Dexmedetomidine ameliorates acute lung injury following orthotopic autologous liver transplantation in rats probably by inhibiting Toll-like receptor 4-nuclear factor kappa B signaling

Journal of Translational Medicine

Volumn 13, Issue 1, 2015, Pages

  Chi, Xinjin ^a   Wei, Xiaoxia ^a   Gao, Wanling ^a   Guan, Jianqiang ^a   Yu, Xiaofan ^b   Wang, Yiheng ^c   Li, Xi ^a   Cai, Jun ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b FUJIAN PROVINCIAL HOSPITAL   (China)

^c UNIVERSITY OF SOUTH CHINA   (China)

Author keywords

Acute lung injury; Dexmedetomidine; Liver transplantation; Toll like receptor 4

Indexed keywords

2 (1 METHYL 2 ISOINDOLINYLMETHYL) 2 IMIDAZOLINE; 2 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 4,4 DIMETHYL 1,3(2H,4H) ISOQUINOLINEDIONE; ATIPAMEZOLE; DEXMEDETOMIDINE; EOSIN; HEMATOXYLIN; INTERLEUKIN 1BETA; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEROXIDASE; PROTEIN SUBUNIT; TUMOR NECROSIS FACTOR;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOTRANSPLANTATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; DRUG RESPONSE; HISTOLOGY; LAPAROTOMY; LIVER; LIVER TRANSPLANTATION; LUNG EDEMA; LUNG WEIGHT; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; ANIMAL; DRUG EFFECTS; LUNG; METABOLISM; ORGAN SIZE; PATHOLOGY; PHOSPHORYLATION; PROTEIN SUBUNIT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ACUTE LUNG INJURY; ANIMALS; DEXMEDETOMIDINE; INTERLEUKIN-1BETA; LIVER TRANSPLANTATION; LUNG; MALE; NF-KAPPA B; ORGAN SIZE; PEROXIDASE; PHOSPHORYLATION; PROTEIN SUBUNITS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TRANSPLANTATION, AUTOLOGOUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84931267179     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-015-0554-5     Document Type: Article

References (36)

1. Hong SK, Hwang S, Lee SG, Lee LS, Ahn CS, Kim KH et al (2006) Pulmonary complications following adult liver transplantation. Transplant Proc 38:2979-2981
2. Yao W, Luo G, Zhu G, Chi X, Zhang A, Xia Z et al (2014) Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model. Oxid Med Cell Longev 2014:258567
3. Chi XJ, Cai J, Luo CF, Cheng N, Hei ZQ, Li SR et al (2009) Relationship between the expression of Toll-like receptor 2 and 4 in mononuclear cells and postoperative acute lung injury in orthotopic liver transplantation. Chin Med J (Engl) 122:895-899
4. Feltracco P, Carollo C, Barbieri S, Pettenuzzo T, Ori C (2013) Early respiratory complications after liver transplantation. World J Gastroenterol 19:9271-9281
5. Yang Z, Deng Y, Su D, Tian J, Gao Y, He Z et al (2013) TLR4 as receptor for HMGB1-mediated acute lung injury after liver ischemia/reperfusion injury. Lab Invest 93:792-800
6. Sabroe I, Parker LC, Dower SK, Whyte MK (2008) The role of TLR activation in inflammation. J Pathol 214:126-135
7. O'Neill LA (2003) Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases. Curr Opin Pharmacol 3:396-403
8. Hei Z, Chi X, Cheng N, Luo G, Li S (2010) Upregulation of TLR2/4 expression in mononuclear cells in postoperative systemic inflammatory response syndrome after liver transplantation. Mediators Inflamm 2010:519589
9. Mantz J, Josserand J, Hamada S (2011) Dexmedetomidine: new insights. Eur J Anaesthesiol 28:3-6
10. Olli-Lähdesmäki T, Kallio J, Scheinin M (1999) Receptor subtype-induced targeting and subtype-specific internalization of human alpha(2)-adrenoceptors in PC12 cells. J Neurosci 19:9281-9288
11. Brede M, Philipp M, Knaus A, Muthig V, Hein L (2004) Alpha2-adrenergic receptor subtypes-novel functions uncovered in gene-targeted mouse models. Biol Cell 96:343-348
12. Malmberg AB, Hedley LR, Jasper JR, Hunter JC, Basbaum AI (2001) Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine. Br J Pharmacol 132:1827-1836
13. Engelhard K, Werner C, Eberspacher E, Bachl M, Blobner M, Hildt E et al (2003) The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-d-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats. Anesth Analg 96:524-531
14. Sugita S, Okabe T, Sakamoto A (2013) Continuous infusion of dexmedetomidine improves renal ischemia-reperfusion injury in rat kidney. J Nippon Med Sch 80:131-139
15. Shen J, Fu G, Jiang L, Xu J, Li L, Fu G (2013) Effect of dexmedetomidine pretreatment on lung injury following intestinal ischemia-reperfusion. Exp Ther Med 6:1359-1364
16. Curtis FG, Vianna PT, Viero RM, Fiorio PM, Silva LM, Braz JR (2011) Dexmedetomidine and S(+)-ketamine in ischemia and reperfusion injury in the rat kidney. Acta Cir Bras 26:202-206
17. U.S. Office of Science and Technology Policy (1985) Technology, Laboratory animal welfare; U.S. government principles for the utilization and care of vertebrate animals used in testing, research and training; notice. Fed Regist 50:20864-5
18. Chi X, Zhang A, Luo G, Xia H, Zhu G, Hei Z et al (2013) Knockdown of myeloid differentiation protein-2 reduces acute lung injury following orthotopic autologous liver transplantation in a rat model. Pulm Pharmacol Ther 26:380-387
19. Hanci V, Yurdakan G, Yurtlu S, Turan IÖ, Sipahi EY (2012) Protective effect of dexmedetomidine in a rat model of alpha-naphthylthiourea-induced acute lung injury. J Surg Res 178:424-430
20. Mullane KM, Kraemer R, Smith B (1985) Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods 14:157-167
21. Deng JC, Standiford TJ (2011) Growth factors and cytokines in acute lung injury. Compr Physiol 1(1):81-104
22. Ma K, Dai XW, Wang RP, Pu XM (1998) Intra inferior vena cava shunt: a new hamster model of orthotopic hepatic transplantation. J China Med Univ 27:356-358
23. von Dossow-Hanfstingl V (2012) Advances in therapy for acute lung injury. Anesthesiol Clin 30:629-639
24. Hu R, Xu H, Jiang H, Zhang Y, Sun Y (2013) The role of TLR4 in the pathogenesis of indirect acute lung injury. Front Biosci 18:1244-1255
25. Tolle LB, Standiford TJ (2013) Danger-associated molecular patterns (DAMPs) in acute lung injury. J Pathol 229:145-156
26. Zingarelli B, Piraino G, Hake PW, O'Connor M, Denenberg A, Fan H et al (2010) Peroxisome proliferator-activated receptor delta regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis. Am J Pathol 177:1834-1847
27. Kaplan J, Nowell M, Chima R, Zingarelli B (2013) Pioglitazone reduces inflammation through inhibition of NF-kappaB in polymicrobial sepsis. Innate Immun 20:519-528
28. Baumgarten G, Knuefermann P, Wrigge H, Putensen C, Stapel H, Fink K et al (2006) Role of Toll-like receptor 4 for the pathogenesis of acute lung injury in Gram-negative sepsis. Eur J Anaesthesiol 23:1041-1048
29. Lorenz E, Patel DD, Hartung T, Schwartz DA (2002) Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide. Infect Immun 70:4892-4896
30. Smith LS, Kajikawa O, Elson G, Wick M, Mongovin S, Kosco-Vilbois M et al (2008) Effect of Toll-like receptor 4 blockade on pulmonary inflammation caused by mechanical ventilation and bacterial endotoxin. Exp Lung Res 34:225-243
31. Leon CG, Tory R, Jia J, Sivak O, Wasan KM (2008) Discovery and development of toll-like receptor 4 (TLR4) antagonists: a new paradigm for treating sepsis and other diseases. Pharm Res 25:1751-1761
32. Opal SM, Laterre PF, Francois B, LaRosa SP, Angus DC, Mira JP et al (2013) Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA 309:1154-1162
33. Yang CL, Tsai PS, Huang CJ (2008) Effects of dexmedetomidine on regulating pulmonary inflammation in a rat model of ventilator-induced lung injury. Acta Anaesthesiol Taiwan 46:151-159
34. Wang J, Zhang H, Su C, Chen J, Zhu B, Zhang H et al (2014) Dexamethasone ameliorates H(2)S-induced acute lung injury by alleviating matrix metalloproteinase-2 and -9 expression. PLoS One 9:e94701
35. Cussac D, Schaak S, Gales C, Flordellis C, Denis C, Paris H (2002) Alpha(2B)-adrenergic receptors activate MAPK and modulate proliferation of primary cultured proximal tubule cells. Am J Physiol Renal Physiol 282:F943-F952
36. Paris A, Mantz J, Tonner PH, Hein L, Brede M, Gressens P (2006) The effects of dexmedetomidine on perinatal excitotoxic brain injury are mediated by the alpha2A-adrenoceptor subtype. Anesth Analg 102:456-461