Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase

Molecular Pain

Volumn 11, Issue 1, 2015, Pages

  Marcus, David J ^a,b   Zee, Michael ^a,b   Hughes, Alex ^b   Yuill, Matthew B ^a   Hohmann, Andrea G ^b   Mackie, Ken ^b   Guindon, Josée ^b,c   Morgan, Daniel J ^a,b  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

^c TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

Chemotherapy; Cisplatin; Desensitization; Fentanyl; GPCR; GRK; JNK; Morphine; Mu opioid receptor; Tolerance

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CISPLATIN; FENTANYL; FORMALDEHYDE; MORPHINE; STRESS ACTIVATED PROTEIN KINASE; ANALGESIC AGENT; ANTHRACENE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRAZOLANTHRONE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; AREA UNDER THE CURVE; ARTICLE; CHRONIC DRUG ADMINISTRATION; COLD ALLODYNIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG TOLERABILITY; ENZYME ACTIVITY; ENZYME INHIBITION; HOTPLATE TEST; HYPOTHERMIA; LOW DRUG DOSE; MECHANICAL ALLODYNIA; MONOTHERAPY; MOUSE; MULTIPLE CYCLE TREATMENT; NEUROPATHIC PAIN; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TAIL FLICK TEST; THERMAL STIMULUS TEST; TREATMENT DURATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; C57BL MOUSE; DRUG EFFECTS; DRUG TOLERANCE; HYPERALGESIA; INDUCED HYPOTHERMIA; METABOLISM; NOCICEPTION; PATHOLOGY;

ANALGESICS; ANIMALS; ANTHRACENES; CISPLATIN; DRUG TOLERANCE; FENTANYL; FORMALDEHYDE; HYPERALGESIA; HYPOTHERMIA, INDUCED; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MORPHINE; NOCICEPTION; PROTEIN KINASE INHIBITORS;

EID: 84931264002     PISSN: 17448069     EISSN: 17448069     Source Type: Journal    
DOI: 10.1186/s12990-015-0031-4     Document Type: Article

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