Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts

Toxicology in Vitro

Volumn 29, Issue 1, 2015, Pages 34-43

  Krais, Annette M ^a   Mühlbauer, Karl Rudolf ^b   Kucab, Jill E ^a   Chinbuah, Helena ^a   Cornelius, Michael G ^b   Wei, Quan Xiang ^b   Hollstein, Monica ^b,c   Phillips, David H ^a   Arlt, Volker M ^a   Schmeiser, Heinz H ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

Carcinogen activation; Cytochrome P450; DNA adduct formation; Mouse embryonic fibroblasts; Mouse embryonic stem cells; NADP(H)quinone oxidoreductase

Indexed keywords

3 NITROBENZANTHRONE; ARISTOLOCHIC ACID; BENZO[A]PYRENE; PHOSPHORUS 32; PROTEIN P21; PROTEIN P53; 3-NITROBENZANTHRONE; ARISTOLOCHIC ACID I; BENZ[A]ANTHRACENE DERIVATIVE; CARCINOGEN; DNA ADDUCT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL AGING; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CHEMICAL STRUCTURE; CHROMATIN; CONTROLLED STUDY; CYP1A1 GENE; DNA BINDING; DNA DAMAGE; EMBRYO; FIBROBLAST; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; ISOTOPE LABELING; METABOLIC ACTIVATION; METHYLATION; MOUSE; MOUSE EMBRYONIC STEM CELL; NONHUMAN; NQO1 GENE; POINT MUTATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANALYSIS; ANIMAL; C57BL MOUSE; COMPARATIVE STUDY; DNA ADDUCT; DNA METHYLATION; DRUG EFFECTS; EMBRYONIC STEM CELL; GENE EXPRESSION PROFILING; METABOLISM;

ANIMALS; ARISTOLOCHIC ACIDS; BENZ(A)ANTHRACENES; BENZO(A)PYRENE; BLOTTING, WESTERN; CARCINOGENS, ENVIRONMENTAL; DNA ADDUCTS; DNA METHYLATION; EMBRYONIC STEM CELLS; FIBROBLASTS; GENE EXPRESSION PROFILING; MICE; MICE, INBRED C57BL; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84930982021     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2014.09.004     Document Type: Article

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