Prediction of drug induced liver injury using molecular and biological descriptors

Combinatorial Chemistry and High Throughput Screening

Volumn 18, Issue 3, 2015, Pages 315-322

  Muller, Christophe ^a   Pekthong, Dumrongsak ^b,c   Alexandre, Eliane ^b   Marcou, Gilles ^a   Horvath, Dragos ^a   Richert, Lysiane ^b,d   Varnek, Alexandre ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b KaLy Cell   (France)

^c NARESUAN UNIVERSITY   (Thailand)

^d UNIVERSITÉ DE FRANCHE COMTÉ   (France)

Author keywords

Biological descriptor; Drug induced liver injury; Human hepatocyte cultures; Machine learning methods; Molecular descriptors

Indexed keywords

AMIODARONE; CHLORPROMAZINE; CYCLOSPORIN A; DICLOFENAC; PARACETAMOL; ROSIGLITAZONE; TICLOPIDINE; TROGLITAZONE; VALPROIC ACID; WARFARIN; DRUG;

ARTICLE; ARTIFICIAL NEURAL NETWORK; CALCULATION; CHEMICAL STRUCTURE; CHOLESTASIS; COMPUTER MODEL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CULTURE; LIVER CIRRHOSIS; LIVER TOXICITY; METABOLITE; MOLECULAR DIAGNOSIS; OXIDATIVE STRESS; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RANDOM FOREST; STEATOSIS; SUPPORT VECTOR MACHINE; TOXIC HEPATITIS; ADVERSE DRUG REACTION; FACTUAL DATABASE;

DATABASES, FACTUAL; DRUG-INDUCED LIVER INJURY; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84931265612     PISSN: 13862073     EISSN: 18755402     Source Type: Journal    
DOI: 10.2174/1386207318666150305144650     Document Type: Article

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