11-14. (Pubitemid 29042336)
49. Ubaldi F, Smitz J, Wisanto A, Joris H, Schiettecatte J, Derde MP, Borkham E, Van Steirteghem A, Devroey P. Oocyte and embryo quality as well as pregnancy rate in intracytoplasmic sperm injection are not affected by high follicular phase serum progesterone. Hum Reprod 1995;10:3091-3096. (Pubitemid 26026501)
50. Ubaldi F, Albano C, Peukert M, Riethmuller-Winzen H, Camus M, Smitz J, Van Steirteghem A, Devroey P. Subtle progesterone rise after the administration of the gonadotrophin-releasing hormone antagonist cetrorelix in intracytoplasmic sperm injection cycles. Hum Reprod 1996;11:1405-1407. (Pubitemid 26335085)
51. Ubaldi F, Bourgain C, Tournaye H, Smitz J, Van Steirteghem A, Devroey P. Endometrial evaluation by aspiration biopsy on the day of oocyte retrieval in the embryo transfer cycles in patients with serum progesterone rise during the follicular phase. Fertil Steril 1997;67:521-526. (Pubitemid 27085969)
52. Vankrieken L. IMMULITE Reproductive Hormone Assays: Multicenter Reference Range Data. Document No. ZB157-D. Los Angeles: Diagnostic Products Corporation, 2000.
53. Venetis CA, Kolibianakis EM, Papanikolaou E, Bontis J, Devroey P, Tarlatzis BC. Is progesterone elevation on the day of human chorionic gonadotrophin administration associated with the probability of pregnancy in in vitro fertilization? A systematic review and metaanalysis. Hum Reprod Update 2007;13:343-355. (Pubitemid 47062828)
54. Younis JS, Haddad S, Matilsky M, Ben-Ami M. Premature luteinization: could it be an early manifestation of low ovarian reserve? Fertil Steril 1998;69:461-465.
55. Younis JS, Matilsky M, Radin O, Ben-Ami M. Increased progesterone/ estradiol ratio in the late follicular phase could be related to low ovarian reserve in in vitro fertilization-embryo transfer cycles with a long gonadotropin-releasing hormone agonist. Fertil Steril 2001; 76:294-299. (Pubitemid 32703817)