TLR2 Signaling Decreases Transmission of Streptococcus pneumoniae by Limiting Bacterial Shedding in an Infant Mouse Influenza A Co-infection Model

PLoS Pathogens

Volumn 10, Issue 8, 2014, Pages

  Richard, Aimee L ^a   Siegel, Steven J ^a   Erikson, Jan ^b   Weiser, Jeffrey N ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CD11B ANTIGEN; CD4 ANTIGEN; TOLL LIKE RECEPTOR 2; TLR2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL SHEDDING; CELL COUNT; CONTROLLED STUDY; DISEASE TRANSMISSION; FEMALE; FLOW CYTOMETRY; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOFLUORESCENCE TEST; INFANT; INFLAMMATION; INFLUENZA A; INFLUENZA A VIRUS; INNATE IMMUNITY; INTRACELLULAR SIGNALING; MALE; MIXED INFECTION; MOUSE; NASAL LAVAGE FLUID; NASOPHARYNX; NEUTROPHIL; NONHUMAN; PNEUMOCOCCAL INFECTION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; STREPTOCOCCUS PNEUMONIAE; VIRUS LOAD; ANIMAL; C57BL MOUSE; COMPLICATION; DISEASE MODEL; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOLOGY; INFLUENZA VIRUS A; KNOCKOUT MOUSE; METABOLISM; NEWBORN; ORTHOMYXOVIRUS INFECTION; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSMISSION;

ANIMALS; ANIMALS, NEWBORN; BACTERIAL SHEDDING; COINFECTION; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; INFLUENZA A VIRUS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORTHOMYXOVIRIDAE INFECTIONS; PNEUMOCOCCAL INFECTIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIAE; TOLL-LIKE RECEPTOR 2;

EID: 84930981924     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004339     Document Type: Article

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