Intranasal administration of the TLR2 agonist pam2Cys provides rapid protection against influenza in mice

Molecular Pharmaceutics

Volumn 9, Issue 9, 2012, Pages 2710-2718

  Tan, Amabel C L ^a   Mifsud, Edin J ^a   Zeng, Weiguang ^a   Edenborough, Kathryn ^a   McVernon, Jodie ^b   Brown, Lorena E ^a   Jackson, David C ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

antigen independent immunity; influenza A virus; innate immunity; Pam2Cys; Toll like receptor 2

Indexed keywords

DIPALMITOYL GLYCERYL CYSTEINE; GAMMA INTERFERON; IMMUNOSTIMULATING AGENT; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CYTOKINE RELEASE; DISEASE TRANSMISSION; FEMALE; IMMUNOSTIMULATION; INFLAMMATION; INFLUENZA; INFLUENZA VIRUS A; INNATE IMMUNITY; MACROPHAGE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; VIRUS RESISTANCE; WEIGHT REDUCTION;

ADAPTIVE IMMUNITY; ADMINISTRATION, INTRANASAL; ANIMALS; ANTIVIRAL AGENTS; CD8-POSITIVE T-LYMPHOCYTES; CHEMOKINE CCL2; FEMALE; IMMUNITY, INNATE; INFLAMMATION; INFLUENZA A VIRUS; INTERFERON-GAMMA; INTERLEUKINS; LIPOPEPTIDES; LUNG; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUTROPHILS; ORTHOMYXOVIRIDAE INFECTIONS; TOLL-LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84865967870     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300257x     Document Type: Article

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