메뉴 건너뛰기




Volumn 32, Issue 2, 2014, Pages 182-190

Smac mimetics and innate immune stimuli synergize to promote tumor death

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS REGULATORY PROTEINS; CELL DEATH; CYTOKINES; DRUG SYNERGISM; FEMALE; HEK293 CELLS; HT29 CELLS; HUMANS; MICE; MICE, INBRED BALB C; NEOPLASMS, EXPERIMENTAL; OLIGODEOXYRIBONUCLEOTIDES; ONCOLYTIC VIROTHERAPY; POLY I-C;

EID: 84893825107     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.2806     Document Type: Article
Times cited : (103)

References (47)
  • 1
    • 84856495152 scopus 로고    scopus 로고
    • Targeting IAP proteins for therapeutic intervention in cancer
    • Fulda, S. & Vucic, D. Targeting IAP proteins for therapeutic intervention in cancer. Nat. Rev. Drug Discov. 11, 109-124 (2012
    • (2012) Nat. Rev. Drug Discov , vol.11 , pp. 109-124
    • Fulda, S.1    Vucic, D.2
  • 2
    • 84876071466 scopus 로고    scopus 로고
    • Pulling the plug on a cancer cell by eliminating XIAP with AEG35156
    • LaCasse, E.C. Pulling the plug on a cancer cell by eliminating XIAP with AEG35156. Cancer Lett. 332, 215-224 (2013
    • (2013) Cancer Lett , vol.332 , pp. 215-224
    • LaCasse, E.C.1
  • 3
    • 77957729423 scopus 로고    scopus 로고
    • IAP inhibitors enhance co-stimulation to promote tumour immunity
    • Dougan, M. et al. IAP inhibitors enhance co-stimulation to promote tumour immunity. J. Exp. Med. 207, 2195-2206 (2010
    • (2010) J. Exp. Med , vol.207 , pp. 2195-2206
    • Dougan, M.1
  • 4
    • 84858760109 scopus 로고    scopus 로고
    • Combining immunotherapy and targeted therapies in cancer treatment
    • Vanneman, M. & Dranoff, G. Combining immunotherapy and targeted therapies in cancer treatment. Nat. Rev. Cancer 12, 237-251 (2012
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 237-251
    • Vanneman, M.1    Dranoff, G.2
  • 5
    • 77954930632 scopus 로고    scopus 로고
    • IAPs: From caspase inhibitors to modulators of NF-kappaB, inflammation and cancer
    • Gyrd-Hansen, M. & Meier, P. IAPs: From caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. Nat. Rev. Cancer 10, 561-574 (2010
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 561-574
    • Gyrd-Hansen, M.1    Meier, P.2
  • 6
    • 84870242006 scopus 로고    scopus 로고
    • The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling
    • Vandenabeele, P. & Bertrand, M.J. The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling. Nat. Rev. Immunol. 12, 833-844 (2012
    • (2012) Nat. Rev. Immunol , vol.12 , pp. 833-844
    • Vandenabeele, P.1    Bertrand, M.J.2
  • 7
    • 84858627919 scopus 로고    scopus 로고
    • Cellular inhibitors of apoptosis are global regulators of NF-kappaB and MAPK activation by members of the TNF family of receptors
    • Varfolomeev, E. et al. Cellular inhibitors of apoptosis are global regulators of NF-kappaB and MAPK activation by members of the TNF family of receptors. Sci. Signal. 5, ra22 (2012
    • (2012) Sci. Signal , vol.5
    • Varfolomeev, E.1
  • 8
    • 84867902828 scopus 로고    scopus 로고
    • Modulation of immune signalling by inhibitors of apoptosis
    • Beug, S.T., Cheung, H.H., LaCasse, E.C. & Korneluk, R.G. Modulation of immune signalling by inhibitors of apoptosis. Trends Immunol. 33, 535-545 (2012
    • (2012) Trends Immunol , vol.33 , pp. 535-545
    • Beug, S.T.1    Cheung, H.H.2    LaCasse, E.C.3    Korneluk, R.G.4
  • 9
    • 50149121101 scopus 로고    scopus 로고
    • Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation
    • Mahoney, D.J. et al. Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation. Proc. Natl. Acad. Sci. USA 105, 11778-11783 (2008
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 11778-11783
    • Mahoney, D.J.1
  • 10
    • 4444243683 scopus 로고    scopus 로고
    • A small molecule Smac mimic potentiates TRAIL-And TNF{alpha}-mediated cell death
    • Li, L. et al. A small molecule Smac mimic potentiates TRAIL-And TNF{alpha}-mediated cell death. Science 305, 1471-1474 (2004
    • (2004) Science , vol.305 , pp. 1471-1474
    • Li, L.1
  • 11
    • 36048999753 scopus 로고    scopus 로고
    • IAP antagonists induce autoubiquitination of c-IAPs NF-kappaB activation, and TNFalpha-dependent apoptosis
    • Varfolomeev, E. et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell 131, 669-681 (2007
    • (2007) Cell , vol.131 , pp. 669-681
    • Varfolomeev, E.1
  • 12
    • 36148954336 scopus 로고    scopus 로고
    • IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
    • Vince, J.E. et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 131, 682-693 (2007
    • (2007) Cell , vol.131 , pp. 682-693
    • Vince, J.E.1
  • 13
    • 35948994157 scopus 로고    scopus 로고
    • Autocrine TNFalpha signalling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis
    • Petersen, S.L. et al. Autocrine TNFalpha signalling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell 12, 445-456 (2007
    • (2007) Cancer Cell , vol.12 , pp. 445-456
    • Petersen, S.L.1
  • 14
    • 37549000486 scopus 로고    scopus 로고
    • A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumour necrosis factor-Alpha signalling
    • Gaither, A. et al. A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumour necrosis factor-Alpha signalling. Cancer Res. 67, 11493-11498 (2007
    • (2007) Cancer Res , vol.67 , pp. 11493-11498
    • Gaither, A.1
  • 15
    • 70350228525 scopus 로고    scopus 로고
    • Down-regulation of c-FLIP Enhances death of cancer cells by smac mimetic compound
    • Cheung, H.H., Mahoney, D.J., Lacasse, E.C. & Korneluk, R.G. Down-regulation of c-FLIP Enhances death of cancer cells by smac mimetic compound. Cancer Res. 69, 7729-7738 (2009
    • (2009) Cancer Res , vol.69 , pp. 7729-7738
    • Cheung, H.H.1    Mahoney, D.J.2    Lacasse, E.C.3    Korneluk, R.G.4
  • 16
    • 78650403056 scopus 로고    scopus 로고
    • Smac mimetic compounds potentiate interleukin-1 beta-mediated cell death
    • Cheung, H.H. et al. Smac mimetic compounds potentiate interleukin-1 beta-mediated cell death. J. Biol. Chem. 285, 40612-40623 (2010
    • (2010) J. Biol. Chem , vol.285 , pp. 40612-40623
    • Cheung, H.H.1
  • 17
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
    • Kawai, T. & Akira, S. The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors. Nat. Immunol. 11, 373-384 (2010
    • (2010) Nat. Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 18
    • 66149086936 scopus 로고    scopus 로고
    • NOD-like receptors: Role in innate immunity and inflammatory disease
    • Chen, G., Shaw, M.H., Kim, Y.G. & Nunez, G. NOD-like receptors: Role in innate immunity and inflammatory disease. Annu. Rev. Pathol. 4, 365-398 (2009
    • (2009) Annu. Rev. Pathol , vol.4 , pp. 365-398
    • Chen, G.1    Shaw, M.H.2    Kim, Y.G.3    Nunez, G.4
  • 21
    • 84863154799 scopus 로고    scopus 로고
    • Initial testing (stage 1) of LCL161, a SMAC mimetic, by the Pediatric Preclinical Testing Program
    • Houghton, P.J. et al. Initial testing (stage 1) of LCL161, a SMAC mimetic, by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 58, 636-639 (2012
    • (2012) Pediatr. Blood Cancer , vol.58 , pp. 636-639
    • Houghton, P.J.1
  • 22
    • 84984558764 scopus 로고    scopus 로고
    • Inhibition of Bcl-2 improves effect of LCL161, a SMAC mimetic, in hepatocellular carcinoma cells
    • Chen, K.F. et al. Inhibition of Bcl-2 improves effect of LCL161, a SMAC mimetic, in hepatocellular carcinoma cells. Biochem. Pharmacol. 84, 268-277 (2012
    • (2012) Biochem. Pharmacol , vol.84 , pp. 268-277
    • Chen, K.F.1
  • 23
    • 84880315330 scopus 로고    scopus 로고
    • Time-dependent inhibition and induction of human cytochrome P4503A4/5 by an Oral IAP Antagonist, LCL161, in vitro and in vivo in healthy subjects
    • Dhuria, S. et al. Time-dependent inhibition and induction of human cytochrome P4503A4/5 by an Oral IAP Antagonist, LCL161, in vitro and in vivo in healthy subjects. J. Clin. Pharmacol. 53, 642-653 (2013
    • (2013) J. Clin. Pharmacol , vol.53 , pp. 642-653
    • Dhuria, S.1
  • 24
    • 34548062828 scopus 로고    scopus 로고
    • Targeted inflammation during oncolytic virus therapy severely compromises tumour blood flow
    • Breitbach, C.J. et al. Targeted inflammation during oncolytic virus therapy severely compromises tumour blood flow. Mol. Ther. 15, 1686-1693 (2007
    • (2007) Mol. Ther , vol.15 , pp. 1686-1693
    • Breitbach, C.J.1
  • 25
    • 84873828032 scopus 로고    scopus 로고
    • Resistance to two heterologous neurotropic oncolytic viruses, Semliki Forest virus and vaccinia virus, in experimental glioma
    • Vaha-Koskela, M.J. et al. Resistance to two heterologous neurotropic oncolytic viruses, Semliki Forest virus and vaccinia virus, in experimental glioma. J. Virol. 87, 2363-2366 (2013
    • (2013) J. Virol , vol.87 , pp. 2363-2366
    • Vaha-Koskela, M.J.1
  • 26
    • 84879638317 scopus 로고    scopus 로고
    • Model-based rational design of an oncolytic virus with improved therapeutic potential
    • Le Boeuf, F. et al. Model-based rational design of an oncolytic virus with improved therapeutic potential. Nat. Commun. 4, 1974 (2013
    • (2013) Nat. Commun , vol.4 , pp. 1974
    • Le Boeuf, F.1
  • 27
    • 31344461659 scopus 로고    scopus 로고
    • Innate immune recognition of viral infection
    • Kawai, T. & Akira, S. Innate immune recognition of viral infection. Nat. Immunol. 7, 131-137 (2006
    • (2006) Nat. Immunol , vol.7 , pp. 131-137
    • Kawai, T.1    Akira, S.2
  • 28
    • 21644466490 scopus 로고    scopus 로고
    • Identification of TRAIL as an interferon regulatory factor 3 transcriptional target
    • Kirshner, J.R., Karpova, A.Y., Kops, M. & Howley, P.M. Identification of TRAIL as an interferon regulatory factor 3 transcriptional target. J. Virol. 79, 9320-9324 (2005
    • (2005) J. Virol , vol.79 , pp. 9320-9324
    • Kirshner, J.R.1    Karpova, A.Y.2    Kops, M.3    Howley, P.M.4
  • 29
    • 0141814659 scopus 로고    scopus 로고
    • Temporal activation of NF-kappaB regulates an interferon-independent innate antiviral response against cytoplasmic RNA viruses
    • Bose, S., Kar, N., Maitra, R., DiDonato, J.A. & Banerjee, A.K. Temporal activation of NF-kappaB regulates an interferon-independent innate antiviral response against cytoplasmic RNA viruses. Proc. Natl. Acad. Sci. USA 100, 10890-10895 (2003
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 10890-10895
    • Bose, S.1    Kar, N.2    Maitra, R.3    DiDonato, J.A.4    Banerjee, A.K.5
  • 30
    • 78650138274 scopus 로고    scopus 로고
    • A multi-institution phase II study of poly-ICLC and radiotherapy with concurrent and adjuvant temozolomide in adults with newly diagnosed glioblastoma
    • Rosenfeld, M.R. et al. A multi-institution phase II study of poly-ICLC and radiotherapy with concurrent and adjuvant temozolomide in adults with newly diagnosed glioblastoma. Neuro-oncol. 12, 1071-1077 (2010
    • (2010) Neuro-oncol , vol.12 , pp. 1071-1077
    • Rosenfeld, M.R.1
  • 31
    • 57349153494 scopus 로고    scopus 로고
    • A phase II clinical trial of poly-ICLC with radiation for adult patients with newly diagnosed supratentorial glioblastoma: A North American Brain Tumour Consortium (NABTC01-05
    • Butowski, N. et al. A phase II clinical trial of poly-ICLC with radiation for adult patients with newly diagnosed supratentorial glioblastoma: A North American Brain Tumour Consortium (NABTC01-05). J. Neurooncol. 91, 175-182 (2009
    • (2009) J. Neurooncol , vol.91 , pp. 175-182
    • Butowski, N.1
  • 32
    • 57349097681 scopus 로고    scopus 로고
    • A North American brain tumour consortium phase II study of poly-ICLC for adult patients with recurrent anaplastic gliomas
    • Butowski, N. et al. A North American brain tumour consortium phase II study of poly-ICLC for adult patients with recurrent anaplastic gliomas. J. Neurooncol. 91, 183-189 (2009
    • (2009) J. Neurooncol , vol.91 , pp. 183-189
    • Butowski, N.1
  • 33
    • 84859489110 scopus 로고    scopus 로고
    • CpG still rocks! Update on an accidental drug
    • Krieg, A.M. CpG still rocks! Update on an accidental drug. Nucleic Acid Ther. 22, 77-89 (2012
    • (2012) Nucleic Acid Ther , vol.22 , pp. 77-89
    • Krieg, A.M.1
  • 34
    • 84872398313 scopus 로고    scopus 로고
    • Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-Alpha pharmacology
    • Erickson, R.I. et al. Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-Alpha pharmacology. Toxicol. Sci. 131, 247-258 (2013
    • (2013) Toxicol. Sci , vol.131 , pp. 247-258
    • Erickson, R.I.1
  • 35
    • 84867816814 scopus 로고    scopus 로고
    • Dogs are more sensitive to antagonists of inhibitor of apoptosis proteins than rats and humans: A translational toxicokinetic/toxicodynamic analysis
    • Wong, H. et al. Dogs are more sensitive to antagonists of inhibitor of apoptosis proteins than rats and humans: A translational toxicokinetic/ toxicodynamic analysis. Toxicol. Sci. 130, 205-213 (2012
    • (2012) Toxicol. Sci , vol.130 , pp. 205-213
    • Wong, H.1
  • 36
    • 79953268311 scopus 로고    scopus 로고
    • Type I IFN and TNFalpha cross-regulation in immune-mediated inflammatory disease: Basic concepts and clinical relevance
    • Cantaert, T., Baeten, D., Tak, P.P. & van Baarsen, L.G. Type I IFN and TNFalpha cross-regulation in immune-mediated inflammatory disease: Basic concepts and clinical relevance. Arthritis Res. Ther. 12, 219 (2010
    • (2010) Arthritis Res. Ther , vol.12 , pp. 219
    • Cantaert, T.1    Baeten, D.2    Tak, P.P.3    Van Baarsen, L.G.4
  • 37
    • 84926092606 scopus 로고    scopus 로고
    • Type I interferon: A new player in TNF signalling
    • Yarilina, A. & Ivashkiv, L.B. Type I interferon: A new player in TNF signalling. Curr. Dir. Autoimmun. 11, 94-104 (2010
    • (2010) Curr. Dir. Autoimmun , vol.11 , pp. 94-104
    • Yarilina, A.1    Ivashkiv, L.B.2
  • 38
    • 79956006296 scopus 로고    scopus 로고
    • Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, smac mimetic SM-164 in combination with TRAIL for cancer treatment
    • Lu, J. et al. Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, smac mimetic SM-164 in combination with TRAIL for cancer treatment. Mol. Cancer Ther. 10, 902-914 (2011
    • (2011) Mol. Cancer Ther , vol.10 , pp. 902-914
    • Lu, J.1
  • 39
    • 37049019494 scopus 로고    scopus 로고
    • Design, syn thesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP
    • Sun, H. et al. Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP. J. Am. Chem. Soc. 129, 15279-15294 (2007
    • (2007) J. Am. Chem. Soc , vol.129 , pp. 15279-15294
    • Sun, H.1
  • 40
    • 44949240664 scopus 로고    scopus 로고
    • Ciap1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
    • Bertrand, M.J. et al. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol. Cell 30, 689-700 (2008
    • (2008) Mol. Cell , vol.30 , pp. 689-700
    • Bertrand, M.J.1
  • 41
    • 84867805394 scopus 로고    scopus 로고
    • TWEAK and cIAP1 regulate myoblast fusion through the noncanonical NF-kappaB signalling pathway
    • Enwere, E.K. et al. TWEAK and cIAP1 regulate myoblast fusion through the noncanonical NF-kappaB signalling pathway. Sci. Signal. 5, ra75 (2012
    • (2012) Sci. Signal , vol.5
    • Enwere, E.K.1
  • 42
    • 10744223476 scopus 로고    scopus 로고
    • VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents
    • Stojdl, D.F. et al. VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents. Cancer Cell 4, 263-275 (2003
    • (2003) Cancer Cell , vol.4 , pp. 263-275
    • Stojdl, D.F.1
  • 43
    • 77955177289 scopus 로고    scopus 로고
    • Identification of genetically modified Maraba virus as an oncolytic rhabdovirus
    • Brun, J. et al. Identification of genetically modified Maraba virus as an oncolytic rhabdovirus. Mol. Ther. 18, 1440-1449 (2010
    • (2010) Mol. Ther , vol.18 , pp. 1440-1449
    • Brun, J.1
  • 44
    • 77951987824 scopus 로고    scopus 로고
    • Synergistic interaction between oncolytic viruses augments tumour killing
    • Le Boeuf, F. et al. Synergistic interaction between oncolytic viruses augments tumour killing. Mol. Ther. 18, 888-895 (2010
    • (2010) Mol. Ther , vol.18 , pp. 888-895
    • Le Boeuf, F.1
  • 45
    • 78049461363 scopus 로고    scopus 로고
    • Efficacy and safety/toxicity study of recombinant vaccinia virus JX-594 in two immunocompetent animal models of glioma
    • Lun, X. et al. Efficacy and safety/toxicity study of recombinant vaccinia virus JX-594 in two immunocompetent animal models of glioma. Mol. Ther. 18, 1927-1936 (2010
    • (2010) Mol. Ther , vol.18 , pp. 1927-1936
    • Lun, X.1
  • 46
    • 0033991437 scopus 로고    scopus 로고
    • A simple colorimetric method to screen drug cytotoxicity against Leishmania using the dye Alamar Blue
    • Mikus, J. & Steverding, D. A simple colorimetric method to screen drug cytotoxicity against Leishmania using the dye Alamar Blue. Parasitol. Int. 48, 265-269 (2000
    • (2000) Parasitol. Int , vol.48 , pp. 265-269
    • Mikus, J.1    Steverding, D.2
  • 47
    • 0017706693 scopus 로고
    • A simple generalized equation for the analysis of multiple inhibitions of Michaelis-Menten kinetic systems
    • Chou, T.C. & Talaly, P. A simple generalized equation for the analysis of multiple inhibitions of Michaelis-Menten kinetic systems. J. Biol. Chem. 252, 6438-6442 (1977
    • (1977) J. Biol. Chem , vol.252 , pp. 6438-6442
    • Chou, T.C.1    Talaly, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.