Metabolic activation of diesel exhaust carcinogens in primary and immortalized human TP53 knock-in (Hupki) mouse embryo fibroblasts

Environmental and Molecular Mutagenesis

Volumn 53, Issue 3, 2012, Pages 207-217

  Kucab, Jill E ^a,b   Phillips, David H ^a,b   Arlt, Volker M ^a,b  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

DNA adducts; Hupki; Immortalization; Metabolism; Nitro polycyclic aromatic hydrocarbons; TP53

Indexed keywords

1 NITROPYRENE; 1,3 DINITROPYRENE; 1,6 DINITROPYRENE; 1,8 DINITROPYRENE; 3 NITROBENZANTHRONE; 3 NITROFLUORENE; 6 NITROCHRYSENE; BENZO[A]PYRENE; CARCINOGEN; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; POLYCYCLIC AROMATIC COMPOUND; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL IMMORTALIZATION; CELL VIABILITY; COMET ASSAY; DNA ADDUCT; DNA DAMAGE; EMBRYO; EXHAUST GAS; FIBROBLAST; GENE EXPRESSION; GENOTOXICITY; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; METABOLIC ACTIVATION; MOUSE; MUTAGENESIS; NONHUMAN; PROTEIN EXPRESSION; WILD TYPE;

AIR POLLUTANTS; ANIMALS; BIOTRANSFORMATION; CARCINOGENS, ENVIRONMENTAL; CELL LINE; DNA ADDUCTS; EMBRYO, MAMMALIAN; FIBROBLASTS; GENE KNOCK-IN TECHNIQUES; HUMANS; MICE; MUTAGENICITY TESTS; NITRO COMPOUNDS; POLYCYCLIC HYDROCARBONS, AROMATIC; TUMOR SUPPRESSOR PROTEIN P53; VEHICLE EMISSIONS;

EID: 84857798304     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.21679     Document Type: Article

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