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Volumn 35, Issue 12, 2016, Pages 1554-1564

ErbB3 upregulation by the HNSCC 3D microenvironment modulates cell survival and growth

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 3; ERLOTINIB; HEREGULIN BETA 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LAPATINIB; MESSENGER RNA; NEU DIFFERENTIATION FACTOR; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ERBB3 PROTEIN, HUMAN;

EID: 84930999439     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2015.220     Document Type: Article
Times cited : (15)

References (59)
  • 3
    • 84890041471 scopus 로고    scopus 로고
    • The ERBB/HER family of protein-Tyrosine kinases and cancer
    • Roskoski R Jr. The ErbB/HER family of protein-Tyrosine kinases and cancer. Pharmacol Res 2014; 79: 34-74.
    • (2014) Pharmacol Res , vol.79 , pp. 34-74
    • Roskoski, R.1
  • 4
    • 0038461104 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) as a target in cancer therapy: Understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs
    • Ciardiello F, Tortora G. Epidermal growth factor receptor (EGFR) as a target in cancer therapy: understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs. Eur J Cancer 2003; 39: 1348-1354.
    • (2003) Eur J Cancer , vol.39 , pp. 1348-1354
    • Ciardiello, F.1    Tortora, G.2
  • 6
    • 0031041969 scopus 로고    scopus 로고
    • Strong correlation between c-ERBB-2 overexpression and overall survival of patients with oral squamous cell carcinoma
    • Xia W, Lau YK, Zhang HZ, Liu AR, Li L, Kiyokawa N, et al. Strong correlation between c-ErbB-2 overexpression and overall survival of patients with oral squamous cell carcinoma. Clin Cancer Res 1997; 3: 3-9.
    • (1997) Clin Cancer Res , vol.3 , pp. 3-9
    • Xia, W.1    Lau, Y.K.2    Zhang, H.Z.3    Liu, A.R.4    Li, L.5    Kiyokawa, N.6
  • 7
    • 84867885308 scopus 로고    scopus 로고
    • Overcoming resistance to EGFR inhibitor in head and neck cancer: A review of the literature
    • Rabinowits G, Haddad RI. Overcoming resistance to EGFR inhibitor in head and neck cancer: a review of the literature. Oral Oncol 2012; 48: 1085-1089.
    • (2012) Oral Oncol , vol.48 , pp. 1085-1089
    • Rabinowits, G.1    Haddad, R.I.2
  • 8
    • 84896696623 scopus 로고    scopus 로고
    • Current challenges and clinical investigations of epidermal growth factor receptor (EGFR)-And ERBB family-Targeted agents in the treatment of head and neck squamous cell carcinoma (HNSCC)
    • Cohen RB. Current challenges and clinical investigations of epidermal growth factor receptor (EGFR)-And ErbB family-Targeted agents in the treatment of head and neck squamous cell carcinoma (HNSCC). Cancer Treat Rev 2014; 40: 567-577.
    • (2014) Cancer Treat Rev , vol.40 , pp. 567-577
    • Cohen, R.B.1
  • 10
    • 44949141721 scopus 로고    scopus 로고
    • The ERBB3 receptor in cancer and cancer gene therapy
    • Sithanandam G, Anderson LM. The ERBB3 receptor in cancer and cancer gene therapy. Cancer Gene Ther 2008; 15: 413-448.
    • (2008) Cancer Gene Ther , vol.15 , pp. 413-448
    • Sithanandam, G.1    Anderson, L.M.2
  • 11
    • 76249094113 scopus 로고    scopus 로고
    • HER family receptors expression in squamous cell carcinoma of the tongue: Study of the possible prognostic and biological significance
    • Del Sordo R, Angiero F, Bellezza G, Cavaliere A, Mameli MG, Stefani M, et al. HER family receptors expression in squamous cell carcinoma of the tongue: study of the possible prognostic and biological significance. J Oral Pathol Med 39: 79-86.
    • J Oral Pathol Med , vol.39 , pp. 79-86
    • Del Sordo, R.1    Angiero, F.2    Bellezza, G.3    Cavaliere, A.4    Mameli, M.G.5    Stefani, M.6
  • 12
  • 13
    • 0033372557 scopus 로고    scopus 로고
    • Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members
    • Xia W, Lau YK, Zhang HZ, Xiao FY, Johnston DA, Liu AR, et al. Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members. Clin Cancer Res 1999; 5: 4164-4174.
    • (1999) Clin Cancer Res , vol.5 , pp. 4164-4174
    • Xia, W.1    Lau, Y.K.2    Zhang, H.Z.3    Xiao, F.Y.4    Johnston, D.A.5    Liu, A.R.6
  • 15
    • 78449303095 scopus 로고    scopus 로고
    • The role of HER3, the unpretentious member of the HER family, in cancer biology and cancer therapeutics
    • Amin DN, Campbell MR, Moasser MM. The role of HER3, the unpretentious member of the HER family, in cancer biology and cancer therapeutics. Semin Cell Dev Biol 2010; 21: 944-950.
    • (2010) Semin Cell Dev Biol , vol.21 , pp. 944-950
    • Amin, D.N.1    Campbell, M.R.2    Moasser, M.M.3
  • 16
    • 80051578430 scopus 로고    scopus 로고
    • Neuregulin-1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers
    • Wilson TR, Lee DY, Berry L, Shames DS, Settleman J. Neuregulin-1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers. Cancer Cell 2011; 20: 158-172.
    • (2011) Cancer Cell , vol.20 , pp. 158-172
    • Wilson, T.R.1    Lee, D.Y.2    Berry, L.3    Shames, D.S.4    Settleman, J.5
  • 17
    • 84874544754 scopus 로고    scopus 로고
    • High heregulin expression is associated with activated HER3 and may define an actionable biomarker in patients with squamous cell carcinomas of the head and neck
    • Shames DS, Carbon J, Walter K, Jubb AM, Kozlowski C, Januario T, et al. High heregulin expression is associated with activated HER3 and may define an actionable biomarker in patients with squamous cell carcinomas of the head and neck. PLoS One 2013; 8: e56765.
    • (2013) PLoS One , vol.8 , pp. e56765
    • Shames, D.S.1    Carbon, J.2    Walter, K.3    Jubb, A.M.4    Kozlowski, C.5    Januario, T.6
  • 18
    • 0042358985 scopus 로고    scopus 로고
    • Cell culture: Biology's new dimension
    • Abbott A. Cell culture: biology's new dimension. Nature 2003; 424: 870-872.
    • (2003) Nature , vol.424 , pp. 870-872
    • Abbott, A.1
  • 19
    • 84875252390 scopus 로고    scopus 로고
    • Three-Dimensional tissue cultures: Current trends and beyond
    • Page H, Flood P, Reynaud EG. Three-Dimensional tissue cultures: current trends and beyond. Cell Tissue Res 2013; 352: 123-131.
    • (2013) Cell Tissue Res , vol.352 , pp. 123-131
    • Page, H.1    Flood, P.2    Reynaud, E.G.3
  • 22
    • 0033804913 scopus 로고    scopus 로고
    • Apoptosis, cell adhesion and the extracellular matrix in the three-Dimensional growth of multicellular tumor spheroids
    • Santini MT, Rainaldi G, Indovina PL. Apoptosis, cell adhesion and the extracellular matrix in the three-Dimensional growth of multicellular tumor spheroids. Crit Rev Oncol Hematol 2000; 36: 75-87.
    • (2000) Crit Rev Oncol Hematol , vol.36 , pp. 75-87
    • Santini, M.T.1    Rainaldi, G.2    Indovina, P.L.3
  • 23
    • 36849009670 scopus 로고    scopus 로고
    • Experimental anti-Tumor therapy in 3-D: Spheroids-old hat or new challenge?
    • Friedrich J, Ebner R, Kunz-Schughart LA. Experimental anti-Tumor therapy in 3-D: spheroids-old hat or new challenge?. Int J Radiat Biol 2007; 83: 849-871.
    • (2007) Int J Radiat Biol , vol.83 , pp. 849-871
    • Friedrich, J.1    Ebner, R.2    Kunz-Schughart, L.A.3
  • 24
    • 84874700631 scopus 로고    scopus 로고
    • Three-Dimensional cell culture: The missing link in drug discovery
    • Breslin S, O'Driscoll L. Three-Dimensional cell culture: the missing link in drug discovery. Drug Discov Today 2013; 18: 240-249.
    • (2013) Drug Discov Today , vol.18 , pp. 240-249
    • Breslin, S.1    O'Driscoll, L.2
  • 25
    • 84856085546 scopus 로고    scopus 로고
    • Transcriptional profiling identifies upregulated genes following induction of epithelialmesenchymal transition in squamous carcinoma cells
    • Humtsoe JO, Koya E, Pham E, Aramoto T, Zuo J, Ishikawa T, et al. Transcriptional profiling identifies upregulated genes following induction of epithelialmesenchymal transition in squamous carcinoma cells. Exp Cell Res 2012; 318: 379-390.
    • (2012) Exp Cell Res , vol.318 , pp. 379-390
    • Humtsoe, J.O.1    Koya, E.2    Pham, E.3    Aramoto, T.4    Zuo, J.5    Ishikawa, T.6
  • 26
    • 0035674598 scopus 로고    scopus 로고
    • Adhesive mechanisms regulating invasion and metastasis in oral cancer
    • Ziober BL, Silverman Jr. S.S., Kramer RH. Adhesive mechanisms regulating invasion and metastasis in oral cancer. Crit Rev Oral Biol Med 2001; 12: 499-510.
    • (2001) Crit Rev Oral Biol Med , vol.12 , pp. 499-510
    • Ziober, B.L.1    Silverman, S.S.2    Kramer, R.H.3
  • 27
    • 77957784428 scopus 로고    scopus 로고
    • ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells
    • Krig SR, Miller JK, Frietze S, Beckett LA, Neve RM, Farnham PJ, et al. ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells. Oncogene 29: 5500-5510.
    • Oncogene , vol.29 , pp. 5500-5510
    • Krig, S.R.1    Miller, J.K.2    Frietze, S.3    Beckett, L.A.4    Neve, R.M.5    Farnham, P.J.6
  • 28
    • 0028870050 scopus 로고
    • Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: Implications for tumor angiogenesis
    • Shweiki D, Neeman M, Itin A, Keshet E. Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis. Proc Natl Acad Sci USA 1995; 92: 768-772.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 768-772
    • Shweiki, D.1    Neeman, M.2    Itin, A.3    Keshet, E.4
  • 29
    • 65649138377 scopus 로고    scopus 로고
    • Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-Derived cell recruitment
    • Chan DA, Kawahara TL, Sutphin PD, Chang HY, Chi JT, Giaccia AJ. Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-Derived cell recruitment. Cancer Cell 2009; 15: 527-538.
    • (2009) Cancer Cell , vol.15 , pp. 527-538
    • Chan, D.A.1    Kawahara, T.L.2    Sutphin, P.D.3    Chang, H.Y.4    Chi, J.T.5    Giaccia, A.J.6
  • 30
    • 77049120279 scopus 로고    scopus 로고
    • The suppression of hypoxia-inducible factor and vascular endothelial growth factor by siRNA does not affect the radiation sensitivity of multicellular tumor spheroids
    • Zou Y, Cheng C, Omura-Minamisawa M, Kang Y, Hara T, Guan X, et al. The suppression of hypoxia-inducible factor and vascular endothelial growth factor by siRNA does not affect the radiation sensitivity of multicellular tumor spheroids. J Radiat Res 2010; 51: 47-55.
    • (2010) J Radiat Res , vol.51 , pp. 47-55
    • Zou, Y.1    Cheng, C.2    Omura-Minamisawa, M.3    Kang, Y.4    Hara, T.5    Guan, X.6
  • 31
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29: 625-634.
    • Oncogene , vol.29 , pp. 625-634
    • Semenza, G.L.1
  • 32
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992; 12: 5447-5454.
    • (1992) Mol Cell Biol , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 33
    • 59649109230 scopus 로고    scopus 로고
    • Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab
    • Pickl M, Ries CH. Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab. Oncogene 2009; 28: 461-468.
    • (2009) Oncogene , vol.28 , pp. 461-468
    • Pickl, M.1    Ries, C.H.2
  • 34
    • 84875444552 scopus 로고    scopus 로고
    • Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines
    • Luca AC, Mersch S, Deenen R, Schmidt S, Messner I, Schafer KL, et al. Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines. PLoS One 2013; 8: e59689.
    • (2013) PLoS One , vol.8 , pp. e59689
    • Luca, A.C.1    Mersch, S.2    Deenen, R.3    Schmidt, S.4    Messner, I.5    Schafer, K.L.6
  • 36
    • 33846552656 scopus 로고    scopus 로고
    • Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
    • Sergina NV, Rausch M, Wang D, Blair J, Hann B, Shokat KM, et al. Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature 2007; 445: 437-441.
    • (2007) Nature , vol.445 , pp. 437-441
    • Sergina, N.V.1    Rausch, M.2    Wang, D.3    Blair, J.4    Hann, B.5    Shokat, K.M.6
  • 37
    • 77950239573 scopus 로고    scopus 로고
    • HER kinase axis receptor dimer partner switching occurs in response to EGFR tyrosine kinase inhibition despite failure to block cellular proliferation
    • Jain A, Penuel E, Mink S, Schmidt J, Hodge A, Favero K, et al. HER kinase axis receptor dimer partner switching occurs in response to EGFR tyrosine kinase inhibition despite failure to block cellular proliferation. Cancer Res 2010; 70: 1989-1999.
    • (2010) Cancer Res , vol.70 , pp. 1989-1999
    • Jain, A.1    Penuel, E.2    Mink, S.3    Schmidt, J.4    Hodge, A.5    Favero, K.6
  • 38
    • 79953207364 scopus 로고    scopus 로고
    • Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase
    • Garrett JT, Olivares MG, Rinehart C, Granja-Ingram ND, Sanchez V, Chakrabarty A, et al. Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase. Proc Natl Acad Sci USA 2011; 108: 5021-5026.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 5021-5026
    • Garrett, J.T.1    Olivares, M.G.2    Rinehart, C.3    Granja-Ingram, N.D.4    Sanchez, V.5    Chakrabarty, A.6
  • 39
    • 77952338791 scopus 로고    scopus 로고
    • ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation
    • Shi F, Telesco SE, Liu Y, Radhakrishnan R, Lemmon MA. ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation. Proc Natl Acad Sci USA 2010; 107: 7692-7697.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 7692-7697
    • Shi, F.1    Telesco, S.E.2    Liu, Y.3    Radhakrishnan, R.4    Lemmon, M.A.5
  • 41
    • 84859445000 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: Mediators of cancer progression and targets for cancer therapy
    • Semenza GL. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci 2012; 33: 207-214.
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 207-214
    • Semenza, G.L.1
  • 43
    • 84905858377 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha induces ErbB4 signaling in the differentiating mammary gland
    • Paatero I, Seagroves TN, Vaparanta K, Han W, Jones FE, Johnson RS, et al. Hypoxia-inducible factor-1alpha induces ErbB4 signaling in the differentiating mammary gland. J Biol Chem 2014; 289: 22459-22469.
    • (2014) J Biol Chem , vol.289 , pp. 22459-22469
    • Paatero, I.1    Seagroves, T.N.2    Vaparanta, K.3    Han, W.4    Jones, F.E.5    Johnson, R.S.6
  • 44
    • 0035957913 scopus 로고    scopus 로고
    • A family of AP-2 proteins downregulate manganese superoxide dismutase expression
    • Zhu CH, Huang Y, Oberley LW, Domann FE. A family of AP-2 proteins downregulate manganese superoxide dismutase expression. J Biol Chem 2001; 276: 14407-14413.
    • (2001) J Biol Chem , vol.276 , pp. 14407-14413
    • Zhu, C.H.1    Huang, Y.2    Oberley, L.W.3    Domann, F.E.4
  • 45
    • 77957784428 scopus 로고    scopus 로고
    • ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells
    • Krig SR, Miller JK, Frietze S, Beckett LA, Neve RM, Farnham PJ, et al. ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells. Oncogene 2010; 29: 5500-5510.
    • (2010) Oncogene , vol.29 , pp. 5500-5510
    • Krig, S.R.1    Miller, J.K.2    Frietze, S.3    Beckett, L.A.4    Neve, R.M.5    Farnham, P.J.6
  • 46
    • 33847738628 scopus 로고    scopus 로고
    • Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b
    • Scott GK, Goga A, Bhaumik D, Berger CE, Sullivan CS, Benz CC. Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b. J Biol Chem 2007; 282: 1479-1486.
    • (2007) J Biol Chem , vol.282 , pp. 1479-1486
    • Scott, G.K.1    Goga, A.2    Bhaumik, D.3    Berger, C.E.4    Sullivan, C.S.5    Benz, C.C.6
  • 48
    • 84870587105 scopus 로고    scopus 로고
    • Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation
    • He J, Xu Q, Jing Y, Agani F, Qian X, Carpenter R, et al. Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation. EMBO Rep 2012; 13: 1116-1122.
    • (2012) EMBO Rep , vol.13 , pp. 1116-1122
    • He, J.1    Xu, Q.2    Jing, Y.3    Agani, F.4    Qian, X.5    Carpenter, R.6
  • 49
    • 84867281628 scopus 로고    scopus 로고
    • HER3 signalling is regulated through a multitude of redundant mechanisms in HER2-Driven tumour cells
    • Amin DN, Sergina N, Lim L, Goga A, Moasser MM. HER3 signalling is regulated through a multitude of redundant mechanisms in HER2-Driven tumour cells. Biochem J 2012; 447: 417-425.
    • (2012) Biochem J , vol.447 , pp. 417-425
    • Amin, D.N.1    Sergina, N.2    Lim, L.3    Goga, A.4    Moasser, M.M.5
  • 50
  • 51
    • 11144337759 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: Regulation by hypoxic and non-hypoxic activators
    • Dery MA, Michaud MD, Richard DE. Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators. Int J Biochem Cell Biol 2005; 37: 535-540.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 535-540
    • Dery, M.A.1    Michaud, M.D.2    Richard, D.E.3
  • 52
    • 84876880959 scopus 로고    scopus 로고
    • Oxygen-independent regulation of HIF-1: Novel involvement of PI3K/AKT/mTOR pathway in cancer
    • Agani F, Jiang BH. Oxygen-independent regulation of HIF-1: novel involvement of PI3K/AKT/mTOR pathway in cancer. Curr Cancer Drug Targets 2013; 13: 245-251.
    • (2013) Curr Cancer Drug Targets , vol.13 , pp. 245-251
    • Agani, F.1    Jiang, B.H.2
  • 53
    • 36348938884 scopus 로고    scopus 로고
    • Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor
    • Xia C, Meng Q, Liu LZ, Rojanasakul Y, Wang XR, Jiang BH. Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor. Cancer Res 2007; 67: 10823-10830.
    • (2007) Cancer Res , vol.67 , pp. 10823-10830
    • Xia, C.1    Meng, Q.2    Liu, L.Z.3    Rojanasakul, Y.4    Wang, X.R.5    Jiang, B.H.6
  • 54
    • 77951938912 scopus 로고    scopus 로고
    • Reactive oxygen species produced by the knockdown of manganese-superoxide dismutase up-regulate hypoxia-inducible factor-1alpha expression in oral squamous cell carcinoma cells
    • Sasabe E, Yang Z, Ohno S, Yamamoto T. Reactive oxygen species produced by the knockdown of manganese-superoxide dismutase up-regulate hypoxia-inducible factor-1alpha expression in oral squamous cell carcinoma cells. Free Radic Biol Med 2010; 48: 1321-1329.
    • (2010) Free Radic Biol Med , vol.48 , pp. 1321-1329
    • Sasabe, E.1    Yang, Z.2    Ohno, S.3    Yamamoto, T.4
  • 55
    • 79960885569 scopus 로고    scopus 로고
    • Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma
    • Takikita M, Xie R, Chung JY, Cho H, Ylaya K, Hong SM, et al. Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma. J Transl Med 2011; 9: 126.
    • (2011) J Transl Med , vol.9 , pp. 126
    • Takikita, M.1    Xie, R.2    Chung, J.Y.3    Cho, H.4    Ylaya, K.5    Hong, S.M.6
  • 56
    • 0024800110 scopus 로고
    • A study of an in vitro model for invasion of oral squamous cell carcinoma
    • Matsumoto K, Horikoshi M, Rikimaru K, Enomoto S. A study of an in vitro model for invasion of oral squamous cell carcinoma. J Oral Pathol Med 1989; 18: 498-501.
    • (1989) J Oral Pathol Med , vol.18 , pp. 498-501
    • Matsumoto, K.1    Horikoshi, M.2    Rikimaru, K.3    Enomoto, S.4
  • 57
    • 1342281686 scopus 로고    scopus 로고
    • Promoter methylation regulates cadherin switching in squamous cell carcinoma
    • Chen Q, Lipkina G, Song Q, Kramer RH. Promoter methylation regulates cadherin switching in squamous cell carcinoma. Biochem Biophys Res Commun 2004; 315: 850-856.
    • (2004) Biochem Biophys Res Commun , vol.315 , pp. 850-856
    • Chen, Q.1    Lipkina, G.2    Song, Q.3    Kramer, R.H.4
  • 58
    • 77249169359 scopus 로고    scopus 로고
    • Bcl-2 overexpression induces a partial epithelial to mesenchymal transition and promotes squamous carcinoma cell invasion and metastasis
    • Zuo J, Ishikawa T, Boutros S, Xiao Z, Humtsoe JO, Kramer RH. Bcl-2 overexpression induces a partial epithelial to mesenchymal transition and promotes squamous carcinoma cell invasion and metastasis. Mol Cancer Res 2010; 8: 170-182.
    • (2010) Mol Cancer Res , vol.8 , pp. 170-182
    • Zuo, J.1    Ishikawa, T.2    Boutros, S.3    Xiao, Z.4    Humtsoe, J.O.5    Kramer, R.H.6
  • 59
    • 77649182472 scopus 로고    scopus 로고
    • Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway
    • Humtsoe JO, Kramer RH. Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway. Oncogene 2010; 29: 1214-1226.
    • (2010) Oncogene , vol.29 , pp. 1214-1226
    • Humtsoe, J.O.1    Kramer, R.H.2


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