BCL-XL mediates the strong selective advantage of a 20q11.21 amplification commonly found in human embryonic stem cell cultures

Stem Cell Reports

Volumn 1, Issue 5, 2013, Pages 379-386

  Avery, Stuart ^a,i   Hirst, Adam J ^a,b   Baker, Duncan ^c   Lim, Chin Yan ^a   Alagaratnam, Sharmini ^d   Skotheim, Rolf I ^d   Lothe, Ragnhild A ^d   Pera, Martin F ^e,f   Colman, Alan ^a   Robson, Paul ^g   Andrews, Peter W ^b   Knowles, Barbara B ^a,h  

^a INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c SHEFFIELD CHILDREN'S NHS FOUNDATION TRUST   (United Kingdom)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

^e UNIVERSITY OF MELBOURNE   (Australia)

^f WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^g GENOME INSTITUTE OF SINGAPORE   (Singapore)

^h JACKSON LABORATORY   (United States)

ⁱ Fishawack Communications GmbH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BAX; PROTEIN BCL XL; PROTEIN BCL X;

AMPLICON; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL DEATH; CELL DENSITY; CELL DIFFERENTIATION; CELL DIVISION; CELL GROWTH; CELL SURVIVAL; CHROMOSOME 20Q; CHROMOSOME 20Q11.21; CONTROLLED STUDY; COPY NUMBER VARIATION; DAUGHTER CELL; EMBRYONAL CARCINOMA STEM CELL; EMBRYONIC STEM CELL; GENE AMPLIFICATION; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; KARYOTYPE; KARYOTYPING; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL CULTURE; CELL LINE; CHROMOSOME 20; GENE LOCUS; GENETIC SELECTION; GENETICS; METABOLISM; MUTATION;

BCL-X PROTEIN; CELL LINE; CHROMOSOMES, HUMAN, PAIR 20; DNA COPY NUMBER VARIATIONS; EMBRYONIC STEM CELLS; GENE AMPLIFICATION; GENETIC LOCI; HUMANS; MUTATION; SELECTION, GENETIC;

EID: 84888129842     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2013.10.005     Document Type: Article

References (36)

1. B. Aflatoonian, L. Ruban, S. Shamsuddin, D. Baker, P. Andrews, and H. Moore Generation of Sheffield (Shef) human embryonic stem cell lines using a microdrop culture system In Vitro Cell. Dev. Biol. Anim. 46 2010 236 241
2. K. Amps, P.W. Andrews, G. Anyfantis, L. Armstrong, S. Avery, H. Baharvand, J. Baker, D. Baker, M.B. Munoz, S. Beil International Stem Cell Initiative Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage Nat. Biotechnol. 29 2011 1132 1144
3. S.A. Amundson, T.G. Myers, D. Scudiero, S. Kitada, J.C. Reed, and A.J. Fornace Jr. An informatics approach identifying markers of chemosensitivity in human cancer cell lines Cancer Res. 60 2000 6101 6110
4. R. Ardehali, M.A. Inlay, S.R. Ali, C. Tang, M. Drukker, and I.L. Weissman Overexpression of BCL2 enhances survival of human embryonic stem cells during stress and obviates the requirement for serum factors Proc. Natl. Acad. Sci. USA 108 2011 3282 3287
5. D.E. Baker, N.J. Harrison, E. Maltby, K. Smith, H.D. Moore, P.J. Shaw, P.R. Heath, H. Holden, and P.W. Andrews Adaptation to culture of human embryonic stem cells and oncogenesis in vivo Nat. Biotechnol. 25 2007 207 215
6. K.A. Becker, P.N. Ghule, J.A. Therrien, J.B. Lian, J.L. Stein, A.J. van Wijnen, and G.S. Stein Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase J. Cell. Physiol. 209 2006 883 893
7. R. Beroukhim, C.H. Mermel, D. Porter, G. Wei, S. Raychaudhuri, J. Donovan, J. Barretina, J.S. Boehm, J. Dobson, and M. Urashima The landscape of somatic copy-number alteration across human cancers Nature 463 2010 899 905
8. B. Carvalho, C. Postma, S. Mongera, E. Hopmans, S. Diskin, M.A. van de Wiel, W. van Criekinge, O. Thas, A. Matthäi, and M.A. Cuesta Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression Gut 58 2009 79 89
9. C.A. Cowan, I. Klimanskaya, J. McMahon, J. Atienza, J. Witmyer, J.P. Zucker, S. Wang, C.C. Morton, A.P. McMahon, D. Powers, and D.A. Melton Derivation of embryonic stem-cell lines from human blastocysts N. Engl. J. Med. 350 2004 1353 1356
10. J.M. Crook, T.T. Peura, L. Kravets, A.G. Bosman, J.J. Buzzard, R. Horne, H. Hentze, N.R. Dunn, R. Zweigerdt, and F. Chua The generation of six clinical-grade human embryonic stem cell lines Cell Stem Cell 1 2007 490 494
11. J.S. Draper, K. Smith, P. Gokhale, H.D. Moore, E. Maltby, J. Johnson, L. Meisner, T.P. Zwaka, J.A. Thomson, and P.W. Andrews Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells Nat. Biotechnol. 22 2004 53 54
12. F. Edlich, S. Banerjee, M. Suzuki, M.M. Cleland, D. Arnoult, C. Wang, A. Neutzner, N. Tjandra, and R.J. Youle Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol Cell 145 2011 104 116
13. A.M. Elliott, K.A. Elliott, and A. Kammesheidt High resolution array-CGH characterization of human stem cells using a stem cell focused microarray Mol. Biotechnol. 46 2010 234 242
14. C. Greider, A. Chattopadhyay, C. Parkhurst, and E. Yang BCL-x(L) and BCL2 delay Myc-induced cell cycle entry through elevation of p27 and inhibition of G1 cyclin-dependent kinases Oncogene 21 2002 7765 7775
15. K. Gumireddy, A. Li, P.A. Gimotty, A.J. Klein-Szanto, L.C. Showe, D. Katsaros, G. Coukos, L. Zhang, and Q. Huang KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer Nat. Cell Biol. 11 2009 1297 1304
16. N. Hyka-Nouspikel, J. Desmarais, P.J. Gokhale, M. Jones, M. Meuth, P.W. Andrews, and T. Nouspikel Deficient DNA damage response and cell cycle checkpoints lead to accumulation of point mutations in human embryonic stem cells Stem Cells 30 2012 1901 1910
17. J. Inzunza, S. Sahlén, K. Holmberg, A.M. Strömberg, H. Teerijoki, E. Blennow, O. Hovatta, and H. Malmgren Comparative genomic hybridization and karyotyping of human embryonic stem cells reveals the occurrence of an isodicentric X chromosome after long-term cultivation Mol. Hum. Reprod. 10 2004 461 466
18. Y.M. Janumyan, C.G. Sansam, A. Chattopadhyay, N. Cheng, E.L. Soucie, L.Z. Penn, D. Andrews, C.M. Knudson, and E. Yang Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry EMBO J. 22 2003 5459 5470
19. W.J. Kent, C.W. Sugnet, T.S. Furey, K.M. Roskin, T.H. Pringle, A.M. Zahler, and D. Haussler The human genome browser at UCSC Genome Res. 12 2002 996 1006
20. L.C. Laurent, I. Ulitsky, I. Slavin, H. Tran, A. Schork, R. Morey, C. Lynch, J.V. Harness, S. Lee, and M.J. Barrero Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture Cell Stem Cell 8 2011 106 118
21. N. Lefort, M. Feyeux, C. Bas, O. Féraud, A. Bennaceur-Griscelli, G. Tachdjian, M. Peschanski, and A.L. Perrier Human embryonic stem cells reveal recurrent genomic instability at 20q11.21 Nat. Biotechnol. 26 2008 1364 1366
22. M.C. Maiuri, G. Le Toumelin, A. Criollo, J.C. Rain, F. Gautier, P. Juin, E. Tasdemir, G. Pierron, K. Troulinaki, and N. Tavernarakis Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1 EMBO J. 26 2007 2527 2539
23. K. Martins-Taylor, B.S. Nisler, S.M. Taapken, T. Compton, L. Crandall, K.D. Montgomery, M. Lalande, and R.H. Xu Recurrent copy number variations in human induced pluripotent stem cells Nat. Biotechnol. 29 2011 488 491
24. E. Närvä, R. Autio, N. Rahkonen, L. Kong, N. Harrison, D. Kitsberg, L. Borghese, J. Itskovitz-Eldor, O. Rasool, and P. Dvorak High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity Nat. Biotechnol. 28 2010 371 377
25. L.A. O'Reilly, D.C. Huang, and A. Strasser The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry EMBO J. 15 1996 6979 6990
26. B.E. Reubinoff, M.F. Pera, C.Y. Fong, A. Trounson, and A. Bongso Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro Nat. Biotechnol. 18 2000 399 404
27. V.E. Reuter Origins and molecular biology of testicular germ cell tumors Mod. Pathol. 18 Suppl 2 2005 S51 S60
28. A.H. Sillars-Hardebol, B. Carvalho, J.A. Beliën, M. de Wit, P.M. Delis-van Diemen, M. Tijssen, M.A. van de Wiel, F. Pontén, R.J. Fijneman, and G.A. Meijer BCL2L1 has a functional role in colorectal cancer and its protein expression is associated with chromosome 20q gain J. Pathol. 226 2012 442 450
29. A.H. Sillars-Hardebol, B. Carvalho, M. Tijssen, J.A. Beliën, M. de Wit, P.M. Delis-van Diemen, F. Pontén, M.A. van de Wiel, R.J. Fijneman, and G.A. Meijer TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression Gut 61 2012 1568 1575
30. C. Spits, I. Mateizel, M. Geens, A. Mertzanidou, C. Staessen, Y. Vandeskelde, J. Van der Elst, I. Liebaers, and K. Sermon Recurrent chromosomal abnormalities in human embryonic stem cells Nat. Biotechnol. 26 2008 1361 1363
31. B.M. Summersgill, O. Jafer, R. Wang, H. Goker, I. Niculescu-Duvaz, R. Huddart, and J. Shipley Definition of chromosome aberrations in testicular germ cell tumor cell lines by 24-color karyotyping and complementary molecular cytogenetic analyses Cancer Genet. Cytogenet. 128 2001 120 129
32. J.A. Thomson, J. Itskovitz-Eldor, S.S. Shapiro, M.A. Waknitz, J.J. Swiergiel, V.S. Marshall, and J.M. Jones Embryonic stem cell lines derived from human blastocysts Science 282 1998 1145 1147
33. T.E. Werbowetski-Ogilvie, M. Bossé, M. Stewart, A. Schnerch, V. Ramos-Mejia, A. Rouleau, T. Wynder, M.J. Smith, S. Dingwall, and T. Carter Characterization of human embryonic stem cells with features of neoplastic progression Nat. Biotechnol. 27 2009 91 97
34. J. Williams, P.C. Lucas, K.A. Griffith, M. Choi, S. Fogoros, Y.Y. Hu, and J.R. Liu Expression of Bcl-xL in ovarian carcinoma is associated with chemoresistance and recurrent disease Gynecol. Oncol. 96 2005 287 295
35. S. Yang, G. Lin, Y.Q. Tan, D. Zhou, L.Y. Deng, D.H. Cheng, S.W. Luo, T.C. Liu, X.Y. Zhou, and Z. Sun Tumor progression of culture-adapted human embryonic stem cells during long-term culture Genes Chromosomes Cancer 47 2008 665 679
36. Q.L. Ying, J. Nichols, I. Chambers, and A. Smith BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3 Cell 115 2003 281 292