Up-regulation of MUC5AC and MUC5B mucin genes in chronic rhinosinusitis

Archives of Otolaryngology - Head and Neck Surgery

Volumn 130, Issue 6, 2004, Pages 747-752

  Kim, Dae Hoon ^a   Chu, Ho Suk ^a   Lee, Jin Young ^a   Hwang, Soon Jae ^a   Lee, Sang Hag ^a   Lee, Heung Man ^a,b  

^a Korea University College of Medicine   (South Korea)

^b Korea University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MUCIN 5AC; MUCIN 5B;

ADULT; ARTICLE; CELL HYPERPLASIA; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; FEMALE; GENE CONTROL; GOBLET CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MUCUS; MUCUS SECRETION; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RHINOSINUSITIS;

ADULT; CASE-CONTROL STUDIES; FEMALE; HUMANS; MALE; MAXILLARY SINUS; MIDDLE AGED; MUCINS; NASAL MUCOSA; RHINITIS; RNA, MESSENGER; SINUSITIS; UP-REGULATION;

EID: 2642588322     PISSN: 08864470     EISSN: None     Source Type: Journal    
DOI: 10.1001/archotol.130.6.747     Document Type: Article

References (23)

1. Voynow JA. What does mucin have to do with lung disease? Paediatr Respir Rev. 2002;3:98-103.
2. Hovenberg HW, Davies JR, Herrmann A, Linden CJ, Carlstedt I. MUC5AC, but not MUC2, is a prominent mucin in respiratory secretions. Glycoconj J. 1996;13:839-847.
3. Thornton DJ, Carlstedt I, Howard M, Devine PL, Price MR, Sheehan JK. Respiratory mucins: identification of core proteins and glycoforms. Biochem J. 1996;316:967-975.
4. Thornton DJ, Howard M, Khan N, Sheehan JK. Identification of two glycoforms of the MUC5B mucin in human respiratory mucus: evidence for a cysteine-rich sequence repeated within the molecule. J Biol Chem. 1997;272:9561-9566.
5. Majima Y, Sakakura Y, Matsubara T, Miyoshi Y. Possible mechanisms of reduction of nasal mucociliary clearance in chronic sinusitis. Clin Otolaryngol. 1986;11:55-60.
6. Groneberg DA, Eynott PR, Lim S, et al. Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Histopathology. 2002;40:367-373.
7. Voynow JA, Selby DM, Rose MC. Mucin gene expression (MUC1, MUC2, and MUC5/5AC) in nasal epithelial cells of cystic fibrosis, allergic rhinitis, and normal individuals. Lung. 1998;176:345-354.
8. Ashraf N, Bhattacharyya N. Determination of the "incidental" Lund score for the staging of chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2001;125:483-486.
9. Groneberg DA, Peiser C, Dinh QT, et al. Distribution of respiratory mucin proteins in human nasal mucosa. Laryngoscope. 2003;113:520-524.
10. Li JD, Feng W, Gallup M, et al. Activation of NF-kappaB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells. Proc Natl Acad Sci U S A. 1998;95:5718-5723.
11. Borchers MT, Carty MP, Leikauf GD. Regulation of human airway mucins by acrolein and inflammatory mediators. Am J Physiol. 1999;276:L549-L555.
12. Kim CH, Song KS, Kim SS, Kim HU, Seong JK, Yoon JH. Expression of MUC5AC m RNA in the goblet cells of human nasal mucosa. Laryngoscope. 2000;110:2110-2113.
13. Leikauf GD, Borchers MT, Prows DR, Simpson LG. Mucin apoprotein expression in COPD. Chest. 2002;121:166S-182S.
14. Davies JR, Svitacheva N, Lannefors L, Kornfalt R, Carlstedt I. Identification of MUC5B, MUC5AC and small amounts of MUC2 mucins in cystic fibrosis airway secretions. Biochem J. 1999;344:321-330.
15. Wickstrom C, Davies JR, Eriksen GV, Veerman EC, Carlstedt I. MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: identification of glycoforms and C-terminal cleavage. Biochem J. 1998;334:685-693.
16. Basbaum C, Lemjabbar H, Longphre M, Li D, Gensch E, McNamara N. Control of mucin transcription by diverse injury-induced signaling pathways. Am J Respir Crit Care Med. 1999;160:S44-S48.
17. Takeyama K, Dabbagh K, Jeong Shim J, Dao-Pick T, Ueki IF, Nadel JA. Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. J Immunol. 2000;164:1546-1552.
18. Audie JP, Janin A, Porchet N, Copin MC, Gosselin B, Aubert JP. Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization. J Histochem Cytochem. 1993;41:1479-1485.
19. Kawano H, Paparella MM, Ho SB, et al. Identification of MUC5B mucin gene in human middle ear with chronic otitis media. Laryngoscope. 2000;110:668-673.
20. All MS, Wilson JA, Pearson JP. Mixed nasal mucus as a model for sinus mucin gene expression studies. Laryngoscope. 2002;112:326-331.
21. Sheehan JK, Howard M, Richardson PS, Longwill T, Thornton DJ. Physical characterization of a low-charge glycoform of the MUC5B mucin comprising the gelphase of an asthmatic respiratory mucous plug. Biochem J. 1999;338:507-513.
22. Ordonez CL, Khashayar R, Wong HH, et al. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med. 2001;163:517-523.
23. Jung HH, Lee JH, Kim YT, Lee SD, Park JH. Expression of mucin genes in chronic ethmoiditis. Am J Rhinol. 2000;14:63-70.