HER family receptors expression in squamous cell carcinoma of the tongue: Study of the possible prognostic and biological significance

Journal of Oral Pathology and Medicine

Volumn 39, Issue 1, 2010, Pages 79-86

  Del Sordo, Rachele ^a,b   Angiero, Francesca ^c   Bellezza, Guido ^b   Cavaliere, Antonio ^b   Mameli, Maria Grazia ^b   Stefani, Michele ^c   Dessy, Enrico ^d   Sidoni, Angelo ^b  

^a SANTA MARIA DELLA MISERICORDIA HOSPITAL   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d UNIVERSITY OF BRESCIA   (Italy)

Author keywords

HER family; Immunohistochemistry; Squamous carcinoma of the tongue

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2;

ADULT; AGED; ARTICLE; CANCER STAGING; CERVICAL LYMPH NODE; CLINICAL ARTICLE; DIAGNOSTIC KIT; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; LYMPH NODE DISSECTION; MALE; NECK DISSECTION; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; SQUAMOUS CELL CARCINOMA; TONGUE CARCINOMA;

EID: 76249094113     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2009.00815.x     Document Type: Article

References (48)

1. Hoffman HT, Karnell LH, Funk GF, Robinson RA, Menck HR. The national cancer data base report on cancer of the head and neck. Arch Otolaryngol Head Neck Surg 1998 124 : 951 962.
2. Rusthoven K, Ballonoff A, Raben D, Chen Ch. Poor prognosis in patients with stage I and II oral tongue squamous cell carcinoma. Cancer 2008 112 : 345 351.
3. Shiboski CH, Schmidt BL, Jordan RC. Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44 years. Cancer 2005 103 : 1843.
4. Zelefsky MJ, Harrison LB, Fass DE, et al. Postoperative radiotherapy for oral cavity cancer: impact of anatomic subsite on treatment outcome. Head Neck 1990 12 : 470 475.
5. Davis S, Severson R. Increasing incidence of cancer of the young adults. Lancet 1987 2 : 910 911.
6. O-charoenrat P, Rhys-Evans PH, Modjtahedi H, Eccles SA. The role of c-erbB receptors and ligands in head and neck squamous cell carcinoma. Oral Oncol 2002 38 : 627 640.
7. Rogers SJ, Harrington KJ, Rhys-Evans P, O-Charoenrat P. Biological significance of c-erbB family in head and neck cancer. Cancer Met Rev 2005 24 : 47 69.
8. Partidrige M, Gullick WJ, Langdon JD, Sherriff M. Expression of epidermal growth factor receptor on oral squamous cell carcinoma. Br J Oral Maxillofac Surg 1988 26 : 381 389.
9. Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989 244 : 707 712.
10. Shinthani S, Funayama T, Yoshihama Y, Alcalde RE, Matsumura T. Prognostic significance of ERRB3 overexpression in oral squamous cell carcinoma. Cancer Lett 1995 95 : 79 83.
11. O-charoenrat P, Rhys-Evans PH, Archer DJ, Eccles SA. C-erbB receptors in squamous cell carcinomas of the head and neck: clinical significance and correlation with matrix metalloproteinases and vascular endothelial growth factors. Oral Oncol 2002 38 : 73 80.
12. c-Ekberg T, Nestor M, Engstrom M, et al. Expression of EGFR, HER2, HER3, and HER4 in metastatic squamous cell carcinomas of the oral cavity and base of the tongue. Int J Oncol 2005 26 : 1177 1185.
13. Xia W, Lau YK, Zhang HZ, et al. Combination of EGFR, Her-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members. Clin Cancer Res 1999 5 : 4164 4174.
14. Angiero F, Del Sordo R, Dessy E, et al. Comparative analysis of c-erbB-2 (Her-2/neu) in squamous cell carcinoma of the tongue: does over-expression exist? And what is its correlation with traditional diagnostic parameters? J Oral Pathol Med 2008 37 : 145 150.
15. Greene FL, Page DL, Fleming ID, et al. AJCC cancer staging handbook. American Joint Committee on Cancer. New York : Springer, 2002.
16. Waltregny D, Bellahcène A, Van RietFisher LW, et al. Prognostic value of bone sialoprotein expression in clinically localized human prostate cancer. J Natl Cancer Inst 1998 90 : 1000 1008.
17. Hsu CY, Ho DM, Yang CF, Lai CR, Yu IT, Chiang H. Interobserver reproducibility of HER-2/neu protein overexpression in invasive breast carcinoma using DAKO HercepTest. Am J Clin Pathol 2002 118 : 693 698.
18. Santini J, Formento JL, Francoual M, et al. Characterization, quantification, and potential clinical value of the epidermal growth factor receptor in head and neck squamous cell carcinomas. Head Neck 1991 13 : 132 139.
19. Störkel S, Reichert T, Reiffen K, Wagner W. EGFR and PCNA expression in oral squamous cell carcinomas - a valuable tool in estimating the patient's prognosis. Eur J Cancer B Oral Oncol 1993 29B : 273 277.
20. Grandis JR, Melhem MF, Gooding WE, et al. Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst 1998 90 : 824 832.
21. Laimer K, Spizzo G, Gastl G, et al. High EGFR expression predicts poor prognosis in patients with squamous cell carcinoma of the oral cavity and oropharynx: a TMA-based immunohistochemical analysis. Oral Oncol 2007 43 : 193 198.
22. Wen QH, Miwa T, Yoshizaki T, Nagayama I, Furukawa M, Nishjima H. Prognostic value of EGFR and TGF-alpha in early laryngeal cancer treated with radiotherapy. Laryngoscope 1996 106 : 884 888. (Pubitemid 26242129)
23. Werkmeister R, Brandt B, Joos U. Clinical relevance of erbB-1 and-2 oncogenes in oral carcinomas. Oral Oncol 2000 36 : 100 105.
24. Ibrahim SO, Lillehaug JR, Johannessen AC, Liavaag PG, Nilsen R, Vasstrand EN. Expression of biomarkers (p53, transforming growth factor alpha, epidermal growth factor receptor, cerbB-2/neu and the proliferative cellular antigen) in oropharyngeal squamous cell carcinomas. Oral Oncol 1999 35 : 302 313.
25. Fischer C, Zlobec I, Stöckli E, et al. Is immunohistochemical epidermal growth factor receptor expression overestimated as a prognostic factor in head-neck squamous cell carcinoma? A retrospective analyses based on a tissue microarray of 365 carcinomas. Hum Pathol 2008 39 : 1527 1534.
26. Maiorano E, Favia G, Maisonneuve P, Viale G. Prognostic implications of epidermal growth factor receptor immunoreactivity in squamous cell carcinoma of the oral mucosa. J Pathol 1998 185 : 167 174.
27. Cavalot A, Martone T, Roggero N, Brondino G, Pagano M, Cortesina G. Prognostic impact of HER-2/neu expression on squamous head and neck carcinomas. Head Neck 2007 29 : 655 664.
28. Craven JM, Pavelic ZP, Stambrook PJ, et al. Expression of c-erbB2 gene in human head and neck carcinoma. Anticancer Res 1992 12 : 2273 2276.
29. Field JK, Spandidos DA, Yiagnisis M, Gosney JR, Papadimitriou K, Stell PM. c-erbB2 expression in squamous cell carcinoma of the head and neck. Anticancer Res 1992 12 : 613 620
30. Xia W, Lau YK, Zhang HZ, et al. Strong correlation between c-erbB-2 overexpression and overall survival of patients with oral squamous cell carcinoma. Clin Cancer Res 1997 31 : 3 9.
31. Issing WJ, Heppt WJ, Kastenbauer ER. erbB-3, a third member of the erbB/epidermal growth factor receptor gene family: its expression in head and neck cancer cell lines. Oto-Rhino-Laryngol 1993 250 : 392 395.
32. Sakurai K, Urade M, Takahashi Y, et al. Increased expression of c-erbB-3 protein and proliferating cell nuclear antigen during development of verrucous carcinoma of the oral mucosa. Cancer 2000 89 : 2597 2605.
33. Ibrahim SO, Vasstrand E, Liavaag PG, Johannessen AC, Lillehaug JR. Expression of c-erbB proto-oncogene family members in squamous cell carcinoma of the head and neck. Anticancer Res 1997 17 : 4539 4546.
34. Srinivasan R, Benton M, McCormick F, Thomas H, Gullick WJ. Expression of c-erbB-3/HER-3 and c-erbB-4/HER-4 growth factor receptors and their ligands, neuregulin-1 alpha, neuregulin-1 beta, and beta-cellulin, in normal endometrium and endometrial cancer. Clin Cancer Res 1999 5 : 2877 2883.
35. Haugen DR, Akslen LA, Verhaug JE, Lillehaug JR. Expression of c-erbB-3 and c-erbB-4 proteins in papillary thyroid carcinomas. Cancer Res 1996 56 : 1184 1188.
36. Merimsky O, Staroselsky A, Inbar M, et al. Correlation between c-erbB-4 receptor expression and response to gemcitabine-cisplatin chemotherapy in non-small-cell lung cancer. Ann Oncol 2001 12 : 1127 1131.
37. Graber HU, Friess H, Kaufmann B, et al. ErbB-4 mRNA expression in decreased in non metastatic pancreatic cancer. Int J Cancer 1999 84 : 24 7.
38. Gilmour LM, Macleod KG, McCaig A, Gullick WJ, Smyth JF, Langdon SP. Expression of erbB-4/HER-4 growth factor receptor isoforms in ovarian cancer. Cancer Res 2001 61 : 2169 2176.
39. Srinivans R, Gillet CE, Barnes DM, Gullick WJ. Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers. Cancer Res 2000 60 : 1483 1487.
40. Xu S, Kitayama J, Yamashita H, Souma D, Nagawa H. Nuclear translocation of HER-4/c-erbB-4 is significantly correlated with prognosis of esophageal squamous cell carcinoma. J Surg Oncol 2008 97 : 44 50.
41. Elenius K, Paul S, Allison G, Sun J, Klagsbrun M. Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation. EMBO J 1997 16 : 1268 1278.
42. Kainulainen V, Sundvall M, Maatta JA, Santiestevan E, Klagsbrun M, Elenius K. A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis. J Biol Chem 2000 275 : 8641 8649.
43. O-charoenrat P, Rhys-Evans P, Court WJ, Box GM, Eccles SA. Differential modulation of proliferation, matrix metalloproteinase expression and invasion of human head and neck squamous carcinoma cells by c-erbB ligands. Clin Exp Metastasis 1999 17 : 631 639.
44. O-charoenrat P, Rhys-Evans P, Modjtahedi H, Eccles SA. Vascular endothelial growth factor family members are differentially regulated by c-erbB signalling in head and neck squamous carcinoma cells. Clin Exp Metastasis 2000 2 : 155 161.
45. Suo Z, Risberg B, Kalsson MG, et al. EGFR family expression in breast carcinomas C-erbB-2 and c-erbB-4 receptors have different effects on survival. J Pathol 2002 196 : 17 25.
46. Witton CJ, Reeves JR, Going JJ, Cooke TG, Bartlett JM. Expression of the HER1-4 family of receptor tyrosine kinase in breast cancer. J Pathol 2003 200 : 290 297.
47. Lodge AJ, Anderson JJ, Gullick WJ, Haugk B, Leonard RC, Angus B. Type 1 growth factor receptor expression in node positive breast cancer: adverse prognostic significance of c-erbB-4. J Clin Pathol 2003 56 : 300 304.
48. Ulanovski D, Stern Y, Roizman P, Shpitzer T, Popovtzer A, Feinmesser R. Expression of EGFR and Cerb-B2 as prognostic factors in cancer of the tongue. Oral Oncol 2004 40 : 532 537.