Childhood maltreatment and stress-related psychopathology: The epigenetic memory hypothesis

Current Pharmaceutical Design

Volumn 21, Issue 11, 2015, Pages 1413-1417

  Lutz, Pierre Eric ^a   Almeida, Daniel ^a   Fiori, Laura M ^a   Turecki, Gustavo ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Childhood maltreatment; DNA methylation; Early life adversity; Epigenetics; Stress

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; SEROTONIN;

ARTICLE; CHILD ABUSE; CHILDHOOD MALTREATMENT; DNA DETERMINATION; DNA METHYLATION; EPIGENETICS; GENETIC ASSOCIATION; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MEMORY; MENTAL DISEASE; PRIORITY JOURNAL; RISK FACTOR; ADULT; ANIMAL; CHILD; CHILD ABUSE SURVIVOR; COMPLICATION; GENETIC EPIGENESIS; GENETICS; MENTAL DISORDERS; MENTAL STRESS; PATHOPHYSIOLOGY; PSYCHOLOGY;

ADULT; ADULT SURVIVORS OF CHILD ABUSE; ANIMALS; CHILD; CHILD ABUSE; DNA METHYLATION; EPIGENESIS, GENETIC; HUMANS; MENTAL DISORDERS; STRESS, PSYCHOLOGICAL;

EID: 84930985075     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612821666150105124928     Document Type: Article

References (63)

1. Gilbert R, Widom CS, Browne K, Fergusson D, Webb E, Janson S. Burden and consequences of child maltreatment in high-income countries. Lancet 2009; 373: 68-81.
2. Afifi TO, Enns MW, Cox BJ, Asmundson GJ, Stein MB, Sareen J. Population attributable fractions of psychiatric disorders and suicide ideation and attempts associated with adverse childhood experiences. Am J Public Health 2008; 98: 946-52.
3. Green JG, McLaughlin KA, Berglund PA, et al. Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disorders. Arch Gen Psychiatry 2010; 67: 113-23.
4. McLaughlin KA, Green JG, Gruber MJ, Sampson NA, Zaslavsky AM, Kessler RC. Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication II: associations with persistence of DSM-IV disorders. Arch Gen Psychiatry 2010; 67: 124-32.
5. Tyrka AR, Burgers DE, Philip NS, Price LH, Carpenter LL. The neurobiological correlates of childhood adversity and implications for treatment. Acta Psychiatr Scand 2013; 128: 434-47.
6. Tunnard C, Rane LJ, Wooderson SC, et al. The impact of childhood adversity on suicidality and clinical course in treatmentresistant depression. J Affect Disord 2014; 152-154: 122-30.
7. Klein DN, Arnow BA, Barkin JL, et al. Early adversity in chronic depression: clinical correlates and response to pharmacotherapy. Depress Anxiety 2009; 26: 701-10.
8. Du Rocher Schudlich T, Youngstrom EA, Martinez M, et al. Physical and Sexual Abuse and Early-Onset Bipolar Disorder in Youths Receiving Outpatient Services: Frequent, but Not Specific. J Abnorm Child Psychol 2014.
9. Tsankova N, Renthal W, Kumar A, Nestler EJ. Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci 2007; 8: 355-67.
10. Klose RJ, Bird AP. Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci 2006; 31: 89-97.
11. Bock C. Analysing and interpreting DNA methylation data. Nat Rev Genet 2012; 13: 705-19.
12. Plongthongkum N, Diep DH, Zhang K. Advances in the profiling of DNA modifications: cytosine methylation and beyond. Nat Rev Genet 2014; 15: 647-61.
13. Jones PA. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet 2012; 13: 484-92.
14. Heim C, Binder EB. Current research trends in early life stress and depression: review of human studies on sensitive periods, geneenvironment interactions, and epigenetics. Exp Neurol 2012; 233: 102-11.
15. Hertzman C. Putting the concept of biological embedding in historical perspective. Proc Natl Acad Sci USA 2012; 109 Suppl 2: 17160-7.
16. Lutz PE, Turecki G. DNA methylation and childhood maltreatment: from animal models to human studies. Neuroscience 2013; 264: 142-56.
17. Zhou Y, Lutz PE, Turecki G. Epigenetics of Suicidal Behavior. In Advancing the Science of Suicidal Behavior: Understanding and Intervention, Nova Science Publishers, Chapter 2: 21-40.
18. Zhang TY, Labonte B, Wen XL, Turecki G, Meaney MJ. Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans. Neuropsychopharmacology 2013; 38: 111-23.
19. Weaver IC, Cervoni N, Champagne FA, et al. Epigenetic programming by maternal behavior. Nat Neurosci 2004; 7: 847-54.
20. Heim C, Newport DJ, Heit S, et al. Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. JAMA 2000; 284: 592-7.
21. Frodl T, O'Keane V. How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans. Neurobiol Dis 2013; 52: 24-37.
22. McGowan PO, Sasaki A, D'Alessio AC, et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 2009; 12: 342-8.
23. Labonte B, Yerko V, Gross J, et al. Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse. Biol Psychiatry 2012; 72: 41-8.
24. Tyrka AR, Price LH, Marsit C, Walters OC, Carpenter LL. Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults. PLoS One 2012; 7: e30148.
25. Perroud N, Paoloni-Giacobino A, Prada P, et al. Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma. Transl Psychiatry 2011; 1: e59.
26. Turecki G. The epigenetic basis of behavioral phenotypes: is there reason for continued optimism? Depress Anxiety 2013; 30: 1147- 50.
27. Melas PA, Wei Y, Wong CC, et al. Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities. Int J Neuropsychopharmacol 2013; 16: 1513-28.
28. Binder EB, Bradley RG, Liu W, et al. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA 2008; 299: 1291-305.
29. Roy A, Gorodetsky E, Yuan Q, Goldman D, Enoch MA. Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide. Neuropsychopharmacology 2010; 35: 1674-83.
30. Appel K, Schwahn C, Mahler J, et al. Moderation of adult depression by a polymorphism in the FKBP5 gene and childhood physical abuse in the general population. Neuropsychopharmacology 2011; 36: 1982-91.
31. Klengel T, Mehta D, Anacker C, et al. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat Neurosci 2013; 16: 33-41.
32. Caspi A, Sugden K, Moffitt TE, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003; 301: 386-9.
33. Surtees PG, Wainwright NW, Willis-Owen SA, Luben R, Day NE, Flint J. Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. Biol Psychiatry 2006; 59: 224-9.
34. Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE. Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 2010; 167: 509-27.
35. Beach SR, Brody GH, Todorov AA, Gunter TD, Philibert RA. Methylation at SLC6A4 is linked to family history of child abuse: an examination of the Iowa Adoptee sample. Am J Med Genet B Neuropsychiatr Genet 2010; 153B: 710-3.
36. Beach SR, Brody GH, Todorov AA, Gunter TD, Philibert RA. Methylation at 5HTT mediates the impact of child sex abuse on women's antisocial behavior: an examination of the Iowa adoptee sample. Psychosom Med 2011; 73: 83-7.
37. Beach SR, Brody GH, Lei MK, et al. Impact of child sex abuse on adult psychopathology: A genetically and epigenetically informed investigation. J Fam Psychol 2013; 27: 3-11.
38. Vijayendran M, Beach SR, Plume JM, Brody GH, Philibert RA. Effects of genotype and child abuse on DNA methylation and gene expression at the serotonin transporter. Front Psychiatry 2012; 3: 55.
39. Kang HJ, Kim JM, Stewart R, et al. Association of SLC6A4 methylation with early adversity, characteristics and outcomes in depression. Prog Neuropsychopharmacol Biol Psychiatry 2013; 44: 23-8.
40. Wang D, Szyf M, Benkelfat C, et al. Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression. PLoS One 2012; 7: e39501.
41. Martinowich K, Lu B. Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology 2008; 33: 73-83.
42. Comasco E, Aslund C, Oreland L, Nilsson KW. Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression: a replication study. Eur Neuropsychopharmacol 2013; 23: 1300-6.
43. Tortorella A, Brambilla F, Fabrazzo M, et al. Central and peripheral peptides regulating eating behaviour and energy homeostasis in anorexia nervosa and bulimia nervosa: a literature review. Eur Eat Disord Rev 2014; 22: 307-20.
44. Thaler L, Gauvin L, Joober R, et al. Methylation of BDNF in women with bulimic eating syndromes: Associations with childhood abuse and borderline personality disorder. Prog Neuropsychopharmacol Biol Psychiatry 2014; 54C: 43-49.
45. Groleau P, Joober R, Israel M, Zeramdini N, DeGuzman R, Steiger H. Methylation of the dopamine D2 receptor (DRD2) gene promoter in women with a bulimia-spectrum disorder: associations with borderline personality disorder and exposure to childhood abuse. J Psychiatr Res 2014; 48: 121-7.
46. Perroud N, Salzmann A, Prada P, et al. Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene. Transl Psychiatry 2013; 3: e207.
47. Suderman M, McGowan PO, Sasaki A, et al. Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus. Proceedings of the National Academy of Sciences of the United States of America 2012; 109 Suppl 2: 17266-72.
48. Labonte B, Suderman M, Maussion G, et al. Genome-wide epigenetic regulation by early-life trauma. Arch Gen Psychiatry 2012; 69: 722-31.
49. Naumova OY, Lee M, Koposov R, Szyf M, Dozier M, Grigorenko EL. Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents. Dev Psychopathol 2012; 24: 143-55.
50. Yang BZ, Zhang H, Ge W, et al. Child abuse and epigenetic mechanisms of disease risk. Am J Prev Med 2013; 44: 101-7.
51. Weder N, Zhang H, Jensen K, et al. Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry. J Am Acad Child Adolesc Psychiatry 2014; 53: 417-24 e5.
52. Essex MJ, Boyce WT, Hertzman C, et al. Epigenetic vestiges of early developmental adversity: childhood stress exposure and DNA methylation in adolescence. Child Dev 2013; 84: 58-75.
53. Suderman M, Borghol N, Pappas JJ, et al. Childhood abuse is associated with methylation of multiple loci in adult DNA. BMC Med Genomics 2014; 7: 13.
54. Mehta D, Klengel T, Conneely KN, et al. Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder. Proc Natl Acad Sci USA 2013; 110: 8302-7.
55. Zhang H, Wang F, Kranzler HR, Zhao H, Gelernter J. Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls. PLoS One 2013; 8: e65648.
56. Heim CM, Mayberg HS, Mletzko T, Nemeroff CB, Pruessner JC. Decreased cortical representation of genital somatosensory field after childhood sexual abuse. Am J Psychiatry 2013; 170: 616-23.
57. Murgatroyd C, Patchev AV, Wu Y, et al. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci 2009; 12: 1559-66.
58. Mellen M, Ayata P, Dewell S, Kriaucionis S, Heintz N. MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System. Cell 2012; 151: 1417-30.
59. Lister R, Mukamel EA, Nery JR, et al. Global epigenomic reconfiguration during mammalian brain development. Science 2013; 341: 1237905.
60. Tylee DS, Kawaguchi DM, Glatt SJ. On the outside, looking in: a review and evaluation of the comparability of blood and brain "- omes". Am J Med Genet B Neuropsychiatr Genet 2013; 162B: 595- 603.
61. Aberg KA, McClay JL, Nerella S, et al. Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults. JAMA Psychiatry 2014; 71: 255-64.
62. Provencal N, Suderman MJ, Guillemin C, et al. The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. J Neurosci 2012; 32: 15626-42.
63. Davies MN, Volta M, Pidsley R, et al. Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol 2012; 13: R43.